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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol. 55, No. 1" : 15 Documents clear
Thrombocytopenia in a Patient Undergoing Primary Percutaneous Coronary Intervention Oktaviono, Yudi Her; Meuthia, Feranti
Folia Medica Indonesiana Vol. 55, No. 1
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Thrombocytopenia is a common abnormality in patients presenting with acute coronary syndrome. Baseline thrombocytopenia in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention is associated with early adverse events, related to both ischemia and bleeding. Treatment for acute coronary syndrome usually involves antiplatelet, anticoagulant, antithrombotic therapy, and the performance of percutaneous coronary intervention. The safety of antiplatelet therapy and percutaneous coronary intervention patients who have acute coronary syndrome and thrombocytopenia is unknown, and there are no guidelines or randomized studies that specifically suggest a treatment approach in such patients. One of the institutions in Italy recommends medical and interventional strategy with radialis as first choice for access site, bare metal stent (BMS) implantation, followed by double antiplatelet therapy (DAPT) for one month. After DAPT discontinuation, at least one antiplatelet drug (aspirin) is recommended for life.
Blowout Fracture Complex Type Helmi, Fauzi; Santoso, Boedy Setya
Folia Medica Indonesiana Vol. 55, No. 1
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Functional problems and appearance may emerge if careful therapy is not applied in orbital fracture caused by maxillofacial trauma. Recently, the focus of fracture management on fragment fixation most possibly uses anatomy approach. The management of blowout fracture should be overcome by involving several departments. First, identification was carried out in emergency room and then it is consulted to occuloplasty and maxillofacial trauma surgeon. Multidisciplinary management will provide better outcome to retrieve face structural function and improve the appearance. We reported two cases of blowout fracture complex in Dr. Soetomo Hospital, Surabaya, Indonesia, done by Plastic Reconstruction Division of ORL-HNS Department in collaboration with Plastic Reconstruction Division of Ophthalmology Department. In the first case, a 64-year-old female was consulted by Plastic Reconstruction Division of Ophthalmology Department with diagnosis of right orbital adnexal injury, open eye globe injury, scleral laceration, and blowout fracture. In the second case, a 37-year-old male came to Plastic Reconstruction Division of ORL HNS Department, consulted by Plastic Reconstruction of Ophthalmology Department with diagnosis of left cornea and scleral laceration, left full thickness laceration palpebral at 1/3 nasal inferior, rupture of lacrimal canal, and blowout fracture. These cases of blowout fracture with rim orbita fracture complex type were managed well by Plastic Reconstruction Division of ORL-HNS and Plastic Reconstruction Division of Ophthalmology Department. It is apparent that multidisciplinary management was required for optimum outcome.
Incidence of Emergence Agitation in Pediatric Patient after General Anesthesia Andriyanto, Lucky; Utariani, Arie; Hanindito, Elizeus; Santoso, Kohar Hari Santoso Hari; Hamzah, Hamzah; Puspita, Eka Ari
Folia Medica Indonesiana Vol. 55, No. 1
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Post anesthesia agitation is common problem in pediatric post anesthesia care unit. The incidences range from 10 to 80%. EA has been described as a dissociated state of consciousness in which the child is inconsolable, irritable, and uncooperative typically thrashing, crying, moaning or incoherent. This study was done to determine the incidence of emergence agitation and associated risk factors in pediatric patients who underwent general anesthesia. This descriptive and analytic study was performed on 105 pediatric patient aged 1-12 years that underwent general anesthesia for various elective diagnostic and surgeries at Dr. Soetomo Hospital between January and February 2016. The presence of emergence agitation was recorded using Pediatric Anesthesia Emergence Delirium (PAED) scale. The factors that linked with Emergence Agitation were recorded in a questionnaire. The data were analyzed using SPSS software with logistic regression. p - values less than 0.05 were considered as significant. Forty two (40%) children had Emergence Agitation. Preoperative anxiety (p = 0.006) and Pain (p=0.035) were associated with higher rates of post anesthetic emergence agitation. This study identified preoperative anxiety and pain as risk factors, which are associated with emergence agitation in children. To minimize the incidence of post anesthetic emergence agitation, these risk factors should be considered in the routine care by anesthetist.
