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Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Published by Universitas Ma Chung
ISSN : 29868270     EISSN : 29865972     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Pharmaceutical Technology Pharmacology and Toxicology Pharmaceutical Chemistry Drug Discovery Pharmacokinetics Pharmaceutical Biology Herbal Medicine Pharmaceuticals Pharmaceutical Microbiology and Biotechnology Clinical and Community Pharmaceutical Management Pharmaceutical Bioinformatics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 76 Documents
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The Impact of Educational Intervention on Public Knowledge Regarding Fenugreek Seeds (Trigonella foenum-graecum L.) as a Galactagogue Supplement in Cibening Village Shalsa Dewinta Fani; Varda Arianty; Amalina Fakhriah
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.179

Abstract

Fenugreek seeds (Trigonella foenum-graecum L.) are an herbal plant that has long been used as a natural supplement to boost the production of breast milk. This plant has active ingredients like flavonoids, saponins, and phytoestrogens that help nursing moms produce more prolactin. The lack of public knowledge regarding the use of natural ingredients, especially fenugreek seeds as a lactation supplement, is one of the reasons for the need for further education. The aim of this study is to ascertain how education affects public awareness of the use of fenugreek seeds as a supplement to boost breast milk production. The quantitative descriptive study conducted used a one-group pretest-posttest method. A total of 62 respondents were selected using purposive sampling. The data collection instrument was a questionnaire administered before and after the educational intervention. Data normality was assessed using the Kolmogorov-Smirnov test; based on the distribution, a Wilcoxon signed-rank test for non-normal data. The results of the study using the Wilcoxon test showed an increase in respondents' knowledge after education, indicating a statistically significant difference in knowledge levels before and after the educational intervention, with a p-value of 0.000 (p < 0.001). In addition, the N-Gain test results showed an average knowledge increase of 0.96, which falls into the high category. Thus, education has been proven to increase public knowledge about the use of fenugreek seeds as a supplement to enhance breast-milk production.
Service Quality and Patient Loyalty: Roles of Satisfaction and Customer Relationship Management Ayi Sanego; Jason Merari Peranginangin; Lucia Vita Inandha Dewi
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.182

Abstract

Service quality is a key factor in enhancing patient satisfaction and loyalty toward hospital pharmacy services. In addition, the implementation of Customer Relationship Management (CRM) plays a role in building long-term relationships between patients and hospitals. This study aims to analyze the effect of service quality on patient loyalty at the Pharmacy Department of X Hospital in Surakarta, with patient satisfaction and the implementation of CRM serving as mediating variables. The study employed a quantitative design with a cross-sectional approach. A total of 240 respondents were selected using purposive sampling. Data were collected via a questionnaire that had passed validity and reliability tests, then analyzed using Generalized Structured Component Analysis (GSCA) based on estimated values and 95% Confidence Intervals (CI). The results of the study indicate that service quality has a positive effect on patient loyalty (estimate = 0.272; 95% CI = 0.085–0.413) and patient satisfaction (estimate = 0.213; 95% CI = 0.083–0.389), and hurts CRM implementation (estimate = -0.135; 95% CI = -0.309 to -0.018). CRM (estimate = 0.200; 95% CI = 0.102–0.336) and patient satisfaction (estimate = 0.212; 95% CI = 0.055–0.348) have a positive effect on patient loyalty. Then, the mediation analysis revealed that patient satisfaction and Customer Relationship Management (CRM) did not mediate the relationship between service quality and patient loyalty, as all indirect effects had confidence intervals that included zero. Therefore, service quality exerted a direct contribution to patient loyalty.
Evaluation of HAM and LASA Medication Management: Alignment Between Standards, Procedures, and Practice Nelly Kurniawati; Tarsisius Jemading; Abraham Christian MacArthur Lameng; Fransiskus Xaverius Lameng
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.183

Abstract

Medication errors are an important patient safety concern that can occur at various stages of the medication-use process and result in preventable harm. This study aimed to evaluate High-Alert Medication (HAM) and Look-Alike Sound-Alike (LASA) medication management at RSUD dr. T.C. Hillers Maumere by assessing medication-list concordance, compliance with applicable STARKES 2024 and hospital SOP requirements, and item-level and process-level gaps. A descriptive observational study with an evaluative approach was conducted through document review and direct observation at the Pharmacy Department, emergency trolley, Operating Room, and Intensive Care Unit (ICU) in July 2026. Of the 10 medication-safety indicators assessed according to STARKES 2024, 7 (70.0%) were compliant. The main gaps included the absence of periodic HAM list updating, inconsistent HAM and LASA management across hospital service area, particularly in the emergency trolley, and non-compliance with concentrated electrolyte storage requirements in the Operating Room and ICU. Among 39 observed HAM items, labeling on outer packaging and medication containers achieved 100% compliance, while storage compliance was 32/39 (82.1%). Among 104 LASA items, LASA labeling and physical separation achieved 100% compliance, whereas Tall Man Lettering was applied to 29/94 sound-alike items (30.9%). Neostigmine was included in the hospital HAM list but not in the ISMP reference list. Overall, HAM and LASA management practices assessed at the study sites were generally well implemented, but periodic, risk based evaluation and updating of the HAM and LASA lists are needed to ensure that medication safety practices remain aligned with actual risks.
D-Optimal Mixture Design Optimization of Curcumin SNEDDS and Its Development into an Antioxidant Gel Emmelia Yunitha; Ilham Kuncahyo; Nuraini Harmastuti
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.185

Abstract

Curcumin is a natural polyphenol with high antioxidant capacity, but its topical use is restricted by poor aqueous solubility, low stability and limited skin permeability. This study developed a curcumin self-nanoemulsifying drug delivery system (SNEDDS), optimised its composition with a D-optimal mixture design, and incorporated the optimum system into a hydrogel. Isopropyl myristate (IPM, 10–20%), Cremophor RH 40 (40–70%) and Transcutol P (10–40%) served as the oil, surfactant and co-surfactant. Sixteen design runs were characterised for droplet size, emulsification time, transmittance, drug loading, polydispersity index and zeta potential; models were fitted in Design-Expert 13 and the optimum composition was selected using the desirability function. All six response models were significant (p<0.05) with a non-significant lack of fit (p>0.05). The optimum composition was IPM 19.91%, Cremophor RH 40 70.00% and Transcutol P 10.08% (desirability 0.777), giving a droplet size of 44.25 nm, an emulsification time of 32.64 s, a transmittance of 93.20%, a drug loading of 22.84 mg/mL and a zeta potential of −12.66 mV, with no significant difference from the predicted values (p>0.05). The resulting gel was homogeneous, with pH 5.14±0.02, viscosity 26,330±1.54 cP, adhesion 5.95±0.47 s and spreadability 5.66±0.03 cm, and remained stable over six freeze–thaw cycles. DPPH assay gave an IC₅₀ of 8.73±0.004 µg/mL (AAI 4.52) for the SNEDDS gel versus 12.62±0.033 µg/mL (AAI 3.13) for the conventional gel. Franz diffusion showed a 49.1% higher flux and 79.3% higher cumulative diffusion at 120 min for the SNEDDS gel.
Optimized Resveratrol-Loaded SNEDDS Gel Enhances Antioxidant Activity and In Vitro Release Shella Pradina Pradina; Ilham Kuncahyo; Nuraini Harmastuti
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.187

Abstract

Resveratrol is a potent polyphenolic antioxidant with poor aqueous solubility and light sensitivity, which limit its topical application. This study developed and optimized a resveratrol self-nanoemulsifying drug delivery system (SNEDDS), incorporated the optimized system into a gel, and compared its physical characteristics, antioxidant activity, and in vitro release with those of a conventional resveratrol gel. A 16-run D-optimal mixture design was employed using virgin coconut oil (10–20%), Tween 80 (50–80%), and polyethylene glycol 400 (10–30%) as the oil, surfactant, and co-surfactant. The optimized composition consisted of 13.8131% virgin coconut oil, 61.7834% Tween 80, and 24.4036% polyethylene glycol 400, with a desirability value of 0.829. Experimental verification yielded a droplet size of 15.23 nm, emulsification time of 8.12 s, transmittance of 99.63%, drug loading of 46.51 mg/mL, polydispersity index of 0.157, and zeta potential of −11.77 mV, with no significant differences from the predicted values (p>0.05). The optimized SNEDDS gel exhibited good homogeneity and physical stability. DPPH radical-scavenging activity was stronger for the SNEDDS gel than for the conventional resveratrol gel, with IC₅₀ values of 7.25±0.02 and 9.01±0.03 µg/mL and antioxidant activity indices of 5.45±0.012 and 4.38±0.013, respectively. At 120 min, cumulative resveratrol release reached 155.28 µg/cm² (62.11%) for the SNEDDS gel compared with 134.35 µg/cm² (53.74%) for the conventional gel, representing a 15.6% higher release (p=0.046). Overall, the optimized SNEDDS gel enhanced antioxidant activity and in vitro release, demonstrating potential for improved topical resveratrol delivery.
Cost-Effectiveness of Sodium Hyaluronate versus Carboxymethylcellulose in Patients with Dry Eye Disease Following Cataract Surgery Rodhi Anshari; Tri Murti Andayani; Jason Merari Peranginangin
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.190

Abstract

Dry eye disease is a common complication after cataract surgery and often requires artificial tear therapy to alleviate symptoms and improve tear film function. This study aimed to analyse the cost-effectiveness of sodium hyaluronate and carboxymethylcellulose in patients with dry eye following cataract surgery. This study provides clinical and economic evidence to support the selection of effective and efficient artificial tear therapy. A prospective cohort analytical observational design with a Cost-Effectiveness Analysis (CEA) approach was conducted from the healthcare provider perspective. The observation period was 14 days. A total of 151 patients met the inclusion criteria, comprising 71 patients receiving sodium hyaluronate and 80 receiving carboxymethylcellulose. Cost-effectiveness was evaluated using the average cost-effectiveness ratio (ACER), incremental cost-effectiveness ratio (ICER), and one-way sensitivity analysis, with the Schirmer test as the main effectiveness parameter. Sodium hyaluronate demonstrated greater effectiveness than carboxymethylcellulose, with a reduction of 6.7 points in DEQ-5 score, a symptom-free duration of 10.23 days, and an increase of 3.0 mm in Schirmer test values. Based on the Schirmer test, the ACER was IDR 119,305 for carboxymethylcellulose and IDR 128,900 for sodium hyaluronate. The ICER showed that sodium hyaluronate required an additional cost of IDR 176,870 to obtain one additional 1 mm improvement in Schirmer test value compared with carboxymethylcellulose. One-way sensitivity analysis showed that changes in effectiveness had a greater influence on the ICER than changes in cost. Sodium hyaluronate therefore provided greater effectiveness but required higher costs than carboxymethylcellulose.

Page 8 of 8 | Total Record : 76

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