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JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Published by Badan Analisis dan Pengembangan Ilmiah Nasional ISMKI
ISSN : 23026391     EISSN : 27211924     DOI : https://doi.org/10.53366/jimki
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmiah Mahasiswa Kedokteran Indonesia (JIMKI) adalah jurnal yang dikelola oleh Badan Analisis dan Pengembangan Ilmiah Nasional (BAPIN). JIMKI berfokus menjadi wadah untuk publikasi penelitian mahasiswa kedokteran.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 326 Documents
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Personalized Fecal Microbiota Transplantation: Upaya Restorasi Keseimbangan Mikrobiota Usus dengan Cross-kingdom miRNA pada Individu Obesitas Aisyah Farah Nisrina; Nadia Yasmine; Yumna Shafa Yananda; Rio Jati Kusuma
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.212

Abstract

Introduksi : Obesitas atau kegemukan merupakan salah satu masalah utama kesehatan di Indonesia dengan angka kejadian yang tinggi. Pasien obesitas mengalami disbiosis sehingga menyebabkan terjadinya gangguan kesehatan lain. Saat ini mulai dikembangkan terapi Fecal Microbiota Transplantation (FMT) untuk mengatasi obesitas dengan restorasi keseimbangan mikrobiota usus pada pasien obesitas.Tujuan : Literature review ini dibuat untuk mendiskusikan potensi terapi Personalized FMT, yaitu memodifikasi FMT pada donor feses yang berasal dari pasien obesitas dengan teknik cross-kingdom miRNA. Metode : Penulis melakukan pencarian artikel pada beberapa sistem basis data jurnal kedokteran seperti PubMed, ScienceDirect, dan beberapa jurnal yang dipublikasikan dalam Google Scholar menggunakan logika pencarian Boolean. Hasil dan Pembahasan : FMT terbukti memiliki efek positif dalam menyeimbangkan mikrobiota usus pasien obesitas, namun hal tersebut terjadi secara temporal. Penerapan personalized FMT adalah dengan mengambil feses pasien obesitas itu sendiri dan dilakukan perlakukan dengan teknik cross-kingdom miRNA dari sumber hewani dan nabati. miRNA yang telah dikultur dengan mikrobiota usus secara in vitro sebelum memasuki tahap FMT akan meningkatkan komposisi bakteri baik seperti Bacteriodetes dan menekan Firmicutes, sehingga dapat langsung ditransplantasikan kembali kepada pasien obesitas untuk memperbaiki kondisi disbiosis dan kemudian mempertahankan komposisi mikrobiota usus secara permanen. Kata Kunci : Obesitas, Fecal Microbiota Transplantation, Disbiosis, Cross-kingdom miRNA, Restorasi Mikrobiota
PENGARUH PEMBERIAN MINYAK ZAITUN Olive oil TERHADAP GAMBARAN HISTOPATOLOGI LAMBUNG TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR Spargue dawley YANG DIINDUKSI ALKOHOL Muhammad Reqza Pratama
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.223

Abstract

Uncontrolled use of alcohol can cause variety damage to the gastric mucosa. Olive oil as an herbal plant is an important source for protecting and regenerating damaged gastric mucosa. This study is an experimental laboratory study with a post-test only control group design, which conducted at Animal House of Faculty of Medicine, University of Lampung by using 30 samples of male white rat (Rattus norvegicus) Sprague dawley which divided into 5 groups namely; negative control group (K-) only given distilled water 2ml / day, positive control group (K +) given alcohol 2.4ml / day for 14 days; treatment group 1 (P1) was given alcohol 2.4 ml / day and olive oil 0.27 ml / day for 14 days; treatment group 2 (P2) given alcohol 2.4ml / day and 0.54ml olive oil / day for 14 days; and treatment group 3 (P3) given alcohol 2.4 ml / day and 1.08 ml of olive oil / day for 14 days.Data were observed with the Kruskal-Wallis Non-Parametric Test, obtained p = 0,000 (p <0.05). The expected results obtained by Ho are expected. Statistical results with the Mann-Whitney test obtained also found a significant difference in each group.There is an influence of olive oil administration on histopathological decription of white rat gaster (Rattus norvegicus) male Spargue dawley strain alcohol-induced.
POTENSI SENYAWA DERIVAT 2-AMINOIMIDAZOLE SEBAGAI AGEN AJUVAN TERHADAP INFEKSI MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII MELALUI SIFAT ANTIBIOFILM DAN RESENSITISASI ANTIBIOTIK Grady Krisandi; Aditya Parawangsa
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.229

