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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : 10.25026/jtpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Tropical Pharmacy and Chemistry is a Six monthly (June and December), international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry publishes manuscripts (Original research Article, review articles, Mini-reviews, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics & Biopharmaceutics, Novel &Targeted Drug Delivery, Nanotechnology & Nanomedicine, Pharmaceutical Chemistry, Pharmacognosy & Ethnobotany, Phytochemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Pharmacogenomics, Pharmacovigilance, Natural Product Research, Drug Regulatory Affairs, Case Study & Full clinical trials, Biomaterials & Bioactive polymers, Analytical Chemistry, Organic Chemistry, Physical Pharmacy, Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 298 Documents
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Overview of Nutritional Status of Pregnant Women with Preeclampsia: Case Study in Aru Islands Regency, Dobo City, Southeast Maluku Rifatolistia Tampubolon; Hapsari Probowati; Judith Devi Manutilaa
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.272

Abstract

Background: Preeclampsia is a syndrome in terms of hypertension after 20-week pregnancy referring to a pregnant woman that previously had normal blood pressure, followed by having hypertension, proteinuria, edema and generally occurs in the third trimester of pregnancy. Preeclampsia is one of five main causes of maternal mortality up to 12% in the world as well. Objective: This study was conducted to describe nutritional status of pregnant women with preeclampsia in Aru Islands Regency, Dobo City, Southeast Maluku. Methodology: This study used mix methods, namely, quantitative and qualitative research with Case Study design. Qualitative research was to determine nutritional status of pregnant women with preeclampsia and quantitative research was to record nutrition intake of pregnant women and measure nutritional status of pregnant women with preeclampsia. Results & Discussion: Characteristics of participants with preeclampsia were more than 27 years old, worked as housewife that could be one of stress triggers and had some risk to increase preeclampsia cases because of stress that caused blood pressure increase. Preeclampsia was detected in pregnancy term of participants about 20-30 weeks according to Maternal and Child Health data. Preeclampsia risk was doubly by every increase in body weight (5-7 kg). Participants had body weight increase ranging from 8-25 kg which caused preeclampsia risk increase. Parameters of recommended dietary allowances of pregnant women including energy excess, protein deficit, fat excess, calcium and zinc deficiency were secondary factor of preeclampsia risk increase in Aru Islands Regency, Dobo City, Southeast Maluku.
Determination of 4,4-(propane-2,2-diyl) diphenol (Bisphenol A) Concentration in Canned Tomatoes G.P Fabusola; V.O.E Akpambang
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.273

Abstract

Bisphenol A (BPA) is a chemical used in the production of polycarbonate plastics and for lining metal cans, used in canned foods. BPA is a well-known endocrine disrupting chemical, it therefore, is very hazardous to human health. BPA levels were determined in three brands of canned tomatoes (Gino, Super Mama, Derica) as sold in Nigerian markets. The samples were analyzed using solvent extraction, separation and quantitation by gas chromatography- mass spectrometric method. The recovery value for BPA in the method was 89% with the relative standard deviations of 3%.The BPA concentration in the samples ranged from 0.124 to 0.141 (), which are higher than the European Food Safety Authority Specific Migration Limit (SML) of 0.05 mg/kg in food sample. The samples analyzed in this work may be, therefore, of a potential health concern to the consumers.
Phytochemical, Proximate, and Vitamin C Content in Morinda citrifolia (Noni) Selina Ama Saah; David Adu-Poku
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.274

Abstract

Morinda citrifolia, L commonly called noni, has a long history as a medicinal plant and is reported to have a broad range of therapeutic effects, including antibacterial, antiviral, antifungal, antitumor, antihelmin, analgesic, hypotensive, anti-inflammatory, and immune enhancing effects. Photochemical analyses of ethanol and hexane extracts of noni fruit revealed the presence of flavonoids, terpenoids, alkaloids and steroids. Proximate composition of the noni fruit revealed a moisture content of 54.21, crude protein 2.18, crude fat 3.25, crude fiber 4.49, ash 0.73 and carbohydrate 35.14%. The Vitamin C content was estimated using iodometric titration and found to be 134.10 mg/100g. This suggests that the noni fruit can if consumed can help promote good health.
Metformin Role in Diabetic Patients with Tuberculosis: a Review Esravila Ariya Wibisono
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.275

Abstract

Tuberculosis (TB) epidemic is a global health challenge, and WHO estimated the incidence of the new cases reaching 11.1 million people in 2017. Indonesia is classified as a high TB burden country, with 8% of its population infected by TB and ranks third in the world. Type-2 diabetes mellitus (T2DM) is known comorbidity for TB patients. TB-T2DM patients have a higher chance of morbidity, mortality, relapse, bacterial resistance, treatment failure, and slower sputum conversion than TB patients without T2DM. Recent studies suggest that metformin may have a potential synergistic role for TB-T2DM patients. Metformin has immunomodulator properties that can improve the body's immune response and inflammatory response against TB in individuals with T2-DM.
Use of CMC Na as Gelling Agent in Nanoemulgel Formulation of Methanol Extract of Sappan Wood (Caesalpinia sappan L) Dwi Saryanti; Iwan Setiawan; Hendri Hari Dayanto
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.276

Abstract

Sappan wood ( Caesalpinia sappan L.) contains brazilin including isoflavonoids which act as antimicrobials (against bacteria on skin) and antioxidants. Nano technology increases surface area, enhance stability, reduces skin irritation, protects from degradation, and has good drug delivery. Nano emulsion preparations can help permeability of the drug on the membrane surface. Nanoemulgel preparations can provide stability and good drug release compared to mixing drugs directly in a gel base. The purpose of this study were to determine the effect of different concentrations of CMC-Na gelling agents and which concentration of CMC-Na gelling agents that can produce the best nanoemulgel preparations. Nanoemulsion made from isopropyl myristate as oil phase, tween 80 as surfactant and polyethylenglycol as co-surfactant. Nanoemulsion formulations were tested by measurement of % transmittance by UV-Vis spectrophotometry at a wavelength 650nm. Nanoemulgel is made from nano emulsions used basis of CMC-Na at concentrations 3%, 4%, and 5%. The results showed percent transmittance was 71.86%. The results of physical quality and stability tests of the nanomulgel wood preparations showed an influence on the physical properties such as adhesion, dispersion and viscosity, the greater concentration of CMC-Na gelling agents in nanoemulgel preparations, the greater values adhesion and viscosity, while the spreadability was smaller. Concentration of CMC-Na gelling agent that produced the best of sappan wood nanoemulgel ( Caesalpinia sappan L.) was 5% that stable by freeze-thaw testing.
Phytochemical Screening, Cytotoxicity and Antioxidant Activities of Leaves Extracts from Eucalyptus citriodora Musa Maikudi Idris; Adamu Mohammed Yelwa; Aminu Muhammad
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.280

Abstract

The genus Eucalyptus has been used in African traditional medicine for the treatment of cardiovascular diseases and diabetes. In this work, chloroform and methanol extracts from the leaves of Eucalyptus citriodora was investigated for their phytochemicals, cytotoxicity and antioxidant potentials. Phytochemical screening of the extracts showed the presence of alkaloid, flavonoid, phenols, reducing sugar and steroids in the methanol extract. IR absorptions of the extract supported the presence of these phytochemicals by revealing the bands 3335 cm-1 (O-H), 1613, 1480 cm-1 (C=C) and 1721 cm-1 (C=O). Evaluation of the cytotoxicity of the methanol extract using brine shrimp assay, suggested that, the extract was not toxic with LC50 value of 1.64 mg/mL. Antioxidant potentials of both chloroform and methanol extracts were determined using phenolic content quantification and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. Methanol extract (37.32 ?g TAE/mg) had higher phenolic content than the chloroform extract (12.09 ?g TAE/mg). The radical scavenging potentials of the extracts recorded inhibitory activities of IC50 values of 892.7 ?g/mL (chloroform extract) and 8.3 ?g/mL (methanol extracts) relative to the positive control values of 31.1 ?g/mL (butylated hydroxytoluene) and 3.5 ?g/mL (ascorbic acid). These results showed that E. citriodora might contain promising antioxidant agents.
The Effectiveness of Sea Urchin Extract (Echinometra matthaei) for Wound Healing on Deep Second-Degree in White Rats (Rattus norvegicus) Wistar Angelica Kresnamurti; Dita Nurlita R; Fitri Budiarti
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.281

Abstract

Background: Burns is a form of tissue damage caused by high temperatures. Echinometra matthaei sea urchins have several secondary metabolites that can potentially help in the healing process of burns. In this study, 70% E. matthaei ethanol extract was formulated in the form of O / W (oil in water) type cream preparations which were applied topically. Objective: This study aims to determine the effectiveness of E. matthaei ethanol extract cream preparations on the healing of second-degree burns in Wistar strain rats. In this study preparations were made in 3 formulations, namely Formulation 1 (extract concentration of 1%), Formulation 2 (extract concentration of 3%), and Formulation 3 (extract concentration of 5%). This research was conducted for 7 days with the method used is the post-test only control group design. Experiments were given induction of burns using a hot plate with a diameter of 20 mm at a temperature of ± 200ºC for 15 seconds. Wound healing is observed periodically by observing macroscopically healing inflammation of the inflammatory phase and observing tissue growth in the proliferation phase. Results: The average percentage of inflammation healing showed improvement in the F2: 100%, F1: 80%, F3: 71% results were better than the wound group: 50% as evidenced by the value ? = 0.012 (
Anti-Inflammatory Effects of Miang Bean Leaves (Mucuna pruriens) Fadilaturahmah Fadilaturahmah; Firman Syukri; Yona Afriani; Putra Santoso
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.284

Abstract

Inflammation is a serious health problem that needs treatment. The use of steroids and non-steroidal anti-inflammatory drugs (NSAIDs) can actually relieve inflammatory reactions well, but their long-term use can have many side effects and are uneconomical. Therefore, the use of natural ingredients that are effective and economical is needed. One of the plants that are considered anti-inflammatory is the leaves of miang beans (Mucuna pruriens). The purpose of compiling this narrative review is to analyze the phytochemical content of miang beans leaves and its mechanisms for inflammatory reactions. The narrative study of this preparation was carried out using the literature study method from August to September 2020. The phytochemical content of miang bean leaves are alkaloids, flavonoids, saponins, cyanogenic glycosides, and tannins. Phytochemicals that have a direct anti-inflammatory effect are alkaloids, flavonoids, saponins, and tannins. Alkaloids are antibacterial. If there are bacteria that cause inflammation, the alkaloids will damage the bacterial peptidoglycan cell walls, thus causing bacterial cell death and preventable inflammatory reactions. Flavonoids have anti-inflammatory effects by inhibiting macrophages from producing NO (nitric oxide) and inhibiting the cyclooxygenase pathway. Saponins affect the inflammatory reaction by inhibiting the lipoxygenase pathway and inhibiting the release of inflammatory mediators. Meanwhile, tannins affect the inflammatory reaction by inhibiting macrophages from producing ROS (Reactive Oxygen Species). Potential which is fatal because it can turn into cyanide acid. However, the content of these cyanogenic glycosides can be minimized by drying at low temperatures. So, mung bean leaves are effective as anti-inflammatory drugs because the alkaloids, flavonoids, saponins, and tannins they contain are anti-inflammatory.
Antioxidant Activity Test of Effervescent Granules Morinda citrifolia L Leaf Extract with DPPH Free Radical Absorption Method Muthmainah Tuldjanah; Niluh Puspita Dewi; Dian Rahmawati
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 4 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i4.285

Abstract

Morinda citrifolia. L leaf is a plant that has the potential as an antioxidant due to the presence of compounds in the form of flavonoids and other phenolic compounds that can function as natural antioxidants. In connection with this, research was carried out to Morinda citrifolia. L formulate leaf extract in the form of effervescent granules. Morinda citrifolia leaf extract was macerated with ethanol 96% as solvent. Phytochemical screening showsthat the extract contains flavonoids, tannins, saponins and alkaloids. The extract was formulated with various concentrations of F1 (20%), F2 (25%), F3 (4%). Determination of antioxidant activity using the DPPH free radical immersion method. The results showed that the concentration in the granules influenced antioxidant activity with IC50 values of 109.05 ppm, 101.33 ppm and 73.28 ppm, respectively
Test of the Aphrodisiac Effect of Ethanol Extract of Roots, Stems and Leaves of Packaged Plants (Smilax rotundifolia) on Male White Rats (Sprague Dawley) Kiki Rizki Handayani; Ayu Wulandari
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 4 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i4.286

Abstract

Developing countries use medicinal plants for aphrodisiac treatment, one of which is a pack plant (Smilax rotundifolia) which is commonly used to enlarge male genitalia in Papua Indonesia. Because these claims are not scientifically tested and proven, at this time This study aims to determine the effect of the ethanol extract of S. rotundifolia stem and leaf tubers on the parameters of sexual behavior in male Sprague Dawley rats. As well as fear the most effective plant parts have aphrodisiac activity. Thirty rats were divided into 5 groups (A-E) consisting of group A given 0.5% Na CMC colloid solution (normal control), group B given X-gra® suspension dosage 51.37 mg / kgBW (control positive), group C was given root ethanol extract dosage 200mg / kgBB, group D was given stem ethanol extract dosage 200mg / kgBB and group E was given leaf ethanol extract dosage 200mg / kgBB. The aphrodisiac test was observed on the 31st day with a ratio of male and female rats (1: 2). All parameters tested in the extract group showed significant differences with the normal group. This showed an aphrodisiac effect in all extract groups. The 200 mg / KgBB stem extract group reduced latent rates and intromission mounts as well as increased copulation rates, showing a marked increase in the number of intromissions, reduced ejaculatory latency and inter-intromission interval, and increased ejaculation frequency. which was not significant in the X-gra group (positive control) (p

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