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JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia

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Published by Badan Analisis dan Pengembangan Ilmiah Nasional ISMKI

ISSN : 23026391 EISSN : 27211924 DOI : https://doi.org/10.53366/jimki

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmiah Mahasiswa Kedokteran Indonesia (JIMKI) adalah jurnal yang dikelola oleh Badan Analisis dan Pengembangan Ilmiah Nasional (BAPIN). JIMKI berfokus menjadi wadah untuk publikasi penelitian mahasiswa kedokteran.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 326 Documents

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Pengaruh Radioterapi Terhadap Parameter Hasil Pemeriksaan Darah Lengkap Pasien Karsinoma Nasofaring di Rumah Sakit Pendidikan Universitas Hasanuddin Periode 2016-2018 imam hermansyah; Eddy Zulfikar; Aton Prasetya Sibala'; William Chandra Papendang; Ahmad Fachry Toaha; Yuyun Widaningsih
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.361

ABSTRACT Itroduction: Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck areas. Recently, radiotherapy remain to be the treatment of choice for NPC, especially for the loco-regional type that hasn’t extend into distant metastasis. However, radiotherapy may cause side effect on the hematopoietic system, which has made complete blood tests mandatory for NPC patient that undergo radiotherapy treatment. Unfortunately, data regarding the effect of radiotherapy on complete blood test parameter of NPC patients are still very limited in Indonesia. Therefore, this study aims to analyse the effect of radiotherapy on the hematopoietic system in NPC patient based on the leukocyte count, hemoglobin concentration, and platelet count. Method: This study was an observational analytic study with cross sectional design using medical records of NPC patients that undergo full cycle of radiotherapy at the Teaching Hospital of Hasanuddin University in 2016-2018. The collected data analysed by using Friedman method. Results: Of the 41 patients included in this study, the mean significant difference on complete blood test parameter post-radiotherapy was only found in the leukocyte count (p<0,05) compared to the hemoglobin and platelet count variable (p>0,05). Discussion: Radiation on the bone marrow will cause a depression in the number of blood cells due to the destruction of hematopoietic stem cells and progenitor which are very sensitive to radiation. Based on the level of sensitivity to radiotherapy, leukocytes are the most radiosensitive, followed by platelets then erythrocytes. Conclusion: Radiotherapy has a significant effect on the changes of leukocyte count in patients with NPC. Keywords: Complete blood test, nasopharyngeal carcinoma, radiotherapy

VAKSIN DNA HEAT SHOCK PROTEIN 65 (HSP65) DENGAN KLK YANG TERENKAPSULASI NANOPARTIKEL PLGA SEBAGAI INOVASI TERAPI PREVENTIF DAN KURATIF TUBERKULOSIS Jaya Firmansyah; Hana Nafisah; Nabila Rayhan Yasmin
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.364

Background: Tuberculosis has high mortality rate. BCG vaccine is used for preventing tuberculosis infection. However, the protective effect of the BCG vaccine varies from 0-80% and decreases significantly after 10-15 years. So, new vaccine innovations that are more protective are needed. The purpose is to determine the effectiveness of using the hsp65 DNA vaccine with KLK adjuvant encapsulated PLGA nanoparticles as a preventive and curative therapeutic innovation for tuberculosis. Methods: Reviewed papers were obtained using search engines such as Google Scholar, Proquest, Sciencedirect, and PubMed with publication range from 2010 to 2020 and paper were selected theirs validity and reliability. Then literature review and article writing are conducted. Discussion: The hsp65 DNA vaccine can trigger cytokine production, such as IFN-?, IL-2, higher CD4 +, CD8 +, T cell activity than the BCG vaccine. There was significant decrease in the level of MTB in mice injected with the hsp65 vaccine. The combination of the Hsp65 + KLK vaccine showed the least lung damage and area of inflammation and the highest Th1 response and IL-10 production among the other vaccines. To increase the efficiency of the DNA hsp65 + KLK vaccine, a dose reduction was made to a single dose using biodegradable PLGA nanoparticles as an antigen-carrying system. Conclusion: The combination of DNA hsp65 and KLK vaccines can trigger specific immune responses against MTB and with PLGA encapsulation can increase its efficiency, so it has high potential as a preventive and curative therapy for tuberculosis.

