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JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Published by Badan Analisis dan Pengembangan Ilmiah Nasional ISMKI
ISSN : 23026391     EISSN : 27211924     DOI : https://doi.org/10.53366/jimki
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmiah Mahasiswa Kedokteran Indonesia (JIMKI) adalah jurnal yang dikelola oleh Badan Analisis dan Pengembangan Ilmiah Nasional (BAPIN). JIMKI berfokus menjadi wadah untuk publikasi penelitian mahasiswa kedokteran.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 326 Documents
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POTENSI EKSTRAK BUNGA KAMBOJA (PLUMERIA SP.) DAN BUNGA KLUWIH (ARTOCARPUS CAMANSI) SEBAGAI BIOLARVASIDA NYAMUK ANOPHELES SP. DALAM UPAYA PENCEGAHAN PENYAKIT MALARIA Luh Gde Sri Adnyani Suari; Abiyyu Didar Haq; Luh Ade Dita Rahayu
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.267

Abstract

ABSTRACT Background: Malaria is one of many health problem that attracts attention in a lot of countries, especially Indonesia as a tropical country. To minimalize the spread of malaria, many efforts is done to control Anopheles sp as the vector of malaria. Some of many effort that has been done to control malaria is larvaciding. Conventional insecticide such as malathion, DDT, and pyrethroid that is widely used for vector control is known to cause problem such as pollution, residual effect, and resistance of the mosquitoes. Therefore, it is very much needed to find an alternative of the overuse of insecticide and find a better and safer solution both for us and for the environment . Methods: This literature review used a variety of sources that are being retrieved from online publication portal. Discussion: Extract of Plumeria sp. ‘s flower showed the existance of steroid, alkaloid, flavonoid, glycoside, tannin, and essential oil. Steroid, flavonoid, and alkaloid substance are the substances that is expected to have the larvicidal effect. Steroid is able to restrict insect’s growth in the transition phase from larvae to pupae and vice versa. Flavonoid works as a respiratory toxin. Alkaloid acts as a contact toxic and inhibits the acetylcholinesterase which will cause a bitter taste which then interrupts the mealtime of the larvae. Meanwhile Artocarpus camansi contains a substances such as saponin, flavonoid, and polyphenol whose effect is lowering the appetite, inhibiting the respiratory system, and inhibiting the moulting hormone. Conclusion: The combination of kamboja flower (Plumeria sp.) and kluwih flower (Artocarpus camansi) has a potential to be used as biolarvacide of Anopheles sp. Keywords: Kamboja, Kluwih, Biolarvacide, Malaria
BMV-CSC Patch: Sel Punca Jantung dengan Biomimetic Microvessel berbasis HUVEC sebagai Inovasi Potensial untuk Terapi Infark Miokardium Akut Yitzchak Millenard Sigilipu
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.269

Abstract

Coronary Heart Disease (CHD) is the main global cause of morbidity and mortality. The most common form of CHD is myocardial infarction which contributes to more than 15% of death. Cardiac stem cell-based therapy (CSC) is a promising approach to treat the condition. The main issue hindering efficacy and further development of the approach is the low retention and viability of stem cells after intra myocardial injection on ischemic heart. In order to address the issue, a novel strategy to create a vascularized cardiac patch using the microfluid with hydrodynamic focusing technique. The cardiac patch will be integrated Biomimetic Micro Vessels (BMV) alongside human umbilical vein endothelial cells (HUVEC) on the luminal surface. A study reported that the endothelium of BMV mimics the architecture and natural functioning of the capillaries. Vascularized cardiac patch (BMV-CSC) will release paracrine factors higher than original co-cultured human CSC and HUVEC after seven days of in vitro culture. In acute myocardial infract (AMI) rat model, the BMV-CSC patch induced mitotic activities of cardiomyocytes in peri-infarcted area after 4 weeks of implantation. Significant increase in the density of myocardial capillaries in infarct area compared to the conventional cardiac patch was also reported. The significant benefits of BMV-CSC patch showed that this approach is a potential method for AMI therapy.
Patofisiologi Acute Mountain Sickness Muhammad Orri Baskoro
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.271