Abstract

Background: Antibiotic resistance in hospital-acquired infection (HAI) is a big problem for healthcare. It becomes worse by the trend of antibiotic resistance that is more common in gram-negative bacteria. Acinetobacter baumannii is a gram-negative bacteria that causes HAI and is considered multidrug-resistant. This trend raises the need for an agent to resensitize antibiotics. 2-aminoimidazole found in sea sponges Leucetta and Clathrina and rich in Indonesian seas is a potential agent to resensitize antibiotics in A. baumannii. Methods: Literature searching worked using specific keywords in the search engine (Google and Google Scholar) and online databases (PubMed and SCOPUS). Twenty-three studies from various journals were retrieved. Discussion: 2-AI has various derivative compounds followed by pharmacophores. 2-Aminoimidazole triazole (2-AIT) is one of the potential derivates with antibiofilm character to resensitize Acinetobacter baumannii. Optimization of the tail group 2-AIT carries out by several methods such as simple organic chemical reactions and Suzuki-Miyaura cross-coupling. The optimized group works as an antibiofilm by binding to the bfmR protein, which plays a role in forming biofilms. The toxicity of this compound in the hemolysis test and C. elegans is relatively low. Conclusion: 2-AI has an antibiofilm activity that allows antibiotic diffusion in A. baumannii blocked by biofilm. This activity enables the resensitization of A. baumannii towards antibiotics. The safety of 2-AI has also been proven in vitro and in vivo. These findings conclude that 2-AI that extracted in sea sponges from Indonesian seas can be an agent to resensitize antibiotics in multidrug-resistant A. baumannii.
Hiperplasia Prostat Jinak: Manajemen Tatalaksana dan Pencegahan Mutakhir Reynardi Larope Sutanto
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.230

Abstract

Background: Benign prostatic hyperplasia (BPH) is a histologic diagnosis which referred to a proliferation of ephitelial and smooth muscle tissues in the transitional zone of the prostate. BPH affects roughly 18-25% of all male aged 40 years and above and 90% of all male aged beyond 80. BPH is known to be able to significantly decrease quality of life and hence people with BPH need treatments to help them alleviate its effects. Methods: The research was conducted using literature review from the most actual and respected clinical guidelines, scientific literatures, websites, and textbooks on BPH. Discussion: There are three main groups of treatment, which are conservative, pharmacological, and surgical treatments. Treatment should be chosen from the least invasive first with the aim of increasing quality of life. Even if it is hard to prevent, several preventive measures could be conducted, such as limiting usage of BPH-inducing drugs, doing healthy lifestyle which involves no smoking, active exercise, body weight control, and balanced diet. Conclusion: BPH is a very prevalent condition on elderly male population. Even though it is not deadly, a proper treatment management need to be done by virtue of its ability to significantly decrease quality of life.
PERBANDINGAN EFEK PEMBERIAN EKSTRAK JINTAN HITAM (NIGELLA SATIVA) DAN TEMULAWAK (CURCUMA XANTHORRHIZA) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR TIKUS YANG DIINDUKSI PARASETAMOL Chairunna Amalia; Des Suryani
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.234

