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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol. 52, No. 2" : 13 Documents clear
Nucleotide variance of mitochondrial dna d-loop 126 bp (nt: 34-159) region in madurese Sulistyorini, Nilly; Yudianto, Ahmad; Margaret, Nola
Folia Medica Indonesiana Vol. 52, No. 2
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Abstract

Endogamy continues to occur among the Madurese people in rural areas of the island of Madura, especially those areas of the smallest islands around the mainland of Madura. Endogamy as seen from a genetic standpoint will increase the frequency of homozygous genotypes. With regard to genetic variations, STRs of nuclear DNA and polymorphisms in mtDNA are frequently examined. Mitochondrial variations in the human undergo an evolutionary process through the accumulation of changes in DNA sequence, i.e. through the process of nucleotide substitutions that evolves in number with the directional development of lineage. So far, the genetic variations among the populations in Madura Island have not been known. The present study was an observational analytical research with the purpose of determining the genetic variations in the polymorphisms of 126-bp mtDNA D-Loop HV2 (nt: 34-159) in the populations of Madura Island. Results indicated that, based on the homology analysis with rCRS sequence, there were 9 variants consisting of two transition mutations, 6 transversion mutations, and one insertion mutation. This indicates that a transversion mutation had a higher probability than transition and insertion mutations. According to Mustama (2007), a gene pool is not only a collection of genes but a dynamic system organized and containing the past history of a population. Any genetic information has certain historical, anthropological and statistical aspects necessitating an interdisciplinary coordination and collaboration.
Language and visuomotor development in children aged 1-3 years in subdistrict bulak, surabaya Susanti, Dwi
Folia Medica Indonesiana Vol. 52, No. 2
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Abstract

Monitoring childhood activities especially for toddlers is important to review because this period is a golden period for chilhood development. The aim of this research to review determine the prevalence of irregularities childhood development for toddler that aged 1-3 years in District of Bulak, Surabaya. This research is a descriptive cross-sectional study. The study subjects were 98 children aged 1-3 Years that obtained by cluster random sampling. The examination conducted using a screening tool prospective development of the Capute scale (CAT test - SHELL). The result, total of value development (FSDQ) average of 97.88 ± 12.26, visuomotor development value (CAT) average 92.58 ± 16.10 while value language development (CLAMS) average 102.67 ± 13.63. Based on FSDQ score, 84.2% of child had > 85 (normal). The remaining 2.1% including developmental disorders had <75 and 13.7% had score 75-85 (suspected). So, the prevalence of irregularities childhood development for toddlers that aged 1-3 years in District of Bulak around 15.8%.
Review article: does intra-arterial heparin flushing (iahf) can actually increase manual muscle test (mmt) score in chronic ischemic stroke patients? Machfoed, Moh Hasan; Kurniawan, Mohammad; Usman, Fritz Sumantri
Folia Medica Indonesiana Vol. 52, No. 2
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Stroke is still a major health problem in the world. Ischemic stroke accounts for 87% of all acute stroke occurrences. In 2013, the American Heart Association (AHA)/American Stroke Association (ASA), published a Guideline for the Early Management of Patients with Acute Ischemic Stroke. The managements consist of the use of recombinant tissue plasminogen activator (rtPA), endovascular treatment, etc. Unlike acute ischemic stroke, until now, no guidelines have been provided about the management of chronic ischemic stroke that approved universally. The result of the study with the title of "Intra Arterial Heparin Flushing Increases Manual Muscle Test – Medical Research Councils (MMT-MRC) Score in Chronic Ischemic Stroke Patient” is very interesting, because it is a new attempt to treat patients with chronic ischemic stroke. The purpose of this article is to review the study mentioned above, in accordance with the applied scientific principles and is based on the standard literatures and guidelines. Our review is limited only to the discussion of the study results. From this discussion can be proved the existing references that support and/or refuse the study results. Based on the discussions and conclusions of this study, there were no references to support that IAHF can improve motor functions (muscles) in patients with chronic ischemic stroke.
High blood glucose level increase cardiovascular disease risk in type 2 diabetes mellitus Marchelia, Laili Zahrina; Purwati, Purwati; Wironegoro, Rio
Folia Medica Indonesiana Vol. 52, No. 2
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Abstract

