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INDONESIA
Jurnal Kedokteran Methodist
Published by Universitas Methodist Indonesia
ISSN : 26847132     EISSN : 26847132     DOI : DOI: https://doi.org/10.46880/jkm.v20i1
Core Subject : Health, Science, Education, Agriculture, Social,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other
Jurnal Kedokteran Methodist (JKM) is a peer-reviewed, open-access journal that welcomes manuscripts in basic and clinical research, encompassing all aspects of medicine, health sciences, and pharmacy. Reports on genomics, epigenetics, and stem cells are welcome as well. The journal covers original research articles, case reports, and review articles.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 44 Documents
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A ANTIBODY MEDIATED IMMUNITY: ANTIBODY MEDIATED IMMUNITY Sembiring, Budi Darmanta
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

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Abstract

Keeping the integrity and the individual balance needed an adequate immunity system. Therefore the immunity mechanism to the dangerous antigen consists of physical immunity and chemical, symbiosis with a normal flora bacteria, innate immunity with a specific immunity which is got, consist of humoral immunity and cell immunity (cell-mediated immunity). The antibody is the component of immunity that is gotten which protects the body from microorganism infection and the product which is toxic. Because of that, the interaction between antigen and antibody is very important and much used in vitro for diagnostic purposes. The use of this reaction in vitro between antigen-antibody is called serology.
A TERAPI METHOTREXATE PADA PENDERITA PSORIASIS VULGARIS: TERAPI METHOTREXATE PADA PENDERITA PSORIASIS VULGARIS Tarigan, Juliyanti; Simanjuntak, Evirosa; Marpaung, Alexander P.
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

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Abstract

Psoriasis merupakan penyakit peradangan kronik pada kulit berupa perubahan pertumbuhan dan diferensiasi epidermis, serta abnormalitas biokimiawi, imunologik, dan vaskular. Psoriasis dapat bermanifestasi pada kulit, kuku, dan persendian. Diagnosis psoriasis biasanya ditegakkan berdasarkan anamnesis dan gambaran klinis lesi kulit. Pada kasus-kasus tertentu, dibutuhkan pemeriksaan penunjang seperti pemeriksaan biopsi histopatologi dan pemeriksaan              laboratorium.                                   Secara histopatologi akan tampak akantosis, parakeratosis, elongasi rete ridge. Tampak neutrofil dan limfosit yang bermigrasi membentuk mikroabses Munro. Pada dermis akan tampak tanda-tanda inflamasi seperti hipervaskularitas dan dilatasi serta edema papila dermis. Pemeriksaan laboratorium pada psoriasis bersifat tidak spesifik. Pengobatan anti psoriasis berspektrum luas baik secara topikal maupun sistemik telah tersedia. Sebagian besar obat-obatan ini bekerja sebagai imunomodulator. Sebelum memilih regimen pengobatan, penting untuk menilai perluasan serta derajat keparahan psoriasis. Salah satu cara yang paling sering digunakan untuk menilai derajat keparahan psoriasis adalah dengan menghitung skor Psoriasis Area and Severity Index (PASI).
A HUBUNGAN NILAI ALBUMIN SERUM DENGAN TINGKAT KEPARAHAN DAN LAMA RAWATAN PASIEN DM TIPE 2 DENGAN COVID-19 DI RSU BINA KASIH: HUBUNGAN NILAI ALBUMIN SERUM DENGAN TINGKAT KEPARAHAN DAN LAMA RAWATAN PASIEN DM TIPE 2 DENGAN COVID-19 DI RSU BINA KASIH Tarigan, M.Bastanta; Situmorang, Nasib Mangoloi; Hutahaean, Reinhard
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

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Abstract

Introduction Coronavirus disease 2019 (COVID-19) is an infectious disease that affects the respiratory system caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-COV-2), which has become a health problem in Indonesia. The duration of treatment and the severity of COVID-19 will increase the risk of death and significant costs, which undoubtedly burden patients and the country. A marker is needed to determine the severity of the disease and the duration of treatment for COVID-19 patients with diabetes. Albumin is a protein that plays anti-inflammatory, antioxidant, anti-infection roles, and also participates in drug transfer within the human body. Poor glucose control, insulin resistance, insulin deficiency in type 2 diabetes (type 2 DM), and viral load in COVID-19 lead to hypoalbuminemia. Hypoalbuminemia will disrupt its function, leading to increased inflammation, oxidative stress, infection, and disturbance in drug distribution, thus hypoalbuminemia is suspected to play a role in increasing the severity and duration of treatment in type 2 DM patients with COVID-19. Method This study is an observational analytical study with a cross-sectional design conducted at Bina Kasih Medan General Hospital. The research subjects were type 2 DM patients infected with COVID-19 who underwent inpatient care from August to October 2021 with consecutive sampling that met the inclusion and exclusion criteria. Patients were categorized into moderate and severe severity levels. The duration of treatment was divided into less than and greater than or equal to 11 days, and serum albumin levels were evaluated. The independent variable was albumin, and the severity level and duration of treatment were dependent variables. The data used were secondary data from medical records, and bivariate analysis was performed to see the relationship between independent and dependent variables using the Chi-Chisqure test. Results During the period from August to October 2021, 82 subjects with type 2 DM who were infected with COVID-19 and underwent inpatient care were obtained. Out of 82 subjects who met the inclusion criteria, 34 subjects were included. Of the 34 study subjects, the majority were male, namely 26 subjects (76.4%), and 8 subjects (23.5%). Subjects who underwent inpatient care for <11 days were 15 (44.1%) and those who underwent inpatient care ≥11 days were 19 (55.9%). 18 subjects (52%) had moderate severity levels, and 16 subjects (47.05%) had severe severity levels. Based on the results of bivariate analysis, there was an inverse relationship between serum albumin levels and the severity of the disease (P <0.032), but there was no significant relationship between albumin levels and the duration of hospitalization (P <0.350). Conclusion A decrease in albumin levels is associated with the severity of the disease but not with the duration of treatment.
CHF ec STENOSIS AORTA ec RHD + PH SEKUNDER Manullang, Doharjo; Tarigan, Menang Bastanta; Simanjuntak, Salomo G U; Situmeang, Ivonne; Simanjuntak, Evi Rosa; Hutahaeng, Reinhard DJ
Jurnal Kedokteran Methodist Vol. 18 No. 1 (2025): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

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Abstract

Stenosis is the most common valvular heart disease in Europe and North America with fear of calcification in the elderly (2-7% of the population> 65 years) while congenital aortic stenosis is usually caused by rheumatic heart disease which is now rare and usually found in young age. Classification of Aortic Stenosis. Classification of Aortic Stenosis can be divided based on the severity divided into 3 parts of mild, moderate, severe and very severe. Echocardiography modality is one of the gold standard tools for determining Aortic Stenosis which in echocardiography can capture Peak aortic jet velocity, the mean pressure gradient aortic valve area. The following is a case report of a 36 year old man with CHF ec Aortic Stenosis ec Rheumatic Heart Disease. This case was only diagnosed about 1 month ago with complaints of shortness of breath and chest pain. And the patient immediately went to RSMH for further treatment. This case was appointed for the management and preparation for surgery as a definitive therapy so that it is expected to give the best results in this patient

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