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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 17 Documents
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Search results for , issue "Vol. 59, No. 2" : 17 Documents clear
Maternal Deaths caused by COVID-19 Infection in the First Year of the Pandemic Wave Akbar, Muhammad Ilham Aldika; Mulawardhana, Pungky; Wardhana, Manggala Pasca; Gumilar, Khanisyah Erza; Raheestyningtyas, Ecccita; Laksana, Muhammad Ardian Cahya; Anas, Jimmy Yanuar; , Ernawati; Joewono, Hermanto Tri; Bachnas, Muhammad Adrianes; Tjokroprawiro, Brahmana Askandar
Folia Medica Indonesiana Vol. 59, No. 2
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Highlights: • These cases of maternal deaths caused by COVID-19 infections illustrated the significant risk factors for maternal mortality during the early phases of the pandemic, while studies had not extensively reported this. • COVID-19 infections increase the risk of maternal and neonatal mortality, with infants having a lower chance of survival even if they are delivered. • Respiratory support, antiviral medications, antibiotics, anticoagulants, and supportive care are the primary treatments for severe COVID-19 in pregnancy. Abstract This article presents seven cases of maternal deaths attributed to COVID-19 during the first year of the pandemic wave. These cases provide insights into the natural progression of COVID-19 in pregnant women who were not vaccinated. This study showed that COVID-19 significantly increased maternal and neonatal mortality and morbidity. All of the patients exhibited symptoms of fever, cough, and dyspnea upon admission to the hospital. They were admitted with elevated respiratory rates (26–32 times/minute) and low oxygen saturation (<95%). Four patients had obesity, while one patient had pregestational diabetes. The COVID-19 diagnosis was established using a rapid antibody or antigen test and chest X-ray, which indicated pneumonia. Medical interventions administered to the patients included antiviral therapy (5 patients), antibiotics (6 patients), and anticoagulants (4 patients). From a total of five babies delivered, four babies were delivered via cesarean section. