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Rizal Irfandi
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Jl. Bumi 18 Blok A 15 No. 1 Bumi Permata Hijau, Makassar, Sulawesi Selatan, Indonesia
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INDONESIA
Hayyan Journal
Published by Education and Talent Development Center Indonesia
ISSN : -     EISSN : 30466679     DOI : https://doi.org/10.51574/hayyan.v1i1.1130
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Medicine & Pharmacology
Focus and Scope This journal publishes articles related to chemistry. The scope of this journal includes: Inorganic Chemistry Organic Chemistry Physical Chemistries Chemical Instruments Analytical Chemistries Materials Chemicals Industrial chemistry Biochemistry Applied Science Applied Chemistry
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 79 Documents
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Bioactive Potential of Endophytic Fungi from the Genus Aspergillus: A Comprehensive Review of Secondary Metabolites and Their Biological Activities jumrah, elfira
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4222

Abstract

This review provides a comprehensive synthesis of current knowledge on the bioactive potential of endophytic fungi belonging to the genus Aspergillus, emphasizing their secondary metabolites and associated biological activities. A systematic literature search was conducted across major scientific databases, including Scopus, Web of Science, PubMed, ScienceDirect, and Google Scholar, covering publications from January 2020 to October 2025. Studies were selected based on inclusion criteria focusing on the isolation, metabolite characterization, and bioactivity evaluation of endophytic Aspergillus species. Relevant data on fungal species, host plants, metabolite classes, and biological functions were extracted, organized, and analyzed qualitatively using a thematic and comparative approach. The analysis revealed that Aspergillus species are prolific producers of diverse secondary metabolites such as alkaloids, polyketides, terpenoids, xanthones, and peptides, exhibiting a broad range of biological activities including antimicrobial, antioxidant, anticancer, anti-inflammatory, antifungal, and antiparasitic effects. Key compounds such as gliotoxin, terrein, and vitexin demonstrate strong pharmacological properties and highlight the genus’s biotechnological significance. Overall, endophytic Aspergillus species represent an underexploited reservoir of natural bioactive compounds with high pharmaceutical and industrial relevance. Future research integrating genomics, metabolomics, and bioengineering is essential to unlock their full biosynthetic potential and advance sustainable drug discovery.
Systematic Literature Review: Isolation of Anthocyanin Compounds from Sweet Potato (Ipomoea batatas) Salnus, Subakir
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Anthocyanins are natural pigments belonging to the flavonoid group, widely found in various plant parts, particularly fruits, flowers, and peels, where they are responsible for red, purple, and blue colors. These compounds possess extensive potential in the fields of food, health, cosmetics, and pharmaceuticals due to their bioactive properties, especially as antioxidants. However, anthocyanins exhibit low stability against environmental factors such as temperature, pH, light, oxidation, and processing conditions, which affects the effectiveness of their isolation and utilization in practical applications. Therefore, an appropriate modern technological approach and process optimization ranging from extraction and purification to product stabilization—are required. This Systematic Literature Review (SLR) aims to comprehensively analyze various isolation techniques for anthocyanins from sweet potatoes, including conventional and technology-assisted extraction methods, purification techniques, stability challenges, and opportunities for developing sustainable industrial methods. Literature searches were conducted on published scientific articles between 2016–2026 , initially yielding a total of 274 publications, from which 13 articles were selected according to the inclusion criteria. The majority of studies utilized the tubers as the source of anthocyanins. The review findings indicate that the optimization of extraction methods is proven to be crucial. Methods such as ASE, UAE, HPCD, and SCCO2 offer significantly higher yields compared to conventional extraction. This review is expected to serve as a scientific reference for the development of efficient, eco-friendly, and commercially valuable anthocyanin isolation technology.
Isolation and Medicinal Applications of Clove Eugenol : Systematic Literature Review Salnus, Subakir
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