Type 2 diabetes mellitus (DM) is the 10th leading cause of death in the world and had a risk 4.06 times greater to have cardiovascular disease (CVD). Fasting plasma glucose and 2-hours postprandial glucose level as diagnostic tests to evaluate DM and also as a predictive factors to CVD. This research uses descriptive analytic research with cross sectional design. The subject of this study is Type 2 DM patients came to Dr Soetomo hospital from January-October 2014. Data was recorded from medical records of patients and was analyzed with Chi Square test with p<0.05. As result, there is 102 Type 2 DM patients with 36 patients have CVD manifestation and 66 patients without complication. There is a significant association between fasting plasma glucose (FPG), 2-hours postprandial glucose (2hPPG) level, and CVD manifestation (p=0.00). So FPG and 2hPPG have a significant association with CVD manifestation. There are other factors that influencing the formation of CVD, hence, further research is needed.
Case report: endovascular stenting in peripheral arterial disease of lower extremity Oktaviono, Yudi Her
Folia Medica Indonesiana Vol. 52, No. 2
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Abstract

Peripheral arterial disease (PAD) is usually caused by multilevel atherosclerotic disease, typically in patients with a history of cigarette smoking, diabetes mellitus, or both. Intermittent claudication (IC), an early manifestation of PAD, commonly leads to reduced quality of life for patients who are limited in their ambulation. Percutaneous intervention for peripheral artery disease has evolved from balloon angioplasty for simple focal lesions to multimodality techniques that enable treatment of severe arterial insufficiency. Especially for high-grade stenoses or short arterial occlusions, percutaneous transluminal angioplasty (PTA) should be the method of first choice followed by the best surgical procedure later on. To achieve good long-term efficacy, a close follow-up including objective tests of both the arterial lesion and hemodynamic status, surveillance of secondary preventive measures and risk factor control is mandatory.
Neurogenic modulation by neurokinin-1 receptor antagonist, cp-96,345 to inhibit rheumatoid arthritis development in adjuvant induced arthritis rat model Wirasasmita, Yuyun; Rahmadi, Mahardian; Susilo, Imam; Khotib, Junaidi
Folia Medica Indonesiana Vol. 52, No. 2
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Abstract

Rheumatoid arthritis (RA) is a chronic form of persistent inflammation. Meanwhile, Substance P is the most associated neuropeptide in neurogenic inflammation and hyperalgesia commonly found in chronic pain. Substance P act by binding to neurokinin-1 receptor. The present study was conducted to evaluate the effect of neurokinin-1 receptor antagonist (CP-96,345) on Adjuvant Induced Arthritis rat model, induced by Complete Freund's Adjuvant (CFA). The objective is to attenuate neurogenic inflammation which in turn will increase the latency time of hyperalgesia response, decreases neurokinin-1 receptor expression, and inhibits the development of RA in AIA rat model. Rats were intra-articularly injected with CFA 1 hour after the administration of CP-96,345 either by 0.63 µg/gr; 1.25 µg/gr; or 2.5 µg/gr also intra-articularly. Caliper measurements and hot-plate test were performed on day 0, 3, 5, 7, 9, 11, and day 13. Expression of neurokinin-1 receptor in joint tissue were evaluated by immunohistochemistry, and RA progress in joint tissue were observed hystopathologically. CP-96,345 at 2.5 µg/gr significantly increases the latency of hyperalgesia response time on CFA induced rats (p=0.044) and decreased the neurokinin-1 receptor expression in joint tissue (p=0.029) compared to CFA induced rats. There was no significant difference for caliper measurements and RA progress between CFA incduced rats and treated group. Conclusively, CP-96,345 increases the latency of hyperalgesia response time and decreases the NK-1 receptor expression in rat joint but could not inhibit RA progression.
Correlation between coping mechanism and safety behavior in construction workers of fabrication division in a steel construction company Widajati, Noeroel; Martiana, Tri; Mulyono, Mulyono
Folia Medica Indonesiana Vol. 52, No. 2
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Abstract

Unsafe act become the most cause of accidents. One of human factors causing accidents is work stress. The aim of this study was to analyze correlation between coping mechanism and safety behavior at workers of fabrication division in a steel construction company. The study was carried out with cross-sectional analytical observational methods. The study population was 200 workers of fabrication division in a steel construction company. By using simple random sampling method, the number of samples was 134 respondents. Data collection was performed by observation, interviews, and questionnaires. The independent variables were age, education level, K3 experience, coping mechanism, emotional focused coping, and problem focused coping, while the dependent variable was safety behavior. Intervariables correlation were tested by Chi-square test (α=0.05). Correlation between age and safety behavior was categorized on relation (p=0.016; r=0.301). Correlation between education level and safety behavior was not categorized on relation (p=0.260; r=0.315). Correlation between tenure and safety behavior was categorized on relation (p=0.001; r=0.422). Correlation between coping mechanism and safety behavior was not categorized on relation (p=1.0; r=0.015). The conclusion was age and tenure have unidirectional and strong relation with safety behavior, while the level of education and coping mechanism have no relation with safety behavior. Company should have given understanding to workers about safety behavior through K3 training and safety talk and held safety inspection and or safety patrol to supervise workers.
Analysis of antibiotics use in pediatric pneumonia patients aged 3 months - 5 years Aryani, Dhita Evi; Hasmono, Didik; Zairina, Nun; Setiawan, Landia
Folia Medica Indonesiana Vol. 52, No. 2
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Abstract