Abstract

ABSTRAK Latar Belakang : Parasetamol sebagai analgesik dan antipiretik yang paling sering digunakan, memiliki efek samping terbesar pada hati. Jintan hitam dan temulawak telah diteliti memiliki efek hepatoprotektor, namun belum ada peneliti yang membandingkan efektifitasnya sebagai hepatoprotektor. Karenanya, peneliti ingin mengetahui perbedaan efek antara keduanya. Tujuan: Untuk membandingkan efektifitas pada pemberian jintan hitam (Nigella sativa) dan temulawak (Curcuma xanthorrhiza) sebagai hepatoprotektor terhadap gambaran histopatologi hepar tikus yang di induksi parasetamol. Metode: Penelitian ini menggunakan hewan uji sebanyak 24 ekor tikus jantan galur wistar yang dibagi dalam 4 kelompok, yaitu: kontrol negatif ( aquades), kelompok positif ( parasetamol), kelompok perlakuan 1 (ekstrak jintan hitam 500mg/KgBB+ parasetamol 500mg/kgbb), dan kelompok perlakuan 2 (ekstrak temulawak 500mg/kgBB+ parasetamol 500mg/kgbb) selama 7 hari, Pada hari ke delapan hewan di matikan dan dilakukan pembuatan sediaan preparat histologi hepar dan diamati dibawah mikroskop , untuk menilai derajat kerusakan hepar tikus antar kelompok , kemudian dianalisis dengan uji Kruskal Wallis dan uji Man Whitney. Hasil: Uji Kruskal Walis, menunjukkan terdapat perbedaan signifikan antar seluruh kelompok perlakuan(p>0.05). Selanjutnya pada uji post hoc Mann- Whitney dijumpai perbedaan bermakna antar kelompok KN dan KP, juga pada KP dengan P1 dan P2. Kesimpulan: Efektifitas ekstrak jintan hitam dosis 500mg/KgBB sama dengan ekstrak temulawak dosis 500mg/KgBB. ABSTRACT Background: Paracetamol as the most commonly used analgesic and antipyretic has the biggest side effects on the liver. Black cumin and Temulawak have been investigated to have a hepatoprotector effect, but no researchers have compared its effectiveness as a hepatoprotector. Hence, the researchers wanted to see the difference in effect between the two. Objective: To compare the effectiveness of administration of black cumin (Nigella sativa) and temulawak (Curcuma xanthorrhiza) as a hepatoprotector against the histopathological picture of rat liver induced by parasetamol. Method: This study used 24 test animals of Wistar strain male rats divided into 4 groups, namely: negative control (aquades), positive group (p arasetamol), treatment group 1 (black cumin extract 500mg / KgBB + paracetamol 500mg / kgbb), and treatment group 2 (temulawak extract 500mg / kgBB + paracetamol 500mg / kgbb) for 7 days, on the eighth day the animals were killed and made preparations for liver histology preparations and observed under a microscope, to assess the degree of liver damage between groups, then analyzed with the Kruskal Wallis test and the Man Whitney test. Results: Kruskal Walis test, showed that there were significant differences between all treatment groups (p> 0.05). Furthermore, in the Mann-Whitney post hoc test, there were significant differences between the KN and KP groups, also in the KP with P1 and P2. Conclusion: The effectiveness of black cumin extract dose of 500mg / KgBB is the same as temulawak extract dose of 500mg / KgBB.
Association of Uric Acid Level With Severe Preeclampsia in Pregnancy Women in RSUD Dr. H Abdul Moeloek Province Lampung Citara Tri Utami
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.235

Abstract

Background: Preeclampsia is a syndrome of pregnancy after 20 weeks gestation and is one of obstetric emergencies. An early detection to diagnosis of preeclampsia is needed to avoid a poor prognosis of preeclampsia. Uric acid during pregnancy is one of preeclampsia biomarkers that can be used as a diagnostic assessment of preeclampsia. The purpose of this study is to know the association of uric acid level with severe preeclampsia in pregnancy women in RSUD Dr. H. Abdul Moeloek Lampung Province. Method: The design of this research is case control. Case population were pregnant women with preeclampsia and control population were pregnant women without preeclampsia. sample of case consist 31 respondents and case-control consist 31 respondents. Incidence preeclampsia data obtained while the examination acid levels obtained from laboratory tests. Chi-Square analysis is used to do bivariate analysis. Results: Pregnant women with preeclampsia have elevated uric acid levels of (74.2%) than the control (without preeclampsia) group (35.5%). Based on bivariate analysis, the value of p = 0.0005 and OR 5.227 (95% CI = 1.7 to 15.5). Discussion: The failure of abnormal spiral artery remodeling in preeclampsia causes placental cellular ischemia which will increase the activity of Xanthine Oxidase which can increase uric acid production from maternal, fetal or placental tissues. Conclusion: There is a assosiation high levels of uric acid during pregnancy that increased the risk of preeclampsia by 5 times when compared with normal uric acid levels during pregnancy. Keywords: preeclampsia, pregnancy, uric acid
UJI EFEKTIVITAS MADU KONSENTRASI 50% DAN 100% DIBANDINGKAN DENGAN POVIDONE IODINE TERHADAP PENYEMBUHAN LUKA SAYAT PADA MENCIT (MUS MUSCULUS) M. Fahriza Winaldha Nasution; Yenita Muslimdjas
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.237

