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Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Published by Universitas Ma Chung
ISSN : 29868270     EISSN : 29865972     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Pharmaceutical Technology Pharmacology and Toxicology Pharmaceutical Chemistry Drug Discovery Pharmacokinetics Pharmaceutical Biology Herbal Medicine Pharmaceuticals Pharmaceutical Microbiology and Biotechnology Clinical and Community Pharmaceutical Management Pharmaceutical Bioinformatics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 76 Documents
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Clinical Significance of the Potential Amlodipine–Metformin Interaction: A Systematic Review Yusna Fadliyyah Apriyanti; Rizki Oktarini; Yona Harianti Putri
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.120

Abstract

Amlodipine and metformin are frequently co-administered in patients with hypertension and type 2 diabetes mellitus (T2DM). Although their concomitant use has been identified as a potential drug–drug interaction (pDDI), the clinical significance of this interaction remains uncertain. This systematic review aimed to evaluate the frequency, severity, proposed mechanism, and clinical significance of the potential interaction between amlodipine and metformin. A comprehensive literature search was conducted using PubMed, ScienceDirect and supplementary searches through Google Scholar with the keywords “amlodipine” AND “metformin” AND “drug interaction”. Study selection was conducted according to the PRISMA framework. Methodological quality was assessed using the appropriate Joanna Briggs Institute (JBI) Critical Appraisal Tools according to the design of each study. A total of 702 records were identified, 42 full-text articles were assessed for eligibility, and seven studies met the inclusion criteria and were included in the final narrative synthesis. Concomitant amlodipine and metformin use was consistently identified as a potential DDI, although the reported frequency varied across studies and was based on different reporting units, including patients, prescriptions, and total identified DDI events. The interaction was generally classified as moderate or requiring monitoring, with pharmacodynamic antagonism and a potential reduction in metformin effectiveness being the most frequently reported interaction profile. Current evidence demonstrates a recurring potential interaction signal between amlodipine and metformin but does not establish that concomitant use causes clinically meaningful deterioration in glycemic control
Analysis of Drug Receiving Procedures in Hospital Pharmacy Services to Ensure Optimal Service Quality Rully Fidayatul Akhmad Syah Putri; M. Ibnu Fateh; Aulia Fauziah Bening Hanani; Nurika Sofiani; Adinugraha Amarullah; Puspita Raras Anindita; Gladis Jingga Agnesia
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.151

Abstract

Drug receiving in hospital pharmacy installations is an initial stage of quality control that plays an important role in ensuring the availability, efficiency, and quality of pharmaceutical services, as it involves administrative and physical verification before medicines are stored and distributed. This study aims to analyze the pattern of drug receiving and identify common challenges in hospital pharmacy practice. The method used was a literature review of studies published between 2020 and 2026, predominantly employing descriptive qualitative designs, with data collected through observation, in-depth interviews, checklists, and questionnaires, and compared with hospital pharmaceutical service standards. The results indicate that the drug receiving process generally complies with standard operating procedures, including verification of drug type and quantity, batch number, expiration date, packaging condition, distributor validation, as well as proper documentation for traceability. Some healthcare facilities achieved compliance levels of up to 100%. However, several challenges remain, such as discrepancies in delivered medicines, damaged packaging, short expiration dates, limited human resources, delays from suppliers, and suboptimal information systems. Therefore, improvements in quality control, accuracy, and information system integration are necessary to support optimal and sustainable pharmaceutical services.
Physicochemical Characteristics, Calcium Content, and Storage Stability of Anchovy (Stolephorus commersonnii) Extract Gummy Candies Ema Hermawati; Dian Farida Ismyama; Marybet Tri Retno Handayani; Nova Intan Putri; Ricky alfandy rachman; Fahira Fitriani mansu; Nisa futri Yani
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.169