Hubungan Kebiasaan Merokok Dan Mengkonsumsi Kafein Dengan Kejadian Osteoporosis Pada Usia Lanjut Dwi Nonita Nugraheni; Sri Wahyu Basuki; Anika Candrasari; Budi Hernawan
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.368

Osteoporosis is a disease that is classified as a silent killer because it is not detected early and only known after the fracture occurs. Smoking habits are a risk factor for osteoporosis, because smokers lose bone mass faster than nonsmokers. Excess caffeine intake is associated with the effect of caffeine on bone homeostasis. The purpose of this study was to analyze the relationship between smoking and caffeine consumption and the incidence of osteoporosis in the elderly.The design of this research is a literature study or literature review. This study draws sources from Pubmed, Science Direct, and Google Scholar with the keywords: (smoking OR smoking habits) AND (caffeine OR caffeine consumption OR drink coffee) AND (osteoporosis) AND (elderly OR aged). The search results showed 1,136 articles were found, then after the duplicates were removed the remaining 1,104 articles. Then identified based on the title, abstract, and eligibility in accordance with the restriction criteria, 8 articles were reviewed. The research results from the article stated that smoking can increase the risk of osteoporosis. High caffeine consumption can put you at risk for osteoporosis, while low to moderate caffeine consumption can lower your risk of osteoporosis. Based on the results of the research that has been done, it can be concluded that there is a significant relationship between smoking habits and high consumption of caffeine on the risk of osteoporosis in the elderly.

THE POTENTIAL OF CELL-FREE DNA METHYLATION BIOMARKER AS AN EARLY DETECTION FOR LUNG CANCER Muhammad Yusuf; Nasim Amar; Shintya Octaviana Baliulina
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.369

Background: Lung cancer is still the leading cause of cancer deaths. Current screening methods still have many limitations in diagnosing lung cancer, thus a more precise and applicable screening method is needed in diagnosing individuals with lung cancer. One of the screening methods that has the potential to help diagnose lung cancer is DNA methylation which is thought to have an advantage as a biomarker in lung cancer. Method: This literature review was conducted by including validated studies extracted through PubMed, ScienceDirect, and Cochrane Library databases. A total of 13 studies fulfilled the inclusion criteria. Discussion: DNA methylation could occur in the early stages of cancer development and was specific to different tumor types. In lung cancer, DNA methyltransferase (DNMT) regulation and ten-eleven translocation (TET) enzymes were disrupted resulting in tumor suppressor gene inactivation and cancer development. Overall, DNA methylation in the genes HOXD10 / PAX9 / PTPRN2 / STAG3, SHOX2 / PTGER4 / FOXL2, SOX17 / TAC1 / HOXA7 / CDO1 / HOXA9 / ZFP42, and CDO1 / SOX17 / HOXA7 had a sensitivity above 90%. Several other DNA methylation panels such as DCC, TMEM196, SHOX2 / PTGER4, and CDO1 / SOX17 / HOXA7 had a high specificity of up to 90-100%. AUC scores were above 0.80 in the majority of studies. DNA methylation as a support for screening methods could increase the effectiveness of early detection and reduce the rate of false positives. Conclusion: DNA methylation biomarker is an effective method for an early detection of lung cancer.

POTENSI BIOSUPLEMEN SINBIOTIK DALAM SOYGURT SEBAGAI TERAPI ADJUVAN PADA PASIEN NEFROPATI DIABETIK ratna krismondani
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.373

Background: Currently the prevalence of type 2 diabetes mellitus (DM) worldwide reaches a pandemic proportion that affects more than 8% of the global population (nearly over 350 million people) and will increase to more than 550 million people by 2035. Persistent hyperglycemia in diabetic mellitus patients can develop into a chronic kidney disease called diabetic nephropathy. It is estimated that 25% to 40% of diabetic mellitus patients will develop into diabetic nephropathy progressively after 15 years of the duration of the disease and 20% of diabetic nephropathy patients will develop into end stage kidney disease (ESKD) that requires organ transpalanation or dialysis. Therapeutic interventions given to DM patients with diabetic nephropathy have not been able to prevent the progressiveness of renal damage. Recent research has found the potential of soygurt synbiotic biosuplemen as a potential adjuvant therapy for diabetic nephropathy patients. Discussion: Soygurt is a biosuplemen derived from fermented soy milk. Its potential as adjuvant therapy in diabetic nephropathy patients through two mechanisms is a direct and indirect mechanism. In direct mechanisms useful in repairing and preventing kidney damage by acting as an antioxidant, inhibiting the release of inflammatory mediators and blood coagulation factors, as well as improving and inhibiting the occurrence of fibrosis in the kidneys. While indirect mechanisms are useful in lowering risk factors for complications of diabetes mellitus in the kidneys such as obesity, insulin resistance, hyperglycemic, hypertension and dyslipidemia. Conclusion: Soygurt synbiotic biosuplemen have great potential in preventing progressiveity and improving risk factors for kidney damage in diabetic nephropathy patients.

POTENSI UMBILICAL CORD BLOOD DERIVED STEM CELLS DALAM MEMPERBAIKI KERUSAKAN OTAK AKIBAT PENYALAHGUNAAN NARKOTIKA Irfan Hasbullah Putra
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 6 No 1 (2018): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 6.1 Edisi April - Sep
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

ntroduce: The prevalence of drug abuse in the world has increased. In Indonesia, Thenumber of cases of narcotics abuse has increased in the last 5 years while thoseincluded in other additives decreased the number of cases. Opiates, one of narcotics,have the most evident addictive effects, involving tolerance, withdrawal, and a high rate of relapse. Beside that, the mechanisms involved in the neurotoxicity of these drugsinclude oxidative stress, apoptosis, mitochondrial dysfunction, and inhibition ofneurogenesis. Neural system is incapable to self-repair and renewal. In contrast, neuralstem cells can repair and treat the neurogical disorders. Stem cells can be self-adaptiveto the host environment providing multi-folded roles, from neuronal protection,neurotrophic effect to direct neuronal replacement to facilitate the repair and regenerative process of the injured CNS following brain damage. Discussion: Human cord bloodstem cell express nestin which effective in promoting differentiation of oligodendrocytes, astroglia, and neurons nd recruit them to repair damaged area in brain caused by drug abuse. Conclusion: Umbilical cord blood derived stem cells can be an alternative,innovative and effective therapy to repair repairing brain demage caused by narcotics abuse

PERAN WHEY-ACIDIC-PROTEIN FOUR DISULFIDE CORE DOMAIN 2 (WFDC2) SEBAGAI BIOMARKER MUTAKHIR DALAM DETEKSI DAN DIAGNOSIS DINI KANKER OVARIUM Natalia Desy
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 6 No 1 (2018): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 6.1 Edisi April - Sep
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Introduction: Ovarian cancer has a major role as the causes of prevalence and deathsworldwide and has been estimated at 2025 they will rise over heart disease as the largestcause of death. Indonesia is one of the developing countries that have the death ratefrom ovarian cancer is the third-highest in Asia after China and India. The prevalence of ovarian cancer could be suppressed if the detection and early diagnosis can beestablished. However, detection of which is currently used is CA125 is still inadequate asa diagnosis of early-stage ovarian cancer because this biomarker has high sensitivity andspecificity only at an advanced stage which is the stage is already quite late to be treated.Discussion: The overexpression WFDC in vitro and in vivo indicate a significantcontribution to the proliferation, cell growth rate, invasive capability, and independentgrowth in tumor cells. Additionally, WFDC2 has a higher sensitivity and specificity inearly-stage cancer (stage 1 and 2) compared to CA125 and combination ofCA125+WFDC2 so it is very advantageous for clinician to detect ovarian cancer earlier.Conclusion: WFDC2 can be used as a biomarker for the detection and early diagnosis ofovarian cancer.

MULTIGRAVIDA DENGAN MAKROSOMIA DAN INTRA UTERINE FETAL DEATH: SUATU STUDI KASUS DI RS ABDUL MOELOEK BANDAR LAMPUNG Fauziah Lubis
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 7 No 1 (2019): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 7.1 Edisi Januari - A
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v7i1.378

Background: Macrosomia is the term for newborn with birthweight greater than 4000 grams or are in the 90th percentile for the infant’s gestational age. Macrosomia increases the risk of injury to the mother and fetus during labor. Macrosomia can be prevented or early detected by controlling risk factors. Ilustration case: In this case, macrosomia has caused complication that is intrauterine fetal death. The patient was diagnosed with a G3P1A1, 37-week pregnant in the first phase of the active phase with 3 hours of premature rupture of membranes (outside), a single fetus die, head presentation with macrosomic suspect. Management: Trial of labor performed on patient. The trial of labor failed and the patients can be diagnose with cephalopelvic disproportion, so the patient was treated with caesarean section. Physical Examination: Born baby boy in a dead condition, weight 5400 grams, body length 62 cm with grade I maceration. During surgery, a brownish and thick green amniotic color was obtained which indicates a chronic hypoxic process in the fetus that causes fetal death in this case. The risk factor found on a patient is a history of a previous large baby birth (4100 grams). Antenatal visits are rarely done so that weight during pregnancy is not monitored. Discussion: This case report shows that macrosomia can increase the risk of complications for the mother and baby, especially during labor. Complications can be reduced by preventing and early diagnosing macrosomia by controlling risk factors. Controlling of risk factors can be done with routine antenatal visits.

PENATALAKSANAAN HOLISTIK DAN KOMPREHENSIF PADA BATITA DENGAN TONSILITIS KRONIS DAN RIWAYAT KEJANG DEMAM Faridah Alatas
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 7 No 1 (2019): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 7.1 Edisi Januari - A
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v7i1.379

Tonsillitis is an inflammation of the palatine tonsils that are part of the Waldeyer ring. Inflammation of the tonsils can be caused by bacteria or viruses, one of the most common causes of tonsilitis is group A Streptococus beta hemolytic (GABHS) bacteria, 30% of child tonsillitis and 10% of adult cases and is also a cause of strep throat. Predisposing factors of chronic tonsillitis are the chronic stimuli of cigarettes, certain foods, poor oral hygiene, weather effects, physical fatigue and inadequate acute tonsillitis treatment. Repeated fever conditions have a serious impact on children with a history of febrile seizures. Seizures that occur when the fever is easy to meet in children, therefore the cause of recurrent fever should be immediately in the management. A febrile seizure is a seizure upset occurring in the rise of the body (rectal temperature above 38°C) caused by an extracranium process. Febrile seizures usually occur in 2-4% of children 6 months to 5 years. Complications of febrile seizures that are not handled quickly and precisely can cause permanent disruption such as epilepsy and mental retardation.

UJI DAYA PROTEKSI EKSTRAK METANOL BUAH PARE (Momordica charantia L.) SEBAGAI REPELAN TERHADAP NYAMUK Aedes aegypti Ajeng Fitria N; Hanna Mutiara
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 7 No 1 (2019): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 7.1 Edisi Januari - A
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v7i1.380

Demam Berdarah Dengue (DBD) merupakan penyakit infeksi yang ditularkan melalui gigitan nyamuk Aedes aegypti. Salah satu cara pencegahan penularan penyakit DBD adalah menghindari gigitan nyamuk dengan menggunakan repelan. Repelan yang beredar umumnya mengandung senyawa kimia yang dapat bersifat korosif sehingga upaya pencarian senyawa alami sebagai repelan lebih diutamakan. Buah Pare memiliki kandungan zat aktif alkaloid, flavonoid, saponin, dan tanin yang dapat berperan sebagai repelan. Dengan demikian perlu untuk mengetahui daya proteksi serta Effective Time 50% (ET50) dan Effective Concentration 50% (EC50) ekstrak metanol buah pare sebagai repelan terhadap nyamuk Aedes aegypti. Penelitian ini merupakan penelitian eksperimental dengan metode rancangan acak lengkap mengikuti anjuran pedoman World Health Organization Pesticides Evaluation Scheme (WHOPES) yang dilakukan dari bulan November hingga Desember 2017. Kelinci yang telah diolesi losio ekstrak metanol buah pare konsentrasi 0%, 12,5%, 25%, dan 50% dimasukkan ke dalam kurungan berisi 25 ekor nyamuk Aedes aegypti dewasa lalu diujikan dengan menghitung jumlah nyamuk yang hinggap selama 3 menit selama 6 jam. Daya proteksi masing-masing ekstrak metanol buah pare dianalisis. Ekstrak metanol buah pare konsentrasi 12,5%, 25% dan 50% memberikan rerata daya proteksi sebesar 49,41%, 67,05% dan 65,38% dengan ET50 terdapat pada satu jam pertama dengan EC50 sebesar 9,8%. Kata Kunci: Aedes aegypti, daya proteksi, ekstrak metanol buah pare, repelan

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Contact Name Norbertus Marcell Prayogi

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Journal Mail Official editor@jimki.bapin.or.id

Editorial Address Jl. Dr. G.S.S.Y. Ratulangi No. 29, Menteng, Jakarta Pusat 10350

Location Kota adm. jakarta pusat, Dki jakarta INDONESIA

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Contact Name
Norbertus Marcell Prayogi

Contact Email
editor.jimki.bapin@gmail.com

Phone
+6281372545321

Journal Mail Official
editor@jimki.bapin.or.id

Editorial Address
Jl. Dr. G.S.S.Y. Ratulangi No. 29, Menteng, Jakarta Pusat 10350

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA