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Jurnal Kedokteran Methodist
Published by Universitas Methodist Indonesia
ISSN : 26847132     EISSN : 26847132     DOI : DOI: https://doi.org/10.46880/jkm.v20i1
Core Subject : Health, Science, Education, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other
Jurnal Kedokteran Methodist (JKM) is a peer-reviewed, open-access journal that welcomes manuscripts in basic and clinical research, encompassing all aspects of medicine, health sciences, and pharmacy. Reports on genomics, epigenetics, and stem cells are welcome as well. The journal covers original research articles, case reports, and review articles.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 54 Documents
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A ANTIBODY MEDIATED IMMUNITY: ANTIBODY MEDIATED IMMUNITY Sembiring, Budi Darmanta
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

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Abstract

Keeping the integrity and the individual balance needed an adequate immunity system. Therefore the immunity mechanism to the dangerous antigen consists of physical immunity and chemical, symbiosis with a normal flora bacteria, innate immunity with a specific immunity which is got, consist of humoral immunity and cell immunity (cell-mediated immunity). The antibody is the component of immunity that is gotten which protects the body from microorganism infection and the product which is toxic. Because of that, the interaction between antigen and antibody is very important and much used in vitro for diagnostic purposes. The use of this reaction in vitro between antigen-antibody is called serology.
A TERAPI METHOTREXATE PADA PENDERITA PSORIASIS VULGARIS: TERAPI METHOTREXATE PADA PENDERITA PSORIASIS VULGARIS Tarigan, Juliyanti; Simanjuntak, Evirosa; Marpaung, Alexander P.
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

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Abstract

Psoriasis merupakan penyakit peradangan kronik pada kulit berupa perubahan pertumbuhan dan diferensiasi epidermis, serta abnormalitas biokimiawi, imunologik, dan vaskular. Psoriasis dapat bermanifestasi pada kulit, kuku, dan persendian. Diagnosis psoriasis biasanya ditegakkan berdasarkan anamnesis dan gambaran klinis lesi kulit. Pada kasus-kasus tertentu, dibutuhkan pemeriksaan penunjang seperti pemeriksaan biopsi histopatologi dan pemeriksaan              laboratorium.                                   Secara histopatologi akan tampak akantosis, parakeratosis, elongasi rete ridge. Tampak neutrofil dan limfosit yang bermigrasi membentuk mikroabses Munro. Pada dermis akan tampak tanda-tanda inflamasi seperti hipervaskularitas dan dilatasi serta edema papila dermis. Pemeriksaan laboratorium pada psoriasis bersifat tidak spesifik. Pengobatan anti psoriasis berspektrum luas baik secara topikal maupun sistemik telah tersedia. Sebagian besar obat-obatan ini bekerja sebagai imunomodulator. Sebelum memilih regimen pengobatan, penting untuk menilai perluasan serta derajat keparahan psoriasis. Salah satu cara yang paling sering digunakan untuk menilai derajat keparahan psoriasis adalah dengan menghitung skor Psoriasis Area and Severity Index (PASI).
A HUBUNGAN NILAI ALBUMIN SERUM DENGAN TINGKAT KEPARAHAN DAN LAMA RAWATAN PASIEN DM TIPE 2 DENGAN COVID-19 DI RSU BINA KASIH: HUBUNGAN NILAI ALBUMIN SERUM DENGAN TINGKAT KEPARAHAN DAN LAMA RAWATAN PASIEN DM TIPE 2 DENGAN COVID-19 DI RSU BINA KASIH Tarigan, M.Bastanta; Situmorang, Nasib Mangoloi; Hutahaean, Reinhard
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

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Abstract

Introduction Coronavirus disease 2019 (COVID-19) is an infectious disease that affects the respiratory system caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-COV-2), which has become a health problem in Indonesia. The duration of treatment and the severity of COVID-19 will increase the risk of death and significant costs, which undoubtedly burden patients and the country. A marker is needed to determine the severity of the disease and the duration of treatment for COVID-19 patients with diabetes. Albumin is a protein that plays anti-inflammatory, antioxidant, anti-infection roles, and also participates in drug transfer within the human body. Poor glucose control, insulin resistance, insulin deficiency in type 2 diabetes (type 2 DM), and viral load in COVID-19 lead to hypoalbuminemia. Hypoalbuminemia will disrupt its function, leading to increased inflammation, oxidative stress, infection, and disturbance in drug distribution, thus hypoalbuminemia is suspected to play a role in increasing the severity and duration of treatment in type 2 DM patients with COVID-19. Method This study is an observational analytical study with a cross-sectional design conducted at Bina Kasih Medan General Hospital. The research subjects were type 2 DM patients infected with COVID-19 who underwent inpatient care from August to October 2021 with consecutive sampling that met the inclusion and exclusion criteria. Patients were categorized into moderate and severe severity levels. The duration of treatment was divided into less than and greater than or equal to 11 days, and serum albumin levels were evaluated. The independent variable was albumin, and the severity level and duration of treatment were dependent variables. The data used were secondary data from medical records, and bivariate analysis was performed to see the relationship between independent and dependent variables using the Chi-Chisqure test. Results During the period from August to October 2021, 82 subjects with type 2 DM who were infected with COVID-19 and underwent inpatient care were obtained. Out of 82 subjects who met the inclusion criteria, 34 subjects were included. Of the 34 study subjects, the majority were male, namely 26 subjects (76.4%), and 8 subjects (23.5%). Subjects who underwent inpatient care for <11 days were 15 (44.1%) and those who underwent inpatient care ≥11 days were 19 (55.9%). 18 subjects (52%) had moderate severity levels, and 16 subjects (47.05%) had severe severity levels. Based on the results of bivariate analysis, there was an inverse relationship between serum albumin levels and the severity of the disease (P <0.032), but there was no significant relationship between albumin levels and the duration of hospitalization (P <0.350). Conclusion A decrease in albumin levels is associated with the severity of the disease but not with the duration of treatment.
CHF ec STENOSIS AORTA ec RHD + PH SEKUNDER Manullang, Doharjo; Tarigan, Menang Bastanta; Simanjuntak, Salomo G U; Situmeang, Ivonne; Simanjuntak, Evi Rosa; Hutahaeng, Reinhard DJ
Jurnal Kedokteran Methodist Vol. 18 No. 1 (2025): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

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Abstract

Stenosis is the most common valvular heart disease in Europe and North America with fear of calcification in the elderly (2-7% of the population> 65 years) while congenital aortic stenosis is usually caused by rheumatic heart disease which is now rare and usually found in young age. Classification of Aortic Stenosis. Classification of Aortic Stenosis can be divided based on the severity divided into 3 parts of mild, moderate, severe and very severe. Echocardiography modality is one of the gold standard tools for determining Aortic Stenosis which in echocardiography can capture Peak aortic jet velocity, the mean pressure gradient aortic valve area. The following is a case report of a 36 year old man with CHF ec Aortic Stenosis ec Rheumatic Heart Disease. This case was only diagnosed about 1 month ago with complaints of shortness of breath and chest pain. And the patient immediately went to RSMH for further treatment. This case was appointed for the management and preparation for surgery as a definitive therapy so that it is expected to give the best results in this patient
Hubungan Kadar Kolesterol Total Dengan Kolesterol LDL Pada Pasien Hipertensi So Hanggrainy, Octavia; Lim, Hadyanto; Singh, Surjit
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.1392

Abstract

The Background: Cholesterol is an essential structural component that forms the cell membrane and the external layer of plasma lipoproteins. The increase of total cholesterol is always accompanied by the increase in LDL cholesterol especially in hypertensive patients. The present study was conducted to find the correlation between total cholesterol and LDL cholesterol of the patients with hypertension Method: It is an observational analytic using cross sectional study in which the data were collected by clinical laboratory examination of Prodia Jl. S.Parman no. 17/223G Medan, North Sumatra Indonesia. The population included all patients with hypertension in which the samples were taken by consecutive sampling method so the total were 19 samples. Results: Majority of samples had normal total cholesterol of 8 persons (42.1%) and the majority of the study samples had high LDL cholesterol of 8 persons (42.1%). Conclusion: There is a significant correlation between total cholesterol and LDL cholesterol. It is indicated by the sig-p value = 0.004 (p <0.05). There is a significant correlation between total cholesterol and LDL cholesterol of the patients with hypertension. It is indicated by the correlation coefficient value r-count = 0.635 which is between 0.6 - 0.79
Hubungan Hipertensi Dengan Mikroalbumin Urin Pada Usia Diatas 40 Tahun Cristianto Sagala, Rudy; Lim, Hadyanto; Singh, Surjit
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.1410

