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Jurnal Kedokteran Methodist
Published by Universitas Methodist Indonesia
ISSN : 26847132     EISSN : 26847132     DOI : DOI: https://doi.org/10.46880/jkm.v20i1
Core Subject : Health, Science, Education, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other
Jurnal Kedokteran Methodist (JKM) is a peer-reviewed, open-access journal that welcomes manuscripts in basic and clinical research, encompassing all aspects of medicine, health sciences, and pharmacy. Reports on genomics, epigenetics, and stem cells are welcome as well. The journal covers original research articles, case reports, and review articles.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 79 Documents
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. Pengaruh Teh Hijau Pada Epigenetik dan Antiaging: The Effect of Green Tea on Epigenetics and AntiAging Imelda, Imelda; Lim, Hadyanto
Jurnal Kedokteran Methodist Vol. 18 No. 1 (2025): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v20i1.4467

Abstract

Background: The global increase in aging population poses major public health challenges. Green tea, especially its bioactive compound epigallocatechin gallate (EGCG), has shown promising effects on healthspan and age-related diseases. Recent studies have explored its potential role in epigenetic regulation and antiaging mechanisms. Discussion: Green tea is rich in polyphenols, especially catechins like EGCG, which act as powerful antioxidants. EGCG modulates epigenetic mechanisms by inhibiting histone deacetylases (HDAC), altering DNA methylation, and regulating non-coding RNAs. These modifications support the expression of genes involved in cellular protection, stress resistance, and longevity. In addition to systemic benefits, green tea also demonstrates topical antiaging effects by reducing oxidative stress and improving collagen synthesis in the skin. Experimental models reveal EGCG’s capacity to delay aging through activation of key signaling pathways (e.g., AMPK, SIRT1, FOXO) and modulation of inflammatory and apoptotic mediators. Clinical studies further confirm that consistent green tea intake is associated with reduced epigenetic age and improved biological markers of aging Conclusion: Green tea, through its epigenetic influence and antioxidant properties, presents itself as a natural and effective antiaging agent. Regular consumption may contribute to the prevention of age- related diseases and the promotion of healthy aging.
KETERKAITAN FAKTOR JARINGAN ADIPOSA DAN OBESITAS YANG MENDASARI TERJADINYA SINDROMA METABOLIK Rita Kusuma; Rimbun, Surjadi
Jurnal Kedokteran Methodist Vol. 18 No. 1 (2025): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v20i1.4716

Abstract

ABSTRACT With the increasing prevalence of physical inactivity, particularly in urban areas, and the widespread consumption of unhealthy foods, the prevalence of overweight and obesity (adiposity) has increased. This condition gives rise to a pathophysiological disorder in adipose tissue, an endocrine organ, known as metabolic syndrome. Atherogenic dyslipidemia significantly contributes to the development of atherosclerosis, which leads to cardiovascular disease. Inflammatory substances released by diseased fat cells also contribute to certain cancers. This review examines obesity and adipose tissue, which are fundamental to the development of metabolic syndrome, to deepen our understanding of metabolic syndrome and encourage further research to develop effective strategies for preventing and managing this complex metabolic disease. Keywords : Adipose tissue, OBESITY, METABOLIC SYNDROME
The Incidence of Pulmonary Tuberculosis in HIV/AIDS Patients at Deli Serdang Regional General Hospital, 2013–2015 Soniya Krishna; Parluhutan Sigian; Surjit Singh
Jurnal Kedokteran Methodist Vol. 17 No. 2 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i2.5371

Abstract

Background: In 2010, the number of TB patients rose to 330,000 and in2012, the number of TB patients is quite sharp, ie 583,000 people. TB isthe number one killer among infectious diseases and ranking third in thelist of top ten diseases in Indonesia which causes about 100,000 deathsannually, or in a day occurred 300 deaths due to TB.Methods: This study is a descriptive and cross sectional study conductedat the Medical Records Regional General Hospital Deli Serdang years2013-2015 total of 49 samples were selected with a total samplingtechnique.Results: Based on the research that has been done, the highest age groupwith pulmonary tuberculosis in people with HIV / AIDS is as much as32.65% of 25-30 years, by sex more dominant male is 79.59%, based onthe most common residence is outside city field as much as 83.67%, thehighest frequency based on the self- employed work is as much as 38.77%,the highest frequency of risk factors based on sex is as much as 71.42%and the highest frequency based on CD4 count is <200 as much as91.83%.Conclusion: Based on this study concluded that the incidence ofpulmonary TB in people with HIV / AIDS are still very high, the highest inthe age group 25-30 years of age and male gender, the dominantoccupation were self-employed, the highest risk factor was sexual relationswith CD4 count <200.
The Relationship Between Knowledge and Education Levels of Pregnant Women and the Regularity of Antenatal Care Visits at Tigapanah Community Health Center in 2024 Alfri Yoganta Sembiring; Maestro Simanjuntak; Juli Jamnasi
Jurnal Kedokteran Methodist Vol. 17 No. 2 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i2.5373

Abstract

Background: Maternal and prenatal mortality remain serious healthissues, primarily due to behaviors and a lack of understanding regardinghealthcare, particularly Antenatal Care (ANC). The irregularity inprenatal check-ups is influenced by factors such as the educational leveland knowledge of pregnant women.Objective: To analyze the relationship between knowledge and educationallevel of pregnant women with the regularity of prenatal check-ups atTigapanah Health Center.Methods: This study employed a quantitative approach with a cross-sectional design. The sample consisted of 77 pregnant women selectedthrough purposive sampling. Data were collected using a validated andreliable questionnaire, and analyzed using the Chi-Square statistical test.Results: The results from a total of 77 samples indicate a significantrelationship between knowledge and the regularity of prenatal check-ups(p = 0.002). The educational level also showed a significant relationshipwith the regularity of prenatal check-ups (p = 0.001).Conclusion: There is a significant relationship between knowledge andeducational level with the regularity of prenatal check-ups.Keywords: Knowledge, Educational Level, Pregnant Women, Regularityof Prenatal Check-Ups, ANC
The Impact of a High-Fat Diet on Blood Glucose Levels Atta Celine Nouli Saruksuk; Jekson Martiar Siahaan; Irene Ruminta Tua Damanik; Endy Juli Anto; Jadeny Sinarta
Jurnal Kedokteran Methodist Vol. 17 No. 2 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i2.5374

Abstract

Background: Diabetes mellitus (DM) sufferers in the world and even inIndonesia are expected to continue to increase, especially type 2 DM(DMT2). DMT2 often occurs in people who are obese, the cause of obesityis often consuming foods that contain a lot of fat. Hyperlipidemia plays arole in the pathogenesis of pancreatic β-cell dysfunction.Research method: This study is an experimental laboratory study with apretest-posttest only controlled group design, using male white rats(Rattus norvegicus) with a sample size of 30 divided into 6 groups, namelythe normal group, the negative control group, the positive control group,the group given a high fatty diet (HFD). The independent variable is HFD,while the dependent variable is blood sugar levels. Data were analyzedusing the Anova test.Results: Giving HFD of 4 ml/day for 4 weeks has not been able to increaseKGD to hyperglycemic, this is thought to be because the HFD was notgiven for long enough so that insulin resistance had not occurred in thetest animals.Conclusion: Based on the results of the study, it was concluded that givingHFD for 4 weeks still could not increase KGD in male white mice tobecome hyperglycemic
Antihyperglycemic Effect of Polyherbal Tea From Moringa oleifera, Cymbopogon citratus, and Stevia rebaudiana Leaves in Alloxan and HFD-Induced Mice (Mus musculus) Barukh Saro Talenta Zebua; Jekson Martiar Siahaan; Alex M. T. LumbanRaja; Suryati Sinurat; Salomo Garda Utama Simanjuntak
Jurnal Kedokteran Methodist Vol. 17 No. 2 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i2.5375

Abstract

Diabetes Mellitus (DM) is a disease with metabolic disorders characterized by chronichyperglycemia and disorders of carbohydrate, fat, and protein metabolism due to insulinsecretion disorders. In general, DM patients require pharmacotherapy such as injectedinsulin or oral antidiabetic drugs. Pharmacological treatment is relatively expensive andneeds to consider its efficacy and safety. Therefore, this study explores natural sources suchas medicinal plants. The aim of this study was to determine the antihyperglycemic effect of acombination of boiled moringa leaves, lemongrass leaves and stevia leaves on mice (Musmusculus) induced by alloxan. In this study, 25 mice were divided into 5 groups. The micewill undergo adaptation for 7 days and then given HFD for 30 days. After 30 days, the micewill be given alloxan 170 mg/kgBW for 3 days to induce DM. After DM was successfullyinduced in mice, polyherbal tea combination of moringa leaves, lemongrass leaves and stevialeaves was made and given, then continued with evaluation blood glucose, blood glucosepercentage, body weight, body weight percentage, index lee and liver organ index. The groupgiven herbal tea combination of moringa leaves (Moringa oleifera), lemongrass leaves(Cymbopogon citratus) and stevia leaves (Stevia rebaudiana) with a concentration of 3.6mg/mL showed a better decrease in KGD and %KGD compared to other treatment groups.The decrease in BB, %BB and lee index was better in the group given a combination ofMoringa leaves (Moringa oleifera), Lemongrass leaves (Cymbopogon citratus) and Stevialeaves (Stevia rebaudiana) with a concentration of 7.2 mg/mL. The decrease in the liverorgan index was also better seen in the group given a combination of Moringa leaves(Moringa oleifera), Lemongrass leaves (Cymbopogon citratus) and Stevia leaves (Steviarebaudiana) with a concentration of 7.2 mg/mL. The group given herbal tea combination ofMoringa leaves (Moringa oleifera), Lemongrass leaves (Cymbopogon citratus) and Stevialeaves (Stevia rebaudiana) with a concentration of 3.6 mg/mL reduced BG and BGpercentage, while the group given herbal tea combination of Moringa leaves (Moringaoleifera), Lemongrass leaves (Cymbopogon citratus) and Stevia leaves (Stevia rebaudiana)with a concentration of 7.2 mg/mL reduced BW, BW percentage, Lee index, and hait organindex.
The Relationship Between Myopia and Hypertension in Open-Angle Glaucoma Patients at Methodist Hospital in 2023 Billy Cristover Tarigan; Lylys Surjani; Inda Meirani Sinaga; Mawar Gloria Tarigan; Dwi Lunarta Siahaan
Jurnal Kedokteran Methodist Vol. 17 No. 2 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i2.5376

Abstract

Background: Glaucoma is the second leading cause of global blindnessafter cataract. Glaucoma is thought to occur due to increased intraocularpressure (IOP) causing changes in the optic nerve and field of vision.Objective: To find out whether there is a relationship betweenhypertension and myopia in open angle glaucoma patients at MethodistHospital in 2023.Method: This research was conducted in an analytical observationalmanner with an approach using a cross sectional design, namely only for amoment or looking at the relationship between Myopia and Hypertensionin Open Angle Glaucoma Patients at Methodist Hospital in 2023 at thetime the research took place with medical record data of 74 samples basedon inclusion and exclusion criteria. .Results: From the results of this study, it was found that there was arelationship between myopia and open angle glaucoma with p – value =0.000 (<0.05). There is a relationship between hypertension and openangle glaucoma with p – value = 0.016 (<0.05).Conclusion: There is a relationship between hypertension and myopia inopen angle glaucoma patients
The Relationship Between Soil-Transmitted Helminths (STH) Infection and the Stunting Incidence in Toddlers at the Kedai Durian Community Health Center, Medan, Johor, in 2023 Brian Nicolas Sanpratama Lumbangaol; Ronald Tambunan; Sanggam B, Hutagalung; Surjadi Rimbun; Adrian khu
Jurnal Kedokteran Methodist Vol. 17 No. 2 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i2.5377

Abstract

Background:Worldwide, around 1 in 4 toddlers experience stunting. Stunting can causedisorders in the form of stunted brain growth and immune systemdisorders in toddlers. Malnutrition at an early age is found to occur in thefirst 1000 days of life can increase the risk of infant and child mortality. Itis known that chronic STH infection can cause stunting in children.Purpose: this study was to determine whether there is a relationshipbetween Soil Transmitted Helminths (STH) infection and the incidence ofstunting in toddlers at the Kedai Durian Health Center, Medan Johor in2023.Research Method: this was carried out in an analytical observationalmanner with an approach using a cross-sectional design, which is onlymomentary or sees the relationship between soil transmitted helminthsinfection and the incidence of stunting in toddlers at the Kedai DurianHealth Center, Medan Johor in 2023 when the study was taking place. Thesampling technique used purposive sampling. Which is to obtain a sampleof 35 respondents based on inclusion and exclusion criteria.Results: from this study, the most respondents were children infected withSTH worms, as many as 19 respondents (54.3%), and those who were notinfected were 16 respondents (45.7%), it was obtained that the mostchildren who were stunted were 17 respondents (48.6%), and those whowere not stunted were 18 respondents (51.4%). and There is a relationshipbetween STH worm infection and stunting with (chisquare count 10.493>chisquare table (0.05(1)) 3.841, P value 0.01 and RP (3.8). [95% CI 1.37 -11.28]. From these results, it was also found that children who suffer fromSTH infection have a prevalence of stunting 3.8 times more than those whoare not infected with STH, so that STH infection is a high risk factor forstunting in toddlers.Conclusion: The results of the study found a relationship between STHinfection and the incidence of stunting
Correlation Between Platelet Count and Hematocrit Value in Hospitalized Patients with Dengue Hemorrhagic Fever at RSUD Dokter Pirngadi Medan, 2022-2023 Damayanti Saragih
Jurnal Kedokteran Methodist Vol. 18 No. 2 (2025): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v18i2.5456

Abstract

Background : Dengue Hemorrhagic Fever (DHF) is an infectious diseasecaused by the dengue virus transmitted through the bite of the Aedesaegypti mosquito. This disease remains a global health issue, including inIndonesia. One of the main complications of DHF is thrombocytopeniaand hemoconcentration, which can lead to serious conditions such ashypovolemic shock. Objective: The objective of this study is to determinethe correlation between platelet count and hematocrit levels in DHFpatients at Dr. Pirngadi General Hospital, Medan City, in 2022-2023.Research Method: This research is observational with a cross-sectionaldesign. The sampling technique used is purposive sampling. The data usedin this study are secondary data obtained from medical records, involvingthe collection of information from existing patient medical records at Dr.Pirngadi General Hospital, Medan. Data presentation includes univariateand bivariate analysis using the Spearman correlation test. Results: Theresults of this study, with a total of 280 samples, show a significantnegative correlation between platelet count and hematocrit levels in DHFpatients, both in males (rs calculated (0.619) > rs table (0.350); 0.05) andfemales (rs calculated (0.296) > rs table (0.169); 0.05). Conclusion:There is a significant negative correlation between platelet count andhematocrit levels in DHF patients hospitalized at Dr. Pirngadi GeneralHospital, Medan City
The Correlation Between Erythrocyte Sedimentation Rate (ESR) and Platelet Count with Fever Levels in Pediatric Patients with Typhoid Fever at Methodist General Hospital Medan in 2023 Donitha Rorescki Simanjuntak
Jurnal Kedokteran Methodist Vol. 18 No. 2 (2025): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v18i2.5457

Abstract

Background : typhoid fever is an acute febrile disease caused bySalmonella typhi bacterial infection and can be caused also by SalmonellaParatyphoid a, Salmonella Typhi B, and Salmonella Paratyphoid C.Found endotoxin in bacterial polysaccharide S.typhi stimulate theproduction of cytokines and cause systemic symptoms such as fever,vomiting, headache, diarrhea, constipation. Endotoxins induce changes inbone marrow cells and affect ESR values and platelet counts. At the levelof fever, there are 3 levels of temperature increase, namely febris,subfebris and hyperpyrexia. Objective: this study was conducted todetermine the relationship of the value of ESR and platelet count to feverlevels in pediatric patients with typhoid fever.Method: research method with observational analytical measurementthrough retrospective approach with cross sectional design, usingsecondary data in medical records, researchers make observations ormeasurements of variables at a particular time.Results : In the analysis there is a significant relationship between thevalue of the LED with fever level with a value of p=0.039 and there is norelationship between platelet count with fever level with a value ofp=0.089.Conclusion: there is a relationship between the value of LED with fever level and there is no relationship between platelet count with fever levelwith a value of p= 0.089.

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