cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Zulda Musyarifah
Contact Email
penelitian.diklit@gmail.com
Phone
+627518956666
Journal Mail Official
admin@frontiersonhealthcare.org
Editorial Address
Jalan Perintis Kemerdekaan Sawahan Timur Padang West Sumatra
Location
Kota padang,
Sumatera barat
INDONESIA
Frontiers on Healthcare Research
Published by RSUP Dr M Djamil Padang
ISSN : 30327725     EISSN : -     DOI : https://doi.org/10.63918/fhr.v2.n2
Core Subject : Health,
Health Professions Public Health
The principal aim of Frontiers on Healthcare Research is to catalyze advancements in healthcare research that directly inform and improve the efficacy of health system operations, enrich patient experiences, and guarantee fairness in health service access
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 66 Documents
 3   4   5   6   7 
Factors Associated with Platelet Recovery in Dengue Patients on Fever Day 7 Ghina Shofi Ikrima; Elfira Yusri; Fadrian Fadrian; Efrida Efrida; Mutia Lailani; Yustini Alioes
Frontiers on Healthcare Research Vol. 3 No. 2 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n2.p31-40.2026

Abstract

Background: Thrombocytopenia is a common hematological feature of dengue infection, and platelet recovery is a reliable prognostic indicator. The seventh day of fever typically marks the beginning of the recovery phase, but some patients show delayed platelet recovery. This study aimed to identify the factors affecting platelet recovery in adult dengue patients on fever day 7. Methods: This cross-sectional study was conducted from April 2024 to April 2025 at Universitas Andalas Hospital and involved 35 adult dengue patients selected through total sampling. Retrospective data on clinical and laboratory characteristics were collected. Platelet recovery was defined as an increase in platelet count of more than 20,000/mm³ within 48 hours between fever days 5 and 7. Patients who received platelet transfusion or corticosteroid therapy were excluded. Associations between variables were analyzed using the Chi-square test and Fisher’s Exact Test. Results: A significant association was found between platelet recovery and thrombocytopenia status at admission (p = 0.037). Age, sex, comorbidity, hematocrit level, leukocyte count, and day of fever at admission were not significantly associated with platelet recovery (p > 0.05). Only 10 of the 35 patients (28.6%) showed platelet recovery on fever day 7. Most patients were male (57.1%) and aged ≤40 years (80.0%), while 22.9% had comorbidities. Conclusion: Thrombocytopenia status at hospital admission was significantly associated with platelet recovery in dengue patients. Early recognition of this factor may help identify clinically at-risk patients and enable more effective clinical management.
Effectiveness of Subcutaneous Bupivacaine–Ketamine Wound Infiltration in Reducing Post-Cesarean Section Pain: A Randomized, Double-Blind, Controlled Trial Nadra Septiadi; Riyadh Firdaus; Besthadi Sukmono; Rafidya Indah Septica
Frontiers on Healthcare Research Vol. 3 No. 2 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n2.p12-21.2026

Abstract

Background: Effective postoperative analgesia supports maternal recovery after cesarean delivery, yet subcutaneous local anesthetic infiltration, a simple technique well suited to resource-limited settings, typically provides only 3–6 hours of relief. Ketamine, an NMDA-receptor antagonist with analgesic activity at subanesthetic doses, may extend this window, but evidence in cesarean delivery remains limited.Objective: To determine whether adding subcutaneous ketamine to bupivacaine infiltration reduces rescue opioid requirement after cesarean delivery. Methods: In this randomized, double-blind, controlled trial at Tangerang Regional General Hospital, Indonesia, 60 women undergoing cesarean delivery under spinal anesthesia were allocated 1:1 to subcutaneous infiltration of 0.25% bupivacaine with ketamine 0.9 mg/kg (Group A, n = 30) or 0.25% bupivacaine alone (Group B, n = 30) before wound closure. The primary outcome was total rescue fentanyl requirement in the first 24 postoperative hours. Results: The median 24-hour fentanyl requirement was lower with ketamine (30 [0–90] vs 90 [0–150] mcg; p < 0.001), and fewer participants required rescue fentanyl at all (56.7% vs 76.7%), with a lower cumulative group dose (840 vs 2240 mcg). Group A also had lower pain scores from hour 7 onward, a longer interval to the first rescue request (810 vs 420 min; p = 0.019), and earlier first mobilization (585 vs 810 min; p < 0.001). No serious adverse events occurred in either group. Conclusion: Adding subcutaneous ketamine to bupivacaine infiltration lowered the rescue opioid requirement and supported faster recovery after cesarean delivery, offering a practical, low-cost addition to multimodal analgesia in resource-limited settings.
A Little of Everything, Just In Time: Multimodal Opioid-Sparing Anesthesia for a Twin Pregnancy in Decompensated Heart Failure Caused by Severe Mitral Stenosis Muhammad Imam Mulia; Arief Cahyadi
Frontiers on Healthcare Research Vol. 3 No. 2 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n2.p76-85.2026

