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Rizal Irfandi
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rizalirfandi043@gmail.com
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Jl. Bumi 18 Blok A 15 No. 1 Bumi Permata Hijau, Makassar, Sulawesi Selatan, Indonesia
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INDONESIA
Hayyan Journal
Published by Education and Talent Development Center Indonesia
ISSN : -     EISSN : 30466679     DOI : https://doi.org/10.51574/hayyan.v1i1.1130
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Medicine & Pharmacology
Focus and Scope This journal publishes articles related to chemistry. The scope of this journal includes: Inorganic Chemistry Organic Chemistry Physical Chemistries Chemical Instruments Analytical Chemistries Materials Chemicals Industrial chemistry Biochemistry Applied Science Applied Chemistry
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol. 2 No. 3 (2025): October" : 15 Documents clear
Exploration of Traditional and Modern Values of Bidara (Ziziphus mauritiana) Leaf in the Community of Tancung Village, Tanah Sitolo Sub-District, Wajo District nurhaeda, zahra
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.3448

Abstract

This study aims to explore the utilization and meaning of bidara leaves (Ziziphus mauritiana) in the lives of people from various generational and professional backgrounds. Data were obtained through interviews with six resource persons, namely traditional healers, housewives, fathers, grandmothers, millennial aunts, and local residents. The results of the interviews showed that bidara leaves have strong traditional values, such as being used in the ritual of bathing corpses, treating wounds, and treating supernatural disorders. On the other hand, modern uses are starting to develop, such as being used in beauty products, skincare, and as a symbol of spiritual healing on social media. The findings show that bidara leaves have not only survived as part of tradition, but have also been successfully adapted into modern lifestyles, reflecting the continuity and transformation of values in society.
Characterization of Active Carbon Pineapple Skin (Ananas comosus) as Absorbent of Heavy Metal Copper (Cu) with NaOH and NH4OH Activators Abd Haris, Miftahul Jannah; Musdalifah1; Herdie Idriawien Gusti; Syahdam Karneng
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.3524

Abstract

This research aims to evaluate the potential of pineapple peel as a raw material for making activated carbon, as well as comparing the effectiveness of NaOH and NH4OH activators in the activation process. Activated carbon is produced through a carbonization and chemical activation process, then its quality is tested based on the Indonesian National Standard (SNI) 06-3730-1995. The research results show that activated carbon from pineapple peel meets SNI standards in terms of ash content and water content, with each not exceeding the maximum limits of 10% and 15%. The yield of activated carbon activated with NH4OH (87.5%) was higher than NaOH (79.4%). In addition, the water content of activated carbon with NH4OH (1.07%) is lower than NaOH (1.42%). Although the iodine absorption capacity of activated carbon from pineapple peel is still below the minimum SNI standard (750 mg/g), NH4OH shows better results in adsorption of the heavy metal Cu (0.0041 mg/g) than NaOH (0.0015 mg/g ). The FTIR spectrum shows the presence of diverse functional groups, indicating complex chemical interactions. Based on the results of this research, pineapple peel has good potential as a raw material for activated carbon, with NH4OH as a more effective activator in improving the quality and adsorption ability of activated carbon.
The content of Compounds and Bioactivity of the Eucalyptus sp species Abd Haris, Miftahul Jannah; Andi Nur Fitriani Abubakar; Karneng, Syahdam; Indriani, Iin; Idriawien Gusti, Herdie; Surahmat; Febrianti, Triana
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.3580

Abstract

Eucalyptus sp. is one of the plant genera from the Myrtaceae family which is widely known for its diverse secondary metabolite content and high biological activity. This study aims to systematically examine the diversity of active compounds and potential bioactivity of various Eucalyptus species, especially in the leaves, bark, seeds, and essential oils. Various compounds such as 1,8-cineole, citronellal, flavonoids, and phenolic compounds have been shown to contribute to pharmacological activities such as antioxidants, antimicrobials, anti-inflammatory, immunomodulators, anticancer, as well as natural insecticides and repellents. The results of the review indicate that these activities have great relevance in the development of biopharmaceutical products, cosmetics, and other health applications. The diversity of compounds and broad pharmacological effects place Eucalyptus as a very potential source of natural materials to be developed sustainably.
Review of the Agronomic and Biochemical Potential of Eucalyptus Plants ( Melaleuca cajuputi ) as Essential Oil Producers Siti Fatimah; Ilda Yangti; Andi Nurfitri Abubakar; Karneng, Syahdam; Indriani, Iin; Surahmat; Febrianti, Triana
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.3615

Abstract

Studi ini mengeksplorasi potensi agronomi dan biokimia Melaleuca cajuputi (kayu putih) melalui tinjauan pustaka komprehensif penelitian Indonesia yang diterbitkan antara tahun 2019 dan 2024. Tujuannya adalah untuk mengevaluasi efektivitas berbagai strategi budidaya khususnya sistem agroforestri, pemupukan organik, dan perbaikan genetik dalam meningkatkan produktivitas dan kualitas minyak atsiri kayu putih. Hasil menunjukkan bahwa pola agroforestri menggunakan serai wangi ( Cymbopogon nardus ) yang ditumpangsarikan dengan varietas Sitrona 2 Agribun menghasilkan produksi minyak tertinggi (2,84%) dan kandungan 1,8-sineol (hingga 52,98%). Pemupukan organik menggunakan kompos tandan kosong kelapa sawit meningkatkan kesuburan tanah dan pertumbuhan tanaman, sementara inokulasi mikoriza arbuskular secara signifikan meningkatkan kelangsungan hidup bibit dan perkembangan daun. Lebih lanjut, varietas yang dipilih secara genetik menghasilkan 1,2–1,3% hasil minyak dengan kadar sineol mencapai 68–75%. Temuan ini menunjukkan manfaat sinergis dari praktik agronomi terpadu dan pemuliaan tanaman dalam menghasilkan minyak kayu putih berkualitas tinggi untuk aplikasi industri dan lingkungan yang berkelanjutan.
Kinetics of Phenol Degradation Using TiO₂/Zeolite Composite Kartika, Andi Eka; Side, Sumiati; Eka Pratiwi, Diana; Afni, Nur
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4138

Abstract

Phenol is a hazardous organic pollutant commonly found in industrial wastewater and is difficult to degrade through conventional treatment methods, thus requiring more effective and sustainable approaches. Photocatalytic degradation using TiO₂ has been widely explored; however, its performance is limited by rapid electron–hole recombination and low surface area. Combining TiO₂ with zeolite enhances adsorption capability and increases the availability of active sites, offering a promising strategy to improve photocatalytic efficiency. This study aims to analyze the kinetic behavior of phenol degradation using a TiO₂/zeolite composite and to determine the optimum irradiation time based on a pseudo-first-order kinetic model. Irradiation times of 15, 30, 45, 60, and 75 minutes were applied, and phenol concentrations were measured using UV–Vis spectrophotometry at 270,20 nm. The results show rapid degradation during the first phase (15-30 minutes), with removal efficiency increasing from 83,014% to 87,315%. After 30 minutes, the degradation rate becomes nearly constant, indicating the attainment of photocatalytic dynamic equilibrium. The -ln(Ct/C0) plot reveals two distinct reaction phases: an initial high-rate phase followed by a plateau phase. Therefore, 30 minutes is identified as the most efficient irradiation time, representing the point at which maximum degradation is achieved before the reaction rate significantly decreases. These findings provide meaningful insight into the photocatalytic kinetics of TiO₂/zeolite composites and support their potential application in phenolic wastewater treatment.
A Narrative Review of Natural Bioactive Agents for Wound Healing: Mechanistic Insights on Anti-Inflammatory, Angiogenic, Antimicrobial, and Tissue Regeneration Pathways Afni, Nur
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4211

Abstract

Wound healing is a complex biological process involving the coordinated progression of hemostasis, inflammation, proliferation, and extracellular matrix (ECM) remodeling. Chronic and infected wounds often fail to progress through these stages due to persistent inflammation, oxidative stress, and microbial biofilm formation. In recent years, natural bioactive compounds have gained attention as potential therapeutic agents due to their multi-target biological functions and biocompatibility. This review synthesizes evidence from original in vitro, in vivo, and clinical studies to evaluate the mechanisms of natural compounds, including curcumin, Centella asiatica derivatives, honey-based molecules, flavonoids, and chitosan biomaterials in modulating the wound-healing process. The findings demonstrate that natural compounds can enhance platelet-mediated hemostasis, suppress inflammatory cytokines through NF-κB inhibition and Nrf2 activation, stimulate angiogenesis via VEGF and TGF-β signaling, promote fibroblast proliferation and collagen synthesis, and exert antimicrobial and antibiofilm effects against drug-resistant pathogens. Formulation strategies such as hydrogels and nanoparticle delivery systems were also shown to improve compound stability, tissue penetration, and therapeutic outcomes. These results indicate that natural bioactive wound-healing agents provide a promising avenue for managing both acute and chronic wounds, particularly in contexts where antibiotic resistance or delayed healing presents clinical challenges.
Bioactive Potential of Endophytic Fungi from the Genus Aspergillus: A Comprehensive Review of Secondary Metabolites and Their Biological Activities jumrah, elfira
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4222