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Abstract

This review synthesizes research on "Good techniques for isolation and purification of chemical composition of clove compounds, focusing on eugenol, and their medicinal uses" to address inconsistencies in extraction efficacy and bioactivity preservation. The review aimed to evaluate extraction and purification methods for eugenol isolation, benchmark yield and purity, identify associated medicinal properties, compare conventional and green technologies, and analyze extraction parameters influencing bioactivity. A systematic analysis of studies employing hydro-distillation, Soxhlet, microwave-assisted, ultrasound-assisted, supercritical CO2, and deep eutectic solvent extractions was conducted, alongside chemical and chromatographic purification techniques. Findings indicate that microwave-assisted and ultrasound-assisted methods achieve higher eugenol yields (up to ~20%) and maintain bioactivity more effectively than conventional methods, while green technologies reduce solvent toxicity and energy consumption. Chemical purification attains high purity (>95%) but often compromises yield and sustainability. Analytical methods such as GC-MS and HPLC provide robust purity assessment, though standardization remains limited. Bioactivity assays confirm strong antioxidant, antibacterial, and antiinflammatory effects linked to extraction parameters and purity levels. Integration of extraction and purification processes is emerging but underdeveloped, with scalability and reproducibility challenges persisting. These findings underscore the need for standardized, sustainable protocols optimizing yield, purity, and medicinal efficacy of eugenol, informing future pharmaceutical and nutraceutical applications.
Molecular Docking of Quercetin for Inhibition of Enoyl-Acyl Carrier Protein Reductase in Mycobacterium tuberculosis Irfandi, Rizal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4345

Abstract

Tuberculosis remains a global health issue, with treatment hindered by drug resistance. This study aims to identify the potential of Quercetin as an inhibitor of Enoyl-Acyl Carrier Protein Reductase (M. tuberculosis), a key enzyme in the fatty acid biosynthesis of the bacteria. Using molecular docking, Quercetin is evaluated based on its binding affinity and stability with the target protein. The docking results show that Quercetin binds to the active site of Enoyl-Acyl Carrier Protein Reductase through hydrogen bonds, π-alkyl, and π-sigma interactions, with an RMSD value of 1.6466 Å, indicating valid results. Comparison with the control compound, 5-hexyl-2-(2-methylphenoxy)phenol, reveals that Quercetin has a stronger binding affinity, supporting its potential as a more effective enzyme inhibitor. These findings open new opportunities for the development of natural compound-based anti-Tuberculosis therapies that can address the growing problem of drug resistance. Further research is needed for experimental validation in biological models and the development of more efficient Quercetin formulations.
Antifouling Membrane Modification for Water Desalination: Study of Synthesis and Modification Alam, Muhammad Nur
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4370

Abstract

One of the most important ingredients on earth that everyone needs is water. Consumption of large amounts of water is needed in various human activities such as agriculture, power generation, sanitation, drinking water needs and others. Membrane technology has developed into an indispensable platform technology for water purification, including seawater and brackish water desalination, due to its energy-saving and cost-effective qualities. However, membrane fouling, which results from the non-specific interaction between the membrane surface and foulants, severely impedes the effective deployment of membrane technology. Therefore, this review aims to provide a complete overview of the fabrication and modification of polymer or biopolymer based membranes as an antifouling membrane that focused on the method and performance of antifouling membrane, including water flux, salt rejection, and fouling properties. This review will first outline the main foulants and the primary mechanisms of membrane fouling, followed by a discussion of the development of antifouling membranes, including antifouling tactics and preparation methods. In the final site, the author will be show about the application, challenges and potential future of the antifouling membrane for water desalination.
A Systematic Literature Review: Chitosan-Based Membrane for Pollutant Removal from Wastewater Alam, Muhammad Nur
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4371

Abstract

This review synthesizes research on development of synthesis techniques and modification methods for chitosan- based membranes, all application areas for pollutant separation to address inconsistencies in membrane performance and limited comparative analyses across pollutant classes. The review aimed to evaluate synthesis and chemical modification strategies, benchmark fabrication methods for mechanical strength and selectivity, identify nanomaterial integration approaches, compare pollutant removal efficiencies, and analyze challenges in membrane applications. A systematic analysis of studies from diverse synthesis methods—including phase inversion, electrospinning, and 3D printing—and modification approaches such as chemical crosslinking and nanomaterial incorporation was conducted. Findings reveal that nanocomposite and crosslinked membranes exhibit enhanced mechanical stability, permeability, and selective removal of heavy metals, dyes, and organic pollutants, with adsorption capacities reaching up to 1500 mg/g and oil-water separation efficiencies exceeding 98%. However, variability in synthesis protocols, limited regeneration data, and insufficient real wastewater evaluations constrain practical scalability. Integration of photocatalytic and antifouling modifications improves fouling resistance and operational longevity, though long-term durability remains underexplored. These results underscore the potential of tailored chitosan-based membranes for multifunctional pollutant separation while highlighting the need for standardized methodologies and comprehensive regeneration studies. The synthesis informs future research directions to optimize membrane design and facilitate broader implementation in sustainable water treatment technologies.
Transition Metal Layered Double Hydroxide Nanosheets for Breast Cancer Drug Delivery Irfandi, Rizal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4375

