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JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Published by Badan Analisis dan Pengembangan Ilmiah Nasional ISMKI
ISSN : 23026391     EISSN : 27211924     DOI : https://doi.org/10.53366/jimki
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmiah Mahasiswa Kedokteran Indonesia (JIMKI) adalah jurnal yang dikelola oleh Badan Analisis dan Pengembangan Ilmiah Nasional (BAPIN). JIMKI berfokus menjadi wadah untuk publikasi penelitian mahasiswa kedokteran.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 326 Documents
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Potensi Campuran Ekstrak Air Daun Salam (Syzygium polyanthum) dan Daun Sambiloto (Andrographis paniculata) sebagai Terapi Adjuvan dalam Tatalaksana Penyakit Diabetes Melitus Tipe 2 di Indonesia Meidina, Adinda Nezma; Ramadhanti, Nafilah; Triandra, Akbar; Putri, Yolanda Delia; Muftaridi, Rajwa Fairuz Putri
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 11 No 3 (2025): Vol. 11 No. 3 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 1
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v11i3.772

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder that continues to increase in prevalence every year, especially in Indonesia. In molecular mechanisms, T2DM is closely related to oxidative stress and inflammation. This literature review is intended to further examine the potential of a mixture of aqueous extracts of S. polyanthum and A. paniculata leaves as an adjuvant therapy for T2DM in Indonesia. Methods: Literature was searched using Google Scholar, Scopus, ResearchGate, and NCBI search sites. Inclusion and exclusion criteria were used to eliminate unrelated literature, resulting in 23 pieces of literature. Discussion: Based on phytochemical screening, S. polyanthum leaves and A. paniculata leaves contain compounds with beneficial effects in modulating the metabolic profile of T2DM patients by reducing oxidative stress, inhibiting ?-glycosidase, increasing insulin levels, regenerating pancreatic ?-cells, increasing glycolytic enzyme activity, and reducing pro-inflammatory biomarker levels. Conclusion: The mixture of aqueous extracts of S. polyanthum and A. paniculata leaves or combined with conventional drugs in the treatment of T2DM showed significant antidiabetic effects.
Peran Penerapan Program Vaksinasi HPV dengan Optimalisasi Skrining dan Pengobatan Kanker Serviks sebagai Strategi Ambisius Penurunan Prevalensi Kanker Serviks di Negara-Negara Berkembang: Sebuah Tinjauan Pustaka Meidina, Adinda Nezma; Putri, Yolanda Delia; Nugraha, M. Aditya; Fadhlan, Muhammad Muhadzdzab; Ramadhanti, Nafilah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 11 No 3 (2025): Vol. 11 No. 3 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 1
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v11i3.780

Abstract

Background: Cervical cancer is the fourth most common type of cancer in women in the world, with 94% of total deaths worldwide occurring in developing countries in 2022. In response to this problem, WHO initiated a movement to eliminate cervical cancer, known as the 90-90 strategy, through implementing vaccination programs and optimizing screening and treatment for cervical cancer cases. This literature review aims to describe the role of these strategies in eliminating cervical cancer, especially in developing countries. Methods: Literature was searched using search sites such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria were used to eliminate unrelated literature to obtain 36 literature. Discussion: HPV vaccination has been proven to provide protective benefits in reducing the incidence of neoplastic lesions and shows a relatively decreasing trend in the group receiving the vaccine. Cervical screening plays a very important role in the early detection and therapy of precancer, which shows a trend in preventing cancer cases in the next 50 years. Modeling studies show that successful implementation of the WHO 90-70-90 intervention by 2030 will reduce the incidence of cervical cancer to 0.7 per 100,000 women and the death rate to 0.2 per 100,000 women in all developing countries. Conclusion: The implementation of the HPV vaccination program with the optimization of cervical cancer screening and treatment is believed to be a solution modality to reduce morbidity and mortality rates due to cervical cancer in the world, especially in developing countries.
THE EFFECTIVENESS, IMMUNOGENICITY, AND SAFETY OF THE Escherichia coli BASED BIVALENT HUMAN PAPILLOMAVIRUS (TYPES 16 AND 18) VACCINE PREVENTING CERVICAL CANCER: A Systematic Review Masykur, Umar Jundullah; Janet, Karensa Abby
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 11 No 3 (2025): Vol. 11 No. 3 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 1
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v11i3.795

Abstract

Background: Cervical cancer is the fourth most prevalent cancer worldwide and ranks second in Indonesia, with a high mortality rate among women. Cervical cancer ranks highest in treatment costs in Indonesia. HPV-16/18 infection causes nearly all cases of cervical cancer. The HPV-16/18 bivalent vaccine made with E. coli holds potential as a more affordable HPV vaccine than other commercial vaccines. Objective: This systematic review aimed to discuss the effectiveness, immunogenicity, and safety of the bivalent HPV-16/18 vaccine produced by E. coli based on evidence from available studies. Methods: This systematic review included valid experimental studies retrieved from PubMed, Cochrane, ScienceDirect, and Taylor and Francais databases that met the inclusion criteria. The search method used Boolean operators, with the literature cited from 2014 to 2024. Results and Discussion: Seven studies met the inclusion criteria. The results of all studies indicate that the bivalent HPV-16/18 vaccine produced by E. coli has a high effectiveness and good immunogenicity. There were no significant side effects associated with vaccination, and most of the side effects were minor. Conclusion: The bivalent HPV-16/18 vaccine produced by E. coli could serve as a reliable and economical alternative to prophylactic HPV vaccination for cervical cancer prevention.
Bahasa Inggris Saifana, Qanita; Ganta, Ahmad Reza Rafi; Suryandaru, Muhammad Kynan Rafii; Nusantara, Muhammad Radja; Enigo, Muhammad Ricad; Bages, Nouv Aqila
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 11 No 3 (2025): Vol. 11 No. 3 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 1
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v11i3.798

Abstract

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes pain, stiffness, and joint damage, as well as other systemic symptoms. The prevalence of RA worldwide is around 1-2%. The disease is influenced by genetic and environmental factors such as infection, pollution, and diet. Diet can affect RA symptoms; foods such as red meat, alcohol, and sodas can aggravate, while fish and berries can alleviate symptoms. The Mediterranean diet, which is rich in herbs and olive oil, as well as gluten-free vegetarian and vegan diets, show positive effects on RA. Research suggests that this diet may contribute to the lower prevalence of RA in Southern Europe compared to other regions. Methods: This study used PubMed and Google Scholar as the main databases. Key words were used, such as “Rheumatoid Atritis”, “Diet”. Considering the relevance of the topic under study, the literature selected for inclusion in this paper covered publications from 2019 to 2024. Discussion: The results of this systematic review suggest that anti-inflammatory, Mediterranean, and gluten-free diets may provide benefits in reducing pain and inflammation in adults with RA. The Mediterranean diet in particular has been shown to be effective in improving quality of life and reducing RA disease activity. Conclusion: Dietary management, especially anti-inflammatory, Mediterranean, and gluten-free diets may play an important role in the control of RA symptoms in adults. Recommendations to adopt a healthy and anti-inflammatory diet may be an effective strategy in RA management. Keywords: Rheumatoid Arthritis, Diet
Penggunaan Probiotik sebagai Terapi Adjuvan pada Inflammatory Bowel Disease (IBD): Suatu Tinjauan Sistematis Hafizh, Ahmad Fauzan; Widjaja, Jovan; Prayogi, Norbertus Marcell; Djausal, Anisa Nuraisa; Graharti, Risti
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i2.828

Abstract

Pendahuluan: Inflammatory Bowel Disease (IBD) merupakan kelompok penyakit inflamasi kronis pada saluran pencernaan. Terapi konvensional seperti aminosalisilat dan kortikosteroid seringkali menimbulkan efek samping dan belum optimal dalam meningkatkan kualitas hidup pasien. Probiotik mulai dilirik sebagai terapi adjuvan karena potensinya dalam memodulasi mikrobiota usus dan respons imun. Tinjauan ini bertujuan mengevaluasi efektivitas probiotik sebagai terapi tambahan pada pasien IBD. Metode: Tinjauan sistematis ini disusun berdasarkan pedoman PRISMA dengan pencarian literatur pada PubMed, Science Direct, dan Scopus. Studi yang diinklusikan adalah uji klinis terkontrol acak (RCT) lima tahun terakhir yang membandingkan probiotik dengan plasebo atau terapi standar pada pasien IBD. Data yang dikumpulkan meliputi karakteristik studi, jenis dan dosis probiotik, lama perlakuan, serta outcome klinis, imunologis, dan kualitas hidup. Pembahasan: Delapan studi RCT terpilih menunjukkan bahwa pemberian probiotik atau sinbiotik, khususnya multi-strain seperti Lactobacillus dan Bifidobacterium, secara konsisten meningkatkan remisi klinis, menurunkan skor aktivitas penyakit, memperbaiki parameter inflamasi (penurunan IL-6, IL-8, TNF-?), perbaikan status nutrisi (BMI, albumin), dan kualitas hidup pasien (skor IBDQ, SF-36). Simpulan: Probiotik terbukti bermanfaat sebagai terapi adjuvan pada pasien IBD ringan hingga sedang, baik dalam meningkatkan remisi klinis, menurunkan inflamasi, maupun memperbaiki kualitas hidup dan status nutrisi. Namun, diperlukan penelitian lebih lanjut untuk menentukan strain, dosis, dan durasi terapi probiotik yang paling optimal pada populasi IBD.
AI-Powered De Novo Antibiotics Discovery: Is It The Answer to Overcome Antimicrobial Resistance? A Systematic Review of Preclinical Evidence Across In Vitro and In Vivo Studies Nabilah Nurul Iftitah; Nurfajrianty Jamaluddin; Alia Zhafira Agus
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Book of Abstrack RCIMS 2025
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.vi.933

