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INDONESIA
Jurnal Kedokteran Methodist
Published by Universitas Methodist Indonesia
ISSN : 26847132     EISSN : 26847132     DOI : DOI: https://doi.org/10.46880/jkm.v20i1
Core Subject : Health, Science, Education, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other
Jurnal Kedokteran Methodist (JKM) is a peer-reviewed, open-access journal that welcomes manuscripts in basic and clinical research, encompassing all aspects of medicine, health sciences, and pharmacy. Reports on genomics, epigenetics, and stem cells are welcome as well. The journal covers original research articles, case reports, and review articles.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 54 Documents
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A Case of Complete Recovery From Recurrent Bell’s Palsy After Peripheral Blood Stem Cell Transplantation : A Case of Complete Recovery From Recurrent Bell’s Palsy After Peripheral Blood Stem Cell Transplantation lim, hadyanto; Hutasoit, Eka Samuel P; Endy Juli Anto
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.2812

Abstract

Background Recurrent Bell’s palsy is a rare condition that can affect the ipsilateral or contralateral to the affected side of the primary attack. There is still no consensus on treatment guidelines for recurrent Bell’s palsy. Therefore, we report a case of idiopathic recurrent contralateral facial palsy treated with autologous peripheral blood stem cell (PBSC) transplantation. Case Presentation A 72-year-old man presented with the sudden onset of right facial weakness, which was contralateral to the affected side of the first episode of facial palsy. The weakness had progressed with difficulty in closing the right eye, drooling the water from the right side of the mouth, and chewing impairment which was consistent with House Brackmann grade IV or moderately severe facial nerve grading system. He had exposure to cold stimulation, and a history of hypertension. He was given G-CSF 10 ug/kg/day for 5 days to mobilize stem cells, followed by apheresis on the 5th day. He did not receive acupuncture treatment. He had a complete recovery in 3 weeks with House Brackmann grade I or normal function of facial nerve. Conclusion Peripheral blood stem cell transplantation had a beneficial effect on the complete recovery of this recurrent Bell’s palsy and provides a treatment strategy in patients with unilateral facial palsy.
A ANTIBODY MEDIATED IMMUNITY: ANTIBODY MEDIATED IMMUNITY Sembiring, Budi Darmanta
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.2897

Abstract

Keeping the integrity and the individual balance needed an adequate immunity system. Therefore the immunity mechanism to the dangerous antigen consists of physical immunity and chemical, symbiosis with a normal flora bacteria, innate immunity with a specific immunity which is got, consist of humoral immunity and cell immunity (cell-mediated immunity). The antibody is the component of immunity that is gotten which protects the body from microorganism infection and the product which is toxic. Because of that, the interaction between antigen and antibody is very important and much used in vitro for diagnostic purposes. The use of this reaction in vitro between antigen-antibody is called serology.
A TERAPI METHOTREXATE PADA PENDERITA PSORIASIS VULGARIS: TERAPI METHOTREXATE PADA PENDERITA PSORIASIS VULGARIS Tarigan, Juliyanti; Simanjuntak, Evirosa; Marpaung, Alexander P.
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v19i1.2898

Abstract

Psoriasis merupakan penyakit peradangan kronik pada kulit berupa perubahan pertumbuhan dan diferensiasi epidermis, serta abnormalitas biokimiawi, imunologik, dan vaskular. Psoriasis dapat bermanifestasi pada kulit, kuku, dan persendian. Diagnosis psoriasis biasanya ditegakkan berdasarkan anamnesis dan gambaran klinis lesi kulit. Pada kasus-kasus tertentu, dibutuhkan pemeriksaan penunjang seperti pemeriksaan biopsi histopatologi dan pemeriksaan              laboratorium.                                   Secara histopatologi akan tampak akantosis, parakeratosis, elongasi rete ridge. Tampak neutrofil dan limfosit yang bermigrasi membentuk mikroabses Munro. Pada dermis akan tampak tanda-tanda inflamasi seperti hipervaskularitas dan dilatasi serta edema papila dermis. Pemeriksaan laboratorium pada psoriasis bersifat tidak spesifik. Pengobatan anti psoriasis berspektrum luas baik secara topikal maupun sistemik telah tersedia. Sebagian besar obat-obatan ini bekerja sebagai imunomodulator. Sebelum memilih regimen pengobatan, penting untuk menilai perluasan serta derajat keparahan psoriasis. Salah satu cara yang paling sering digunakan untuk menilai derajat keparahan psoriasis adalah dengan menghitung skor Psoriasis Area and Severity Index (PASI).
A HUBUNGAN NILAI ALBUMIN SERUM DENGAN TINGKAT KEPARAHAN DAN LAMA RAWATAN PASIEN DM TIPE 2 DENGAN COVID-19 DI RSU BINA KASIH: HUBUNGAN NILAI ALBUMIN SERUM DENGAN TINGKAT KEPARAHAN DAN LAMA RAWATAN PASIEN DM TIPE 2 DENGAN COVID-19 DI RSU BINA KASIH Tarigan, M.Bastanta; Situmorang, Nasib Mangoloi; Hutahaean, Reinhard
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.2900

Abstract

Introduction Coronavirus disease 2019 (COVID-19) is an infectious disease that affects the respiratory system caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-COV-2), which has become a health problem in Indonesia. The duration of treatment and the severity of COVID-19 will increase the risk of death and significant costs, which undoubtedly burden patients and the country. A marker is needed to determine the severity of the disease and the duration of treatment for COVID-19 patients with diabetes. Albumin is a protein that plays anti-inflammatory, antioxidant, anti-infection roles, and also participates in drug transfer within the human body. Poor glucose control, insulin resistance, insulin deficiency in type 2 diabetes (type 2 DM), and viral load in COVID-19 lead to hypoalbuminemia. Hypoalbuminemia will disrupt its function, leading to increased inflammation, oxidative stress, infection, and disturbance in drug distribution, thus hypoalbuminemia is suspected to play a role in increasing the severity and duration of treatment in type 2 DM patients with COVID-19. Method This study is an observational analytical study with a cross-sectional design conducted at Bina Kasih Medan General Hospital. The research subjects were type 2 DM patients infected with COVID-19 who underwent inpatient care from August to October 2021 with consecutive sampling that met the inclusion and exclusion criteria. Patients were categorized into moderate and severe severity levels. The duration of treatment was divided into less than and greater than or equal to 11 days, and serum albumin levels were evaluated. The independent variable was albumin, and the severity level and duration of treatment were dependent variables. The data used were secondary data from medical records, and bivariate analysis was performed to see the relationship between independent and dependent variables using the Chi-Chisqure test. Results During the period from August to October 2021, 82 subjects with type 2 DM who were infected with COVID-19 and underwent inpatient care were obtained. Out of 82 subjects who met the inclusion criteria, 34 subjects were included. Of the 34 study subjects, the majority were male, namely 26 subjects (76.4%), and 8 subjects (23.5%). Subjects who underwent inpatient care for <11 days were 15 (44.1%) and those who underwent inpatient care ≥11 days were 19 (55.9%). 18 subjects (52%) had moderate severity levels, and 16 subjects (47.05%) had severe severity levels. Based on the results of bivariate analysis, there was an inverse relationship between serum albumin levels and the severity of the disease (P <0.032), but there was no significant relationship between albumin levels and the duration of hospitalization (P <0.350). Conclusion A decrease in albumin levels is associated with the severity of the disease but not with the duration of treatment.

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