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JOURNAL OF Pharmacy and Tropical Issues
Published by Indonesian Public Health-Observer Information Forum
ISSN : 28074319     EISSN : 28074122     DOI : https://doi.org/10.56922/pti.v4i2
Core Subject : Health,
Medicine & Pharmacology
Jurnal penelitian dibidang kesehatan meliputi ilmu keparmasian. Penelitain sesuai tren pengobatan sesuai sumber alam di negara tropis. Pengembangan obat dan pendistribusian kepada pelanggan, dan sesuai aturan Badan Pengawas Obat dan Makanan (BPOM) - Republik Indonesia
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 63 Documents
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Evaluasi efektivitas fotokatalis zno/biochar terhadap degradasi antibiotik tetrasiklin menggunakan spektrofotometri uv-vis Husein, Saddam; Setiawan, Fatma Aris; Alkausar, Radho
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 1 (2026): May Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i1.3046

Abstract

Background: Tetracycline contamination in aquatic environments has become a serious issue due to its persistence and resistance to conventional degradation methods. Photocatalysis using ZnO/Biochar composite is an Advanced Oxidation Process (AOP) capable of degrading complex organic compounds through reactive radical formation. Purpose: To evaluate the effectiveness of ZnO/Biochar photocatalyst in degrading tetracycline based on catalyst dosage and irradiation time under UV-Vis light. Method: This experimental laboratory study used UV-Vis spectrophotometry at a maximum wavelength of 378 nm. Results: The 0.5 g dosage showed the highest degradation efficiency of 84% at 120 minutes. Increasing catalyst dosage up to 0.5 g improved degradation, while 1 g reduced efficiency due to increased turbidity. Degradation increased with irradiation time. The reaction followed pseudo-first-order kinetics with a rate constant of 0.0142 min⁻¹. Conclusion:  ZnO/Biochar effectively degrades tetracycline under UV-Vis irradiation, with optimal performance at 0.5 g catalyst dosage following pseudo-first-order kinetics.   Keywords: Photocatalysis; Tetracycline; UV-Vis; ZnO/Biochar.   Pendahuluan: Pencemaran antibiotik tetrasiklin di perairan menjadi permasalahan lingkungan karena sifatnya yang persisten dan sulit terdegradasi secara konvensional. Fotokatalisis menggunakan komposit ZnO/Biochar merupakan metode Advanced Oxidation Processes (AOPs) yang efektif dalam mendegradasi senyawa organik melalui pembentukan radikal reaktif. Tujuan: Mengetahui efektivitas fotokatalis ZnO/Biochar dalam mendegradasi tetrasiklin berdasarkan variasi dosis katalis dan waktu iradiasi menggunakan lampu UV-Vis. Metode: Penelitian eksperimental laboratorium menggunakan spektrofotometri UV-Vis pada panjang gelombang 378 nm. Hasil: Dosis 0,5 g menunjukkan degradasi tertinggi sebesar 84% pada menit ke-120. Peningkatan dosis hingga 0,5 g meningkatkan efisiensi, sedangkan pada 1 g terjadi penurunan akibat kekeruhan larutan. Degradasi meningkat seiring waktu iradiasi. Kinetika reaksi mengikuti orde satu semu dengan konstanta laju 0,0142 menit⁻¹. Simpulan: ZnO/Biochar efektif mendegradasi tetrasiklin dengan kondisi optimum pada dosis 0,5 g dan penyinaran UV-Vis, serta mengikuti kinetika orde satu semu.
Evaluasi penggunaan obat golongan statin pada pasien hiperlipidemia Meithia, Artha; Zatara, Tubagus Puspa; Angin, Martianus Perangin; Wijaya, Satria
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 1 (2026): May Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i1.3132

Abstract

Beground: Hyperlipidemia is a condition characterized by high concentrations of lipids, cholesterol, and triglycerides in the blood. Hyperlipidemia is one of the most serious and deadly diseases worldwide. Purpose: To evaluate the use of statin drugs in hyperlipidemia patients with the criteria of correct diagnosis, correct patient, correct indication, correct drug, correct dose, and correct method of administration. Method: This study used descriptive qualitative research, utilizing primary medical record data, considering inclusion and exclusion criteria. Sampling was conducted using a purposive sampling method. The study was conducted at Imanuel Way Halim Hospital in Bandar Lampung and has received research ethics approval No. 4397/EC/KEP-UNMAL/VI/2024. Result: Based on the calculation, the criteria obtained were 100% correct diagnosis, 100% correct patient, 100% correct indication, 100% correct drug, 100% correct dose, 100% correct method of administration, and 100% correct time of administration. The most commonly used hyperlipidemia drug was simvastatin 20 mg with a percentage of 30.77%. In addition, the characteristics of patients based on age were the most common, namely 55-65 years old with a percentage of 32.69%, based on gender, namely women with a percentage of 53.85%, and based on comorbidities, namely hypertension with a percentage of 31.37%. Conclusion: The use of statin drugs in patients with hyperlipidemia is rational. The most commonly used hyperlipidemia medication is simvastatin 20 mg.   Keywords: Drug Use Evaluation; Hyperlipidemia; Statin.   Pendahuluan: Hiperlipidemia merupakan penyakit yang mengacu pada konsentrasi tinggi dari lipid, kolesterol, dan trigliserida dalam darah. Penyakit hiperlipidemia termasuk salah satu penyakit serius serta mematikan di dunia. Tujuan: Untuk mengevaluasi penggunaan obat golongan statin pada pasien hiperlipidemia dengan kriteria tepat diagnosa, tepat pasien, tepat indikasi, tepat obat, tepat dosis, dan tepat cara pemberian. Metode: Menggunakan jenis penelitian kualitatif deskriptif yang dilakukan dengan menggunakan data primer rekam medik yang mempertimbangkan kriteria inklusi dan eksklusi. Pengambilan sampel dilakukan dengan metode purposive sampling. Penelitian yang dilakukan di Rumah Sakit Imanuel Way Halim Bandar Lampung dan sudah mendapat perizinan etik penelitian No.4397/EC/KEP-UNMAL/VI/2024. Hasil: Berdasarkan perhitungan diperoleh kriteria tepat diagnosa 100%, tepat pasien 100%, tepat indikasi 100%, tepat obat 100%, tepat dosis 100%, tepat cara pemberian 100%, tepat waktu pemberian 100%. Penggunaan obat hiperlipidemia yang banyak digunakan yaitu simvastatin 20 mg dengan persentase 30.77%. Selain itu, karakteristik pasien berdasarkan usia yang paling banyak yaitu usia 55-65 tahun persentase 32.69%, berdasarkan jenis kelamin yaitu perempuan dengan persentase 53.85%, dan berdasarkan penyakit penyerta yaitu hipertensi dengan persentase 31.37%. Simpulan: Penggunaan obat golongan statin pada pasien hiperlipidemia sudah rasional. Penggunaan obat hyperlipidemia yang banyak digunakan yaitu simvastatin 20 mg.   Kata Kunci: Evaluasi Penggunaan Obat; Hiperlipidemia; Statin.
Studi kasus asuhan keperawatan pada pasien pneumonia dengan diagnosa sekunder hypertensive hearth disease Sriwiyati, Lilik; Christina, Tri Yahya; Safaruddin, Safaruddin; Andika, I Putu Juni
JOURNAL OF Pharmacy and Tropical Issues Vol. 5 No. 2 (2025): December Edition 2025
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v5i2.3226

Abstract

Background: Pneumonia is the leading cause of death among children under five years of age. In addition to infants, the elderly and individuals with weakened immune systems are also highly susceptible to pneumonia. The incidence of pneumonia in Indonesia is on the rise. The prevalence of pneumonia in Java Province remains quite high, warranting serious attention. Nursing care for patients with pneumonia is essential, given that this disease is quite serious and significantly impairs the patient’s ability to meet the body’s oxygen needs. Purpose: To analyze nursing care for patients with pneumonia and a secondary diagnosis of hypertensive heart disease, covering the assessment, establishment of nursing diagnoses, interventions, implementation, and evaluation. Method: This study is a descriptive-analytical study using a case study approach. The purpose of the study is to describe the implementation of nursing care for a patient with pneumonia and a secondary diagnosis of hypertensive heart disease. The subject of the case study was one patient with pneumonia. Data analysis was performed using descriptive analysis.. Results: A patient with pneumonia and a secondary diagnosis of hypertensive heart disease presented with signs and symptoms of shortness of breath, chest heaviness, palpitations, and weakness; blood pressure readings indicated stage 1 hypertension. ECG revealed sinus rhythm with first-degree AV block, alternating episodes of TAVB with junctional escape rhythm and multiple PJCs; blood gas analysis indicated compensated metabolic acidosis; the P/F ratio indicated mild respiratory failure; chest X-ray showed pneumonia; and the chest X-ray revealed cardiomegaly accompanied by aortosclerosis. Based on these findings, the nursing diagnoses were established as impaired gas exchange and decreased cardiac output. The established SLKI (Specific Nursing Interventions) were acid-base balance and increased cardiac output. The established SIKI (General Nursing Interventions) were respiratory monitoring and cardiac care. Conclusion: Following treatment of a patient with pneumonia and a secondary diagnosis of hypertensive heart disease, who presented with gas exchange abnormalities and reduced cardiac output, the patient was able to achieve acid-base balance and an increased cardiac output.   Keywords: Hypertensive Heart Disease; Nursing Care; Pneumonia.   Pendahuluan: Pneumonia merupakan penyebab kematian terbesar pada anak di bawah usia lima tahun. Selain pada balita, lansia dan individu dengan sistem imun yang rendah juga sangat rentan menderita pneumonia. Kejadian pneumonia di Indonesia menunjukkan adanya peningkatan. Prevalensi pneumonia di Provinsi Jawa masih cukup tinggi sehingga memerlukan perhatian serius. Asuhan keperawatan pada pasien dengan pneumonia sangat diperlukan mengingat penyakit ini cukup serius dan sangat mengganggu kemampuan pasien dalam memenuhi kebutuhan oksigen tubuh. Tujuan: Untuk menganalisis asuhan keperawatan pada pasien pneumonia dengan diagnosa sekunder hypertensive hearth disease mulai dari pengkajian, penegakan diagnose keperawatan, intervensi, implementasi dan evaluasi. Metode: Penelitian ini adalah jenis penelitian deskriptif analitik dengan pendekatan studi kasus. Tujuan penelitian untuk mengetahui gambaran pelaksanaan asuhan keperawatan pada pasien pneumonia dengan diagnose sekunder hypertensive hearth disease. Subyek studi kasus adalah satu pasien dengan pneumonia. Analisa data menggunakan analisis deskriptif. Hasil: Pasien dengan pneumonia dengan diagnose sekunder hypertensive hearth disease didapatkan tanda dan gejala sesak nafas, dada terasa berat, jantung berdebar-debar, tubuh terasa lemah, tekanan darah menunjukkan hipertensi derajat 1, EKG didapatkan Irama sinus dengan AV block derajat 1, alternating episode TAVB dengan irama lolos junctional dengan multiple PJC, analisa gas darah menunjukkan asidosis metabolic terkompensasi, P/F rasio menunjukkan gagal napas ringan, rontgen thorax menunjukkan pneumonia, thorax menunjukkan cardiomegaly disertai aortosclerosis. Berdasarkan data tersebut ditegakkan masalah keperawatan gangguan pertukaran gas dan penurunan cardiac output. SLKI yang ditegakkan adalah keseimbangan asam basa dan curah jantung meningkat. SIKI yang ditegakkan adalah pemantauan respirasi dan perawatan jantung. Simpulan: Setelah dilakukan perawatan pada pasien pneumonia dengan diagnosa sekunder hypertensive hearth disease dengan masalah pertukaran gas dan penurunan cardiac output, pasien mampu mencapai keseimbangan asam basa dan mencapai cardiac output yang meningkat.   Kata Kunci: Asuhan Keperawatan; Hypertensive Hearth Disease; Pneumonia.
Formulasi dan uji aktivitas antibakteri serum antijerawat yang mengandung naringenin 2.5% Putri Rovita Sari; RR Sri Wulandari; Iqbal Wahid Abdullah; Bangkit Riska Permata
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 4 (2026): August edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i4.3838

Abstract

Background: Facial serums are advanced cosmetic formulations designed to deliver high concentrations of active ingredients, allowing for intensive penetration into deeper layers of the skin. Naringenin at a concentration of 2.5% can inhibit Staphylococcus aureus bacteria with an inhibition zone of 15.10 mm, indicating strong antibacterial activity. S. aureus is one of the bacteria responsible for causing acne. Purpose: This study aims to develop a facial serum containing the active ingredient naringenin, which is expected not only to meet physical quality standards and be safe for the skin but also to effectively treat acne due to the antibacterial properties of 2.5% naringenin. Method: The method used was a laboratory experiment in which a naringenin (NAR) serum preparation was made, followed by an evaluation of its physical properties, including a homogeneity test, a pH test, a spreadability test, an adhesion test, a viscosity test, and an antibacterial test. Results: The results showed that, in the organoleptic test, the preparation was a blue, odorless semisolid. The NAR serum had a homogeneous texture with a pH of 5.7; a spreadability of 6.8 cm; an adhesion time of 7.8 seconds; a viscosity of 3,707 Cps; and an inhibition zone diameter of 14.3 mm, classified as strong. Conclusion: The NAR serum preparation exhibits good physical quality in accordance with standards and may possess strong antioxidant activity. This indicates that NAR serum has great potential as an agent for combating S. aureus, the bacterium that causes acne.   Keyword: Acne Serum; Antibacterial; Naringenin; Serum; Staphylococcus Aureus.
Tingkat pengetahuan beyond use date (BUD) tetes mata Ni Made Nadya Tika Putri; Made Prita Artika; Ni Luh Kade Wiradani
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 4 (2026): August edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i4.3854

Abstract

Background: Beyond Use Date (BUD) is the recommended period for using sterile pharmaceutical preparations after the primary packaging has been opened. Limited patient knowledge regarding BUD may increase the risk of contamination, reduce therapeutic effectiveness, and compromise patient safety, particularly in ophthalmic preparations. Purpose: To determine the level of patient knowledge regarding Beyond Use Date (BUD) of eye drops and to analyze its relationship with respondent characteristics. Method: A quantitative descriptive study with a cross-sectional approach was conducted among 244 respondents selected using purposive sampling. Data were collected using a validated and reliable questionnaire. Descriptive analysis was performed to describe respondent characteristics and knowledge level, while Spearman’s Rank correlation test wa used to examine the relationship between respondent characteristics and knowledge level with a significance level of p<0.05. Results: The majority of respondents fell into the fair knowledge category (51.2%). Significant associations were found between knowledge level and age (p=0.001), education level (p=0.001), occupation (p=0.001), source of information (p=0.001), and history of eye drop use (p=0.001). Conversely, gender did not show a significant association with the respondents' knowledge level (p=0.081). Conclusion: Most respondents demonstrated a moderate level of knowledge regarding Beyond Use Date of eye drops. Educational level, age, occupation, information source, and previous experience using eye drops were significantly associated with knowledge level, indicating the importance of continuous pharmaceutical education to improve safe medication use.   Keywords: Beyond Use Date; Eye Drops; Knowledge; Patient; Pharmacy
Hubungan dukungan keluarga dengan kepatuhan minum obat pasien hipertensi Ni Putu Trisna Sintya Dewi; Ni Putu Ayu Deviana Gayatri; A.A Bagus Suryantara
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 4 (2026): August edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i4.3888

Abstract

Background: Hypertension is a chronic disease requiring long-term therapy; thus, treatment success is heavily influenced by patient adherence to antihypertensive medication. Family support plays a crucial role in enhancing patient adherence by providing emotional, informational, appraisal, and instrumental support. Such support can boost patient motivation to adhere to the treatment regimen, help control blood pressure, prevent complications, and improve the patient's quality of life. Purpose: To analyze the relationship between family support and medication adherence among hypertensive patients. Method: A descriptive-analytic design with a cross-sectional approach was employed. The study sample consisted of 95 outpatients with hypertension, selected using consecutive sampling whereby all patients meeting the inclusion and exclusion criteria were recruited sequentially until the required sample size was reached. Data were collected using a family support questionnaire, the Morisky Medication Adherence Scale (MMAS-8), and the pill count method. Data analysis was performed using the Spearman Rank correlation test. Results: The majority of respondents received a "good" level of family support (90.5%). Medication adherence levels were high: 95.7% according to the MMAS-8 instrument and 92.6% based on the pill count method. Analysis revealed a significant relationship between family support and medication adherence (p=0.034; r=0.218), with a weak correlation strength and a positive relationship. Conclusion: The better the family support received by patients, the higher their level of treatment adherence. Therefore, the involvement of families alongside healthcare professionals needs to be further strengthened to support successful hypertension treatment.   Keywords: Family Support; Hypertension; Medication Adherence.
Studi etnomedisin tumbuhan obat yang digunakan oleh masyarakat Maria Lorensa Destiana Perada Bali; Tadeus Andreas Lada Regaletha; Nurul Fatmawati Pua Upa
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 4 (2026): August edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i4.3902

Abstract

Beground: Use of medicinal plants as traditional medicine is still practiced by community of Mangaaleng Village, Kelubagolit District, East Flores Regency. Knowledge regarding use of these medicinal plants has been passed down through generations and has become an integral part of community's local wisdom. To date, scientific documentation regarding the utilization of medicinal plants by Mangaaleng Village community remains unavailable. Purpose: Identify types of medicinal plants utilized, determine their specific benefits, plant parts used, as well as preparation methods and their usage in traditional medicine by Mangaaleng Village community. Method: This was a qualitative descriptive study employing a purposive sampling technique. Research informants consisted of 2 key informants and 42 triangulation informants. Data were collected through in-depth interviews, observations, and documentations, which were subsequently analyzed using Miles and Huberman model, encompassing data reduction, data display, and conclusion drawing. Results: Mangaaleng Village community utilizes 48 species of medicinal plants to treat various diseases and health complaints. Highest utilization is aimed at treating coughs (13%). Most frequently used plant part is leaves (49%). Majority of these medicinal plants are obtained through self-cultivation (73%). Most common preparation method is boiling (45%), while dominant mode of administration is by drinking (67%). Conclusion: Mangaaleng Village community still maintains ethnomedicinal practices based on medicinal plants as part of their traditional medical heritage passed down through generations. Diversity of the utilized plants reflects community's extensive local knowledge in harnessing natural resources for health maintenance and disease treatment.   Keywords: Ethnomedicine; Medicinal Plants; Mangaaleng; Pharmacy.  
Profil kromatogram ekstrak etanol 95% dan etil asetat jahe merah (Zingiber officinale var. rubrum) Fitrya Rahmawaty Saleh; Muntasir Muntasir; Matias Nataniel Kolobani; Antonius Rolling Basa Ola
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 4 (2026): August edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i4.3962

Abstract

Background: Red ginger (Zingiber officinale var. Rubrum) is rich in bioactive compounds, such as gingerol and shogaol, which are highly sensitive to type of extraction solvent. Therefore, a chromatogram profile analysis is required to determine most effective solvent. Purpose: This study aims to compare chromatogram profiles of 95% ethanol and ethyl acetate extracts of red ginger rhizome using High-Performance Liquid Chromatography (HPLC). Method: This descriptive laboratory study extracted 90 gr of red ginger crude drug (simplisia) powder from Ende Regency, Flores, via maceration using 95% ethanol and ethyl acetate for 3 × 24 hours. Resulting filtrates were evaporated to obtain thick extracts, which were then analyzed using HPLC to evaluate the number of peaks, retention time, and peak area. Results: 95% ethanol extract produced a more complex chromatogram profile with 30 peaks, whereas the ethyl acetate extract yielded 22 peaks. This difference indicates superiority of 95% ethanol in extracting secondary metabolite compounds across a wider polarity range compared to ethyl acetate. Conclusion: There is a significant difference in chromatogram profiles between two extracts. 95% ethanol solvent proved to be more effective in extracting bioactive compounds from red ginger rhizome than ethyl acetate, serving as a baseline for herbal raw material standardization and a foundation for future research.   Keywords: HPLC; Red ginger; Zingiber officinale var. Rubrum.
Analisis efektivitas gel silver nanopartikel (AgNPs) berbasis ekstrak daun Eucalyptus terhadap percepatan penyembuhan luka pasca sirkumsisi Nasrullah Amin; Rinto Hardiarto; Debi Arivo; Dwi Marlina Syukri
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 4 (2026): August edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i4.3965

Abstract

Background: Circumcision is a minor surgical procedure requiring optimal wound care to prevent inflammation and infection and to accelerate the healing process. Silver nanoparticles (AgNPs) synthesized using *Eucalyptus* leaf extract possess antibacterial and anti-inflammatory properties that have the potential to accelerate wound healing. Purpose: To determine the effectiveness of AgNP gel based on *Eucalyptus* leaf extract on post-circumcision wound healing. Method: This study employed an experimental design with a quantitative approach, involving a sample of 20 respondents aged 7 to 13 years who underwent circumcision; the sample was selected using the total sampling technique. Data were collected through direct observation of the wound condition following the circumcision procedure. Data analysis was performed using the Chi-square test with a significance level of 0.05.Results: Application of the AgNP gel reduced the levels of inflammation and exudate. Chi-square test results indicated a significant association between pre- and post-treatment conditions. Significant differences were observed in the levels of inflammation (p=0.010) and exudate (p<0.001). Conclusion: The use of a silver nanoparticle (AgNP) gel based on *Eucalyptus* leaf extract has proven effective in accelerating the post-circumcision wound healing process in children. Following treatment, significant reductions were observed in various wound healing parameters including the degree of inflammation, redness, and exudate as well as a decrease in wound diameter.   Keywords: Silver Nanoparticles; Agnps, Eucalyptus; Circumcision; Wound Healing.
Penentuan kadar metabolit sekunder dan aktivitas antioksidan ekstrak faloak (Sterculia quadrifida R.Br.) Theodora Liefanda Bunga; Muhajirin Dean; Mathias N. Kolobani; Muntasir Muntasir
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 4 (2026): August edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i4.3982

Abstract

Background: Faloak (Sterculia quadrifida R.Br.) is a medicinal plant native to East Nusa Tenggara that has potential as an antioxidant. Purpose: To determine total flavonoid, tannin, and phenolic contents of 95% ethanol and aqueous extracts of faloak root bark, stem bark, and twigs, and to evaluate antioxidant activity of selected extract. Method: This quantitative descriptive-exploratory research used maceration (95% ethanol) and decoction (water) methods. Metabolite contents were determined spectrophotometrically, while antioxidant activity was tested using the DPPH method ( ). Results: Highest secondary metabolite content was consistently found in the twigs. In the 95% ethanol extract, flavonoid, tannin, and phenolic contents of twigs were 0.7495, 38.8472, and 94.2777 mg/g extract, respectively, while in aqueous extract, they were 0.8093, 31.6775, and 59.7342 mg/g extract. 95% ethanol extract was selected as superior extract because it yielded higher metabolite levels than aqueous extract. DPPH testing showed  values for root bark, stem bark, and twigs of 26.502, 36.110, and 21.524 ppm, respectively, classifying all samples into very strong antioxidant category. Conclusion: Flavonoid, tannin, and phenolic contents vary depending on the plant part and solvent type. Faloak twigs possess highest metabolite content and most potent antioxidant activity.   Keywords: Antioxidant; Faloak; Metabolites; Sterculia Quadrifida R.Br.

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