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Frontiers on Healthcare Research
Published by RSUP Dr M Djamil Padang
ISSN : 30327725     EISSN : -     DOI : https://doi.org/10.63918/fhr.v2.n2
Core Subject : Health,
Health Professions Public Health
The principal aim of Frontiers on Healthcare Research is to catalyze advancements in healthcare research that directly inform and improve the efficacy of health system operations, enrich patient experiences, and guarantee fairness in health service access
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 55 Documents
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Psychological Well-Being Among People Living with HIV/AIDS: A Systematic Review of Psychosocial and Contextual Determinants Roza, Defia; Sastra, Lenni
Frontiers on Healthcare Research Vol. 3 No. 1 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n1.p8-17.2026

Abstract

Background: Advances in antiretroviral therapy have transformed HIV into a chronic condition, yet psychological well-being remains inadequately addressed. Persistent stigma, psychological distress, and social inequities continue to compromise holistic health among people living with HIV/AIDS. Objectives: This systematic review aimed to synthesize evidence on psychosocial and contextual determinants of psychological well-being among people living with HIV/AIDS and to identify implications for research and practice. Methods: A systematic literature review was conducted following PRISMA guidelines. Peer-reviewed studies examining psychological well-being, mental health, stigma, coping, social support, and psychosocial interventions among adults living with HIV/AIDS were identified across major databases. Ten eligible studies, including observational studies, intervention trials, and systematic reviews, were critically appraised and synthesized using a thematic approach. Results: Five interrelated themes emerged. HIV-related stigma consistently showed a negative association with psychological well-being across settings. High levels of depression and anxiety persisted despite antiretroviral treatment. Psychosocial resources, particularly social support, counseling, and adaptive coping, functioned as protective factors. Psychosocial interventions demonstrated beneficial but variable effects, with modest effect sizes and limited long-term evidence. Finally, psychological well-being was closely linked to behavioral outcomes, including treatment adherence and substance use, highlighting bidirectional relationships. Conclusion: Psychological well-being among people living with HIV/AIDS is shaped by multilevel psychosocial and structural factors. Integrating standardized mental health assessment, stigma reduction strategies, and context-sensitive psychosocial interventions into routine HIV care is essential to improve holistic outcomes. Such integration may enhance quality of life, resilience, and long-term engagement in care worldwide across health systems and sociocultural contexts globally.
Epithelial–Mesenchymal Transition in Cancer Progression: Biological Basis and Histopathological Implications Gestin, Dustia; Oktavia, Ria
Frontiers on Healthcare Research Vol. 3 No. 1 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n1.p39-52.2026

Abstract

Background: Epithelial–mesenchymal transition (EMT) is a fundamental biologic process that plays a critical role in tumor invasion, metastasis, and dedifferentiation. While extensively investigated in molecular oncology, its relevance to routine surgical pathology practice remains underemphasized. Many morphologic alterations observed in daily histopathologic evaluation represent phenotypic manifestations of EMT, yet these findings are often interpreted descriptively without integration into a unified biologic framework. Methods: This review aims to provide a practical overview of EMT from a surgical pathology perspective by correlating biologic mechanisms with histomorphologic features, immunohistochemical findings, and clinical implications across solid tumors.A narrative literature review was conducted using PubMed/MEDLINE databases to identify relevant studies published between 2020 and 2025. Keywords related to EMT, histopathology, tumor progression, and immunohistochemistry were applied. Selected articles were qualitatively synthesized with emphasis on clinicopathologic relevance and applicability to routine diagnostic practice. Results: EMT is characterized by loss of epithelial differentiation, acquisition of mesenchymal traits, and increased cellular plasticity. Histologically, EMT correlates with recognizable features including loss of cellular cohesion, tumor budding, single-cell invasion, spindle cell transformation, and tumor dedifferentiation. Immunohistochemical alterations such as decreased E-cadherin expression and increased mesenchymal marker expression further support EMT-associated phenotypes. Across multiple organ systems, these morphologic changes are consistently associated with aggressive tumor behavior, metastatic potential, and therapeutic resistance. Conclusion: EMT provides a unifying concept linking molecular cancer biology with routine histopathologic observations. Recognition of EMT-associated morphologic patterns may enhance prognostic assessment and strengthen clinicopathologic interpretation, reinforcing the essential role of histopathology in the era of precision oncology.
Differences in Knowledge of Mothers with Small Babies Regarding Small Baby Care in Areas Using and Not Using the Special Maternal Child Health Handbook for Small Babies Sari, Nissa Prima; Amir, Arni; Mayetti, Mayetti
Frontiers on Healthcare Research Vol. 3 No. 1 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n1.p61-68.2026

Abstract

Background: The implementation of the special Maternal and Child Health (MCH) Handbook for small babies has been introduced in several regions in Indonesia. This is because the existing MCH Handbook, which is widely used in Indonesia, has not fully accommodated the needs of mothers and families as a guide for caring for and monitoring small babies. This study aims to analyze the differences in knowledge of mothers with small babies regarding small baby care in areas using and not using the special MCH Handbook for small babies. Methods: This study employed a cross-sectional comparative design. The study was conducted in the working area of Tanjung Paku Public Health Center in Solok City, West Sumatra, Indonesia, as the group using the special MCH Handbook for small babies, and in the working area of Pariaman Public Health Center in Pariaman City, West Sumatra, Indonesia, as the group not using the special MCH Handbook for small babies. The study was conducted from September to October 2024. The required sample size was 46 participants per group, with a total of 92 participants. A simple random sampling technique was used. Data were analyzed using the Mann-Whitney test, with a significance level of P<0.05. Results: The median total score for maternal knowledge about small baby care in areas using the special MCH Handbook was 14, higher than the score of 12 in areas that did not use the handbook. A significant difference was found in maternal knowledge regarding small baby care between areas using and not using the special MCH Handbook (P<0.05). Conclusion: There is a significant difference in the knowledge of mothers with small babies regarding small baby care between areas using and not using the special MCH Handbook for small babies. Strengthening policies and promoting the importance of the special MCH Handbook for small babies is crucial to improving maternal knowledge in small baby care, especially in areas with high rates of preterm births.
Letter to the Editor: Strengthening Antimicrobial Resistance Control Practice at Dr. M. Djamil Central General Hospital Padang, Indonesia Djanas, Dovy
Frontiers on Healthcare Research Vol. 3 No. 1 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n1.p69-71.2026

Abstract

Dr. M. Djamil Central General Hospital (RSUP Dr. M. Djamil) Padang has been at the forefront of efforts to combat antimicrobial resistance (AMR) through a comprehensive antimicrobial stewardship program guided by the Antimicrobial Resistance Control Committee (KPRA). The program focuses on three key components: surveillance, research, and education. Notable achievements include significant reductions in inappropriate antibiotic use, enhanced treatment strategies, and improved patient outcomes. A robust surveillance system has tracked both the quantity and quality of antibiotic use, leading to a marked increase in rational antibiotic prescriptions. Additionally, the implementation of antibiotic sensitivity patterns has allowed for more targeted therapies, particularly in treating multidrug-resistant organisms. Multidisciplinary collaboration through the Forum Kajian Kasus Infeksi Terintegrasi (FORKKIT) has further optimized patient care. Ongoing research into advanced diagnostic tools, such as RT-PCR, has advanced AMR control efforts, contributing to more precise treatments. Despite these successes, the continued prevalence of multidrug-resistant infections highlights the need for sustained efforts in surveillance, research, and education. Looking forward, RSUP Dr. M. Djamil Padang aims to reduce the incidence of these infections, improve prophylactic antibiotic administration, and align practices with national and international guidelines. The hospital’s commitment to advancing research and collaboration is vital in the global effort to preserve antibiotic effectiveness for future generations
Maternal Factors and Their Relationship with Low Birth Weight: Evidence from a Case-Control Study Salahin, Kazi Fayzus; El Khairah, Siti Mardiah
Frontiers on Healthcare Research Vol. 3 No. 1 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n1.p79-85.2026

Abstract

Background: Low birth weight (LBW) remains a major public health concern due to its association with neonatal morbidity and mortality. Maternal factors during pregnancy may influence birth weight outcomes. This study aimed to examine the relationship between maternal factors and low birth weight using a case-control design. Methods: A case-control study was conducted involving 55 mother–infant pairs, consisting of 27 LBW cases and 28 normal birth weight controls. Maternal characteristics, including age, education, employment status, gestational age, pre-pregnancy weight, post-pregnancy weight, hemoglobin levels before and after pregnancy, and infant sex, were collected. The ponderal index was also assessed. Categorical variables were analyzed using appropriate comparative tests, and continuous variables were compared using mean differences. A p-value <0.05 was considered statistically significant. Results: Most mothers were aged 20–35 years (80.0%) and unemployed (76.4%). Nearly half had completed senior high school (49.1%). There were no significant associations between infant sex, maternal age, education, employment status, gestational age, pre-pregnancy weight, post-pregnancy weight, hemoglobin levels before pregnancy, or hemoglobin levels after pregnancy and birth weight outcome (p>0.05). However, the mean ponderal index was significantly lower in the LBW group compared to the normal birth weight group (2.47±0.36 vs. 2.84±0.24; p<0.001). Conclusion: Among the maternal factors examined, only the ponderal index showed a significant association with low birth weight. These findings suggest that neonatal body proportionality may be an important indicator related to birth weight outcomes.

Page 6 of 6 | Total Record : 55

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