Back Matter Vol. 55, No. 1 March (2019) Matter, Back
Folia Medica Indonesiana Vol. 55, No. 1
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Emulgel Formulation of Purified Extract of Moringa (Moringa oleifera L.) Leaf Wuryandari, Tutik; Sugihartini, Nining; Kintoko, Kintoko
Folia Medica Indonesiana Vol. 55, No. 1
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Moringa oleifera, known as moringa, is reported to have a high source of natural antioxidants, especially vitamin E. The formulation of purified Moringa leaf extract is needed so that the vitamin E content in it is more maximal. This study aimed to determine the levels of vitamin E in extracts after purification, physical property test of emulgel with variations in extract concentration and vitamin E levels in emulsions. The study was started from the extraction using maceration method with petroleum ether solvent, followed by extract purification using column chromatography with n-hexane solvent. The results of the purified extract were then formulated into emulgel with three concentrations of 3% (F1), 6% (F2) and 9% (F3). Emulgel was then evaluated for physical characteristics (pH, viscosity, adhesion, dispersion and stability). Determination of vitamin E levels was carried out on purified extract samples and on each formula. The results of non-specific standardization of extracts included ash content, acidic insoluble ash content were higher than those of Indonesian Herbal Pharmacopoeia literature and drying losses were lower compared to literature. Specific standardization of extracts was the content of vitamin E in 1.40% PE extract and 8.02% purified extract. In the test of emulgel physical characteristics, an increase in the concentration of the extract caused an increase in viscosity and decreased emulgel dispersion power. Whereas, tthe pH and sticky power remained the same. Storage hds an effect on decreasing the physical characteristics of emulsions especially on adhesion. Increased extracts also caused an increase in the levels of vitamin E in the purified extract of moringa leaf emulgel.
Correlation between the Bacteriostatic and Bactericide Effect with Antibiofilm and Anticolony Spreading from Javanese Citronella Oil on Methicillin-Resistant Staphylococcus aureus (MRSA) Hidayah, Amaliyah Nurul; Wasito, Eddy Bagus; Debora, Kartuti; Basori, Achmad; Isnaeni, Isnaeni; Utomo, Budi
Folia Medica Indonesiana Vol. 55, No. 1
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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium that has been resistant to various types of antibiotics, so it is not easy to be treated with antibiotics and needs other solutions. Javanese citronella oil distilled from the Cymbopogon nardus plant is proven to function as an antibacterial agent (bacteriostatic and bactericidal), fungicide and repellent. This study aimed to prove that there is a positive correlation between bacteriostatic and bactericidal effects with antibiofilm and anticolony spreading from Javanese citronella oil on MRSA. The intended antibiofilm is a barrier to biofilm formation and eradication. Bacteriostatic and antibiofilm effects were tested using microtiter plates assay, bactericidal effect test with subculture into the media and anticolony spreading effect test with spot inoculation in Tryptic Soy Broth media supplemented with 0.24% agar. The bacteriostatic effect test data were analyzed using paired t-test, bactericidal effect using the Friedman test, antibiofilm effect test using Kruskall-Wallis and the results of all the tests correlated using Pearson and Spearman correlation. The statistical significance used was p<0.05. The results showed that Javanese citronella oil had a bacteriostatic concentration of 0.02% (v/v) and bactericidal concentration of 0.78% (v/v). The Pearson correlation test showed that there was a negative correlation between bacteriostatic and bactericidal effects on biofilm formation with r = -0.956 (p = 0.000), but the correlation was positive for biofilm eradication with r = 0.918 (p = 0.000) and anticolony spreading with r = 1.000 (p = 0.000).
The Effect of Hypercholesterolemia on Cortical Bone Thickness of Wistar Rats (Rattus norvegicus) Sofka, Auliya Dzaqiyatus; Lestari, Pudji; Sari, Gadis Meinar
Folia Medica Indonesiana Vol. 55, No. 1
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Abstract

There have been several studies reporting the effect of hypercholesterolemia on cortical thickness, but it remains a controversy. Some studies suggest that hypercholesterolemia can decrease osteoblast activity and increase osteoclast activity. Meanwhile other studies suggest that hypercholesterolemia is a protective factor of osteoporosis. Therefore, it is necessary to conduct a study to determine the effect of hypercholesterolemia on cortical bone thickness. Method: This study used 8 rats (Rattus norvegicus) that were divided into 2 groups, including control group (K0) that was given standard diet and experimental group (K1) that was given high fat diet for 28 days and all were executed to obtain the femur bone. The cortical bone thickness was measured by using Optilab Viewer and Optilab Image Raster software. Result: The data analysis was conducted using independent t-test. A p value of <0.05 is considered significant. The results showed that hypercholesterolemia had significant effect on cortical bone thickness. The average cortical bone thickness in the control group was 146.92 µm whereas in the experimental group was 124.53 µm, the mean difference between the two groups was 22.39 µm. There was a 6% decrease of cortical bone thickness. In conclusion, hypercholesterolemia can decrease cortical bone thickness of wistar rats (Rattus norvegicus).
Front Matter Vol. 55, No. 1 March (2019) Matter, Front
Folia Medica Indonesiana Vol. 55, No. 1
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Microbiological Assessment of Fresh Expressed Breast Milk on Room Temperature at Dr. Soetomo Hospital Neonatal Unit Widjaja, Nur Aisyah; Hardiyani, Kartika; Hanindita, Meta Herdiana; Irawan, Roedi
Folia Medica Indonesiana Vol. 55, No. 1
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Abstract

Storing EBM at room temperature in several hours before consuming, frequently found in Indonesia. Based on Academy of Breastfeeding Medicine guidelines EBM can last for 6 to 8 hours in room temperature (25oC or 77oF). However, currently there hasn't been study in tropical country especially Indonesia for the guidelines. This study aimed to assess microbiological quality of EBM on room temperature, including bacterial growth and major bacterial found on EBM for health care and society recommendations. An observational study of 30 expressed breast milk samples provided by 30 healthy women with term baby below 6 month old. The samples were kept sterile and laid at plates for 0 hours, 2 hours, 4 hours and 6 hours in room temperature (26°-32° C) and used drop plate technique on several culture media. Data was analyzed by Chi-square and paired sample T-test. Thirty of unheated fresh EBM from 30 lactating mothers were stored at room temperature, examined for the degree of bacterial contamination at 0 hour, 2 hours, 4 hours, and 6 hours. All the EBM samples were contaminated at 2 hour. Bacterial species identified was Coagulase-negative Staphylococcus (CNS), Escherichia coli, Klebsiella pneumoniae and Streptococcus faecalis, range of growth 109 cfu/ml-63 x 109 cfu/mm3 after 6 hour of storage. The EBM exposed at room temperature (30-36 0C) for more than two hour reduce the quality and do not recommended to be given to the infants.
Disease Free Survival of Stage I Endometrial Cancer after Surgery with or without Adjuvant Treatment Moradokkasem, Woraluk; Saeaib, Nungrutai; Liabsuetrakul, Tippawan
Folia Medica Indonesiana Vol. 55, No. 1
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This study aimed to define the disease free survival (DFS) and factors associated with recurrence in stage I endometrial cancer after surgery with and without adjuvant treatment. The demographic data, pathological results, adjuvant treatment (AT) and the outcome of patients with endometrial cancer stage I after surgery in Songklanagarind Hospital between January 2002 and July 2014 were collected. The DFS was analyzed by survival analysis and represented by Kaplan–Meier curves. The difference of DFS between AT and non-adjuvant treatment (NAT) groups was tested by the log-rank test. Distributions of risk factors by AT and recurrent status were analyzed using chi-square or Fisher exact tests for discrete factors, and unpaired t or Wilcoxon rank-sum tests for continuous factors. The 5-year DFS was; 91.6%, from a total of 268 patients. DFS in the NAT group was significantly better than that in the AT group (95.2 versus 86.5%, p-value = 0.01). Factors associated with recurrence in the NAT group were age, tumor grading, tumor size, and presence of lymphovascular involvement. Among the AT group, age and ratio of myometrial invasion were associated with recurrence. DFS in NAT was better than in AT and the potential factors associated with recurrence, after surgery with or without AT, were not the same.

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