cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
dhanang prawira nugraha
Contact Email
jurnalfarmasi.machung@machung.ac.id
Phone
-
Journal Mail Official
jurnalfarmasi.machung@machung.ac.id
Editorial Address
Villa Puncak Tidar Blok N-01, Karangwidoro, Kecamatan Dau, Kabupaten Malang, Jawa Timur, Indonesia
Location
Kota malang,
Jawa timur
INDONESIA
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Published by Universitas Ma Chung
ISSN : 29868270     EISSN : 29865972     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Pharmaceutical Technology Pharmacology and Toxicology Pharmaceutical Chemistry Drug Discovery Pharmacokinetics Pharmaceutical Biology Herbal Medicine Pharmaceuticals Pharmaceutical Microbiology and Biotechnology Clinical and Community Pharmaceutical Management Pharmaceutical Bioinformatics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 52 Documents
 2   3   4   5   6 
Edukasi Anemia pada Remaja Prakonsepsi Terhadap Risiko Kejadian Stunting di Desa Lumingser Kecamatan Adiwerna Dwi Ajeng Larasati; Osie Listina; Oktariani Pramiastuti
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 3 No. 2 (2025): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v3i2.77

Abstract

Anemia merupakan kondisi ketika jumlah sel darah merah dan kemampuan hemoglobin untuk mengangkut oksigen tidak mencukupi kebutuhan fisiologis tubuh, dengan kadar hemoglobin kurang dari 12 g/dl. Remaja putri yang mengalami anemia berisiko tetap mengalami kondisi tersebut hingga dewasa, dan berpotensi menjadi ibu hamil yang menderita anemia, sehingga meningkatkan risiko melahirkan anak yang mengalami stunting. Penelitian ini bertujuan mengetahui pengaruh pengetahuan dan sikap sebelum dan sesudah pemberian edukasi pengetahuan remaja prakonsepsi terhadap kejadian anemia di Desa Lumingser Kecamatan Adiwerna. Metode yang digunakan Pra-Eksperiment dengan jenis one group pretest and posttest design. Dalam pengambilan data sampel digunakan teknik purposive sampling dan dihitung menggunakan rumus Slovin dan didapatkan hasil 82 sampel yang sesuai dengan kriteria inklusi dan eksklusi yang telah ditetapkan. Data dianalisis menggunakan SPSS. Hasil penelitian dapat disimpulkan bahwa metode pretest-postest design memberikan pengaruh yang signifikan pada pengetahuan risiko anemia dengan tingkat kepercayaan p<0,011 dan sikap risiko anemia dengan tingkat kepercayaan p<0,001.
Potensi Senyawa pada Tanaman Secang (Caesalpinia Sappan) dalam Menghambat Enzim COX-2 sebagai Antiinflamasi Lealita; Anastasia Risvina Easter Ajie Pramesti; Rollando; Michael Resta Surya Yanuar
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 3 No. 2 (2025): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v3i2.79

Abstract

Inflamasi merupakan respon imun terhadap infeksi atau kerusakan jaringan yang melibatkan enzim Siklooksigenase-2 (COX-2) dalam sintesis prostaglandin. Menghambat COX-2 merupakan strategi penting dalam pengembangan obat antiinflamasi. Penelitian ini bertujuan untuk menyalakan potensi senyawa aktif dari kayu secang (Caesalpinia sappan L.) sebagai inhibitor COX-2 melalui pendekatan in silico. Docking molekuler dilakukan pada protein COX-2 (PDB ID: 5KIR) menggunakan PyRx, dilanjutkan dengan metode validasi dan analisis interaksi ligan. Simulasi dinamika molekuler (MD) menggunakan YASARA dilakukan pada senyawa dengan afinitas terbaik. Hasil docking menunjukkan bahwa protosappanin A memiliki afinitas pengikatan sebesar –9,7 kkal/mol, lebih tinggi dari brazilin (–9,2 kkal/mol) dan sappanone B (–9,3 kkal/mol), meskipun masih lebih rendah daripada ligan asli (–10,3 kkal/mol). Simulasi MD selama 100 ns menunjukkan stabilitas stabilitas dengan nilai RMSD 1,5–2,0 Å dan RMSF rata-rata 1,0 Å. Hasil ini menunjukkan bahwa protosappanin A berpotensi sebagai inhibitor COX-2 dan kandidat antiinflamasi alami yang menjanjikan. Temuan ini memerlukan validasi lebih lanjut untuk mengonfirmasi potensinya. Oleh karena itu, penelitian ini dapat menjadi titik awal yang kuat untuk penelitian lebih lanjut melalui uji in vitro dan in vivo, untuk mendukung potensi terapeutiknya yang menjanjikan dan membuka peluang baru untuk mengembangkan pengobatan yang lebih efektif.
Analisis Hubungan Hambatan Terhadap Kepatuhan pada Pasien Diabetes Melitus Rafica Tri Oktaviasari; Godeliva Adriani Hendra; Dhanang Prawira Nugraha
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 3 No. 2 (2025): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v3i2.86

