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Journal of Biomedical and Techno Nanomaterials
Published by Yayasan Adra Karima Hubbi
ISSN : 30481120     EISSN : 30481155     DOI : 10.70177/jbtn
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
Journal of Biomedical and Techno Nanomaterials is an international forum for the publication of peer-reviewed integrative review articles, special thematic issues, reflections or comments on previous research or new research directions, interviews, replications, and intervention articles - all pertaining to the research fields of medicine, pharmaceuticals, biomaterials, biotechnology, diagnosis and prevention of diseases, biomedical devices, bioinformatics, and all other related fields of biomedical and life sciences. All publications provide breadth of coverage appropriate to a wide readership in Biomedical and Techno Nanomaterials research depth to inform specialists in that area. We feel that the rapidly growing Journal of Biomedical and Techno Nanomaterials community is looking for a journal with this profile that we can achieve together. Submitted papers must be written in English for initial review stage by editors and further review process by minimum two international reviewers.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 66 Documents
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PERSONALIZED NANOMEDICINE APPROACHES ENABLED BY BIOINFORMATICS AND MACHINE LEARNING Zhang Li; Chen Mei; Wang Jing
Journal of Biomedical and Techno Nanomaterials Vol. 3 No. 1 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v3i1.3559

Abstract

Personalized nanomedicine has emerged as a promising approach to tailor treatments to individual patients, enhancing therapeutic efficacy while minimizing side effects. The integration of bioinformatics and machine learning (ML) has the potential to revolutionize this field by enabling more precise and efficient drug delivery systems, biomarker identification, and therapeutic strategies. However, the full potential of these technologies in personalized nanomedicine remains underexplored. This study aims to explore how bioinformatics and machine learning can enable personalized nanomedicine approaches, particularly in the areas of drug delivery optimization, patient-specific treatment planning, and biomarker discovery. The research investigates the application of these technologies in identifying individualized treatment strategies and improving patient outcomes. A systematic review of the current literature on bioinformatics, machine learning, and personalized nanomedicine was conducted. Case studies and experimental research using these technologies were analyzed to identify trends, applications, and challenges. Machine learning models were applied to bioinformatics datasets to predict drug responses and optimize nanomedicine formulations. The study found that bioinformatics and ML significantly enhance the accuracy of drug efficacy predictions, biomarker identification, and the design of personalized nanomedicine treatments. Furthermore, these technologies have improved patient-specific therapy optimization in clinical trials. The combination of bioinformatics and machine learning holds great promise for advancing personalized nanomedicine, offering tailored therapeutic solutions that improve patient outcomes and treatment efficiency.
BIOMIMETIC NANOMATERIALS FOR ADVANCED BIOMEDICAL IMPLANTATION Aom Thai; Nong Chai; Som Chai
Journal of Biomedical and Techno Nanomaterials Vol. 3 No. 1 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v3i1.3560

Abstract

Biomimetic nanomaterials, inspired by natural systems, have gained significant attention in the field of biomedical implants due to their ability to mimic the properties of biological tissues. These materials offer advantages such as enhanced biocompatibility, improved mechanical properties, and the potential to promote tissue regeneration. The integration of biomimetic nanomaterials into biomedical implants could revolutionize the field of medical devices by improving their functionality and longevity. This study aims to explore the development and application of biomimetic nanomaterials for advanced biomedical implantation. The research focuses on evaluating their mechanical, biological, and functional properties to determine their suitability for use in medical implants. A systematic review of the latest studies on biomimetic nanomaterials for biomedical applications was conducted. Materials such as hydroxyapatite, collagen-based nanomaterials, and nanostructured metals were analyzed for their properties, performance, and potential for use in various implant types. In vitro and in vivo studies were included to assess biocompatibility and efficacy. The findings demonstrate that biomimetic nanomaterials significantly improve the performance of biomedical implants. These materials exhibit superior biocompatibility, enhanced cell adhesion, and promote better tissue integration compared to conventional materials. Biomimetic nanomaterials offer promising solutions for advanced biomedical implants. Their ability to closely mimic biological tissue properties enhances implant functionality and integration, leading to improved patient outcomes.
PRECLINICAL EVALUATION OF NANOMATERIAL-BASED THERAPEUTICS FOR TRANSLATIONAL MEDICINE Ryan Teo; Ethan Tan; Ava Lee
Journal of Biomedical and Techno Nanomaterials Vol. 3 No. 1 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v3i1.3561

Abstract

Nanomaterial-based therapeutics have shown immense promise in translational medicine, offering innovative solutions for targeted drug delivery, cancer therapy, and regenerative medicine. The unique properties of nanomaterials, including their high surface area, biocompatibility, and ability to be engineered for specific functions, make them ideal candidates for improving the precision and efficacy of medical treatments. However, the preclinical evaluation of these nanomaterials is critical to ensuring their safety, efficacy, and clinical applicability. This study aims to evaluate the preclinical performance of nanomaterial-based therapeutics in the context of translational medicine. The research focuses on assessing the pharmacokinetics, biocompatibility, and therapeutic efficacy of nanomaterials in animal models to determine their potential for clinical translation. A series of preclinical tests were conducted using animal models to assess the pharmacokinetics, biodistribution, and toxicity of various nanomaterials. Therapeutic efficacy was evaluated through specific disease models, including cancer and wound healing, using both in vitro and in vivo techniques. The study demonstrated that nanomaterial-based therapeutics exhibited promising pharmacokinetics and high therapeutic efficacy, with minimal toxicity. Nanomaterials showed targeted drug delivery and enhanced therapeutic outcomes in preclinical models, particularly in cancer therapy. Nanomaterial-based therapeutics hold significant potential for advancing translational medicine. Preclinical evaluations confirm their promise for targeted therapy, though further research on long-term safety and clinical translation is needed.
INTEGRATION OF NANOTECHNOLOGY AND REGENERATIVE MEDICINE FOR NEXT-GENERATION HEALTHCARE SOLUTIONS Kiran Iqbal; Ahmed Shah; Sara Hussain
Journal of Biomedical and Techno Nanomaterials Vol. 3 No. 1 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v3i1.3562

Abstract

Nanotechnology and regenerative medicine are two rapidly evolving fields with the potential to transform healthcare by providing advanced solutions for tissue repair, disease treatment, and personalized medicine. The integration of nanotechnology with regenerative medicine offers the opportunity to enhance the efficacy of stem cell therapies, drug delivery systems, and tissue engineering, enabling more precise and effective treatments. Despite promising results, challenges remain regarding the scalability, biocompatibility, and long-term safety of nanomaterials in clinical applications. This study aims to explore the integration of nanotechnology with regenerative medicine to develop next-generation healthcare solutions. It focuses on evaluating the potential applications, challenges, and future directions of nanomaterial-based therapies in tissue regeneration and disease management. A systematic review of the current literature on nanotechnology and regenerative medicine was conducted. The review included studies on nanomaterials used for tissue engineering, drug delivery, and stem cell therapies. In vitro and in vivo research data were analyzed to assess the effectiveness and biocompatibility of nanomaterial-based approaches. The findings indicate that nanomaterial-based systems significantly improve the performance of regenerative medicine therapies, offering enhanced tissue regeneration, targeted drug delivery, and better integration with biological systems. However, issues like material stability and immune response remain. The integration of nanotechnology and regenerative medicine holds significant potential for advancing healthcare solutions. Addressing the current challenges will be critical for the successful translation of these technologies into clinical practice.
PHARMACEUTICAL NANOTECHNOLOGY FOR IMPROVING BIOAVAILABILITY AND THERAPEUTIC EFFICACY Fatima Ahmed; Ali Omar; Muntasir Muntasir
Journal of Biomedical and Techno Nanomaterials Vol. 3 No. 2 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v3i2.3211

Abstract

Pharmaceutical nanotechnology has emerged as a promising approach to enhance the bioavailability and therapeutic efficacy of drugs. Many drugs suffer from poor solubility, limited absorption, and rapid metabolism, leading to suboptimal therapeutic outcomes. Nanotechnology-based drug delivery systems offer solutions to these challenges by improving the stability, solubility, and controlled release of pharmaceuticals. This study explores the use of nanotechnology in the design and development of drug delivery systems aimed at enhancing bioavailability and optimizing therapeutic efficacy. The primary objective is to evaluate the effectiveness of various nanocarriers, including liposomes, dendrimers, and polymeric nanoparticles, in improving drug solubility and ensuring targeted delivery. The research employs in vitro and in vivo models to assess drug release profiles, absorption rates, and pharmacokinetic properties. The results demonstrate that nanotechnology-based systems significantly improve drug bioavailability and extend therapeutic efficacy by providing controlled and sustained drug release, reducing side effects, and enhancing cellular uptake. In conclusion, pharmaceutical nanotechnology offers a powerful strategy to overcome the limitations of conventional drug delivery systems, providing a pathway for more effective treatments in various therapeutic areas.
A LAB-ON-A-CHIP DEVICE WITH INTEGRATED GOLD NANOSENSORS FOR THE ULTRASENSITIVE ELECTROCHEMICAL DETECTION OF DENGUE VIRUS BIOMARKERS Andri Setiawan; Luis Santos; Josefa Flores
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 3 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i3.2479

Abstract

Dengue fever is a significant global health threat, where rapid and accurate diagnosis is crucial for timely clinical intervention and outbreak management. Conventional diagnostic methods are often centralized, time-consuming, and require sophisticated equipment, limiting their utility in point-of-care (POC) settings. This study reports the development and validation of a novel lab-on-a-chip (LoC) device integrating gold nanosensors for the ultrasensitive electrochemical detection of the Dengue virus non-structural protein 1 (NS1). The microfluidic device was fabricated using soft lithography, and the gold electrode surfaces were functionalized with specific anti-NS1 monoclonal antibodies. Detection was performed using differential pulse voltammetry (DPV), measuring the change in current response upon immunocomplex formation. The developed immunosensor exhibited a wide linear dynamic range and an exceptionally low limit of detection (LoD) of 1.5 pg/mL for the NS1 antigen. Furthermore, the device demonstrated high selectivity against other interfering proteins. Our findings successfully establish a robust, miniaturized LoC platform for the rapid and highly sensitive detection of dengue biomarkers. This device holds significant potential as a powerful POC diagnostic tool for the early detection of dengue fever, particularly in resource-limited environments.  
AN INJECTABLE, THERMOSENSITIVE HYDROGEL AS A CELL DELIVERY VEHICLE FOR CARDIAC REGENERATIVE MEDICINE POST-MYOCARDIAL INFARCTION T. Amirul Muttaqin; Rit Som; Anna Charalambous
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 4 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i4.2661

Abstract

Cell-based therapies for myocardial infarction (MI) are critically limited by poor acute cell retention and viability following direct injection. The harsh, ischemic microenvironment and mechanical washout result in massive cell death, neutralizing therapeutic potential and leading to failed clinical translation. This research aimed to design, synthesize, and evaluate a novel, injectable, thermosensitive hydrogel as a “pro-survival” cell delivery vehicle. The objective was to determine if this biomaterial could solve the critical failure points of retention and viability, thereby enhancing the therapeutic efficacy of mesenchymal stem cells (MSCs) post-MI. A composite hydrogel (Poloxamer/Hyaluronic Acid) was characterized in vitro for its rheological properties (LCST), mechanical stiffness, and cytoprotective capacity under ischemic stress. Its in vivo efficacy was then evaluated in a rat MI model (LAD ligation). The hydrogel+MSCs group (G5) was compared against controls (saline, MSCs-in-saline) via serial echocardiography and post-mortem histomorphometry. In vitro, the hydrogel confirmed ideal thermosensitivity (LCST 37.1°C) and cytoprotection (2.5-fold increase in ischemic cell survival). In vivo, the G5 (hydrogel+MSCs) group demonstrated significantly preserved cardiac function (LVEF 45.2%) compared to the MSCs-only group (G4: 34.1%) at 28 days. This was correlated with significantly reduced infarct size and enhanced border-zone angiogenesis. The thermosensitive hydrogel functions as an essential, enabling technology. It solves the critical failure points of acute retention and viability, demonstrating that an engineered “pro-survival” delivery vehicle is a prerequisite for the successful clinical translation of cardiac cell therapy.    
A THERANOSTIC NANOPLATFORM FOR SIMULTANEOUS MRI-GUIDED IMAGING AND PHOTODYNAMIC THERAPY OF GLIOBLASTOMA Sandra Castro; Antonio Rodríguez; Luisa González
Journal of Biomedical and Techno Nanomaterials Vol. 3 No. 1 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v3i1.2983

