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Rizal Irfandi
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rizalirfandi043@gmail.com
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+6285215254648
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Jl. Bumi 18 Blok A 15 No. 1 Bumi Permata Hijau, Makassar, Sulawesi Selatan, Indonesia
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Kota makassar,
Sulawesi selatan
INDONESIA
Hayyan Journal
Published by Education and Talent Development Center Indonesia
ISSN : -     EISSN : 30466679     DOI : https://doi.org/10.51574/hayyan.v1i1.1130
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Medicine & Pharmacology
Focus and Scope This journal publishes articles related to chemistry. The scope of this journal includes: Inorganic Chemistry Organic Chemistry Physical Chemistries Chemical Instruments Analytical Chemistries Materials Chemicals Industrial chemistry Biochemistry Applied Science Applied Chemistry
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 52 Documents
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Literature Review: Network Pharmacology as a New Approach and Trend in Medicine ihya, Zahratul; Irfandi, Rizal; Rijal, Syamsu; Yani, Ahmad; Arafah, Muhammad; Badli Rompegading, Andi
Hayyan Journal Vol. 1 No. 1 (2024): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i1.1130

Abstract

Network pharmacology is a new approach to medicine that aims to understand drug interactions with body tissues more specifically. This concept involves a deep understanding of the mechanisms of drug action, drug metabolism, and the influence of drugs on tissue function. In recent years, network pharmacology has become a significant trend in drug development. This approach allows researchers to design drugs that are more effective and have fewer side effects. By understanding in detail how drugs interact with specific tissues, specific and targeted drug development can be undertaken. Network pharmacology also opens the door to the development of more particular and existent therapies. By taking into account individual differences in response to drugs, this approach allows for more effective and safer treatment. This article presents a literature review of network pharmacology as a new approach and trend in medicine. This literature review also explores the latest research and current trends in the world of medicine using a network pharmacology approach.This article shows that tissue pharmacology has great potential in more effective and safer treatments. With a better understanding of drug - tissue interactions, we can develop more targeted therapies and reduce the risk of undesirable side effects.
Comparative Analysis Of Chlorine Levels (Cl2) In Rice Before And After Cooking With The Iodometry Method Lidiawati, Dewi; Mubarak, Syarul; Padilla, Nur; Pare Rombe, Yunita
Hayyan Journal Vol. 1 No. 1 (2024): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i1.1133

Abstract

This study aims to determine the ratio of chlorine levels in rice before and after it is cooked using the iodometric method. This research was conducted on June 12 - July 7 2023 at the ITKeSMU Sidrap Chemistry Laboratory. The type of research conducted is laboratory experimental research to investigate certain symptoms or substances through tests and tests with quantitative examination using the iodometric method. Sampling in this study was carried out randomly by taking rice that has a intact shape, is not easily broken, rice has just been milled. The method test and the calculation of the average chlorine content in rice samples before and after cooking. The results showed that there was a large difference between the chlorine content in rice before cooking, which was an average of 127,16% and after cooking, which was an average pf 48,323%
Analysis of Vitamin Content in Tropical Fruits Jumrah, Elfira
Hayyan Journal Vol. 1 No. 1 (2024): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i1.1145

Abstract

Fruits are pointed out as natural sources of antioxidants, playing protective roles against aging, and chronic and degenerative pathologies. In this review it is shown that virtually unknown edible tropical fruits present significantly higher antioxidant activity when compared to temperate fruits considered to be good sources of antioxidantsThe tropical fruits, namely, Psidium Guajava L, Mangifera Indica L, and Carica Papaya L, are tropical fruits that have many benefits for the human body. They are rich in vitamin C, with three times the amount found in oranges, ten times the quantity found in papaya, and thirty times that found in bananas. Papaya is one of the fruit commodities that can be used almost as much. Crystal guava is a tropical fruit that is known to contain a large amount of vitamin A, and can be consumed regularly as a good antioxidant. It has various health benefits, such as antioxidant properties, improving digestive health, helping to lose weight, relieving flu symptoms, maintaining eye health, and nourishing the skin. It is also known that mango is an important source of micronutrients, vitamins, and other phytochemicals. Mango is called mango plants originate from India. The fruit is rich in vitamins A, C, D, and E, and it is also rich in antioxidants. The content of vitamin C is also high. The antioxidant activity test of ethanolic extract from solanum family leaves using methanol is used to reduce inflammation and protect body cells from the effects of free radicals that have the potential to cause various diseases. Further research is needed to better know the content of vitamins and pharmaceutical science natural ingredients with the ultimate goal, fruits that can overcome various health problems.
Analysis of Antioxidant Formulations of Watermelon Peel (citrullus lanatus) and Secang Wood (Caesalpinia sappan l.) as Jelly Candy Fitriani Abubakar, Andi Nur; Zulkarnain, A. Mutiara; Safitri Agustina, Ayu
Hayyan Journal Vol. 1 No. 1 (2024): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i1.1169