Abstract

This review synthesizes research on transition metal layered double hydroxide nanosheets in breast cancerdrug encapsulation to address challenges in targeted delivery, drug resistance, and controlled release. Thereview aimed to evaluate synthesis and functionalization strategies, benchmark drug loading and releaseprofiles, elucidate metal doping effects on targeting and uptake, compare therapeutic outcomes, and identifyclinical translation barriers. Literature selection focused on experimental in vitro and in vivo studies publishedup to mid-2024, emphasizing physicochemical characterization, cellular internalization, and therapeuticefficacy. Findings reveal that transition metal doping and surface modifications enable ultrahigh drug loadingcapacities with pH-responsive, tumor-specific release, enhancing intracellular delivery via receptor-mediatedand endocytic pathways. Multifunctional nanosheets demonstrate synergistic anticancer effects throughcombined chemo-, photothermal, and immunotherapies, with favorable biocompatibility and low systemictoxicity in preclinical models. However, variability in synthesis reproducibility, incomplete mechanisticunderstanding of metal ion interactions, and limited long-term safety data impede clinical translation.Integrating these findings underscores the potential of transition metal-doped LDH nanosheets as versatileplatforms for breast cancer nanotherapy while highlighting the need for standardized evaluation andcomprehensive in vivo assessments. These insights inform future research directions toward optimizingnanosheet design and advancing clinical applications in precision oncology.
Utilization of Yam Extract as an Alternative to Crystal Violet for Staining Streptococcus mutans Bacteria Ridwan, Asriyani; Fatimah; Mutmainnah, Nurul; Faisal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4328

Abstract

Gram staining is a fundamental technique in microbiology, vital for the initial identification of bacteria based on differences in cell wall structure, classifying them as Gram-positive and Gram-negative. This method is crucial for rapid clinical diagnosis. Currently, its primary stain, Crystal Violet, raises serious concerns due to its mutagenic, toxic, and environmentally unfriendly properties, necessitating the search for safer and more sustainable alternatives. This study focuses on the potential of yam tubers (Dioscorea sp.), an abundant local resource, as a substitute for Crystal Violet. Yam tubers are rich in anthocyanins, natural pigments with cationic properties and antibacterial activity, making them a promising dye candidate. The selected test bacterium was Streptococcus mutans, a Gram-positive, coccus-shaped bacterium and a major cause of dental caries, ideal for validating the staining ability of thick cell walls. The aim of this study was to evaluate the effectiveness of yam tuber extract in staining S. mutans and to compare its staining quality with standard Crystal Violet. The expected outcome is the creation of an economical, environmentally friendly, and sustainable staining method.
Visual Detection of Lead Ions (Pb²⁺) Using a Colorimetric Sensor for Fishery Products Fudhail, Ahmad; Irfandi, Rizal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4498

Abstract

The presence of lead ions (Pb²⁺) in fishery products poses potential risks to human health. Therefore, simple, rapid, and easily applicable detection methods are highly required. This study aimed to develop a simple colorimetric sensor for the visual detection of Pb²⁺ based on color change as an analytical signal. The sensor was prepared through the interaction of a complexing indicator with the target metal ion, resulting in a distinct and visually observable color response. The novelty of this work lies in the application of a simple colorimetric sensor with a low visual detection limit and high selectivity toward Pb²⁺, as well as its direct applicability to simulated fishery product samples without the need for complex analytical instruments. The results demonstrate that the developed sensor is capable of selectively detecting Pb²⁺ with a clear visual response, indicating its potential use as a low-cost and practical method for preliminary screening of lead contamination.

Page 8 of 8 | Total Record : 79

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