cover
Contact Name
dhanang prawira nugraha
Contact Email
jurnalfarmasi.machung@machung.ac.id
Phone
-
Journal Mail Official
jurnalfarmasi.machung@machung.ac.id
Editorial Address
Villa Puncak Tidar Blok N-01, Karangwidoro, Kecamatan Dau, Kabupaten Malang, Jawa Timur, Indonesia
Location
Kota malang,
Jawa timur
INDONESIA
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Published by Universitas Ma Chung
ISSN : 29868270     EISSN : 29865972     DOI : -
Core Subject : Health, Science,
Pharmaceutical Technology Pharmacology and Toxicology Pharmaceutical Chemistry Drug Discovery Pharmacokinetics Pharmaceutical Biology Herbal Medicine Pharmaceuticals Pharmaceutical Microbiology and Biotechnology Clinical and Community Pharmaceutical Management Pharmaceutical Bioinformatics
Articles 63 Documents
Clinical Significance of the Potential Amlodipine–Metformin Interaction: A Systematic Review Yusna Fadliyyah Apriyanti; Rizki Oktarini; Yona Harianti Putri
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.120

Abstract

Amlodipine and metformin are frequently co-administered in patients with hypertension and type 2 diabetes mellitus (T2DM). Although their concomitant use has been identified as a potential drug–drug interaction (pDDI), the clinical significance of this interaction remains uncertain. This systematic review aimed to evaluate the frequency, severity, proposed mechanism, and clinical significance of the potential interaction between amlodipine and metformin. A comprehensive literature search was conducted using PubMed, ScienceDirect and supplementary searches through Google Scholar with the keywords “amlodipine” AND “metformin” AND “drug interaction”. Study selection was conducted according to the PRISMA framework. Methodological quality was assessed using the appropriate Joanna Briggs Institute (JBI) Critical Appraisal Tools according to the design of each study. A total of 702 records were identified, 42 full-text articles were assessed for eligibility, and seven studies met the inclusion criteria and were included in the final narrative synthesis. Concomitant amlodipine and metformin use was consistently identified as a potential DDI, although the reported frequency varied across studies and was based on different reporting units, including patients, prescriptions, and total identified DDI events. The interaction was generally classified as moderate or requiring monitoring, with pharmacodynamic antagonism and a potential reduction in metformin effectiveness being the most frequently reported interaction profile. Current evidence demonstrates a recurring potential interaction signal between amlodipine and metformin but does not establish that concomitant use causes clinically meaningful deterioration in glycemic control
Analysis of Drug Receiving Procedures in Hospital Pharmacy Services to Ensure Optimal Service Quality Rully Fidayatul Akhmad Syah Putri; M. Ibnu Fateh; Aulia Fauziah Bening Hanani; Nurika Sofiani; Adinugraha Amarullah; Puspita Raras Anindita; Gladis Jingga Agnesia
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.151

Abstract

Drug receiving in hospital pharmacy installations is an initial stage of quality control that plays an important role in ensuring the availability, efficiency, and quality of pharmaceutical services, as it involves administrative and physical verification before medicines are stored and distributed. This study aims to analyze the pattern of drug receiving and identify common challenges in hospital pharmacy practice. The method used was a literature review of studies published between 2020 and 2026, predominantly employing descriptive qualitative designs, with data collected through observation, in-depth interviews, checklists, and questionnaires, and compared with hospital pharmaceutical service standards. The results indicate that the drug receiving process generally complies with standard operating procedures, including verification of drug type and quantity, batch number, expiration date, packaging condition, distributor validation, as well as proper documentation for traceability. Some healthcare facilities achieved compliance levels of up to 100%. However, several challenges remain, such as discrepancies in delivered medicines, damaged packaging, short expiration dates, limited human resources, delays from suppliers, and suboptimal information systems. Therefore, improvements in quality control, accuracy, and information system integration are necessary to support optimal and sustainable pharmaceutical services.
Physicochemical Characteristics, Calcium Content, and Storage Stability of Anchovy (Stolephorus commersonnii) Extract Gummy Candies Ema Hermawati; Dian Farida Ismyama; Marybet Tri Retno Handayani; Nova Intan Putri; Ricky alfandy rachman; Fahira Fitriani mansu; Nisa futri Yani
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 2 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas [ARTICLE IN PRE
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i2.169

Abstract

Calcium is an essential micronutrient for bone growth and development during childhood. Anchovy (Stolephorus commersonnii) is a local marine resource containing calcium and protein and may be incorporated into food products. This study aimed to evaluate the physicochemical characteristics, calcium content and proximate composition, microbiological quality, heavy metal contamination, and storage stability of anchovy extract gummy candies. Anchovy powder was prepared by drying and milling, followed by aqueous maceration extraction. Gummy candies were formulated using gelatin and taro starch as gelling agents. Five formulations were prepared, and the formulation with the most favorable physical characteristics was selected for further evaluation. The selected formulation contained 25% gelatin and 7.5% taro starch and exhibited a chewy texture, acceptable aroma, and pH of 4.7. The product remained physically stable during 14 days of refrigerated storage at 8–15°C, whereas softening, liquefaction, and fungal growth were observed at room and elevated temperatures. Proximate analysis showed moisture content of 54.42–54.68%, protein content of 31.68–31.96%, carbohydrate content of 13.01%, ash content of 0.61–0.63%, and calcium content of 28.15–28.44 mg/100 g. Lead and mercury were not detected, while total plate count and yeast and mold counts were within the applicable limits under the tested conditions. These findings demonstrate the feasibility of incorporating anchovy extract into a gummy candy matrix with measurable calcium and protein content; however, further optimization is required to increase calcium content and improve stability at room temperature.