Abstract

Jelly candy made from watermelon rind and sappan wood is a candy with a soft texture that is processed with the addition of gelatin and low-calorie sugar. Based on the literature search that has been carried out. There has been no research regarding the antioxidant activity of jelly candy from watermelon rind and sappan wood. Him this research aims to determine the effect of varying concentrations of watermelon rind and wood extracts sappan in making formulations as jelly candy, the potential of jelly candy as an antioxidant, and to know the SNI 3574.2-2008 standard which includes water content, ash content, reducing sugar content and the condition aroma and taste of jelly candy. The results of the chemical properties test show that the water content in F3 meets SNI namely 19.891995%, and the ash content shows results that meet SNI, namely at F1 0.028%, F2 0.02905% and F3 0.02985%. Meanwhile, the reduced sugar content also shows results that meet SNI, namely F1 0.00219%, F2 0.00144% and F3 0.00048%. The organoleptic test results on the color indicator are 6.72 (somewhat like), the indicator of the aroma is 6.43 (somewhat like) and the taste indicator is 6.54 (somewhat like) and has met SNI with the condition normal. The results of the antioxidant activity test are in the medium category with an inhibition value of 36%.
A Design of "SWAFT" Technology for Separation of Fe, Pb, and Cu Metal Waste in Deli River Water Medan (Based on Coagulation-Adsorption Using Activated Carbon from Rice Husks and Aloe Vera Coagulant) Sinuhaji, Tubagus Rayyan Fitra; Purba, Darly Guntur Darris; Sirait, Hormat Gunawan; Ginting, Setia Rifai Matuanta; Nainggolan, Robby Samuel Meligust; Siahaan, Bungaran Immanuel
Hayyan Journal Vol. 1 No. 1 (2024): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i1.1197

Abstract

The increase in population has influenced the rising demand for water, and one way to meet this demand is by utilizing river water. Deli River is one of the rivers that flows through the city of Medan. The development of industries and settlements along the Deli River has affected its water quality due to heavy metal waste, specifically Fe, Pb, and Cu. This is evident from the deterioration of water quality characterized by changes in color and odor. One solution to address this issue is by using rice husk activated carbon as an adsorbent and aloe vera as a biocoagulant. Rice husk contains cellulose which can be converted into carbon and has a carbon content of 48.9%, while aloe vera contains mucilage which is an active coagulant used for water clarification. The principle used in this product is coagulation, which involves mixing chemicals, such as coagulants, with Deli River water followed by the adsorption process, where metal particles accumulate on the surface of the adsorbent. The results obtained showed a decrease in the parameters of Fe, Pb, and Cu metal content successively by 0.0092 mg/liter; 0.0081 mg/liter, and 0.0072 mg/liter. Thus, the filtered water meets the clean water quality standards set by Government Regulation No. 82 of 2001. Based on the existing problems and potentials, this product becomes a smart solution to assist the community, especially those in riverside areas, in water treatment and also addresses the challenges in preparing human resources that are actualized in facing the era 5.0 revolution.
Relationship of Leukocyte Numbers and Triglyceride Levels in Type 2 Diabetes Mellitus Patients Nurhilaliyah
Hayyan Journal Vol. 1 No. 1 (2024): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i1.1256

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to abnormalities in insulin secretion, insulin action or both and is included in the group of non-communicable diseases. In patients with type 2 diabetes mellitus, progressive hyperglycemia occurs resulting in insulin deficiency, where insulin deficiency can damage lipoprotein lipase activity and result in lower HDL levels and higher triglyceride levels. High triglyceride levels in type 2 diabetes mellitus patients result in increased macrophage infiltration into adipose tissue which causes an increase in the number of leukocytes. The aim of this research is to determine the relationship between the number of leukocytes and triglyceride levels in people with type 2 diabetes mellitus. This type of research is a quantitative descriptive laboratory observational approach. The number of samples in this research was 35 samples obtained through techniquespurposive sampling. Based on the results of the Pearson correlation static test analysis to determine the relationship between the number of leukocytes and triglyceride levels in type 2 diabetes mellitus sufferers, the sig value was 0.035, while for thePersonal Correlation namely 0.358 so it was concluded that there was a relationship indicating that there was sufficient correlation between the number of leukocytes and triglyceride levels
Determination of Total Flavonoid Contents of The Antioxidant Herbal Beverage Caesalpinia sappan L. Quantitatively Using The Calorimetry Methods of The AlCl3 Reaction That Forms Complex Compounds syahdam karneng, syahdam karneng
Hayyan Journal Vol. 1 No. 1 (2024): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i1.1264

Abstract

Body health is an important thing, so many choices of methods for maintaining body fitness are offered. One way is to consume herbal plants that contain antioxidant compounds. Antioxidant compounds can neutralize and prevent damage caused by free radicals in the body. The plant that contains high antioxidant compounds is secang (Caesalpinia sappan L.). In previous research, a test of the antioxidant activity of this plant with an IC50 value of 11.37 ppm was reported, but a test to determine the total flavonoid content of the compound had never been carried out. So, this research is interesting to carry out with the aim of finding out the total flavonoid levels in a serving size of 0.05 grams of secang powder. The method for determining total flavonoid content used is the calorimetry method with AlCl3 reagent as a complex compound forming and quantitative analysis using an Ultraviolet Visible (UV-Vis) spectrophotometer. The flavonoid content value obtained was 0.2370% b/b for a serving size of 0.05 grams of sample. These results indicate that the secang sample contains flavonoid compounds which can be useful for increasing the body's immunity.
Contribution of Kurkuminoid Proteins From White Kunyit Root Extract (Curcuma zedoaria rosc.) ss anti-inflammatory zubaedah, Siti; Yanti , Hasvika; Widia , Besse; Rompegading, Andi Badli
Hayyan Journal Vol. 1 No. 2 (2024): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i2.1572

Abstract

This research aims to identify curcuminoid compounds from white turmeric (Curcuma zedoaria Rosc.) rhizome extract as anti-inflammatory drugs. White turmeric rhizomes contain curcuminoids which can be used as anti-inflammatory. Curcuminoids are yellow polyphenols, insoluble in water and acidic solvents but soluble in dimethyl sulfoxide, acetone and ethanol. It has various benefits such as lowering blood sugar levels, acting as an antioxidant, and having anti-carcinogenic properties. The identification of curcuminoid compounds in white turmeric as potential anti-inflammatory drugs provides a significant contribution to the development of natural drugs for inflammation-related disorders. The research method used is descriptive through literature research, with a focus on exploring the contents and benefits of white turmeric in traditional medicine. This research provides evidence that supports the efficacy of curcuminoids from white turmeric rhizome extract as an anti-inflammatory agent. However, to validate the effectiveness and safety of using white turmeric as an anti-inflammatory drug in humans, further research is needed including pharmacodynamic studies, pharmacokinetics and clinical trials. Apart from that, purification of curcuminoid compounds and research on interactions with other drugs also need to be carried out to strengthen the scientific basis and develop more effective drug formulations.
Literature Study: Chemical Content and Benefits of Bidara Leaves (Ziziphus Muritiana) as an Indonesian Herbal hajeriani
Hayyan Journal Vol. 1 No. 2 (2024): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i2.1603

Abstract

Plants with various varieties can be found in various regions in Indonesia. Many varieties of medicinal plants in Indonesia have been used as raw materials for making medicines and several of these plant types have been clinically evaluated for their phytochemical composition, efficacy and safety of use. Bidara leaves, scientifically known as Zizhipus mauritiana L., are often used in Traditional Chinese Medicine to cure a number of diseases, such as urinary problems, digestive disorders, fever, liver complaints, weakness, anemia, obesity, diabetes, bronchitis, skin infections, loss of appetite. eating, pharyngitis, diarrhea, cancer, and insomnia. The reference literature obtained from the search results is then studied and examined to determine research findings, then described using the data or samples collected as is. Based on research and literature studies, bidara leaves have various significant health benefits, especially because of their rich chemical compound content. The flavonoid, tannin, terpenoid, steroid, alkaloid, triterpenoid and saponin compounds in bidara leaves have been proven to have anti-microbial, anti-depressant, anti-inflammatory, anti-oxidant and anti-cancer activity. Furthermore, bidara leaves can also protect body cells such as the kidneys and brain from oxidative stress, which is one of the main risk factors for cancer. Therefore, bidara leaves can be a safe and natural alternative treatment for various diseases and health conditions.
Utilization of SDS-PAGE (Sodium Dodecyl Sulfate-Polyacrylamide Gel) Electrophoresis in Protein Purification Jumrah, Elfira; Sudding, Sudding; Amalia Luqman, Alya; Zachrina, Dwiny; Khairunnisa, Rifqiani; Hardiyanti, Sri; Dwi Gladinda, Virginia
Hayyan Journal Vol. 1 No. 3 (2024): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i3.1619

Abstract

A protein can be identified based on each level of its structure. Every protein contains at least primary, secondary and tertiary structures. Only a few proteins have a quaternary structure as well. The primary structure consists of a linear chain of amino acids. One of the electric field-mediated separation methods that is often applied to analyze proteins based on their size is SDS-PAGE electrophoresis. This technique is based on the assumption that after denaturation, the polypeptide chains covered in SDS micelles have comparable surface charge densities, so that the resulting differences in electrical migration are based on their size. SDS-PAGE separates protein molecules based on their particle size and shape. This gel can be made with varying pore sizes which are determined based on the total amount of acrylamide compound added (gel concentration). The gel pore size will become smaller as the gel concentration increases so that only protein molecules that have a small molecular weight can pass through. This measure of the molecular weight of a protein is useful in mapping proteins (protein profiling). The gel staining used is bromophenol blue which functions to color proteins because it binds weakly to proteins. The higher the protein concentration of a sample being electrophoresed, the resulting band will appear clear and thick. However, if the protein concentration of a protein is low, the resulting band will appear thin.

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