Abstract

Diabetes Melitus adalah Kondisi yang ditandai dengan kadar glukosa darah tinggi yang terus-menerus akibat produksi insulin yang tidak mencukupi atau gangguan kinerja insulin. Tim peneliti di Rumah Sakit Lavalette, Malang, bertujuan untuk mempelajari tantangan yang dihadapi pasien diabetes melitus dan seberapa baik mereka mematuhi rencana perawatan mereka. Desain penelitian ini menggunakan Cross-Sectional dengan pengambilan data secara prospektif yaitu melalui wawancara kuesioner kepada pasien diabetes melitus pada pasien diabetes melitus di poli rawat jalan Rumah Sakit Lavalette Malang pada bulan Mei - Juni 2023. Sampel yang memenuhi kriteria yaitu sejumlah 155 pasien, menggunakan lembar pengumpul data dan kuesioner yaitu Medication Adherence Rating Scale 5 (MARS-5) serta Diabetes Obstacle Quetionnare (DOQ) kemudian dianalisis menggunakan Uji Chi Square. Hasil penelitian ini pada penggunaan OAD oral 30 pasien dan kombinasi 125 pasien DM, analisis hubungan hambatan terhadap kepatuhan pasien DM yaitu hambatan pengobatan p-value 0,008, hambatan pengobatan sendiri p-value 0,007, hambatan pengetahuan dan keyakinan p-value 0,001, hambatan mengatasi diabetes p-value 0,000. Adapun analisis hubungan sosio demografi dengan kepatuhan yaitu pada penggunaan obat antidiabetes. Kesimpulan dari penelitian ini yaitu terdapat hubungan antara hambatan dengan kepatuhan pasien DM, tidak terdapat hubungan antara sosio jenis kelamin, IMT, komorbid, lama menderita, riwayat keluarga, pekerjaan, tingkat pendidikan, perokok kecuali usia yang terdapat hubungan dengan kepatuhan pasien DM.
Peran Lipid Nanoparticles dalam Teknologi Vaksin mRNA: Peluang dan Hambatan feliadewi ruth
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 3 No. 2 (2025): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v3i2.100

Abstract

Lipid nanoparticles (LNP) constitute critical delivery systems for both vaccine formulations and mRNA-based therapeutic strategies; nevertheless, concerns regarding their efficacy, safety, and design optimization continue to be prevalent. This review is designed to systematically evaluate the function of LNP within the framework of mRNA vaccine technologies, emphasizing mechanistic insights, stability assessments, safety considerations, and challenges in manufacturing. Comprehensive literature reviews were conducted utilizing databases such as PubMed, ScienceDirect, and Semantic Scholar for peer-reviewed articles published between the years 2020 and 2025, with the application of relevant keywords. From the 418 articles identified, 57 met the inclusion criteria following rigorous screening and were subjected to thematic analysis based on parameters including efficacy, safety, stability, and optimization strategies. The results reveal that LNP substantially enhances mRNA stability and expression in vivo, fortifies robust immune responses, and serves a vital role in the effective deployment of various mRNA vaccines, particularly those aimed at combating infectious diseases. However, challenges such as sensitive stability, insufficient endosomal escape, hepatic accumulation, toxicity concerns, and complex manufacturing processes remain significant issues of concern. It is concluded that while current formulations of LNP exhibit effectiveness for specific applications, they are not universally optimal; consequently, further advancements in design, targeting, and production methodologies are imperative to improving the efficacy, safety, and accessibility of LNP-based mRNA vaccines.
Medication Therapy Adherence Among Outpatient Patients With Hypertension Dwi Amelia Nur Afifa; Adinugraha Amarullah
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.104