Abstract

Pendahuluan: Acute mountain sickness (AMS) adalah kelainan neurologis yang biasanya menyerang pendaki gunung yang berada di ketinggian akibat hipoksia kronis pada tekanan parsial oksigen rendah. Walaupun seringkali bersifat self-limiting, AMS dapat menyebabkan edema pulmonal dan serebral yang dapat bersifat fatal. Popularitas pendakian gunung yang meningkat dan mudahnya akses beberapa tahun terakhir menyebabkan peningkatan jumlah pendaki yang berisiko mengalami bahaya AMS. Pembahasan: Rendahnya tekanan oksigen pada ketinggian akan memicu 4 mekanisme refleks: respons ventilasi hipoksia, respons ventilasi hiperkapnia, vasodilatasi pembuluh otak terhadap hipoksia, dan vasokonstriksi pembuluh darah otak terhadap hipokapnia. Kejadian ini akan memicu pembengkakan astrosit dan aktivasi sistem trigeminovaskular sehingga menyebabkan gejala neurologis pendaki. Kesimpulan: Pada keadaan di ketinggian, terjadi penurunan tekanan parsial O2 sehingga menyebabkan terjadinya hipoksemia pada pendaki. Kegagalan autoregulasi aliran darah otak akan menyebabkan peningkatan tekanan kranial melalui gaya mekanik dan kebocoran kapiler melalui gaya kimia. Hipertensi intrakranial akan menyebabkan perpindahan dan peregangan serabut saraf sensitif yang tidak termielinisasi pada sistem trigeminovaskular sehingga menyebabkan gejala neurologis pendaki.
Efektivitas Penggunaan Nanopartikel Karbon Sebagai Pewarna Nodus Limfa Dalam Limfadenektomi Pada Kanker Kolorektal: Sebuah Kajian Sistematik Jessica Audrey
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.277

Abstract

Background: Colorectal cancer (CRC) is the third most common malignancy in the world, claiming at least 881,000 lives in a year. Despite numerous treatment options developed in recent years, surgical resection remains the treatment of choice. Considering possible metastasis to nearby lymph nodes, sufficient lymphadenectomy is an important prognostic factor and critical for accurate staging. However, number of lymph nodes harvested is often inadequate. Carbon nanoparticles has recently emerged as an excellent method of lymph node tracer in CRC. Yet, reviews regarding its effectiveness is still lacking.Aim: To evaluate the effectiveness of carbon nanoparticles in detecting lymph nodes and improving staging accuracy for colorectal cancer.Method: A systematic review was conducted through PubMed, Scopus, EBSCOhost, and Cochrane, searching for studies implementing carbon nanoparticles in detecting lymph nodes during surgical resection of CRC. Quality assessments of studies selected were performed with selected risk-of-bias assessment tools.Outcome: The search yielded 10 studies with a total of 1387 subjects. Carbon nanoparticles were effective in increasing the total number of harvested lymph nodes and improving the ability of detecting smaller lymph nodes of <5 mm. Number of positive lymph nodes did not differ significantly with controls; however, carbon nanoparticles effectively improved staging accuracy, thereby signifying a reduction in risk of understaging. Moreover, operative time and blood loss were reduced in comparison to conventional methods. No significant adverse effects were reported.Conclusion: To conclude, carbon nanoparticles showed promising potentials as lymph node tracer to help improve harvest and staging accuracy in CRC patients.
Analisis Potensi Nanopartikel Seng Oksida Sebagai Terapi Alternatif Terhadap Uropathogenic Escherichia coli Penyebab Infeksi Saluran Kemih Kelvin Kohar; Grady Krisandi; Stephanie Amabella Prayogo
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.278

Abstract

Background: To date, urinary tract infection (UTI) is still becoming the world’s major health problem that infected 150 million people annually. Uropathogenic Escherichia coli (UPEC) is the most common cause, accounted for more than 80% of total cases. UPEC infection mechanism is supported by many virulence factors owned that contribute in causing antibiotic resistance. Antibiotics are currently used as main pharmacologic therapy for UTI; therefore, treatment failures often occur. The advancement of nanoparticles technology reveals an antimicrobial activity in zinc oxide nanoparticles. Hence, this literature review is written to discuss the potential of zinc oxide nanoparticles as an alternative as well as to help reaching the third 2030 sustainable development goals.Methods: This article was written using the literature review method. We did literature searching by using some keywords in several databases. Inclusions and exclusions criteria were used. The final result yielded 30 studies related to the topic.Discussion: Zinc oxide nanoparticles can be synthesized from Aloe vera plant extraction. In small concentration, 0.3 µg/ml, nanoparticles show an antiadhesion effect by reducing flu and fimH gene expression as UPEC’s virulence factors. The effectivity and safety of nanoparticles in this concentration have also been proven in vitro. Furthermore, in high concentration, these nanoparticles can act as antibiofilm and antibacterial.Conclusion: Zinc oxide nanoparticle has a promising characteristic of antiadhesion, antibacterial and antibiofilm. The safety have also been proven in vitro and in vivo. Both results show a huge zinc oxide nanoparticles potential as an alternative treatment of UTI caused byUPEC. Keywords: Urinary tract infection, Zinc oxide nanoparticle, Uropathogenic Escherichia coli
FOTOTERAPI 405NM BLUE LIGHT LASER SEBAGAI ALTERNATIF TERAPI GONORE KOINFEKSI KLAMIDIASIS RESISTEN ANTIBIOTIK Alfiani Zukhruful Fitri; Clara Alverina
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.301

Abstract

Background: Gonorrhea is a sexually transmitted infection (STI) caused by Neisseria gonorrhoeae, which generally attacks genital mucosa. The incidence of gonorrhea is pretty high, WHO mentioned 87 million new cases in 2016. The co-infection with Chlamydia trachomatis is around 10-40%. According to WHO 2018, 70% of countries reported antimicrobial resistance to N. gonorrhoeae. Besides, third-generation cephalosporin resistance has also been found in 10 countries. Method: This literature study aims to determine the potential alternative therapy for antibiotic-resistant gonorrhea with chlamydia co-infection. The source used in this literature comes from scientific journals at Google Scholar, PubMed, and WHO publications from 2015-2020. Discussion: Antimicrobial blue light (aBL) is a type of therapy to control antibiotic-resistant bacterial infections based on the use of light. The mechanism of aBL with a wavelength of 405 nm is by inactivating microbes through cytotoxic and genotoxic effects through endogenous photosensitizers on microbes that cause damage to cell membranes and inactivation of bacterial virulence factors, both N. gonorrhoeae, and C. trachomatis. Conclusion: Phototherapy 405 nm Blue Light Laser can be an alternative non-pharmacological therapy for the treatment of gonorrhea, both single infection and chlamydial coinfection. The advantages, are easy to use, non-invasive, require a fairly short duration, have high selectivity so that it does not harm vaginal epithelial cells, and there is no resistance to this phototherapy.
Hubungan Infiltrasi Limfovaskular dengan Subtipe Molekuler Kanker Payudara Invasif : Telaah Sistematis Yosef Yantamajaya Simbolon
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.304

Abstract

Background: Breast cancer should be found at an earlier stage, but this cancer is more often recognized at an advanced stage which causes high mortality. Poor cancer prognosis will affect the patient's quality of life, financial condition, role and function of the patient and family and even death. The prognosis in breast cancer patients is based on the analysis of primary tumor biological markers which include estrogen receptor (ER), progesterone receptor (PR), Human Epidermal Growth Factor Receptor 2 (HER2) and Ki67 which are classified into 4 molecular subtypes, namely Luminal A, Luminal B, HER2 overexpression, and Triple Negative. Method: This type of research uses a systematic review study method with the data to be used are research results that have been circulating in the world. The population of this study is the journal literature search results regarding lymphovascular infiltration of molecular subtypes of breast cancer published in international journals and accessible via the internet. The research sample was determined based on several inclusion and exclusion criteria that have been made. Results: From 5 international journals that have been collected, then analyzed using a forest plot. Based on the data analysis, it was found that P = 0.21, which means that the subgroup difference test showed that there was no statistically significant subgroup effect. Conclusion: There was no association between lymphovascular infiltration and molecular subtypes of invasive breast cancer
Analisis Perubahan Psikososial: Depresi dan Ansietas Selama Pandemi COVID-19 pada Kalangan Pelajar: Depresi dan Ansietas Selama Pandemi COVID-19 pada Kalangan Pelajar Muhammad Mikail Athif Zhafir Asyura; Muhammad Farid Ar-Rizq; Rejoel Mangasa Siagian
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.316

Abstract

Background: The respiratory disease named novel coronavirus disease 2019 (COVID-19) was caused by the Severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) originated initially in Wuhan, China. Furthermore, the exponential spread of the virus forced many officials to employ strict lockdown and physical distancing measures to halt the transmission. Despite this, mass isolation only surfaces a plethora of problems, especially the increased prevalence in depression and generalized anxiety disorder (GAD). Both mental illnesses have been shown to increase during the pandemic due to a myriad of risk factors. Thus, in this study we aim to shed light on those risk factors, via a systematic review to determine which are the pivotal reasons for the increasing prevalence Methods: The review is done in accordance to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guideline from a few online databases including: PubMed, Cochrane, Sciencedirect, Wiley Online Library, dan EBSCOhost Discussion: After analyzing 401 articles, 5 articles were chosen based on the inclusion criteria. The articles unanimously agreed on a few factors, namely: student status, gender, preexisting health conditions, and also emotional management as main risk factors of depression and GAD Conclusion: In conclusion, those risk factors should be put into consideration by policy makers in crafting protective measures against COVID-19 and other pandemics in the future in order to minimize its impact on the mental health of students and the overall community.
Potensi Chimeric Antigen Receptor T Cell (CAR-T Cell) dengan Target Prostate-Specific Membrane Antigen (PSMA) Termodifikasi CRISPR/Cas9 sebagai Terapi Kanker Prostat Ali Habibi; Siti Zulaikha Risqiyani; Dwi Ari Santi Putri
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.321

Abstract

ABSTRACT Introduction : Prostate cancer is a malignancy of prostate cells which is one of the most common malignancies in men with a prevalence of 137.9 new cases per 100,000 men each year. One of the jobs that have a high risk of prostate cancer is farmers because it is caused by exposure to pesticides and other hazardous substances. Currently, Androgen Deprivation Therapy (ADT) is still a widely used therapy. However, ADT can decrease libido, impotence, hot flashes, and an increased risk of fractures. Due to several disadvantages of ADT therapy, therapeutic innovations for prostate cancer are needed. Method : PRISMA which is based on facts and random data collection by entering predetermined keywords. Of the 94 journals that have been reviewed, 64 of them are considered according to the topic of discussion and are used as references. Results and Discussion : CAR-T Cell modified CRISPR / Cas9 injected into mice proved to be efficient and effective in increasing the function of CAR-T Cell. The immunosuppressive mechanism caused by PD-1 binding with PD-L1 can be resolved using the CRISPR / Cas9-mediated anti PD-1 method so that it can maintain CAR-T Cell activation. Evidenced by the increase in CAR-T cell degranulation and tumor clearance in the in vivo test. Conclusion : Chimeric Antigen Receptor T Cell (CAR-T Cell) with a CRISPR/Cas9 modified Prostate-Specific Membrane Antigen (PSMA) target has the potential to be an effective therapeutic innovation for prostate cancer.
Circulating micrornas sebagai novel biomarker untuk diagnosis pasien acute ischemic stroke: sebuah kajian sistematis Arman Caesar Ramadhan; Nur Fatimah Azzahra Latif; Muhammad Ainul Yaqin
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.323

Abstract

ABSTRACT Background: Acute ischemic stroke (AIS) is the types of stroke with the highest incidence, especially in the elderly group. Nowadays, neuroimaging is the main modality in stroke diagnosis, but it still has several drawbacks, such as limited, high cost, long time for the procedure, and in some cases, the results of image interpretation are often inconsistent in the early stroke phase. Therefore we need a fast, precise, and simple diagnostic tool for the diagnosis of AIS. Currently, certain types of circulating microRNA (miRNA) can be biomarker for AIS diagnostics. The goal of this study is to profiling as well as evaluate the diagnostic value of circulating miRNA in AIS patients, hemorrhagic stroke (HS) patients, and healthy individuals. Methods: This systematic review collects literatures from PubMed, Science Direct, Directory of Open Access Journal (DOAJ), Clinical Trials.gov, and Epistemonikos using standardized methods by cochrane guideline for systematic review to evaluate the diagnostic value of circulating MiRNAs as biomarkers for AIS by its sensitivity, specificity, and Area Under the Curve (AUC) score. Discussion: Out of 870 studies, 15 studies matched the inclusion criteria. The studies that reviewed showed that hsa-miR-106b-5P and the combination of miR-125a-5p + miR-125b-5p + miR-143-3p are the most effective types of miRNA as biomarkers in diagnosing AIS and differentiating it from healthy individuals. Meanwhile, miR-124-3p is the most effective type as a biomarker to differentiate AIS and HS. Conclusion: Circulating miRNA isolated from human plasma, serum, and blood can be used as a diagnostic biomarker for AIS. Keyword: acute ischemic stroke, circulating microRNAs, diagnostic

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