Abstract

Glioblastoma is the most aggressive primary brain tumor, characterized by infiltrative growth, poor prognosis, and limited response to conventional therapies. The lack of precise treatment guidance and effective localized therapy remains a major obstacle in clinical management. This study aims to develop a theranostic nanoplatform capable of simultaneous magnetic resonance imaging (MRI)–guided visualization and photodynamic therapy (PDT) to improve treatment precision and therapeutic efficacy in glioblastoma. An experimental nanomedicine approach was employed, involving the synthesis and physicochemical characterization of a multifunctional nanoparticle integrating MRI contrast agents and photosensitizers. Imaging performance, photodynamic activity, cellular uptake, and therapeutic efficacy were evaluated through in vitro assays and in vivo glioblastoma models. The results demonstrate that the theranostic nanoplatform provides strong MRI contrast enhancement, enabling accurate tumor delineation, while simultaneously generating high levels of reactive oxygen species upon light activation. MRI-guided photodynamic therapy resulted in significant tumor cell apoptosis, reduced tumor volume, and minimal damage to surrounding healthy brain tissue compared to non-guided treatments. In conclusion, the developed theranostic nanoplatform successfully integrates diagnostic imaging and therapy into a single system, enabling precise, image-guided photodynamic treatment of glioblastoma. This strategy represents a promising advancement in precision neuro-oncology and offers a foundation for future clinical translation of integrated nanotheranostic approaches.
CELL MATERIAL INTERACTIONS AT THE NANO-BIO INTERFACE: IMPLICATIONS FOR REGENERATIVE MEDICINE Ayesha Begum; Zahidul Islam; Shakib Ahmed
Journal of Biomedical and Techno Nanomaterials Vol. 3 No. 2 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v3i2.3958

Abstract

Cell-material interactions at the nano-bio interface play a pivotal role in the success of regenerative medicine, as these interactions dictate cell behavior, differentiation, and tissue integration. The advent of nanotechnology has enabled the development of materials with tunable properties at the nanoscale, providing new opportunities for enhancing tissue regeneration and healing. Despite the significant progress in this field, understanding the molecular mechanisms underlying these interactions remains a challenge. This study investigates the relationship between cells and nanomaterials, focusing on the impact of surface properties, topography, and chemical composition of materials on cellular behavior. The primary objective is to assess how engineered nanomaterials influence cellular responses such as adhesion, migration, proliferation, and differentiation. Experimental methods, including cell culture on nanostructured substrates, surface characterization using atomic force microscopy (AFM), and gene expression analysis, were employed to evaluate these interactions. The results demonstrate that nanomaterials with specific surface characteristics significantly enhance cell adhesion and proliferation, promoting tissue growth and regeneration. In conclusion, the nano-bio interface offers promising opportunities for developing advanced biomaterials for regenerative medicine, with implications for improving the functionality and biocompatibility of tissue-engineered constructs.
NANOMATERIAL BASED ANTIMICROBIAL SYSTEMS FOR INFECTIOUS DISEASE PREVENTION Raymond Foster; Leon Gittens; Julian Browne
Journal of Biomedical and Techno Nanomaterials Vol. 3 No. 2 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v3i2.3960

Abstract

Nanomaterials have gained significant attention as effective antimicrobial agents for combating infectious diseases due to their unique properties, including high surface area, small size, and enhanced interaction with microbial cells. Traditional antimicrobial therapies, such as antibiotics, have limitations, including the development of resistance, which has spurred the exploration of alternative strategies. This study investigates nanomaterial-based antimicrobial systems, focusing on their efficacy in preventing and treating infections caused by bacteria, fungi, and viruses. The primary aim is to evaluate the antimicrobial properties of various nanomaterials, such as silver nanoparticles, copper oxide nanoparticles, and graphene oxide, and to assess their potential applications in medical devices and surface coatings. The research employs in vitro methods, including disk diffusion assays, minimum inhibitory concentration (MIC) testing, and bacterial growth curve analysis, to evaluate the antimicrobial activity of these nanomaterials. The results show that nanomaterial-based systems exhibit significant antimicrobial activity, with silver nanoparticles demonstrating the highest efficacy in inhibiting bacterial growth, followed by copper oxide and graphene oxide. In conclusion, nanomaterial-based antimicrobial systems offer a promising alternative to traditional antimicrobial treatments, with the potential to address the growing challenge of antimicrobial resistance in infectious diseases.

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