Abstract

Background : Hypertension is the risk factor for cardiovascular disease and it is related with endothelial dysfunction. The disease is marked by microalbuminuria. Microalbuminuria is related with the damage of endothelial glomerulus and predictor of chronic renal failure. Microalbuminuria increases albuminuria. This will manifest as endothelial damage of the glomerulus. This study is to assess the relation between hypertension and microalbuminuria in people over 40 years of age Methods : in 13 subjects of essential hypertension in Medan, basic data down and their blood pressure and microalbumin checked in Clinical Laboratory of Prodia on Jl. S. Parman No. 17/223 G Medan. This research use cross section study. Shapiro-Wilk test conducted to find out normal distribution data and Pearson correlation test conducted to find out the relation between the variables. The significant score is P<0.05. Results : 6 subjects in this research were in category of A2 (moderate): 3-30 mg/mmol creatinine.7 subject in this study were in category A3(Severe): >30 mg/mmol creatinine. There was correlation (r = 0.898, p = 0.000) between systolic hypertension and microalbuminuria and the correlation between diastolic and microalbuminuria was (r = 0.574, p = 0.040). Conclusion: Hypertension is related with the increase of microalbuminuria for both systolic hypertension and diastolic Hypertension.
Perilaku Ibu tentang Makanan selama Masa Kehamilan untuk Mencegah Berat Bayi Lahir Rendah Fernando, Berman; F. Sitompul, Donald; Olivia Napitupulu, Dina
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.1414

Abstract

Background : In developing countries, including indonesia, nutritional problems are still major public healt problem. Low nutritional status of pregnant women during pregnancy may result in various adverse effects for both mother and baby, among them are babies born with low birth weight.In pregnant women need to consume good food during pregnancy. The study aims to determine Mother’s behavior about food during pregnancy to prevent low birth weight in department obstetrics and gynecology Dr. Pirngadi Medan General Hospital on 2017 Methods : This is descriptive study with cross sectional design, the data were collected with questionnaires and analyzed with the SPSS (statistical product and service solutions) program. Population in this research were 80 suffer’s datas with 80 datas as samples, and was taken with total sampling. Results : Mother’s behavior about food during pregnancy in Dr. Pirngadi Medan General Hospital on 2017 the highest age 20-35 years old 92,5%, senior high school eduction level 67,5%, work as housewife noted 87,5%. Mother’s knowledge of food during pregnancy belong to category of good 86,2%, 13,8% belong to category of fair. Mother’s attitude of food during pregnancy belong to category of good 77,5%, 22,5 belong to category of fair. Mother’s action of food during pregnancy belong to category of good 75,5%, 25,5 belong to category of fair. Conclusion : Based on these results it was concluded that Mother’s behavior about food during pregnancy to prevent low birth weight in department obstetrics and gynecology Dr. Pirngadi Medan General Hospital on 2017 had good knowledge, good attitude about food during pregnancy. Keywords : ,
Tingkat Pengetahuan, Sikap Dan Tindakan Siswa-Siswi Kelas XI IPA Terhadap Kusta Di Sman I Kutalimbaru Tutamana Hutabarat, Kalvin; Eka Samuel P. Hutasoit
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.1424

Abstract

Background: Leprosy is a disease caused by M.leprae, which has great affinity in nerve cells. Leprosy is still feared by the community, including some health workers. The dreaded thing of this leprosy disease is the disability caused by this disease. Indonesia is the third country in the world with most leprosy patients. While the city of Medan is the city with the most leprosy patients in the region of North Sumatra. Based on age distribution, most cases of leprosy occur in productive age and high school students are included in the productive age. This study aims to determine the level of knowledge, attitudes, and actions of students of class XI IPA SMA Negeri 1 Kutalimbaru about leprosy. Methods : This research is descriptive research with cross sectional approach. Performed at SMAN 1 Kutalimbaru. Data were taken from 57 samples of students selected by simple random sampling technique. From each sample, data were collected with questionnaires related to knowledge, attitudes and actions on leprosy. Results : Of the 57 people analyzed, 27 data were obtained with sufficient knowledge, 16 were knowledgeable, and 14 had less knowledge. For attitudes of respondents, most respondents have enough attitude, and for the actions of most respondents have enough action. Conclusion : the knowledge that the students of class XI IPA on leprosy is still included in the category enough, while for the attitude also included in the category enough and the act of entry in enough category.
Pengaruh Infusa Daun Kelor (Moringa oleifera) terhadap Penurunan Kadar Glukosa Darah dan Kolesterol Total pada Mencit (Mus musculus) yang Mengalami Ulkus Diabetikum: Pengaruh Infusa Daun Kelor (Moringa oleifera) Napitupulu, Helen Debora; Siahaan, Jekson Martiar; Simangunsong, Batara
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.1671

Abstract

Background: Diabetes mellitus is a chronic disease in the form of metabolic disorders, which is characterized by blood glucose levels (BGL) that exceed normal limits and are accompanied by disorders of carbohydrate, lipid, and protein metabolism, as a result of abnormalities in insulin secretion. Diabetics are known to have slow wound healing. Moringa oleifera leaves contain flavonoid compounds, which can reduce glucose absorption. Objective: This study aims to determine the effect of Moringa leaf infusion on blood sugar levels, glucose tolerance, cholesterol levels, body weight, and speed of wound healing in mice model. Method  : A total of 25 male mice aged 2-3 months weighing 25-30 grams were divided into 5 experimental groups namely: negative control, positive control, 10% Moringa infusion, 20% infusion, 30% infusion. The negative control was not given any treatment. Positive controls were induced by high fat diet and PTU and given sucrose for 3 weeks. The infusion group was the same as the positive control but at the end of each week, 10%, 20%, and 30% Moringa leaf infusion were given successively. Moringa leaf intervention was given for 3 weeks after feed induction and observations were made at that range. The wound was made after feeding induction on the back 1 cm long. Result  : Moringa leaf infusion had a significant effect on reducing the levels of each variable, namely a dose of 10% on body weight, a dose of 30% on KGD, 20% on KGD with glucose loading, 20% on cholesterol, and 20% on wound closure, which proved based on the results of statistical tests. Conclusion: Moringa leaf infusion can reduce blood sugar levels, blood sugar levels by loading glucose, cholesterol levels, body weight, and accelerate wound healing in mice induced by sucrose, high fat diet, and PTU.
FAKTOR KOMORBID YANG MEMPENGARUHI KEJADIAN KEMATIAN PASIEN COVID-19 DI RUMAH SAKIT RSU. ROYAL PRIMA TAHUN 2021 Siregar, Resisca; Sinatra, Jadeny; Surjani, Lylys
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.1674

Abstract

Background. Corona Virus Disease-19, also known as COVID-19, is a disease caused by the Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). COVID-19 became a pandemic outbreak determined by the World Health Organization (WHO) on December 31, 2019, which first occurred in Wuhan, China. Indonesia itself confirmed the first case on March 2, 2020. As of January 2, 2022, the government of the Republic of Indonesia has reported 4,263,168 confirmed cases of COVID-19. There have been around 144,097 reported COVID-19-related deaths. One of the causes of death is the presence of comorbidities. The presence of a history of comorbidities increases the severity leading to death. Research Objectives: To find out the relationship between one comorbid, namely HT, DM or Heart with COVID-19 at the Hospital which can cause death and to find out the relationship between two comorbids, namely HT with DM or HT with Heart or DM with Heart with COVID-19 at home. Illness that can lead to death Results: The results found were that there was a relationship between the type of comorbidity and the number of deaths in COVID-19 patients, this was based on a bivariate statistical test using the chi-square test, p value <0.05. This shows that there is a significant relationship between the type of comorbidity and the number of comorbidities on the severity of patients with confirmed COVID-19. Conclusion: The results of this study show that comorbidities are one of the factors that play a role in causing severity in COVID-19 patients and even death. The most common comorbidities were HT, DM for single comorbid and for multiple comorbids were DM with HT, DM with heart.

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