Abstract

Background: Rheumatic heart disease remains a leading cause of valvular heart disease among women of reproductive age in low- and middle-income countries. Severe mitral stenosis complicating pregnancy substantially increases the risk of acute cardiac decompensation because of the hemodynamic load imposed by gestation, and anesthetic management becomes considerably more complex when it is combined with atrial fibrillation with a rapid ventricular response and a multifetal pregnancy. Reports describing general anesthesia for cesarean delivery in a twin pregnancy complicated by both severe mitral stenosis and atrial fibrillation remain scarce, which limits the guidance available to clinicians who face this specific combination. Case Presentation: A 43-year-old woman, gravida 5 para 4 abortus 0, with a twin pregnancy at 32 weeks’ gestation was referred for emergency cesarean delivery because of acute decompensated heart failure secondary to rheumatic heart disease, with atrial fibrillation with a rapid ventricular response (AF-RVR) and severe mitral stenosis. Severe dyspnea that improved only marginally with upright positioning, together with an ongoing therapeutic heparin infusion, precluded neuraxial anesthesia. General anesthesia was therefore planned using a modified, opioid-sparing induction that combined low-dose propofol, ketamine, and dexmedetomidine under invasive hemodynamic monitoring. Two live infants were delivered; postpartum ventricular rate control was achieved with intravenous digoxin followed by amiodarone, alongside vasopressor and diuretic support. The patient was extubated on postoperative day 1 without further cardiopulmonary complications. Discussion: The anesthetic strategy in mitral stenosis with AF-RVR must be directed toward avoiding tachycardia, preserving preload, and maintaining hemodynamic stability. These goals are difficult to reconcile with the sympathetic blockade produced by neuraxial techniques when these are otherwise contraindicated. A multimodal, opioid-sparing approach that layered dexmedetomidine and ketamine preserved maternal hemodynamics and respiratory drive while limiting opioid exposure before delivery to a single low dose of fentanyl given at induction; definitive antiarrhythmic therapy was deferred until after both infants had been born. Conclusion: General anesthesia with a multimodal opioid-sparing strategy is a feasible and effective approach for high-risk parturients with stenotic valvular disease and arrhythmia when neuraxial techniques are contraindicated, provided that care is delivered through close multidisciplinary collaboration. The principal lesson is that sequencing several low-dose non-opioid agents, rather than avoiding opioids altogether, can preserve both maternal hemodynamic stability and fetal well-being in this setting.
Research Trends and Perspectives on Psychiatric Nursing: A Decade of Progress and Challenges Veolina Irman; Helena Patricia; Dwi Christina Rahayuningrum Rahayuningrum; Emira Apriyeni
Frontiers on Healthcare Research Vol. 3 No. 2 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n2.p94-109.2026

Abstract

Background: Psychiatric nursing continues to evolve in response to changing clinical, social, and professional demands, and the volume of research in this field has grown rapidly. This study aimed to analyse research trends and perspectives in psychiatric nursing over the last decade using bibliometric mapping and a thematic review. Methods: A bibliometric analysis was conducted using the Scopus database for publications indexed between 2015 and 2025, limited to English-language journal articles. Data were analysed with Scopus built-in tools and VOSviewer to identify publication trends, productive countries, institutions, journals, co-authorship networks, and keyword patterns. In addition, the 100 most-cited articles were reviewed to explore major thematic areas in psychiatric nursing. Results: The search initially retrieved 510 publications; after screening and duplicate removal, 236 articles were included in the final analysis. Publication output peaked in 2022, and the United States emerged as the leading contributor, followed by Australia and Iran. Key productive institutions included King’s College London and Turun yliopisto, while the Journal of Psychiatric and Mental Health Nursing was the most active journal. Thematic findings showed that recent psychiatric nursing research focused on interventions and patient outcomes, education and professional development, nurse–patient relationships and communication, technology integration, care for specific populations, and nursing theory in mental health. Conclusion: Psychiatric nursing research has expanded substantially and has become more interdisciplinary and patient-centred. However, persistent challenges remained, particularly in workforce preparedness, therapeutic communication, technological implementation, and support for nurses’ well-being. These findings provide a useful foundation for future research, education, policy, and psychiatric nursing practice.
Effect of Preoperative Lactobacillus acidophilus Supplementation on Postoperative Gastric Residual Volume after Lower Digestive Laparotomy: A Randomized, Double-Blind, Controlled Trial Christophorus Simadibrata; Rudyanto Sedono; Sidharta Kusuma Manggala; Wifanto Saditya Jeo
Frontiers on Healthcare Research Vol. 3 No. 2 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n2.p22-30.2026

Abstract

Background: Gastrointestinal dysmotility is among the most common complications after abdominal surgery and is reflected clinically by an elevated gastric residual volume (GRV), which increases the risk of aspiration and delays enteral feeding. Lactobacillus acidophilus is thought to improve gut motility through luminal acidification, competitive exclusion of pathogens, and direct stimulation of smooth-muscle contractility, but whether this translates into a lower GRV after digestive laparotomy has not been tested. Objective: To determine whether preoperative Lactobacillus acidophilus supplementation reduces postoperative GRV after lower digestive laparotomy. Methods: In this randomized, double-blind, placebo-controlled trial at Dr. Cipto Mangunkusumo National General Hospital, Indonesia, adults scheduled for elective laparotomy of the jejunum, ileum, colon, or rectum received oral Lactobacillus acidophilus 10⁹ CFU or an identical placebo capsule three times daily for three days before surgery. A nasogastric tube inserted during surgery was aspirated every 6 hours after ICU admission; GRV was categorized as normal (<250 mL/24h) or increased (≥250 mL/24h) at 24 and 48 hours. Results: Fifty-five participants were randomized (27 probiotic, 28 placebo); one placebo-group participant was withdrawn because of sepsis, leaving 54 participants analyzed per protocol. GRV was increased in 4/27 (14.8%) probiotic recipients versus 2/27 (7.4%) placebo recipients at 24 hours (p = 0.669; risk ratio for normal GRV 0.92, 95% CI 0.76–1.11) and in 1/27 versus 0/27 at 48 hours (p = 1.000). Stratified analysis identified age, neurological comorbidity, obesity, vasopressor use, opioid exposure, hypercapnia, and hyperglycemia as confounders that shifted the crude risk estimate by more than 10%; opioid and vasopressor exposure were also unevenly distributed between groups at baseline (p = 0.006 and p = 0.026, respectively). Conclusion: A 3-day preoperative course of Lactobacillus acidophilus did not significantly reduce postoperative GRV after lower digestive laparotomy. The trial was underpowered relative to its planned sample size, and an uneven distribution of opioid and vasopressor exposure between groups may have obscured a true effect.
What Explains the Survival Gap? Decomposing Cross-National Inequality in Breast Cancer Mortality-to-Incidence Ratios Using Open Global Data Repositories Siti Mardhiah El-Khairah; Melsi Pita Sari
Frontiers on Healthcare Research Vol. 3 No. 2 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n2.p86-93.2026

Abstract

Background: Women diagnosed with breast cancer in low-resource countries are several times more likely to die from the disease than those in high-income countries, despite lower incidence. The mortality-to-incidence ratio (MIR) captures this survival gap, but previous studies have mainly described its association with national wealth rather than quantified the contribution of specific health-system factors. We aimed to measure inequality in breast cancer MIR across the human development gradient and identify key determinants using freely accessible and redistributable data sources. Methods: We conducted a cross-sectional ecological analysis of 185 countries and territories. Breast cancer incidence and mortality rates for 2022 were obtained from the IARC Global Cancer Observatory. Explanatory variables were derived from UNDP, WHO, and IAEA databases. Associations were assessed using beta regression with a logit link. Inequality was measured using the Erreygers-corrected concentration index and decomposed by determinant contributions. A counterfactual analysis estimated potentially avertable deaths if all countries achieved MIR levels observed in the highest human development quintile. Results: MIR ranged from 0.14 to 0.63 (median 0.31). The concentration index was −0.284 (95% CI −0.331 to −0.237), indicating higher MIR among less developed countries. Radiotherapy machine density contributed 31.2% of inequality, followed by UHC service coverage (22.6%), population-based mammography programmes (14.8%), and health expenditure per capita (11.3%). Approximately 214,600 deaths annually (32.2% of global breast cancer deaths) were potentially avertable. Conclusion: Global inequality in breast cancer survival is strongly associated with measurable health-system capacity gaps, particularly treatment infrastructure. Publicly available data enable reproducible analyses to guide targeted improvements in cancer care equity

Page 7 of 7 | Total Record : 66

 3   4   5   6   7 

Filter by Year

2024 2026


Reset
Filter By Issues
All Issue Vol. 3 No. 2 (2026) Vol. 3 No. 1 (2026) Vol. 2 No. 2 (2025) Vol. 2 No. 1 (2025) Vol. 1 No. 2 (2024) Vol. 1 No. 1 (2024)