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Muhammad Fathurrahman
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Helium: Journal of Science and Applied Chemistry
Published by Universitas Pakuan
ISSN : 27761711     EISSN : 27764508     DOI : https://doi.org/10.33751/helium.v4i2
Core Subject : Science, Social, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Materials Science & Nanotechnology
Helium: Journal of Science and Applied Chemistry is a peer-reviewed journal on chemistry that encompasses all branches of chemistry (Analytical Chemistry, Biochemistry, Physical Chemistry, Inorganic Chemistry, and Organic Chemistry) and applied chemistry (Material Chemistry, Environmental Chemistry, Natural Products Chemistry, Computational Chemistry, etc.), except educational chemistry.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 18 Documents
 1   2 
Targeting Dopamine Transporter (DAT) with Peronema canescens Bioactives: A Molecular Docking Study for Stroke-Related Pain and Sedation Management Rizki Rachmad Saputra; Rifaldi Lutfi Fahmi; Eka Novitasari; Luluil Maknun; Jeddah Yanti; Raiyan Fairozi
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 1 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i1.19

Abstract

Pain and drowsiness are common symptoms of stroke recovery, which can be difficult to manage owing to neurochemical abnormalities in the dopamine system. The Dopamine Transporter (DAT) controls dopamine levels, which influences pain perception and neurological recovery. This study examines bioactive chemicals found in Peronema canescens leaves and their possible interactions with DAT. AutoDock Vina was used to perform molecular docking simulations to determine the binding affinities of Peronemin derivatives (A2, A3, and B2) to the Dopamine Transporter (DAT). The receptor structure (PDB ID: 4M48) was created by eliminating water molecules, introducing polar hydrogens, and optimizing the structure using AutoDockTools. Ligand structures were translated to the proper format, and docking was conducted using a grid box centered on DAT's active site, with an exhaustiveness value of 10. The Peronemin derivatives A2, A3, and B2 demonstrated binding affinities stronger than nortriptyline, native ligand (−10.6, −10.5, and −10.3 kcal/mol, respectively) and binding similarities ranging from 72.2% to 94.4%. These findings suggest that Peronema canescens bioactives may be promising candidates for stroke-related pain and sedative control, warranting further experimental validation.
Combination of Coagulation and Fermentation Technology in Utilizing Liquid Tofu Waste into Liquid Organic Fertilizer for the Growth of Chinese Spinach (Amaranthus dubius) Plants Nina Arlofa; Dama Satya Kusuma; Dwiyan Arya Nugraha; Mochammad Rizal Laksana
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 1 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i1.20

Abstract

Wastewater is known to contain organic compounds, such as proteins, fats, and carbohydrates, which can be utilized more effectively through technology, coagulation, and fermentation, allowing it to be used as an organic liquid fertilizer (OLF), a more environmentally friendly option. Research objectives are to determine the influence of powder seed sour Java as a coagulant on lower COD and BOD levels, the effect of adding EM4 to nutrients in waste liquid, and the impact of POC on the growth of spinach China (Amaranthus dubius). This research is conducted through the process of coagulation and flocculation using a solution seed powder of sour Java with varying concentrations of 500, 1000, 1500, 2000, and 2500 ppm. The concentration of 1500 ppm has resulted in the lowest COD and BOD levels, respectively, 250 ppm and 127 ppm. The solution with the lowest COD and BOD levels is fermented using EM4 with variations of 0, 0.5, 1, 1.5, and 2mL. The addition of EM4 is expected to accelerate the fermentation process and enhance the availability of beneficial nutrients, including N, P, and K, for plant growth and development. The total content of N, P, and K is highest, at 2.087%, following the addition of 1 mL of EM4 to 150 mL of the sample. POC with the addition of 1 mL of EM4 was applied to the spinach plant in China, resulting in a plant 25 cm tall, with nine leaves, and a total fresh weight of 39 grams.
Characterization of Simplicia, Extract, and Mineral Content of Broccoli (Brassica oleracea var. italica) Bina Lohita Sari; Zaldy Rusli; Ananda Putri Kalista
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 1 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i1.22

Abstract

Bioactive compounds and minerals in medicinal plants make them both therapeutic agents and raw materials for producing contemporary medications. Broccoli (Brassica Oleracea var Italica) is one of the possible therapeutic plants that features several nutrients that are high in minerals. This study produced Broccoli ethanol extract and characterized the water, ash, and phytochemical test of simplicia and extract. The mineral content of simplicia, such as calcium, potassium, sodium, and iron, used the flame test Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) method. This method is specifically for analyzing atomic elements or ions, which causes them to be excited and emit light at specific wavelengths. The result of water and ash content of Broccoli simplicia and ethanol extract within a range of values 2-9 – 5.8 %. Positive results for alkaloids, flavonoids, saponins, and tannins in phytochemical tests of simplicia and ethanol extract. The mineral content showed that calcium, potassium, sodium, and iron were 109.52 ± 0.25 mg/100 g, 375.58 ± 0.81 mg/100 g, 9.54 ± 0.092 mg/100 g, and 1.93 ± 0.00 mg/100g, respectively. It was concluded that as a natural ingredient, broccoli contains higher potassium than other minerals, and secondary metabolites in simplex and ethanol extracts have health benefits.
The Catalytic Performance of MnSO4-Doped Natural Zeolite in Ethyl Acetate Synthesis Adelia Natasya Regita Nugroho; Teguh Pambudi; Alfieta Rohmaful Aeni; Retno Utami
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 1 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i1.23

Abstract

Ethyl acetate is a compound that is widely used across various industries. However, its esterification process typically requires a catalyst to improve reaction efficiency. This study focuses on developing a MnSO4-doped natural zeolite catalyst using the impregnation method to enhance its catalytic activity in the esterification of acetic acid and ethanol. The synthesized catalyst was characterized using FTIR, XRD, and SEM-EDS to analyze structural and morphological changes. FTIR characterization revealed the presence of Si-O-Si and Al-O-Si bonds in the 1000 to 1100 cm-1 region, while XRD confirmed that the zeolite with transition metal impregnation shows a decrease in the intensity of the diffraction peak. SEM-EDS analysis demonstrated that the MnSO4-doped natural zeolite exhibited a more uniform morphology, with manganese ions effectively integrated into the surface and pores of the zeolite. Additionally, EDS measurements detected the presence of elements such as Si, O, Al, Na, and Mn, confirming the successful modification of the zeolite to act as a catalyst. Catalytic testing showed that the highest ethyl acetate conversion achieved was 91.27% within 90 minutes, with optimal performance observed at a catalyst mass of 1 g. These findings indicate that modifying zeolite with MnSO4 can significantly enhance catalyst performance in esterification reactions, making it a more efficient and sustainable alternative to conventional catalysts.
Migration of Bisphenol A from Canned Sardines into Food Simulants: Effect of Temperature and Concentration Alfin Ghanesa Putra; Sutanto Sutanto; Muhammad Fathurrahman
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 2 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i2.25

Abstract

Epoxy resin coatings containing Bisphenol A (BPA) are widely used in canned food packaging, including sardine cans. They may pose a risk of chemical migration into food products under specific conditions. This study aimed to evaluate BPA migration into food simulants, acetic acid (1%, 3%, and 10%) and ethanol (10%, 20%, and 50%), at three temperatures (60 °C, 100 °C, and 121 °C). Migration levels were quantified using High-Performance Liquid Chromatography (HPLC) with UV-Vis detection. Preliminary analysis of five sardine can brands revealed BPA concentrations ranging from 0.0052 to 0.0487 mg/kg. Results demonstrated a significant increase in BPA migration with both simulant concentration and temperature. In ethanol, migration increased by 437% when the concentration rose from 10% to 50% at 121 °C, while a 92% increase was observed in acetic acid from 1% to 10% under the same conditions. Temperature had a more pronounced effect: BPA migration in 20% ethanol rose by 3,714% between 60 °C and 121 °C. Migration in 3% acetic acid increased from undetectable to 0.1515 mg/kg across the same temperature range. These findings indicate that BPA migration is significantly influenced by simulant type, concentration, and temperature, underscoring the necessity for stringent control over packaging conditions to ensure food safety.
Analysis of Lead (Pb) In Street Vendors' Urine at Antang Market, Makassar Santi Santi; Lisda Maulina
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 2 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i2.28

Abstract

Lead is a pollutant originating from motor vehicles. As a heavy metal, it is harmful to living organisms and may cause serious health problems. This study aimed to determine the levels of lead (Pb) in the urine of street vendors around the Antang market, Makassar.  This study used an atomic absorption spectrophotometer (AAS) to analyze lead levels in the urine of 10 street vendors who met the study criteria. The results of this study showed that of 10 respondents, 4 had lead levels below the standard threshold, and 6 exceeded it. The highest level was 0.28 mg/L. This suggests that prolonged exposure is associated with higher urinary lead levels.
Silver Nanoparticles in Point-of-Care Diagnostics: Enhancing Sensitivity, Selectivity, and Future Prospects Martina Asti Rahayu
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 2 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i2.29

Abstract

Silver nanoparticles (AgNPs) have emerged as indispensable nanomaterials for point-of-care (POC) medical diagnostics, due to their unique optical, electrical, and chemical properties that enhance sensor sensitivity, selectivity, and stability. This review systematically discusses the fundamental physicochemical characteristics of AgNPs, with emphasis on surface plasmon resonance (SPR) and its role in signal amplification in techniques such as surface-enhanced Raman spectroscopy (SERS), electrochemical biosensors, and immunosensors. Special attention is given to how synthesis strategies, including chemical, physical, and green, affect nanoparticle uniformity, biocompatibility, and functionalization potential. The review also compares surface modification approaches, including polymer coatings for stability, aptamer/antibody conjugation for specificity, and core–shell architectures for fluorescence enhancement, highlighting their impact on biomarker detection in complex biological matrices. By critically analyzing current challenges such as aggregation, oxidation, and nonspecific binding, the paper synthesizes recent advances in antifouling strategies, scalable production, and integration of AgNPs into portable and wearable diagnostic platforms. Unlike previous reviews, this work consolidates developments across synthesis, surface chemistry, and device engineering, and provides a forward-looking perspective on multiparametric and theragnostic applications. Overall, the paper underlines the importance of multidisciplinary collaboration to accelerate the translation of AgNPs-based sensors into clinically viable POC technologies for personalized healthcare and early disease detection.
Anti-cholesterol Activity of Kemuning Leaf Extract (Murraya paniculata (L.) Jack.) Using Different Extraction Methods and Solvents Ardhalya Octarizha; Devy Susanty; Ade Ayu Oksari; Nurlela Nurlela
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 2 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i2.32

Abstract

High cholesterol levels may accumulate in blood vessels, causing blockages. Reducing cholesterol levels using biological materials is an essential area of research currently to minimize the impact of chemical drugs. One of the biological materials with potential as an anti-cholesterol is the Kemuning plant (Murraya paniculata (L.) Jack). This study aims to determine the content of secondary metabolites, total phenolic content, total flavonoid content, and anti-cholesterol activity of Kemuning leaf extract, with variations in extraction methods and solvents. The extraction methods used were ultrasound-assisted extraction (UAE) and maceration. The solvents used in this study had different polarities, namely 96% ethanol, ethyl acetate, and n-hexane. The extract obtained from variations in extraction methods and solvents was tested for phytochemistry, total phenolics, total flavonoids, and in vitro anti-cholesterol activity using the Liebermann-Burchard method. The results showed that Kemuning leaf extract contained secondary metabolite compounds with anti-cholesterol activity. The best extraction method for secondary metabolites was the UAE method using 96% ethanol; however, the best EC50 value was obtained from maceration with ethyl acetate. The total phenolic content of the 96% ethanol extract of Kemuning leaf using the UAE method was 61.48 mg Gallic Acid Equivalent (GAE/g extract), the total flavonoid content was 100.77 mg Quercetin Equivalent (QE/g extract), and the anti-cholesterol activity had an EC₅₀ of 13.03 µg/mL.

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