Pneumonia is an infectious disease that causes acute inflammation of the lung parenchyma and compaction exudate in the lung tissue. In addition to causing significant morbidity and mortality, pneumonia is also difficult to diagnose, treatments are less precise and less taken seriously. Pneumonia caused the death of 14% of children under five in Indonesia, with a mortality rate of 83 children per day. The difficulty of diagnosis, the selection of a less appropriate antibiotics, side effects, differences in pharmacokinetics and pharmacodynamics of the drug in infants and antibiotics resistance is to be a problem in itself. Therefore it is necessary to study the analysis of the use of antibiotics in patients with pneumonia of children aged 3 months till 5 years. The aim of this research to analyze antibiotics therapy in patients with pneumonia of children aged 3 months till 5 years. Method: an observational cohort analysis was carried out in the Pediatrics Respirology Division Dr. Soetomo Hospital Surabaya. Data was collected from February to May 2014. Patients who met the inclusion criteria were observed prospectively and the quantity and quality of antibiotics usage assessed with Gyssens category. Result: from February to May 2014 period, prospectively, the antibiotics usage quantitative evaluation used DDD/patient days shows that ampicillin 34.39DDD/100 patient days. Qualitative evaluation using Gyssens category on 75 antibiotics therapy shows that 32% considered appropriate. So, this study showed that ampicillin is most widely and qualitative analysis, only 32% of rational use of antibiotics.
The potency of alpha lipoic acid as anti inflammatory on the complete freund's adjuvant-induced rheumatoid arthritis in rat model Megawati, Selvi; Rahmadi, Mahardian; Susilo, Imam; Khotib, Junaidi
Folia Medica Indonesiana Vol. 52, No. 2
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Abstract

Rheumatoid arthritis (RA) is an autoimmune diseases which is characterized by chronic inflammation of the synovial tissue in joints. This research was designed to investigate the effect of alpha lipoic acid as antioxidant on rats with complete freund's adjuvant (CFA)-induced RA by intra articular injection of complete freund's adjuvant (CFA). ALA was administered orally once a day for 7 days at 30, 60 and 120 mg doses a week after CFA injection. The severity of arthritis was evaluated by joint diameter and latency time on thermal stimulation. Joint diameter and latency time on thermal stimulation will measured on day 0, 3, 5, 7, 10, 12 and 14. Measurement of malondialdehyde (MDA) level in plasma was performed using thiobarbituric acid (TBA) method to assess lipid peroxidation. Histology of joint was examined by microscope following hematoxylin-eosin staining. The result showed that treatment with ALA at 30 mg and 60 mg significantly decreased the joint diameter compared to CFA group (p=0.003; p=0.001 respectively) and rat's latency time on thermal stimulation was also significantly increased compared to CFA group (p=0.015; p=0.026 respectively). Measurement of MDA in CFA group and ALA group had no significant difference. Histological staining indicated that the recovery of the synovial membranes of joint in ALA group had no effect. Results indicated that ALA has the effect to suppress the development of inflammation in RA but not through oxidative stress pathway.
Early outcome of adult cardial surgery in low volume community hospital experiences of young surgeon from developing country Sembiring, Yan Efrata
Folia Medica Indonesiana Vol. 52, No. 2
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After finishing training, every young cardiac surgeon wants to start a good carrier as fast as they can. We describe the early outcome of adult cardiac surgery that have been done by a young in low volume community hospital in Surabaya – Indonesia within periods December 2010 – December 2013. A retrospective study of 133 adult cardiac cases during December 2010 – December 2013 at Division of Thoracic, Cardiac and Vascular Surgery Dr. Soetomo Hospital Surabaya provides a comprehensive data concerning adult cardiac procedures which collected and analyzed. In last 3 years, the total number of adult cardiac disease which is undergone a surgery was 133 cases. The procedures were involved CABG (85 cases, 63.91%); valve procedures (7 cases, 5.26%); and others procedures (6 cases, 4.51%). All cases were done by a young surgeon. Thirty day early follow up, there were 3 patients suffered from wound infection, 7 patients undergone re-do procedures due to mediastinal bleeding and cardiac tamponade. Mortality rate was 1.5%. The conclusion, good mentoring from senior surgeon and good training give a good result of adult surgery done by a young surgeon in low volume community hospital.

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