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Reza Pratama
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Jurnal Farmasi Galenika
Published by Universitas Bhakti Kencana
ISSN : 24069299     EISSN : 25794469     DOI : https://doi.org/10.70410/jfg
Core Subject : Health,
Medicine & Pharmacology Public Health
The aim of JFG is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences and technology. The scope of the journal is Pharmaceutical sciences, its research and its application. The journal aims to cover the latest outstanding developments in the field of Pharmaceutical science and Technology but not limited to the following branches: Pharmaceutics Pharmaceutical technogy International Regulatory Validation Techniques Industrial Pharmacy Nanotechnology Novel Drug Delivery Systems Quality Control Quality Assurance BioTechnology Bioinformatics Proteomics Biochemistry Pharmacognosy Herbal technology Pharmacology Toxicology Pharmacy Practice Pharmacoinformatics Phytochemistry Pharmaceutical Analysis Chiral Chemistry Synthetic Chemistry Drug Development Clinical Pharmacy Pharmacogenomics Pharmacetical Engineering
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
 1 
Search results for , issue "Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2" : 5 Documents clear
Analisis Hubungan Polifarmasi Dengan Potensi Interaksi Obat Pada Peresepan Pasien Diabetes Melitus Tipe 2 Mulyani, Yani; Siti Balqis, Salwa; Sutrisno, Entris; Anggriani, Ani
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.332

Abstract

The IDF estimates that the prevalence of diabetes mellitus based on age will continue to increase from 2021 to 2045 (24.0% vs 24.7%). Patients with diabetes mellitus have comorbidities that result from elevated blood glucose levels, leading to polypharmacy and potential drug interactions. This study aims to determine the percentage of drug interactions and the relationship between polypharmacy and the potential for drug interactions in patients with type 2 diabetes mellitus at RSU Rama Hadi Purwakarta. The study was conducted using a cross-sectional, retrospective method, analyzing prescriptions of patients with type 2 diabetes mellitus at RSU Rama Hadi from September 1 to 30, 2022. Prescriptions were identified for interaction types and severity using drugs.com, Medscape, and Stockley's Drug Interaction Handbook, 9th edition, with results analyzed using Fisher's exact test. The study found that patients aged 56-65 years (40.1%) were more likely to suffer from type 2 diabetes mellitus, with females having a higher incidence compared to males (70.7% vs 29.3%). Among 147 prescriptions, 97% had drug interactions, with moderate severity predominating (97.8%), and pharmacodynamic interactions being the most common (76%). Fisher's exact test revealed a p-value of 0.001 (p < 0.005). Thus, it can be concluded that there is a significant relationship between polypharmacy and the potential for drug interactions in the prescriptions of type 2 diabetes mellitus patients at the pharmacy department of RSU Rama Hadi Purwakarta.
Evaluasi Efektivitas Penggunaan Obat Antihipertensi Pada Pasien Preeklampsia Rawat Inap Di RSIA Sitti Khadijah 1 Makassar Friska Adelia S; Jangga, Jangga; Kurnia Anjani, Qonita
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.336

Abstract

Preeclampsia is a medical condition that occurs during pregnancy, characterized by high blood pressure and the presence of protein in the urine (proteinuria) after 20 weeks of gestation. This condition poses a risk to pregnant women, fetuses and newborn babies. Mothers with preeclampsia suffer severe morbidity and mortality due to impaired function of organs such as the kidneys and liver, as well as blood clotting problems, which can occur in hypertension in pregnancy. Problems with the placenta and stunted fetal growth are also risks. Therefore, evaluation of the use of antihypertensive drugs is very important. The goal is to ensure that the drugs used are appropriate, effective and safe for pregnant women. This study aims to determine the profile and effectiveness of the use of antihypertensive drugs in inpatient preeclampsia patients at RSIA Sitti Khadijah 1 Makassar. This research uses a non-experimental (observational) descriptive method. The data used is retrospective, namely in the form of secondary data. The data source comes from medical records of inpatients diagnosed with preeclampsia. The research was conducted at RSIA Sitti Khadijah 1 Makassar for the period January 2023 to April 2024. The results of the study showed that the use of antihypertensive drugs in 47 preeclampsia patients, namely nifedipine monotherapy, was 87%, the combination of nifedipine and methyldopa was 9%, the combination of nifedipine and amlodipine was 4%. Most of the antihypertensives used are effective and have achieved the therapy goals of the Queensland Clinical Guideline 2021. Compliance with the use of antihypertensive drugs and doses was achieved at 96%, while 2% were declared inappropriate. As many as 94% were effective in reducing blood pressure according to therapy goals.
Penelusuran in Silico Potensi Antimalaria dari Karang Lunak Lobophytum sp. sebagai Inhibitor Dihydroorotate Dehydrogenase dari Plasmodium falciparum Arfan, Arfan; Rayani, Nur; Ode Aman, La
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.341

