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Journal of Biomedical Sciences and Health
Published by Universitas Karya Husada Semarang
ISSN : 30626854     EISSN : 30477182     DOI : https://doi.org/10.34310/
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health
The Journal of Biomedical Sciences and Health (JBSH) accepts manuscripts in basic sciences and applied clinical research. It covers various fields of biomedical sciences, but is not limited to Medical sciences. Our journal accepts and publishes original articles and review articles that significantly contribute to the understanding of biomedical sciences and health. The Journal of Biomedical Sciences and Health is published biannually in the months of February and August. This journal is available for download to anyone, including students, researchers, and lecturers. Authors are not charged for publication in JBSH. JBSH is a journal that disseminates, discusses, and presents scientific literature to support other communities on health developments, thereby increasing the knowledge of scientists and health workers and ultimately improving the health of the global population. JBSH covers a wide range of topics, including: 1. Biomedical Sciences: Molecular biology, microbiology, anatomy, physiology, biochemistry, etc. 2. Health: Medicine, Nursing, Obstetrics, Public Health, Pharmacy, Radiology, Administration of Community Health Centers, Hospitals, and Health Services, Health analyst. Journal of Biomedical Sciences and Health (JBSH) is published by Program Studi Ilmu Biomedis Fakultas Ilmu Keperawatan dan Kesehatan Universitas Karya Husada Semarang. JBSH is expected to increase its visibility through scientific studies and research findings accessible to academic circles and researchers.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 9 Documents
 1 
Search results for , issue "Vol. 3 No. 1 (2026)" : 9 Documents clear
Enhanced Survival of Lactobacillus Lg71 from Mangrove Sediment Under Simulated Gastric and Intestinal Conditions Kusharyati, Dyah Fitri; Satwika, Taruna Dwi; Alfisah, Rizal Khoirun; Mariana, Afifah; Rovik, Anwar; Oedjijono, Oedjijono
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.291

Abstract

Background: For a probiotic to offer health benefits, it must stay viable through the tough environment of the human gastrointestinal tract. This study assesses the effectiveness of sodium alginate encapsulation in improving the survival of Lactobacillus LG71, a new strain from mangrove sediment, under simulated gastric and intestinal conditions. Objective: This study aims to evaluate the effectiveness of sodium alginate encapsulation in enhancing the viability and survival of Lactobacillus LG71, a probiotic strain isolated from mangrove sediment, during cold storage and under simulated gastric and intestinal conditions. Methods: Lactobacillus LG71 was encapsulated in sodium alginate beads. The viability of both encapsulated and free (non-encapsulated) cells was assessed over a 4-week storage period at 4 °C and during sequential exposure to simulated gastric and intestinal environments. Results: Encapsulation significantly improved survival rates compared to free cells (p < 0.05). Although both groups experienced a decline during the first week of storage, encapsulated cells maintained a high viability of approximately 107 CFU/mL, losing only 2.51 log CFU/g over four weeks. Most notably, encapsulated Lactobacillus LG71 demonstrated greater resilience during digestion, retaining populations of 2.21 log CFU/mL in gastric simulations and 1.00 log CFU/mL in intestinal simulations. In contrast, free cells were much more vulnerable to these acidic and enzymatic conditions. Conclusion: Sodium alginate encapsulation effectively protects Lactobacillus LG71 from environmental and biological stressors. These findings indicate that encapsulation is a crucial step for the commercial application of mangrove-derived probiotics, ensuring that a viable dose of living cells reaches the host's lower gastrointestinal tract to promote health benefits.
The Relationship Between Gender and Students' Knowledge and Attitudes Towards Healthy Snack Selection in Semarang City Public Elementary Schools Mulyawati, Isti; Zulfa, Nely; Sudrajat, Agus
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.292