Abstract

This review provides a comprehensive synthesis of current knowledge on the bioactive potential of endophytic fungi belonging to the genus Aspergillus, emphasizing their secondary metabolites and associated biological activities. A systematic literature search was conducted across major scientific databases, including Scopus, Web of Science, PubMed, ScienceDirect, and Google Scholar, covering publications from January 2020 to October 2025. Studies were selected based on inclusion criteria focusing on the isolation, metabolite characterization, and bioactivity evaluation of endophytic Aspergillus species. Relevant data on fungal species, host plants, metabolite classes, and biological functions were extracted, organized, and analyzed qualitatively using a thematic and comparative approach. The analysis revealed that Aspergillus species are prolific producers of diverse secondary metabolites such as alkaloids, polyketides, terpenoids, xanthones, and peptides, exhibiting a broad range of biological activities including antimicrobial, antioxidant, anticancer, anti-inflammatory, antifungal, and antiparasitic effects. Key compounds such as gliotoxin, terrein, and vitexin demonstrate strong pharmacological properties and highlight the genus’s biotechnological significance. Overall, endophytic Aspergillus species represent an underexploited reservoir of natural bioactive compounds with high pharmaceutical and industrial relevance. Future research integrating genomics, metabolomics, and bioengineering is essential to unlock their full biosynthetic potential and advance sustainable drug discovery.
Systematic Literature Review: Isolation of Anthocyanin Compounds from Sweet Potato (Ipomoea batatas) Salnus, Subakir
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Anthocyanins are natural pigments belonging to the flavonoid group, widely found in various plant parts, particularly fruits, flowers, and peels, where they are responsible for red, purple, and blue colors. These compounds possess extensive potential in the fields of food, health, cosmetics, and pharmaceuticals due to their bioactive properties, especially as antioxidants. However, anthocyanins exhibit low stability against environmental factors such as temperature, pH, light, oxidation, and processing conditions, which affects the effectiveness of their isolation and utilization in practical applications. Therefore, an appropriate modern technological approach and process optimization ranging from extraction and purification to product stabilization—are required. This Systematic Literature Review (SLR) aims to comprehensively analyze various isolation techniques for anthocyanins from sweet potatoes, including conventional and technology-assisted extraction methods, purification techniques, stability challenges, and opportunities for developing sustainable industrial methods. Literature searches were conducted on published scientific articles between 2016–2026 , initially yielding a total of 274 publications, from which 13 articles were selected according to the inclusion criteria. The majority of studies utilized the tubers as the source of anthocyanins. The review findings indicate that the optimization of extraction methods is proven to be crucial. Methods such as ASE, UAE, HPCD, and SCCO2 offer significantly higher yields compared to conventional extraction. This review is expected to serve as a scientific reference for the development of efficient, eco-friendly, and commercially valuable anthocyanin isolation technology.
Isolation and Medicinal Applications of Clove Eugenol : Systematic Literature Review Salnus, Subakir
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This review synthesizes research on "Good techniques for isolation and purification of chemical composition of clove compounds, focusing on eugenol, and their medicinal uses" to address inconsistencies in extraction efficacy and bioactivity preservation. The review aimed to evaluate extraction and purification methods for eugenol isolation, benchmark yield and purity, identify associated medicinal properties, compare conventional and green technologies, and analyze extraction parameters influencing bioactivity. A systematic analysis of studies employing hydro-distillation, Soxhlet, microwave-assisted, ultrasound-assisted, supercritical CO2, and deep eutectic solvent extractions was conducted, alongside chemical and chromatographic purification techniques. Findings indicate that microwave-assisted and ultrasound-assisted methods achieve higher eugenol yields (up to ~20%) and maintain bioactivity more effectively than conventional methods, while green technologies reduce solvent toxicity and energy consumption. Chemical purification attains high purity (>95%) but often compromises yield and sustainability. Analytical methods such as GC-MS and HPLC provide robust purity assessment, though standardization remains limited. Bioactivity assays confirm strong antioxidant, antibacterial, and antiinflammatory effects linked to extraction parameters and purity levels. Integration of extraction and purification processes is emerging but underdeveloped, with scalability and reproducibility challenges persisting. These findings underscore the need for standardized, sustainable protocols optimizing yield, purity, and medicinal efficacy of eugenol, informing future pharmaceutical and nutraceutical applications.
Molecular Docking of Quercetin for Inhibition of Enoyl-Acyl Carrier Protein Reductase in Mycobacterium tuberculosis Irfandi, Rizal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4345

Abstract

Tuberculosis remains a global health issue, with treatment hindered by drug resistance. This study aims to identify the potential of Quercetin as an inhibitor of Enoyl-Acyl Carrier Protein Reductase (M. tuberculosis), a key enzyme in the fatty acid biosynthesis of the bacteria. Using molecular docking, Quercetin is evaluated based on its binding affinity and stability with the target protein. The docking results show that Quercetin binds to the active site of Enoyl-Acyl Carrier Protein Reductase through hydrogen bonds, π-alkyl, and π-sigma interactions, with an RMSD value of 1.6466 Å, indicating valid results. Comparison with the control compound, 5-hexyl-2-(2-methylphenoxy)phenol, reveals that Quercetin has a stronger binding affinity, supporting its potential as a more effective enzyme inhibitor. These findings open new opportunities for the development of natural compound-based anti-Tuberculosis therapies that can address the growing problem of drug resistance. Further research is needed for experimental validation in biological models and the development of more efficient Quercetin formulations.

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