Abstract

Calcium is an essential micronutrient for bone growth and development during childhood. Anchovy (Stolephorus commersonnii) is a local marine resource containing calcium and protein and may be incorporated into food products. This study aimed to evaluate the physicochemical characteristics, calcium content and proximate composition, microbiological quality, heavy metal contamination, and storage stability of anchovy extract gummy candies. Anchovy powder was prepared by drying and milling, followed by aqueous maceration extraction. Gummy candies were formulated using gelatin and taro starch as gelling agents. Five formulations were prepared, and the formulation with the most favorable physical characteristics was selected for further evaluation. The selected formulation contained 25% gelatin and 7.5% taro starch and exhibited a chewy texture, acceptable aroma, and pH of 4.7. The product remained physically stable during 14 days of refrigerated storage at 8–15°C, whereas softening, liquefaction, and fungal growth were observed at room and elevated temperatures. Proximate analysis showed moisture content of 54.42–54.68%, protein content of 31.68–31.96%, carbohydrate content of 13.01%, ash content of 0.61–0.63%, and calcium content of 28.15–28.44 mg/100 g. Lead and mercury were not detected, while total plate count and yeast and mold counts were within the applicable limits under the tested conditions. These findings demonstrate the feasibility of incorporating anchovy extract into a gummy candy matrix with measurable calcium and protein content; however, further optimization is required to increase calcium content and improve stability at room temperature.
Evaluation of Antihypertensive Drug Use on Therapy Effectiveness Based on Patient Characteristics and Adverse Drug Reactions Primasti Adelia Ciptaningrum; Godeliva Adriani Hendra; Rodhi Anshari
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.159

Abstract

Hypertension is a chronic disease that requires long-term management to prevent cardiovascular complications, and antihypertensive therapy success is influenced by both patient characteristics and drug safety. This study aimed to describe patient characteristics, antihypertensive drug use, adverse drug reactions, and treatment effectiveness among outpatients at Baptis Batu Hospital. An analytical observational study with a prospective cross-sectional design was conducted using purposive sampling, yielding 95 eligible patients. Data were obtained from medical records and structured interviews; ADRs were assessed using the Naranjo Algorithm and Therapy effectiveness was defined as a reduction in blood pressure of ≥20/10 mmHg based on the PERHI (2021) criteria. Data were analyzed descriptively and using the Chi-Square test (α = 0.05). Most patients were female (67.4%), aged < 65 years (58.9%), receiving combination therapy (76.8%), and experiencing polypharmacy (65.3%), with amlodipine and candesartan the most frequently prescribed combination. Therapy was effective in 71 patients (74.7%), and ADRs occurred in 33 patients (34.7%). ADR occurrence was significantly associated with therapy effectiveness (p = 0.002). The study described patient characteristics, antihypertensive drug use, ADR occurrence, and therapy effectiveness among outpatients at Baptis Batu Hospital. ADR occurrence was significantly associated with therapy effectiveness (p = 0.002). These findings support individualized antihypertensive treatment and continuous ADR monitoring to optimize therapy effectiveness and safety.
Review Article : Evaluation of Drug Storage Systems in Indonesian Hospital Pharmacy Installations Based on the Minister of Health No.72 of 2016 Annisa Khoiruna; Anggi Dhamayanti; Rr. Aulifia Sari Hersyah Putri; Salwa Arumita Zeintoro; Zelia Anjeli Arum Putri; Adinugraha Amarullah; Puspita Raras Anindita
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.170

Abstract

In hospital-based pharmaceutical care, the Hospital Pharmacy Installation (HPI) is responsible for maintaining appropriate drug-storage conditions and supporting the safety of pharmaceutical services. Proper storage practices are necessary to preserve medication quality and ensure patient safety and availability. This review was conducted to examine drug storage practices in Indonesian hospital pharmacy installations based on previous studies, with particular emphasis on compliance with pharmaceutical service standards, FIFO and FEFO implementation, High-Alert and LASA medication management, environmental controls, and storage infrastructure. A comparative review was conducted using 10 research articles selected from 25 potentially relevant articles identified through Google Scholar. The articles were screened based on their relevance to drug storage systems in Indonesian hospital pharmacy installations and selected according to predetermined inclusion and exclusion criteria. The findings indicate that most hospitals have implemented FIFO and FEFO principles, organized medications according to their type and dosage form, and applied appropriate storage practices for High-Alert and LASA medications. However, several gaps remain, particularly in storage facilities, temperature and humidity monitoring, storage security, and inventory documentation. Overall, effective drug storage management requires not only compliance with established procedures but also adequate infrastructure, environmental monitoring, security systems, and continuous supervision. Periodic evaluation and staff adherence to standard operating procedures are therefore needed to support consistent compliance with pharmaceutical service standards and patient safety.
Study Study In Silico, Synthesis and Analgesic Activity Test of N-Benzoyl-N'-4-Methoxyphenylthiourea Compound in Mus musculus Aulia Juwanti; Rakhmadani Gadis; Alya Maharani; Intan Anggraini
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.173