Abstract

Background: The habit of eating snacks at school is part of the diet of elementary school students who need attention related to their nutritional quality. Knowledge and attitude are often considered determining factors in  choosing  healthy  snacks.  Objective:  This  study aims  to  analyze the relationship  between gender  and  students'  knowledge  and  attitudes  towards  choosing  healthy snacks  at  Semarang  City  State  Elementary  School.  Methods:  Quantitative  study  with  cross- sectional design. The sample consisted of 74 students taken from 21 State Elementary Schools in Semarang  City  using  quota  sampling  techniques.  Data  was  collected  through  a structured questionnaire and  analyzed  using  Chi-Square statistical  tests.  Results:  The univariate  analysis showed that the majority of respondents were female (59.5%), had good knowledge (89.2%), and had good attitudes (41.9%). The results of the bivariate analysis showed no relationship between gender  and knowledge of  healthy snack  selection  (p  value=  1.00)  and  no  relationship between gender and attitudes towards healthy snack selection (p value = 0.196).  Conclusion: Gender is not  a  distinguishing  factor  in students'  knowledge and  attitudes  towards healthy snacks.  This suggests  that  school  health  interventions  should  focus  more  on  strengthening  the  physical environment and the availability of healthy snacks in schools, regardless of gender. 
The Bacteriocin Potential of Lactic Acid Bacteria from Cincalok as an Antibacterial Against Shigella and Salmonella Aprilia, Ineke; Pribadhi, Adhitya Naufal; Suwanto, Yustiana Arie; Widyaningrum, Ratna; Yana, Dian Rudy; Rofiah, Nurul Ummi
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.304

Abstract

Background: Lactic Acid Bacteria are a group of bacteria that have the ability to produce antimicrobial compounds called bacteriocins. Antibacterial of lactic acid bacteria proved effective in inhibiting pathogenic bacteria that cause infection in humans such as Shigella sp and Salmonella sp. Lactic acid bacteria can be found in fermented foods, one of which is fermented food typical of West Kalimantan, namely cincalok Aim: This study was to determine the antibacterial potential of cincalok lactic acid bacteria against Shigella sp and Salmonella sp Methods: This study used a true experimental, with the research design using a post test only control group design with data analyzed using SPSS to evaluate inhibition zone differences among three treatment groups: bacteriocin from Weissella sp. at 24 hours, Weissella sp. at 48 hours, and antibiotics (positive control) Results: The results obtained in the bacteriocin test from Weissella showed that there were differences in the inhibition zones formed, in Shigella sp the average values of the inhibition zones formed were W24 (24.4 mm), W48 (13.2 mm) and Cotrimoxazole (42.2 mm). while in Salmonella sp the average value of the inhibition zone formed is W24 (24.2 mm), W48 (12.8 mm) and Chloramphenicol (45 mm). Conclusion: Bacteriocins from LAB cincalok have an antibacterial effect on the growth of Shigella sp and Salmonella sp bacteria.
Metagenomic Mining of Antimicrobial Compounds from Extreme Environments: A Systematic Review Prayogo, Fitra Adi
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.293

Abstract

Background: Antimicrobial resistance (AMR) is a major global health crisis, necessitating novel drug discovery approaches. Extreme environments harbor unique microbial communities that produce specialized metabolites, yet systematic assessment of their biosynthetic potential through metagenomics remains lacking. Objective: To systematically review evidence on metagenomic mining strategies for discovering biosynthetic gene clusters (BGCs) with antimicrobial potential from extreme environments. Methods: Following PRISMA 2020 guidelines, PubMed/MEDLINE, Web of Science, Scopus, and Google Scholar were searched through December 2025. The primary reviewer screened all 487 records; a blinded second reviewer independently verified a random 20% subset at each stage (κ = 0.79–0.85). Quality assessment used an adapted Newcastle-Ottawa Scale. Fifteen studies met all inclusion criteria. Results: The 15 included studies identified over 14,000 BGCs (excluding the Paoli et al. [2022] global ocean dataset reported separately) across Antarctic/psychrophilic (5 studies), marine/deep-sea (4 studies), halophilic/hypersaline (2 studies), arid/desert environments (2 studies), and extreme soil communities (2 studies). Dominant BGC classes included terpenes, NRPS, RiPPs, and PKS. Studies employing long-read sequencing (Oxford Nanopore/PacBio) recovered substantially more complete BGCs compared with short-read approaches. Between 60–99% of detected BGCs across most environments lacked characterized homologs in the MIBiG database. Experimental validation of predicted antimicrobial activity was limited: only 2 studies (13.3%) confirmed direct antimicrobial or cytotoxic bioactivity through bioassays or compound isolation; 1 additional study (6.7%) provided indirect evidence of active BGC expression via metatranscriptomics; and the remaining 12 studies (80%) relied solely on in silico prediction. Conclusion: Extreme-environment metagenomics reveals remarkable biosynthetic diversity with substantial novelty. Long-read sequencing and updated bioinformatic platforms have significantly enhanced BGC detection. The critical gap between computational prediction and experimental validation of antimicrobial bioactivity remains the primary barrier to therapeutic translation.
Analysis of the Implementation of the "Gass Track Chemotherapy Program" As an Alternative Solution to Improve Oncology Services Ekowati, Sri Indah; Purnaningsih, Enggar
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.296

Abstract

Background: Timeliness in chemotherapy scheduling is essential in oncology practice. In Dr. Kariadi Hospital, increasing patient volume led to long waiting lists and treatment delays averaging 7 days. To address this issue, an innovation called "Gass Track," adapted from the fast-track system, was developed to accelerate chemotherapy services. Objective: This study aimed to analyze the implementation of the Gass Track chemotherapy program as an alternative solution to improve service efficiency and timeliness in oncology care at Dr. Kariadi Hospital, Semarang, Indonesia. Methods: This pre-post observational study used retrospective secondary data from January 2023 to June 2024, conducted at the Oncology Installation of Dr. Kariadi Hospital, Semarang. Individual patient-level chemotherapy delay data were extracted from medical records. Data were analyzed to compare chemotherapy delay distributions, patient flow, and service throughput between the pre-implementation (January May 2023) and post-implementation (June 2023 June 2024) periods. Results: A total of 8,479 programmed chemotherapy patients were recorded. Of 6,273 post-implementation patients, 509 (8.1%) received care via Gass Track. The median chemotherapy delay decreased from 7 days (IQR: 6 8) pre-implementation to 4 days (IQR: 3 5) post-implementation. A Mann-Whitney U test on individual patient-level data confirmed the reduction was statistically significant (U = 12,988,890; p < 0.001; rank-biserial r = 0.877, indicating a large effect). Monthly chemotherapy throughput increased by approximately 9.4% (from 441.2 to 482.5 patients/month). Conclusion: Gass Track improved patient flow, reduced delays, and supported timeliness in oncology chemotherapy services without requiring additional resources.
Cytotoxic Activity of Chromolaena odorata Leaf Extract on WiDr Colon Cancer Cells Anam, Hairul; Aswad, Hijral; Irma, Ade; Wahdaniar
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.300

Abstract

Background: Colorectal cancer (CRC) remains the third most commonly diagnosed cancer and the second leading cause of cancer-related mortality worldwide. In 2020, CRC accounted for approximately 1.9 million new cases and over 935,000 deaths globally. Conventional chemotherapy is frequently limited by systemic toxicity and drug resistance, necessitating the identification of novel plant-derived bioactive compounds. Chromolaena odorata (Asteraceae), a tropical medicinal plant, has demonstrated pharmacological properties including wound healing and anti-inflammatory activity; however, its antiproliferative potential against colorectal cancer cells remains insufficiently explored. Objective: This study aimed to evaluate the cytotoxic and antiproliferative effects of C. odorata n-hexane leaf extract on WiDr human colorectal adenocarcinoma cells using an in vitro MTT assay. Methods: Dried leaves of C. odorata were extracted via n-hexane maceration. WiDr cells were cultured in DMEM supplemented with 10% FBS and antibiotics. Cells were treated with graded extract concentrations (62.5–1000 μg/mL) for 24 hours in triplicate. Cell viability was assessed by the MTT assay and the half-maximal inhibitory concentration (IC₅₀) was determined via nonlinear regression analysis. Results: The extract exhibited concentration-dependent cytotoxicity against WiDr cells. The highest mean inhibition rate (94.3 ± 10.7%) was observed at 1000 μg/mL. The calculated IC₅₀ value was 149.09 ± 20.91 μg/mL, indicating moderate cytotoxic potency consistent with the National Cancer Institute (NCI) classification for biologically active crude extracts (IC₅₀ < 200 μg/mL). Conclusion: Chromolaena odorata n-hexane leaf extract demonstrates significant in vitro antiproliferative activity against WiDr colorectal cancer cells. The cytotoxic activity likely involves lipophilic bioactive compounds, including terpenoids. These findings support further bioassay-guided fractionation, mechanistic investigation, and in vivo validation as potential candidates for anticancer drug development.
Water Jasmine (Echinodorus palaefolius): A Phytoremediation Agent for Environmental Health Improvement and Landscape Enhancement Sari, Mellyaning Oktaviani Sonya Kirana
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.301

Abstract

Background: Heavy metal and organic pollution in water bodies necessitate sustainable, cost-effective remediation. Echinodorus palaefolius is a potential aquatic macrophyte that offers a nature-based solution by combining pollutant removal with aesthetic value. Objective: This review evaluates the dual-purpose efficacy of E. palaefolius in removing contaminants through constructed wetlands (CWs) and its integration into sustainable urban landscapes. Methods: The study synthesizes data on E. palaefolius performance in subsurface flow (SSF-CW) and free water surface (FWS-CW) systems. It analyzes physiological mechanisms, including rhizofiltration and phytoextraction, as well as the influence of substrates such as zeolite and charcoal on removal rates. Results: Findings indicate that E. palaefolius achieves over 90% removal efficiency for heavy metals such as mercury (Hg), iron (Fe), copper (Cu), and lead (Pb). The plant's extensive root system facilitates high bioconcentration, particularly for iron in stems and roots, without compromising metabolic functions. Furthermore, its ornamental features, broad leaves, and white inflorescences enhance the visual and ecological integrity of urban water features. Conclusion: E. palaefolius is a highly effective, multifunctional agent for water quality management. Its implementation as a tertiary treatment in industrial and urban settings provides an eco-friendly strategy for environmental health and landscape beautification.
Feasibility and Preliminary Effects of a Structured Walking Intervention on Body Composition Among Biomedical Science Students: A Pilot Study Amelia, Poppy Fransisca; Prayogo, Fitra Adi
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.303

Abstract

Background: Sedentary behavior among university students contributes to adverse changes in body composition and long-term metabolic risk. Walking represents a simple and accessible form of aerobic activity with potential health benefits. Objective: This pilot study aimed to evaluate the feasibility and explore preliminary trends in body composition changes following a four-week structured walking intervention among biomedical science students. Methods: A pilot quasi-experimental study with a one-group pretest–posttest design was conducted among three undergraduate biomedical science students. Participants performed 30 minutes of light-to-moderate intensity walking, 3–4 times per week, for four weeks. Body composition parameters—including body weight, body mass index (BMI), body fat percentage, muscle percentage, and visceral fat—were assessed using bioelectrical impedance analysis (BIA). Data were analyzed descriptively. Results: After four weeks, varied changes in body composition were observed across participants. One participant showed a tendency toward reduced fat percentage in the later weeks of intervention, while muscle percentage was generally maintained or slightly decreased. Body weight showed modest increases across all participants. No adverse events were reported, and all participants completed the protocol, indicating good feasibility. Conclusion: A structured walking program appeared feasible and was associated with preliminary trends in body composition among young adults, though the direction and magnitude of changes varied individually. The findings should be interpreted cautiously, given the very small sample size. Larger randomized controlled trials with longer follow-up and dietary monitoring are required to confirm these preliminary observations.
Differences in Sugar Concentration on Flavonoid Levels in Roselle Kombucha (Hibiscus sabdariffa L.) As An Antioxidant Beverage Izza, Arifah Nurul; Lestari, Catur Retno; Hidayat, Umar
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.308

Abstract

Background: Kombucha is a fermented tea beverage produced using a symbiotic culture of bacteria and yeast (SCOBY). Sugar concentration plays an essential role in the fermentation process as it influences microbial metabolism and the formation of bioactive compounds. Roselle (Hibiscus sabdariffa L.) is rich in flavonoids and anthocyanins, which act as natural antioxidants. Objective: This study aimed to determine the effect of different sugar concentrations on flavonoid levels in roselle kombucha. Methods: This was an experimental study using a completely randomized design (CRD) with one factor, namely sugar concentration: F1 (15%), F2 (25%), and F3 (35%). Fermentation was carried out with the addition of SCOBY for 14 days at room temperature. Flavonoid levels were analyzed using a spectrophotometric method with quercetin as the standard. Data were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test. Results: The highest average flavonoid level was found in F1 (sugar concentration 15%) at 0.015690%, while the lowest was in F3 (sugar concentration 35%) at 0.011364%. The Kruskal-Wallis test showed a significant difference among treatments (p = 0.002, p < 0.05). The Mann-Whitney test confirmed that all pairwise comparisons between treatments were significantly different. Sugar concentration significantly affects flavonoid levels in roselle kombucha. Conclusion: The 15% sugar concentration produced the highest flavonoid content, suggesting that low sugar formulation is preferable to maintain bioactive compounds and enhance antioxidant potential. Therefore, roselle kombucha with lower sugar concentration can be developed as a functional beverage to prevent degenerative diseases related to oxidative stress.

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