Abstract

Malaria is one of the infectious diseases caused by the Plasmodium parasite and remains a persistent health challenge. Therefore, exploring compounds with potential as antimalarials remains a crucial aspect. This study aims to evaluate the identified compounds from the soft coral Lobophytum sp. as antimalarial candidates using molecular docking techniques, predicting their profiles including pharmacokinetic and drug likeness. The identified compounds from this soft coral were successfully docked into the active site of the Plasmodium falciparum's enzyme dihydroorotate dehydrogenase (DHODH) using AutoDock Vina, and pharmacokinetic profiles and drug likeness were predicted using SwissADME. Compounds Saurufuran B and Oxyphyllacinol from Lobophytum sp. exhibited binding affinity energies of -9.4 kcal/mol and -8.6 kcal/mol against DHODH, which were more negative than other compounds but less negative than the inhibitor F1T (-10.7 kcal/mol). These compounds showed hydrogen bonding with amino acids His185, Lys429, Asn458, and Ser505 and hydrophobic interactions with amino acids Cys175, Leu176, Phe188, Ile263, Arg265 of the DHODH enzyme. The pharmacokinetic profile of these compounds revealed good solubility and high gastrointestinal absorption, making them suitable for drug development. These compounds are expected to inhibit the function of CYP450 isoforms as important metabolizing enzymes in the body. Furthermore, Saurufuran B and Oxyphyllacinol also exhibit a safe toxicity profile and meet the drug-likeness criteria based on Lipinski's Rule of Five. These findings suggest the potential of Saurufuran B and Oxyphyllacinol from Lobophytum sp. as DHODH enzyme inhibitors for P. falciparum with favorable affinity predictions and pharmacokinetic profiles for antimalarial drug development.
Pengembangan Gel Antiseptik Tangan Mengandung Minyak Atsiri Jeruk Lemon Menggunakan Metode Mikroemulsi Gel Husni, Patihul; Cahya Lestari, Riska; Hartono, Kusdi
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.342

Abstract

Hand antiseptic gel preparation is a product that is widely used to protect the body from the entry of bacteria through the hands because of its practical use. Lemon peel (Citrus limon (L) Burm. F) contains essential oils that can inhibit the growth of bacteria so it can be used as a natural antiseptic. This research is aimed at obtaining the best formula preparation of hand antiseptic gel containing lemon essential oil (Citrus lemon (L) Burm. F). The microemulsion formula of lemon essential oil is optimized by making variations in the concentration of surfactant (Tween 80) and cosurfactant (propyleneglycol dan glycerin) which is then formulated into gel dosage form by using a variation in the concentration of the gelling agent. The preparation of the gel carried out a physical stability test that included organoleptic testing, homogeneity, pH, and viscosity. The optimization result of the best microemulsion formula is a formula with a Tween 80 as a surfactant and propylene glycol as a cosurfactant. Hand antiseptic gel preparation containing lemon essential oil (Citrus limon (L) Burm. F) with formula F2 is the best preparation because it is more stable according to the physical stability test of the preparation.
Gambaran Penggunaan Tanaman Obat Di Desa Daya Murni Kecamatan Tumijajar Kabupaten Tulang Bawang Barat Tahun 2024 Mulatasih, Endah; Wulan Syafira, Melsya; Isnenia, Isnenia; Yulyuswarni, Yulyuswarni
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.343

Abstract

Medicinal plants have long been used by Indonesian people as an alternative traditional treatment. Plants have been an important source of medicine for thousands of years. The use of plants for healing is the oldest form of medicine in the world. The medicinal plants chosen are usually plants that can be used for first aid or light medicines such as coughs and fever. Based on a pre-research survey in Dayamurni Village, it was found that many people still use medicinal plants for various health complaints. This study aims to determine the overview of medicinal plant usage in Dayamurni Village, Tumijajar District, West Tulang Bawang Regency in 2024. This research is a quantitative descriptive study with a quota sampling technique of 100 respondents who meet the inclusion and exclusion criteria. Data collection was carried out through interviews using questionnaires. The results showed that the majority of medicinal plant users were women (83%), aged 40-44 years (19%), with high school education (55%). The most widely used type of plant was ginger (27,0%), with the method of use being drunk (92,9%), in fresh form (92,9%). Usage was generally only when sick (88%), aimed at curing diseases (65%), especially for treating coughs (23,0%). The main source of information was parents (67%), and most did not use accompanying medications (60%).

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