Abstract

Introduction. Antimicrobial resistance (AMR) remains a critical global issue. By 2050, it is projected to cause around 10 million deaths if current trends persist. Traditional antimicrobial discovery struggles to keep up with rapidly evolving resistance  due to its lengthy process, high cost, and high failure rate. Developing a single drug can take over a decade of research and cost millions of dollars. These challenges demand more efficient approaches, with artificial intelligence (AI) offering a promising path to accelerate and improve antibiotic development. Methods. GoogleScholar, PubMed, ScienceDirect, and Scopus were systematically searched following the PRISMA 2020, yielding 13 eligible studies. All included in vitro validation, and four extended to in vivo investigations. Risk of bias was evaluated using the QUIN (in vitro) and the SYRCLE (in vivo) tools. Result and Discussions. Across studies, AI supported multiple stages of antibiotic discovery, including target identification, lead compound optimization, also enhancement of pre-clinical testing. In target identification, two studies revealed novel antibacterial targets distinct from classical pathway. During lead optimization, applied in most studies, AI-generated compounds demonstrated strong antimicrobial activity and low MIC values against broad-spectrum and multi-drug resistant bacteria. Four in vivo studies further showed that these de novo antibiotics exhibited superior antimicrobial efficacy to current standard therapies. Finally, in preclinical testing, AI models accurately predicted cytotoxicity and hemolysis, later confirmed experimentally. Conclusions. AI has markedly improved efficiency and accuracy in antibiotic development. While continued model refinement, validation, and ethical oversight remain crucial, AI-intgerated pharmaceutical research indicates growing maturity and transformative potential.
Empowering Healthcare Through AI: The Development of Thalassemia NusaCare for Early Detection of Genetic Blood Disorders in Indonesia Samuel, Thea; Jyoti, Chaitanya; Samuel, Lydia
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Book of Abstrack RCIMS 2025
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.vi.944

Abstract

Introduction  Thalassemia is a prevalent inherited hemoglobinopathies in Indonesia, with an estimated carrier rate of 3-10% of the population. Under-resourced areas struggle with limited diagnostic services like genetic testing or hemoglobin electrophoresis. Prevention and clinical management by early screening and detection of potential thalassemia carriers are critical. This opens the opportunity to leverage computer vision and on-device machine learning to develop an iOS-based application, providing a digital anamnesis tool that is affordable and accessible for early thalassemia risk assessment. Methods Large, diverse datasets were collected to compile the clinical reports and to conduct the AI training. The system architecture of Thalassemia NusaCare AI consists of three integrated computational modules: Vision-Based Analysis using MobileNetV3 for facial and blood image detection, CBC laboratory data Interpretation using OCR and decision-tree algorithms. Digital Anamnesis uses adaptive, federated learning for accurate, real time Thalassemia risk prediction. Results  Preliminary testing using a curated dataset (n=200 images, 120 lab entries, 80 questionnaire records) leads to a mean classification accuracy of 91.3% for detecting thalassemia major, minor, and non-thalassemic anemia, demonstrating high operational efficiency. Hybrid ensemble models result in an F1-score of 0.88 and enhanced sensitivity by 12% relative to single-input models. User experience testing with early adopters also suggested strong usability and intuitiveness (SUS = 89.2). Conclusion Thalassemia NusaCare AI integrates edge AI and inclusive design to deliver adaptive diagnostics in low-connectivity areas. Combining visual, numerical, and behavioral data, enabling on-device screening that aligns with Indonesia’s “Thalassemia-Free 2045” through federated learning and clinical collaboration.  
Pharmacogenomic Regulation Of The NF-KB-NRF2 Axis By Curcumin: A Precision Molecular Approach to Inflammation and Oxidative Stress Alisya, Questa Soundri Alisya; Khairunnisa, Nadiah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Book of Abstrack RCIMS 2025
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.vi.948

Abstract

Introduction: Chronic inflammation and oxidative stress are major mechanisms in degenerative diseases, including cancer, diabetes, and cardiovascular disorders. The NF-kB and Nrf2 pathways play a role in maintaining redox balance and inflammatory response. Curcumin, the main bioactive compound of Curcuma longa L., can simultaneously modulate both pathways through pharmacogenomic mechanisms influenced by individual genetic variations. Methods: This study used the Systematic Literature Review method in accordance with the PRISMA 2020 guidelines. Searches were conducted in PubMed, Scopus, ScienceDirect, and Google Scholar until October 2025 using the keywords “Curcumin,” “NF-kB,” “Nrf2,” “Oxidative Stress,” and “Pharmacogenomics.” Studies assessing the molecular modulation of NF-kB/Nrf2 by curcumin and gene-dependent effects were included. Results and Discussion: A total of 31 studies met the inclusion criteria, including in vitro, in vivo, in silico, and clinical studies. Curcumin suppressed NF-kB activation and activated Nrf2/HO-1, thereby reducing ROS and proinflammatory cytokines. Variations in the ERCC5 rs751402 gene, as well as the expression of SLC7A11 and ATAD3A/B, influenced the cellular response to curcumin. In silico and network pharmacology analyses revealed multigenic targets related to inflammation and oxidative stress. Nanoformulations enhance bioavailability and clinical immune response. Conclusion: Curcumin acts as a dual-regulator pharmacogenomic agent that balances the NF-kB and Nrf2 pathways, reducing inflammation and oxidative stress in a gene-dependent manner. These findings support its potential as a natural biomolecule for the development of precision therapies for chronic diseases involving inflammation and oxidative stress. Keywords: Curcumin, NF-kB, Nrf2, Oxidative Stress, Pharmacogenomics
Cardiovascular Adverse Event Risk in Rheumatoid Arthritis Patients Treated with JAK Inhibitor Tofacitinib versus TNF Inhibitors: a Systematic Review, Meta Analysis, and Meta Regression Kynaya, Erlangga Masykur; Salfistra, Nadia Ramadhina; Hanun, Jauza' 'Athifah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Book of Abstrack RCIMS 2025
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.vi.949

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease, often requiring potent therapies like Tofacitinib or TNF inhibitors. Yet the comparative cardiovascular safety profile of these agents remains a critical and evolving concern. Previous meta-analysis revealed major adverse cardiovascular events (MACE) and thromboembolism was prevalent in tofacitinib treated patients. However, the impact of patient comorbidities on cardiovascular adverse events remains uncertain, requiring systematic assessment through meta-analysis and meta-regression. This study aims to assess the risk of cardiovascular adverse events in RA patients treated with tofacitinib versus TNF inhibitors and to evaluate the influence of baseline comorbidities through meta-regression. A comprehensive search of PubMed, Scopus, Scilit, and Epistemonikos identified RCTs and observational studies up to 2025. Random-effects meta-analysis in R estimated pooled OR and HR for MACE and thromboembolism, while patient comorbidities were evaluated through meta-regression. Four studies (n = 62,009) met inclusion criteria. Tofacitinib was associated with increased risk of MACE (HR = 1.33; 95% CI 1.08–1.65; p = 0.008; I² = 0%) and thromboembolism (HR = 1.79; 95% CI 1.23–2.60; p = 0.002; I² = 37.8%) compared with TNF inhibitors. Meta-regression revealed no significant effect of age, sex, hypertension, diabetes, smoking, heart failure, coronary artery disease, venous thromboembolism history, or corticosteroid use on these risks. Tofacitinib increases the risk of MACE and thromboembolism in RA patients compared with TNF inhibitors, independent of common cardiovascular comorbidities and baseline characteristics.
Exploring the Role of Mitochondria in Alzheimer with Network Pharmacology: A Bioinformatics Analysis Riena, Nadya Ratna; Novalina, Fellen; Heng, Kahtleen Riani
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Book of Abstrack RCIMS 2025
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.vi.950

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disease marked by the pathological accumulation of beta-amyloid peptide and hyperphosphorylated tau. Growing body of evidence indicates that mitochondrial dysfunction plays a pivotal role in AD pathogenesis, by inducing neurotoxicity through the formation of oxidative stress and reactive oxygen species (ROS). This study aims to investigate relevant mitochondrial proteins in Alzheimer by employing network pharmacology. Protein-coding genes associated with AD were identified from the GeneCards database, extracting only genes scoring >1 in relevancy. Datasets associated with mitochondria were extracted from the STRING database. 621 overlapping proteins from both keywords were further enriched and topologically analyzed. This study employed enrichment analyses using ShinyGO to identify relevant biological, cellular, and molecular processes, in addition to disease pathways. Topology analyses were conducted through STRING and Cytoscape by implementing eight different centrality parameters and clustering, the genes were further curated to obtain pivotal proteins in AD and their dysregulation. Aligned with our enrichment analyses, the proteins topologically relevant were components of the mitochondrial oxidative phosphorylation (OXPHOS) pathway, crucial to the respiratory electron transport chain and ATP synthesis system. This study provides a foundation for the discovery of multi-target drugs in AD therapy.

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