Abstract

ABSTRACT Background: Injury is the severity of tissue continuity due to injury or surgery. To accelerate wound healing medically, an antibiotic preparation or wound covering gel can be applied, one of this is povidone iodine 10%. However, these materials have side effects and are less economical. So we need a cheaper and easier alternative to obtain, honey is one kind of option. Honey effects such as acidity, osmotic effects, chemical effects, and antimicrobial activity are the main sources in wound healing. Objective: To prove the effectiveness of wound treatment using 50% honey and 100% on wound healing compared to povidone iodine 10%. Methods: Pure laboratory experimental research. Three groups were treated for a maximum of 14 days and one group was not treated. Results: There was a significant difference between 100% Honey group with the povidone iodine 10% group while the 50% honey group had no significant difference to the povidone iodine 10% group. Conclusion: 100% Honey is more effective in healing wound cuts than 50% honey and povidone iodine 10%.
Coaching Caregiver: Aplikasi Telehealth Berbasis Edukasi dan Konsultasi Kepada Caregiver Pasien Skizofrenia Ni Made Wini Jayesthiwi Wanami Putri; Rovie Hikari Parastan; I Kadek Wahyu Putra Dyatmika; Cokorda Bagus Jaya Lesmana
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.239

Abstract

Schizophrenia is a serious concern in psychiatric problem around the world. In 2018, this disorder has affecting 6.7 per 1000 incidence in Indonesia. Pharmacology and non-pharmacology treatment are recommended treatment for schizophrenia, those treatments will run effectively by supports from their family caregiver. Nowadays, family play an important role in caregiving schizophrenia patients. However, the recent status quo stated that not all caregiver understands how to take care the patients in a proper way. So that, caregiver need some education and other information to understand the schizophrenia patient. Based on Ozkan and Khatri research, providing psychoeducation data via technology (telehealth) to the family caregiver shows a positive and significant result. In reducing family caregiver burden of the patients with schizophrenia, Coaching Caregiver is an innovation to train family caregiver in taking care their family. Some aspects in this program based on DSM V and PPDGJ III such as education, consultation and decision support, psychosocial and behaviour therapy, social support, and monitoring that needed by a caregiver. Using a technology-based approach, this application expected to provide and encourage health services to reach a wider community. In addition, it is expected to reduce the burden of family caregiver in taking care their relatives/family.
Lipid-based Nutrient Supplements Prenatal sebagai Tindakan Preventif Terjadinya Berat Badan Lahir Rendah dan Penurunan Fungsi Kognitif pada Bayi Muhammad Thifan Satyagraha; Rafi Annisa Ulum; Farhan Syafiq Fadhilah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.242

Abstract

Background: Stunting in Indonesia is still high. One of the risk factors is the incidence of low birth weight in infants. If not addressed, the quality of human resources in Indonesia will be low. Thus, giving Lipid-based Nutrient Supplements (LNS), which has been carried out by several countries in order to optimize low birth weight and infant cognitive, needs to be researched. This study aims to collect and analyze articles related to the effect of LNS in pregnant women on birth weight and cognitive power in infants. Methods: The design used is a literature review, articles were collected using the Google search engine through several data sources such as Pubmed, Science Direct, Proquest, Ministry of Health, and BPS RI. The criteria for the articles used are research journals with the Randomized Controlled Trial and Systematic Review methods published in 2015 - 2020. Discussion: Based on the articles, the results show that LNS given to pregnant women can increase body mass and increase brain volume in infants. This is caused by the Brain Specific Fatty Acid which includes docosahexaenoic acid (DHA) and arachidonic acid (ARA) which support tissue formation, immunity, and neurodevelopment. Conclusion: Giving LNS to areas where the prevalence of stunting is still high can be a solution to the problem of stunting in these areas. The suggestion from this research is to create an LNS program, especially in areas where the prevalence of stunting is still high.
SMARTPHONE PULSE OXIMETER: SOLUSI DETEKSI DINI HAPPY HYPOXIA: SOLUSI DETEKSI DINI HAPPY HYPOXIA Fachri Naufal; Alfiani Zukhruful Fitri Rifa&#039;i
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 3 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.3 Edisi September 20
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i3.244

Abstract

Background: Coronavirus disease 2019 (COVID-19) is a global crisis throughout 2020. Furthermore, COVID-19 is also a challenge due to the phenomenon it can cause: happy hypoxia, where patients came with low oxygen saturation but shows no respiration symptoms and no dyspnea. Discussion: Hypotheses about what causes happy hypoxia emerges, trying to explain how happy hypoxia happened, which defies the pathogenesis theory of COVID-19. Because patients does not experience any infection symptoms, early detection is required to get medical attention as soon as possible. Now, smartphones has oxymeter built in and capable to detect happy hypoxia. Conclusion: Smartphone pulse oxymeter is an effective solution because of it’s portability and easy usage so it can be used for early detection of decreasing oxygen saturation. Patients may get help promptly, and COVID-19 mortality rate will decline.

Page 12 of 33 | Total Record : 326

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