Abstract

Hypertension is a chronic disease with an increasing prevalence and is a major risk factor for cardiovascular diseases such as stroke and kidney failure. One of the key components in hypertension management is patient adherence to medication therapy. Good medication adherence is essential to control blood pressure and prevent disease complications. This study aimed to determine the level of medication therapy adherence among patients with hypertension. This study employed a descriptive observational design with a cross sectional approach. Data were collected using purposive sampling by distributing the eight item Morisky Medication Adherence Scale questionnaire to 97 respondents. The results showed that most respondents had a moderate level of adherence, accounting for 41 respondents or 42.3 percent. This was followed by low adherence in 30 respondents or 30.9 percent, high adherence in 19 respondents or 19.6 percent, and the lowest adherence category was non adherence, found in 7 respondents or 7.2 percent. Moderate to low adherence was mainly caused by patients forgetting to take medication or not taking it on time, discontinuing treatment when they felt healthy without consulting a physician, and stopping medication due to perceived side effects after drug consumption. In conclusion, medication adherence among patients with hypertension remains suboptimal and requires improved patient education and continuous monitoring to enhance treatment outcomes.
The Association Between Haloperidol and Clozapine and The Risk of Hyperglycaemia in Patients with Schizophrenia Martanty Aditya; Godeliva Adriani Hendra; Rina Setyowati
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.105

Abstract

First- and second-generation antipsychotics such as haloperidol and clozapine are treatment options for schizophrenia; however, both have the potential for metabolic side effects, including hyperglycemia. This study aimed to analyse the association between using haloperidol or clozapine, either alone or together, and the occurrence of hyperglycemia in patients with schizophrenia. The research used an observational design with a cross-sectional study and retrospective data from 154 medical records of schizophrenia patients. The study was conducted at Dr. Radjiman Wediodiningrat Psychiatric Hospital outpatient clinic, Lawang, from January to March 2025. Data were analysed using the chi-square test and odds ratio with RStudio 2024. The results showed that most patients received clozapine alone or with other medications (70.78%). A significant association was found between clozapine use and male sex (p = 0.014) as well as the 17–40 age group (p = 0.001). Haloperidol use was linked to an increased risk of elevated creatinine levels (p = 0.026). However, there was no significant link between the type of therapy and the risk of hyperglycemia (OR = 1.243; 95% CI: 0.097–66.819). Levels of SGOT (p = 0.913), SGPT (p = 0.258), and urea (p = 1.000) stayed within normal limits in both treatment groups. In summary, clozapine may carry a slightly higher but statistically insignificant risk of causing hyperglycemia. Overall, treatment with haloperidol or clozapine appears safe concerning liver and kidney function, as indicated by normal SGOT, SGPT, and urea levels.
Comparison of Topical Analgesic Activity of Mentha piperita Extract with Ethanol Variations Using Hargreaves Test in Mice Sirilus Deodatus Sawu; Wibowo; Devanus Lahardo
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.107

Abstract

Pain can sometimes significantly disrupt a person's quality of life. Pharmacological pain management, often using synthetic analgesics, remains the primary option, but long-term use can lead to serious side effects and the risk of dependency. Mint leaves (Mentha piperita) are known to contain active compounds such as alkaloids and flavonoids, which have analgesic effects, making them a potential alternative to topical analgesics. This study aims to compare the topical analgesic activity of mint leaf ethanol extract with variations in ethanol solvent concentration (50%, 70%, and 96%) as an extraction solvent using the Hargreaves test method in white mice (Mus musculus). The laboratory experimental research used a posttest-only control group. Mint leaf extract was formulated in the form of a topical gel, then tested using the Hargreaves test method which measures the latency time of pain response to heat stimulation on the soles of the feet of mice. The results showed that the maximum topical analgesic activity occurred at 150 minutes for all three groups of mint leaf ethanol extract gels. The LSD test results showed that the 96% ethanol extract solvent produced significantly higher topical analgesic activity than the 70% and 50% ethanol extracts (p-value <0.05). The concentration of 96% ethanol solvent as a solvent for mint leaf extract produces the most optimal topical analgesic activity based on testing using the Hargreaves test method.
Pharmaceutical Preparation Formulation and Innovation in Active Substance Delivery Technology of Premna serratifolia: Literature Review isnindar isnindar; rise desnita
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.110

Abstract

Background: The Premna serratifolia L. plant is a botanical resource rich in potential secondary metabolites for development into modern pharmaceutical preparations. Over the last decade (2016-2026), research has progressed rapidly from conventional topical formulations to more sophisticated drug delivery systems to overcome the stability issues of active substances. Objective: To systematically review various pharmaceutical formulations of Premna serratifolia leaves and evaluate their biological efficacy based on the latest original studies. Methods: Over the previous 10 years, original scientific literature from reliable databases like Science Direct and Google Scholar was reviewed. Results: Various preparations have been successfully optimized, including a peel-off gel mask with antioxidant activity reaching 77.20%, a sunscreen lotion with an ultra SPF value of up to 34.60, and an anti-inflammatory cream combined with sappanwood. Recent delivery technology innovations include Ethocel/Eudragit polymer-based microparticles with a size of 1.024-1.662 µm, and excellent antibacterial potential is demonstrated by biosynthesized silver nanoparticles (AgNPs). Conclusion: P. serratifolia exhibits high formulation flexibility for cosmetic and therapeutic applications, although standardization of marker compounds and validation through human clinical trials remain major challenges for future development.
Effectiveness Profile of Antihypertension Use in Ischamic Stroke Patients in the Inpatient Installation of Muhammadiyah Hospital, Jombang Puspita Raras Anindita
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.111

Abstract

Background: Cardiovascular disease and cancer are the leading causes of death globally. Stroke is characterized by sudden clinical symptoms lasting more than 24 hours or leading to death due to impaired cerebral circulation. Objective: This study aims to determine the effectiveness of antihypertensive treatment in ischemic stroke patients at the Inpatient Installation of Muhammadiyah Hospital, Jombang. Methods: This research utilized a non-experimental retrospective design with purposive sampling. Evaluated drugs included Angiotensin Receptor Blockers (ARBs), Calcium Channel Blockers (CCBs), Angiotensin-Converting Enzyme Inhibitors (ACEIs), Beta-blockers, and diuretics. Results: The study included 50 patients; 52% were male and 64% were over 60 years old. CCB (Amlodipine) was the most used monotherapy (64.3%), while CCB+ARB (Amlodipine+Candesartan) was the most common combination (62.5%). CCBs showed the highest average blood pressure reduction (14/9 mmHg) and the shortest average length of stay (4.4 days). Conclusion: Both single and combination antihypertensive therapies were effective, with CCBs being the most frequently prescribed and efficient in reducing blood pressure and hospitalization duration.
Anti-Acne Efficacy of a Topical Cream Formulated with Sapodilla (Manilkara zapota (L.) P. Royen) Leaf Extract La Ode Muhammad Fitrawan
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.112

Abstract

Jerawat (acne vulgaris) merupakan gangguan inflamasi kulit kronis yang menyerang hingga 85% populasi remaja dan dewasa secara global. Kondisi ini melibatkan mekanisme patofisiologis yang kompleks, mencakup produksi sebum berlebihan, hiperkeratinisasi folikel, serta kolonisasi oleh Cutibacterium acnes dan Staphylococcus aureus . Meningkatnya resistensi antimikroba dan efek samping agen topikal konvensional mendorong eksplorasi alternatif terapeutik berbasis tanaman. Penelitian ini bertujuan menghasilkan karakteristik fisikokimia, stabilitas, dan aktivitas antibakteri krim topikal minyak dalam air (M/A) yang mengandung ekstrak daun sawo ( Manilkara zapota (L.) P. Royen). Tiga formulasi krim disiapkan dengan sistem emulsifikasi asam stearat–trietanolamin (TEA) menggunakan konsentrasi ekstrak 12,5%, 25%, dan 50% (b/b). Evaluasi fisikokimia meliputi organoleptik, homogenitas, tipe emulsi, pH, daya sebar, dan viskositas. Uji stabilitas dipercepat dilakukan melalui enam siklus termal (4°C/40°C) dan sentrifugasi 3.000 rpm selama 30 menit pada minggu pertama dan keempat. Aktivitas antibakteri diuji menggunakan metode difusi sumuran terhadap P. acnes dan S. aureus . Seluruh formulasi memenuhi persyaratan fisikokimia dan lulus uji stabilitas selama empat minggu. Zona hambat meningkat seiring konsentrasi ekstrak; formulasi 50% menghasilkan inhibisi kuat terhadap kedua patogen (10,75–12,0 mm terhadap S. aureus ; 11,0–13,0 mm terhadap P. acnes ), sebanding dengan krim gentamisin (p > 0,05). Ekstrak daun sawo 50% terbukti menghasilkan krim M/A yang stabil dengan efikasi antibakteri setara gentamisin, memperkuat potensinya sebagai kandidat agen antijerawat fitofarmaka.

Page 5 of 6 | Total Record : 52

 2   3   4   5   6 

Filter by Year

2023 2026


Reset
Filter By Issues
All Issue Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 3 No. 2 (2025): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 3 No. 1 (2025): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 2 No. 2 (2024): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 2 No. 1 (2024): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 1 No. (2) (2023): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 1 No. (1) (2023): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas