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JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia

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Published by Badan Analisis dan Pengembangan Ilmiah Nasional ISMKI

ISSN : 23026391 EISSN : 27211924 DOI : https://doi.org/10.53366/jimki

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmiah Mahasiswa Kedokteran Indonesia (JIMKI) adalah jurnal yang dikelola oleh Badan Analisis dan Pengembangan Ilmiah Nasional (BAPIN). JIMKI berfokus menjadi wadah untuk publikasi penelitian mahasiswa kedokteran.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 326 Documents

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POTENSI EKSTRAK DAUN CAMELLIA SINENSIS SEBAGAI UPAYA PREVENTIF TERHADAP SERANGAN ASMA Angelica Riadi Alim
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.328

Background: Asthma is a respiratory disease that has a high prevalence worldwide. One of the symptoms of asthma is an asthma attack, which is shortness of breath. These symptoms can be fatal if not treated properly. Methods: The caffeine content in Camellia sinensis leaves can function as a bronchodilator so that the use of C. sinensis leaf extract can be the right solution in preventing asthma attacks and reducing asthma mortality. Discussion: contains theories, research results and also the discussion according to the topic Conclusion: The use of Camellia sinensis leaf extract has the potential as a preventive measure against asthma attacks. Keywords: asthma, Camellia sinensis, caffeine

Hemiparesis Alterans: Laporan Kasus Mutia Diah Pratiwi; Fidha Rahmayani
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.329

ABSTRACT Background: Stroke is one of the most frequent cases with high morbidity and mortality. There are particular cases in which ipsilateral cranial nerve signs coexist with contralateral hemiparesis. Case Illustration: A 23-year-old woman experienced right-sided weakness, could not open her left eye, had double vision and slurred speech. Blood pressure measured was 130/100 mmHg on a physical examination. On neurological examination she had both ptosis and dilated pupil on her left eye, negative direct and consensual light reflex on her left eye, paralysis of the occulomotorius and trochlearis cranial nerve on the left, right facial weakness, and tongue deviation to the right on protrution. Tone muscle strength of the upper extremities was rated on a scale of 3/5 and 2/5 on the lower extremities with positive Babinski and Chaddok reflexes on the right side. On a chest x-ray cardiomegaly without pulmonary edema was seen and an ischemic lesion in internal capsule was found on a head CT scan without contrast. The patient was diagnosed with alternating hemiparesis and given 80-mg aspirin once a day. Discussion: Contralateral hemiparesis, ipsilateral occulomotorius nerve paresis, contralateral facialis and hypoglossal nerve paresis were clinically seen on patient. Imaging test result showed ischemic lesion, but further imaging test was needed to investigate brain stem involvement. Eighty milligrams of aspirin once a day was beneficial, yet clopidogrel with initial dose of 300mg and maintenance dose 75mg once a day could as well be prescribed. Conclusion: Superior alternating hemiparesis or Weber syndrome is likely to be the cause of death so immediate diagnosis and treatment are needed for patient diagnosed with alternating hemiparesis. The risk factors of alternating hemiparesis are multifactorial and need to be investigated

Perang Melawan Bahaya Hoaks COVID-19 di Dunia Ridwan Balatif
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.330

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the cause of the Coronavirus Disease 2019 (COVID-19) pandemic. As of February 28, 2021, around 113 million people have confirmed COVID-19 globally. One of the things that hampers the handling of COVID-19 both globally and in Indonesia is the result of the large number of hoaxes circulating about COVID-19. The purpose of this article is written to increase understanding of the circulating COVID-19 hoaxes and the spirit of education against hoaxes related to COVID-19. About 89% of hoaxes circulating on various social media are rumors, 7.8% are in the form of conspiracy theories and the rest are in the form of stigma. This circulating hoax can harm others, such as information that alcohol can kill the corona virus in the body. As a result of this information, 44 Iranians have died from alcohol poisoning which is believed to kill the corona virus. In addition, the existence of hoaxes such as "COVID-19 does not exist" can result in the public ignoring health protocols which have an impact on the handling of COVID-19. Hoaxes circulating on various social media platforms have had a big impact in handling the COVID-19 pandemic. It is hoped that there will be good cooperation between the government and the community so that the COVID-19 pandemic can be resolved immediately

KOMBUCHA: PENDAYAGUNAAN MEKANISME GUT-BRAIN AXIS DALAM PENCEGAHAN DEPRESI Putu Diah Ananda Putri Atmaja; Abiyyu Didar Haq; Visakha Vidyadevi Wiguna
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 3 (2022): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.3 Edisi Desember 202
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i3.333

Background: COVID-9 pandemic brings a devastating change on every aspect of everyday life around the world. The change that is happening has been proven to act as a risk factor for many mental illnesses, including depression. Many efforts that has been done mainly focuses on curative aspect of depression and only a small portion of it focuses on the preventive aspect. Methods: This literature review uses a variety of articles sourced from several online publication databases such as National Center for Biotechnology Information (NCBI), Garba Rujukan Digital (GARUDA), and Google Scholar. Discussion: Many clinical studies has proved that there are indeed a connection between gut microbiote witf the nervous system which researchers called Gut-Brain Axis (GBA). Gut microbiote plays a key role in maintaining GBA homeostasis and its relation with one’s mental health. Probiotic consumption is one of many efforts that people do to maintain that homeostasis in order to maintain their mental health. Made of tea, sugar, and Symbitoic Culture of Bacteria and Yeasts (SCOBY) , kombucha is a fermented beverage that has been proven to bring positve impacts on gut microbiote with more than 50 probiotics and beneficial molecules. Conclusion: Utilization of kombucha to maintain GBA has the potential to completes the fight against depression especially in the aspect of prevention

FAKTOR RISIKO APNEA TIDUR OBSTRUKTIF YANG DAPAT DIMODIFIKASI Kemal Akbar Suryoadji
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.337

Background: Obstructive sleep apnea, also known as OSA (obstructive sleep apnea), is a sleep disorder in the form of a recurring complete or partial collapse of the airway. The prevalence of obstructive sleep apnea in America is 14% in men and 5% in women. The population in Asia is also a risk factor for obstructive sleep apnea. Methods: The literacy scan used 14 most recent and reliable international journals to describe modifiable risk factors for obstructive sleep apnea. Discussion: Obstructive sleep apnea is associated with other diseases such as cardiovascular, metabolic, and neuropsychiatric disorders. There are three important aspects that are modifiable risk factors for obstructive sleep apnea, including ideal body weight, namely to maintain a body mass index of less than 25 kg / m2, optimal physical activity by doing aerobic physical exercise for 150 minutes per week. , and reduce consumption of cigarettes and alcohol. Conclusion: Modifiable risk factors for obstructive sleep apnea include ideal body weight, physical activity, and consumption of cigarettes and alcohol. These factors can be used as a solution and prevention in obstructive sleep apnea to also avoid symptoms and other related diseases.

Faktor – Faktor Terkait Tingkat Keparahan Infeksi Coronavirus Disease 2019 (COVID-19): Sebuah Kajian Literatur Abiyyu Didar Haq; Adli Putra Nugraha; I Komang Gede Andhika Wibisana; Febbi Anggy; Fiana Damayanti; R.R. Ditya Mutiara Syifa; Ni Putu Visty Widhiani; Cut Warnaini
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.338

Background: COVID-19 pandemic that started in the early 2020 triggers the declaration of Public Health Emergency of International Concern (PHEIC) by WHO. Caused by SARS-CoV-2 virus, COVID-19 mainly infects the respiratory tract by binding to the ACE2 receptor. COVID-19 infection can cause many clinical manifestation from no symptom to severe life-threatening symptom depending on many factors. Factors that can determine the severity of clinical manifestation is urgently needed to be recognized by our clinician in order to be able to anticipate patient’s condition before the severe clinical manifestation even begins. This literature review is aimed to summarize and discuss some factors that are most often showed up and determined the severity of COVID-19 infection. Methods: This literature review uses journal article that are sourced from online databases such as PubMed and Google Scholar. The type of article that will be chosen are research article, systematic review and meta-analysis, narrative review, and literature review with the topic of transmission, clinical manifestasion, pathogenesis, immune response, and severity risk factor of COVID-19. Discussion: From our literature search, it is concluded that the factors that are most likely to determine the severity of COVID-19 infection is age, comorbid disease, vitamin D deficiency, and obesity. These four factors are not four independent factors but rather overlapping and interconnecting factors that determines the severity of COVID-19 infection. Conclusion: Most of the factors that determined the severity of COVID-19 mainly are easily preventable factors. Therefore, the knowledge and awareness of our clinician about these factors will really helps anticipating the severe clinical manifestation among COVID-19 patients before the manifestation even starts to appear.

CAR-T-ICI: Kombinasi chimeric antigen receptor T-cell dengan immune checkpoint inhibitor anti PD-1 selaku pilihan terapi terbaru kanker kolorektal: kombinasi chimeric antigen receptor T-cell dengan immune checkpoint inhibitor anti PD-1 selaku pilihan terapi terbaru kanker kolorektal imam hermansyah; Eddy Zulfikar
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.339

ABSTRACT Background: Colorectal cancer (CRC) as the third most common malignancy in the world is generally treated by surgery, radiotherapy, or chemotherapy based on the stage of the cancer. However, due to the invasive procedures and adverse reactions, scientists are developing treatment advancements with immunotherapy, especially Chimeric Antigen Receptor (CAR) T-cell which is considered more specific to tumor cells. However, the effectiveness of CART-T cells to treat solid tumors is still limited by Programmed Cell Death-1 (PD-1) through its immunosuppressive effect on T cells, hence the addition of anti PD-1 to CAR-T cells treatment is deemed necessary to increase its therapeutic potential. Objective: To discuss the potential of CAR-T cell in combination with anti PD-1 therapy for treatment of CRC. Method: The review materials used in this paper were taken from journals found through PubMed then compiled systematically. Results and Discussion: Based on previous studies, high level of IFN-? and TNF-? secretions were found in Epithelial Cell Adhesion Molecule (EpCAM) tumor cells, showing that EpCAM-CAR-T cells have specific cytotoxic effect on target tumor cells. The average colorectal tumor volume in the EpCAM-CAR-T cell group were lower than the control group, indicating that EpCAM-CAR-T cells were able to inhibit both the formation and growth of tumor cells. On the other hand, administration of anti PD-1, nivolumab for metastasis CRC shows a durable responses and disease control, as well as long-term survival. Conclusion: The combination of EpCAM-CAR-Tcell immunotherapy with anti PD-1 nivolumab could be an effective potential novel treatment for CRC. Keywords: anti PD-1, CAR-T cell, colorectal cancer, immunotherapy

HIPERTENSI, DIABETES MELLITUS, DAN OBESITAS SEBAGAI FAKTOR KOMORBIDITAS UTAMA TERHADAP MORTALITAS PASIEN COVID-19: SEBUAH STUDI LITERATUR Luh Ade Dita Rahayu; Jannatul Cahya Admiyanti; Yumna Iftinan Khalda; Fatikha Rudia Ahda; Nur Feby Febiana Agistany; Sastraningsih Setiawati; Nabila Indah Shofiyanti; Cut Warnaini
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.342

Background: COVID-19 patients with comorbid diseases have a higher mortality rate than patients without congenital diseases. The most common comorbids found in COVID-19 patients are diabetes mellitus, hypertension, and obesity. The prevalence of COVID-19 patients with diabetes mellitus reached 41.7%, hypertension reached 56.6%, and obesity reached 41.7%. Methods: The method used in this paper is literature review from various references and focused on the correlation of comorbid with the risk of death in COVID-19 patients. The references are being retrieved from NCBI and Google Scholar. Overall, 21 sources were used which were obtained from various data bases including PubMed, ScienceDirect, Researchgate, and WHO. Discussion: There is an increase in ACE-2 expression which causes a high susceptibility to SARS-CoV-2 infection on COVID-19 patient with hypertension. Impaired T-cell function and increased levels of interleukin-6 (IL-6) also play an important role in increasing the severity on COVID-19 patient with diabetes. Obesity can cause abnormalities in the secretion of cytokines, adipokines, and inferferon which will disrupt the immune system in the human body. Conclusion: The complex pathophysiological mechanisms of hypertension, diabetes mellitus, and obesity as comorbid in COVID-19 patients increase the severity and mortality risk.

Faktor Prediktif Prognosis Pasien dengan Ensefalopati Hipoglikemia Debby Cinthya Damiri Valentina
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.351

Background: Severe hypoglycemia can cause damage to the brain resulting in a permanent coma. This condition is called hypoglycemic encephalopathy (HE). Hypoglycemic encephalopathy has various clinical outcomes, so several predictive values of physical examination as well as laboratory and radiologic investigations are needed to determine the prognosis of the disease. Methods: The method used in this literature review was by literature searches using inclusion and exclusion criteria. Then the steps of analyzing, synthesizing and summarizing were conducted in this literature review. Discussion: Hypoglycemic encephalopathy is diagnosed based on clinical findings in the state of stupor or coma which last ?24 hours despite the management of hypoglycemia. A history of previous illnesses must be explored such as the history of hypotension, hypertension, acidosis, drug intoxication, or infection. The diagnosis of HE must be done precisely by eliminating the possibility of other differential diagnosis through laboratory and radiological investigations. Radiological examination of cerebral MRI can show symmetrical hyperintense lesions in cerebral cortex, hippocampus, internal capsule, amygdala, or basal ganglia. The extent of the affected part of the brain is not significantly correlated to the patient's clinical outcome, so other predictive factors are needed to determine the prognosis of the disease. Predictive factors that can help in determining the prognosis of HE are body temperature, duration of hypoglycemia, blood glucose concentration, and lactic acid levels. Conclusion: History of illness and clinical symptoms along with laboratory and radiological examinations need to be carried out appropriately to diagnose HE and rule out other diagnoses. Thus, examination of predictive factors can be done to determine the prognosis of HE.

THE RELATIONSHIP OF STRESS AND USE BB CREAM OF THE OCCURRENCE OF ACNE VULGARIS IN STUDENT AT UNIVERSITY OF MUHAMMADIYAH SURAKARTA FORCES MEDICAL 2018 Ramadhina Tria Sesanti
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.358

Acne vulgaris is a skin disease that is prevalent in approximately 80-100 % of the population aged 15-18 years and over. Based on Global Burden of Disease (GBD), acne vulgaris affects 85% of young adults aged 12-25 years. This disease causes depression and anxiety. The etiology of acne is not known with certainty, but at puberty it is influenced by several risk factors, namely increased androgen hormones, use of cosmetics, personal hygiene, poor sleep patterns and stress. To determine the relationship between stress levels and use of bb cream on the incidence of acne vulgaris. The study design used a cross sectional study and it was conducted in January 2021 on students of FK UMS 2018. The subjects in this study were 33 respondents who fit the restriction criteria and the sampling used purposive sampling technique. Stress level data and use of bb cream using a questionnaire. Data on the incidence of acne vulgaris with diagnosis by a general practitioner. The data were analyzed using the test chi-square and logistic regression test. The results of the test chi-square showed a relationship between stress levels and the incidence of acne vulgaris (p = 0.001), there was a relationship between the use of BB cream and the incidence of acne vulgaris (p = 0.003). The results of the multivariate stress analysis showed a value of p = 0.010 (p <0.05) and the onset of acne vulgaris and the variable BB cream showed a value of p = 0.027 (p <0.05). There is a relationship between the level of stress and the incidence of acne vulgaris, there is a relationship between the level of stress and the incidence of acne vulgaris.

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Contact Name Norbertus Marcell Prayogi

Contact Email editor.jimki.bapin@gmail.com

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Journal Mail Official editor@jimki.bapin.or.id

Editorial Address Jl. Dr. G.S.S.Y. Ratulangi No. 29, Menteng, Jakarta Pusat 10350

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Contact Name
Norbertus Marcell Prayogi

Contact Email
editor.jimki.bapin@gmail.com

Phone
+6281372545321

Journal Mail Official
editor@jimki.bapin.or.id

Editorial Address
Jl. Dr. G.S.S.Y. Ratulangi No. 29, Menteng, Jakarta Pusat 10350

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA