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Journal of Medicine and Health
Published by Universitas Kristen Maranatha
ISSN : -     EISSN : 24425257     DOI : 10.28932/jmh
Core Subject : Health,
Medicine & Pharmacology Public Health
Journal of Medicine and Health (JMH) focuses on contributing towards science and research development that can be accessed by researchers and academic practitioners. Journal of Medicine and Health (JMH) is an open access journal, published biannually on every February and August. JMH receives original research articles, case report, and review articles related to biomedical sciences, clinical medicine, public health sciences, nutritional sciences, and medical herbs sciences. Articles should be written in good English or Indonesian language. All articles will be processed through peer review process.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 228 Documents
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A Case Report: Clozapine in Diabetic Patient with Bipolar Mood Disorder _ Vera; Christine Sitha
Journal of Medicine and Health Vol 1 No 1 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i1.504

Abstract

Depression and diabetes are often occur together and their morbidity has a significant impact of health outcomes. Antidepressants dan antipsychotics may cause metabolic abnormalities, as well as neurologic abnormalities. 52 years old diabetic woman presented to Immanuel Teaching Hospital with slurred speech. Since ten years ago, she had bipolar  mood  disorder, which was recently treated with clozapine. As patient consumed higher dose of clozapine (beyond her psychiatrist’s supervision), she had uncontrolled blood glucose level, fever, and slurred speech. The side effects of clozapine (weight gain, increased insulin resistance, dysarthria, fever) were discussed in this case report. During hospitalization, with strict supervision of clozapine use, the symptoms resolved. In diabetic patients with comorbid psychiatric disorders, a good collaboration between internist and psychiatrist is required to manage the patients effectively and comprehensively. Keywords: bipolar mood disorder, clozapine, diabetes mellitus, depression
THE INFLUENCE OF COMMON CARP MEAT (Cyprinus carpio) DIET ON BRAIN INDEX AND THE EXPRESSION OF GENE NR2B OF SWISS WEBSTER MICE CEREBRUM Philips Onggowidjaja; M. Nurhalim Shahib
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i2.505

Abstract

This research was to evaluate the influence of common carp meat diet on brain index and  gene NR2B expression of  Swiss Webster mice cerebrum.  The gene expression and performance of ion Ca2+ channel in neuron are influenced by Glycine and Glutamic Acid, which present in relatively high quantities in common carp meat.  Eighteen male mice were divided into 3 diet groups, the standard pellet, 120 mg and 480 mg common carp meat/day.  The brain index differences among groups were analyzed using ANOVA test (p≤0,05) and LSD.  The total RNA of 5 mg mouse cerebrum was isolated, followed by RT-PCR; the DNA quantities were predicted using Geldoc instrument, then were analyzed using ANOVA test (p≤0,05).  The 120 mg diet group brain index did not show difference (p=0,284) against the standard diet group, while the 480 mg diet group showed the increase compared to the standard (p=0,034) and 120 mg diet groups (p=0,004).  No DNA quantity differences of all groups (p=0,195).  It was concluded, the 480 mg common carp meat/ day diet increased the brain index of Swiss Webster mice, while the 120 mg and 480 mg common carp/day diets did not influence the gene NR2B expression of Swiss Webster mice cerebrum. Keywords : brain index, gene NR2B expression, common carp meat diet
COMPARISON OF ROUTINE HEMATOLOGY RESULTS BASED ON LOCAL LABORATORY REFERENCE VALUE AND SYSMEX KX-21 REFERENCE VALUE IN HASAN SADIKIN HOSPITAL BANDUNG Adrian Suhendra
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i2.506

Abstract

Various factors contribute to the routine hematology values in a healthy-looking person. Variability in analysis methods can also influence the results. However, all of the factors above can be standardized. Those variables have to be considered in determining hematology reference values. The aim of this research is to compare routine hematology results based on local RSHS Clinical Pathology laboratory with Sysmex KX-21 reference values in Medical Check Up (MCU) patients. Another aim is to determine own reference values of RSHS Clinical Pathology Laboratory. The subject of research is MCU patients who came to RSHS Clinical Pathology laboratory, Bandung, for medical check-ups and declared healthy by the internist, and meet the inclusion criteria. The method used is diagnostic test research with cross-sectional descriptive design. The result shows that routine hematology values range that is not too different from reference value range used for KX-21 in Japanese population. Nevertheless, the value range acquired in this research is closer to reference values in Wintrobe reference book. In conclusion, this research shows that routine hematology results of normal population in RSHS are closer to Wintrobe reference values compared to Sysmex KX-21 reference value in Japanese population.  Keywords : reference value range, MCU, Wintrobe, Sysmex KX-21
ANALYSIS OF IMMUNOEXPRESSION OF ESTROGEN RECEPTOR BETA AND EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN) ON TESTICULAR SEMINOMAS NONRECURRENCE AND RECURRENCE Antonius Janes Ridwan; Sri Suryanti; Abdul Hadi Hassan; Bethy S Hernowo
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i2.507

Abstract

The most common malignancy of testis is seminoma with prognosis that is not always good because of high recurrence rate and death cases. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a glycoprotein adhesion molecules which plays a role in tumor cell invasion and metastasis as evidenced by immunohistochemistry method in several types of tumor cells and tissue that shows the correlation to the clinical progessivity.This study was conducted by observational descriptive analytics with each seven cases of seminoma nonrecurrences and recurrences diagnosed histopathologically from Dr.Hasan Sadikin Hospital, Advent Hospital and St.Borromeus Hospital in Bandung. This study shows that immunoexpression of estrogen receptor beta is not higher in testicular seminoma recurrence compared with nonreccurence. There was no higher imunoexpression of EMMPRIN receptor on testicular seminoma recurrence compared with nonrecurrence; besides, there was no relationship between immunoexspression of estrogen receptor beta and EMMPRIN in testicular seminoma nonrecurrence and recurrence.In conclusion, immunoexpression estrogen receptor beta expressed in all testicular seminoma, so that the patient could be given an alternative therapy and immunoexspression EMMPRIN, cannot be used to predict a recurrence in patients with seminoma who has received complete therapy.                                                        Keywords: EMMPRIN, Estrogen Receptor Beta, Seminoma Testis nonrecurrence and recurrence
PHYTOPREVENTIVE EFFECT OF BUAH MERAH (Pandanus conoideus Lam.) OIL IN COLITIS-ASSOCIATED CARCINOGENESIS Oeij Anindita Adhika
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i2.508

Abstract

Colorectal cancer has provided a paradigm for the connection between inflammation and cancer. Modulation of intracellular signaling involved in chronic inflammatory response by anti-inflammatory agents represents an important strategy in molecular target-based chemoprevention. The aim of this research is to study the effect of buah merah oil on  IL-6  serum level and histopathology of colon in colitis-associated cancer (CAC) mice model. BALB/c mice were randomly divided into four groups. The negative control and buah merah control were given aquabidest and buah merah, respectively, without CAC induction. The AOM/DSS control and buah merah treatment were given azoxymethane (AOM) followed by dextran sulfate sodium (DSS) to induce CAC. The AOM/DSS control was given aquabidest while the buah merah treatment was given buah merah. Data were analyzed by One-Way ANOVA continued with Tukey-HSD. The result showed that IL-6 level in mice administrated with buah merah was significantly lower than the AOM/DSS control (p=0.000). Histopathological analysis scores  of colon were analyzed by Kruskal-Wallis continued with Mann-Whitney. The result showed that histopathological analysis score in buah merah treatment was significantly lower than in the AOM/DSS control (p=0.002). Taken together, buah merah oil lowered IL-6 level and histopathological analysis score of colon in CAC mice model. Keywords: CAC, buah merah oil,  IL-6 level, histopathological  analysis scores of  colon
POTENCY OF VINEGAR THERAPY IN OTOMYCOSIS PATIENTS Eman Sulaiman; Bambang Purwanto; Lina Lasminingrum; Yussy Afriani Dewi; Sally Mahdiani
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i2.509

Abstract

Otomycosis is an outer ear canal infection caused by fungi. Clinicians are trying to find out the most effective antifungal drug for treating otomycosis. Traditionally Apple cider vinegar has been used for the treatment of various diseases, including antifungal.The high cost in otomycosis treatment effort, long duration of treatment, high recurrence rate, and the difficulty in the application of drugs in the otomycosis treatment have encouraged the researcher to do this study. Having evaluated  the improvement of clinical symptoms, otoscopy view and examination of KOH 10% in patients receiving apple cider vinegar therap, this study uses descriptive study design of four otomycosis patients in the ORL HNS outpatient clinic of Hasan Sadikin Hospital Bandung from July to August 2014. Having evaluated a clinical symptoms improvement, it is found out that there is an increase of otoscopy view and examination of KOH 10% in patients receiving apple cider vinegar. In other words, there is an Improvement of clinical symptoms, otoscopy view, and examination of KOH 10% in patients receiving apple cider vinegar therapy. Topical apple cider vinegar therapy gives a good result in the improvement of clinical symptom,otoscopy view, and examination of KOH 10% in otomycosis  patients. Keywords: otomikosis, sign and symptoms improvement, apple cider vinegar.
RELATIONSHIPS BETWEEN DECIDUOUS TEETH PREMATURE LOSS AND MALOCCLUSION INCIDENCE IN ELEMENTARY SCHOOL IN CIMAHI Hillda Herawati; Novita Sukma; Rainisa Dewi Utami
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i2.510

Abstract

Premature loss of deciduous teeth is defined as the loss of deciduous teeth before they approach the eruption of the permanent teeth. The aim of this study is to find out the relationship between premature loss of deciduous teeth and the malocclusion according to the Angle’s Classification on Elementary School students children in Cimahi. The type of this research is analytic with a cross sectional research design. The samples are 77 students (7-11 year-old). The sampling method is cluster random sampling. The result shows that the prevalence of premature loss of deciduous teeth was 36.4% and the prevalence of malocclusion is 76.62%. Base on Angle’s Classification, it is revealed that 23.4% of the population has normal occlusion. The percentage of Angle’s class I malocclusion is 45,5%, class II is 23.4% and class III is 7.8%. There is a significant relationship between premature loss of deciduous teeth and its malocclusion (p-value = 0,000). It is concluded that all the students have premature loss of deciduous teeth with malocclusion. Keywords: Premature Loss, Deciduous Teeth, Malocclusion
NON MEDICAL FACTORS THAT AFFECT USAGE OF LONG ACTING REVERSIBLE CONTRACEPTIVE (LARC) IN WOMEN AFTER CHILDBIRTH IN INDONESIA Cindra Paskaria
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i2.511

Abstract

The Long Acting Reversible Contraceptive ( LARC) is a method of contraception that is effective and efficient to prevent pregnancy or limit births, but its use in Indonesia is still low especially in women after childbirth.  This may increase the risk of unwanted pregnancy and short birth interval.  The purpose of this research is to find out what factors affect the use of LARC in women after childbirth in Indonesia. This research is an analysis of secondary data Indonesia Demographic and Health Survey 2012, with stamp 3,918 Women’s Reproductive Age, which is between 15-49 years  old and  they had given birth one year before the survey.  The data were analyzed by using simple logistic regression analysis.  This research shows that the proportion of women who used LARC after childbirth in Indonesia in 2012 was 7.31% and it was influenced by the level of socio-economic, domiciles, the husband’s level of education, the number of children born alive, the number of children still living, the desired number of children, the role of husband, and the role of religious figures. Keywords: LARC, women after childbirth, non medical factors
ADIPONECTIN SERUM LEVEL DIFFERENCE IN WOMEN WITH ENDOMETRIOTIC AND NON-ENDOMETRIOTIC CYSTS Ruswana Anwar; Fahdiansyah Fahdiansyah
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i2.512

Abstract

Endometriosis is an estrogen-dependent disease. Low levels of adiponectin resulted in an increased free estrogen levels and the inability to inhibit angiogenesis and the inflammatory process resulting in the development of increasingly severe endometriosis.This study is aimed to determine the differences in serum adiponectin levels in patient with nonendometriotic cyst with endometriosis cyst and its relationship with endometriosis stages. This is an analytical comparative study with cross-sectional method in group of women with endometriotic cyst (n=25) and women with non-endometriotic cysts (n=25), performed either laparoscopic or laparotomy surgery. The serum levels of adiponectin in both groups then compared with statistical analysis.The results showed there were no significant differences (p>0,05) on the characteristics of the study subjects in terms of age (p=0.994) and BMI (p=0.27). Significant differences of adiponectin levels were found between endometriotic patient group (mean=3.91) and nonendometriotic patients group (mean=8.59). There were no significant differences of adiponectin level in stages III endometriosis (mean = 4.24) and stage IV endometriosis (mean = 3.54).It is concluded that serum adiponectin levels in patients with endometriosis is lower than patient with non-endometriotic cyst. There is no relationship between adiponectin levels with endometriosis stage. Keywords: adiponectin, endometriotic cyst, non-endometriotic cyst, endometriosis stage
STUDY ON RUMPUT MUTIARA (Hedyotis Corimbosa) HERBS AS MEDICINE Andreanus A. Soemardji; Ita N. Anisa; Nareswari Alka Damayanti
Journal of Medicine and Health Vol 1 No 2 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i2.513

Abstract

“Rumput Mutiara” or Pearl grass (Hedyotis corymbosa) is one of medicinal plants used empirically by the Indonesian people to cure disease to maintain health. Many people have used pearl grass for a long time. This plant contains hentriacontane, stigmasterol, ursolic acid, oleanolicacid, β-sitosterol, sitisterol-D-glucoside, p-coumaric acid, flavonoid-glycosides, “baihua she she cao su” (possibility coumarin analog), iridoid glycosides, alizarin, korogenin, and bonding antragalol.  Herbaceous plant is used and effetive as a relieve fever (antipyretic), anti-inflammatory, antibacterial, laxative urine(diuretic), removes heat and toxins (detoksikan), blood circulation, anti-cancer, the treatment of peptic ulcers, dysentery, exhausted maternity, and indigestion. This review article is a compilation of Hedyotis corymbosa herb as traditional medicinal plant and pharmacological researches of this herb that can be use as ethnopharmacological and pharmacological information of this medicinal herb. Keywords:  Pearl grass, Hedyotis corymbosa, medicinal plants, ethnopharmacology, pharmacology.

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