Abstract

Pain is an unpleasant sensory and emotional experience resulting from actual or potential tissue damage and is the most common reason individuals seek health care. Nonsteroidal anti-inflammatory drugs (NSAIDs), which act through cyclooxygenase inhibition, provide good analgesic effects but carry a risk of gastrointestinal toxicity. This study aimed to develop a thiourea derivative compound, namely N-benzoyl-N'-4-methoxyphenylthiourea (MFT), as an alternative analgesic candidate with lower side effects. The research stages included silico testing, synthesis, structure confirmation, and in vivo analgesic activity testing. In silico testing was performed by molecular docking using the Molecular Operating Environment (MOE) program against the COX-2 receptor (PDB code 5IKR), validated through redocking (RMSD 0.135-0.136 Å). Synthesis was carried out via the Schotten-Baumann reaction between 4-methoxyphenylthiourea and benzoyl chloride, yielding the MFT compound with a yield of 34.80%, single-spot purity on TLC testing, and a consistent melting point of 171-173°C. Structure confirmation using UV, IR, 1H-NMR, 13C-NMR, and GC-MS spectrophotometry showed that the synthesized compound matched the target structure. In vivo analgesic activity testing in mice (Mus musculus) using the writhing method showed that at a dose of 25 mg/kgBW, the analgesic activity of MFT was not significantly different from mefenamic acid (p>0.05), whereas at a dose of 100 mg/kgBW the two differed significantly (p<0.05). The N-benzoyl-N'-4-methoxyphenylthiourea compound has potential to be developed as a new analgesic drug candidate.
Potential of Cymbopogon citratus Terpenoids as GABA-A Receptor Modulators in Anxiety Disorders In Silico Study Alma Alia Zahra; Muhammad Aqsa Ferdinand; Septina Mariana Siregar; Nisa Nur Fadila; Dina Nurmala Hayati; Mubarika Sekarsari Yusuf; Naura Nurnahari
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.121

Abstract

Studi ini menghasilkan potensi senyawa bioaktif serai ( Cymbopogon citratus ) yaitu geraniol, citral, neral, β-myrcene, dan linalool sebagai kandidat anti-kecemasan melalui penambatan molekuler in silico terhadap reseptor GABA-A manusia subtipe α1β2γ2 (ID PDB: 6X3X). Alur kerja mencakup analisis Aturan Lima Lipinski, penambatan molekuler, visualisasi interaksi, dan prediksi ADMET. Semua senyawa memenuhi kriteria Lipinski, menunjukkan sifat fisikokimia yang menguntungkan dan potensi bioavailabilitas oral. Validasi penambatan menghasilkan RMSD sebesar 0,89 Å, yang mengonfirmasi protokol. Semua senyawa menunjukkan energi pengikatan negatif, yang menunjukkan interaksi dengan protein target. Geraniol menunjukkan afinitas pengikatan terkuat di antara senyawa yang diuji (−4,57 kkal/mol), meskipun lebih rendah dari ligan referensi alprazolam (−6,28 kkal/mol). Citral dan linalool menunjukkan kesamaan residu asam amino 100% dengan ligan asli diazepam, yang menunjukkan pola ikatan yang sebanding. Prediksi ADMET mengungkapkan penyerapan manusia yang tinggi (>90%), permeabilitas Caco-2 yang menguntungkan, tidak ada usus penghambatan CYP2C19, CYP2C9, CYP2D6, atau CYP3A4, dan toksisitas non-mutagenik (uji Ames). Secara keseluruhan, senyawa terpenoid ini menunjukkan sifat-sifat seperti obat yang menjanjikan, bioavailabilitas oral yang dapat diterima, farmakokinetik yang menguntungkan, dan keamanan awal, yang mendukung potensi mereka sebagai kandidat anti-kecemasan, studi meskipun in vitro dan in vivo lebih lanjut diperlukan untuk mengkonfirmasi kemanjuran dan keamanannya.
Comparative Standardization of Moringa oleifera L. Leaf Extracts: Evaluation of Maceration vs. Infusion Using Aqueous Solvent Amalina Fakhriah; Varda Arianti; Yolanda Ongkowidjaya Kuswanda; Ika Aulia Rahmi
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.174

Abstract

Herbal plants traditionally used to treat various diseases and serves as basis for modern drug development. The traditional medicines in Indonesia must meet safety, quality, and efficacy standards, including extract standardization and screening phytochemical. Pharmaceutical industry activities are closely related to implementation of standardization, from raw materials to finished product, in order to ensure efficacy, batch-to-batch consistency, stability, and safety. This study aims to support the utilization of Indonesia herbal plants, particularly moringa leaf. The extract evaluation must be qualified through phytochemical screening and standardization tests. The screening phytochemical result showed both methods contained alkaloids, flavonoids, tannins, saponins, terpenoids, and glycosides. Organoleptically, both extract exhibited similar characteristics besides infusion extract showing a more intense color. The water-soluble extractive values of maceration and infusion methods were 63.95% and 64%. Most non-specific parameters were within the specified limits, including loss on drying (9,07% and 10,23%), specific gravity (1,017 g/mL and 1,007g/mL), total ash content (6,08% and 7,1%), moisture content (9,40% and 10,82%), heavy metal contaminations were negative, while microbial contaminations were at 1,2 x 105 CFU/mL and 3,35 x 102 CFU/mL. Overall, both maceration and infusion methods produced M. oleifera extracts with similar phytochemical profiles and fulfilled most of the evaluated standardization parameters. Infusion produced a higher extraction yield and lower microbial contamination, whereas maceration showes lower moisture content and loss on drying values. However, neither method met all quality requirements nor considered superior overall based on the parameters evaluated, and further optimization is required to obtain a better extract standardization result.
Antibacterial Activity Test Of Facial Serum Formulation Of Pegagan Leaf Extract (Centella asiatica L.) And Pandan Leaf Extract (Pandanus amaryllifolius R.) Against Cutibacterium acnes Bacteria Thoby Tri Jayana; Devilke Yandriyani; Eva Monica
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.176

Abstract

This study aimed to evaluate the physical quality and antibacterial activity of facial serum formulations combining pegagan and pandan leaf extracts. Extraction was performed using maceration with 96% ethanol, yielding 11.75% for pegagan and 14.10% for pandan. The Minimum Inhibitory Concentration (MIC) of pegagan extract against Cutibacterium acnes was 12.5%. Serum formulations consisted of F1 (8% pegagan), F2 (4%:4% combination), and F3 (8% pandan). Physical evaluation showed that all formulations were homogeneous with a slightly viscous liquid consistency. Viscosities were F1 (573.33 cP), F2 (612.00 cP), and F3 (436.00 cP), all fulfilling the requirements with pseudoplastic flow behavior. Spreadability values for F1 (6.00 cm) and F2 (5.46 cm) met the good category criteria, while F3 (7.39 cm) exceeded the standard. Preparations remained stable through 6 freeze-thaw cycles without organoleptic changes, and pH values remained consistent within the range of 5.496–5.847. Well diffusion tests showed that facial serum formulations F1, F2, and F3 did not produce any inhibition zone diameter (0 mm) because the extract concentration in the preparations was below the Minimum Inhibitory Concentration (MIC). The combination facial serum demonstrated good physical stability but had not yet provided inhibitory activity against Cutibacterium acnes bacteria at these concentration levels.
Digital Health for Tuberculosis Detection, Adherence, and Treatment Outcomes: A Systematic Review Sufiyatin Riski Adawiyyah; Eko Setiawan; Fauna Herawati
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.177

Abstract

Digital health technologies are increasingly used across the tuberculosis (TB) care cascade, from case detection to treatment monitoring. However, evidence regarding their effectiveness in improving TB detection, adherence, and treatment outcomes remains inconsistent. This systematic review evaluated the effectiveness of digital health technologies across the TB care cascade and identified intervention characteristics associated with successful implementation. Eleven articles published between 2017 and 2026 met the predefined inclusion criteria and were synthesized narratively. The included studies comprised randomized controlled trials, cluster-randomized trials, diagnostic accuracy studies, and study protocols. Ten studies reported effectiveness outcomes, while one described the development of a digital intervention. Technologies evaluated included computer-aided detection, self-screening applications, electronic medication monitors, 99DOTS, video-observed therapy, ingestible medication sensors, mobile health applications, and digitally delivered economic support. Computer-aided detection showed good performance for TB triage, whereas text message-based self-screening achieved limited user participation. Video-observed therapy and ingestible sensors improved objective verification of medication intake. Electronic medication monitors produced inconsistent clinical outcomes, with greater benefits when integrated with two-way communication, active follow-up, patient support, and adequate connectivity. Mobile health applications and digital cash transfers combined with counselling also improved adherence and treatment outcomes. This review provides an integrated mapping of digital technologies across the TB care cascade while distinguishing technical, behavioural, and clinical outcomes. Digital health technologies may strengthen TB detection and treatment adherence, particularly when digital data trigger timely healthcare-provider responses and individualized patient support.

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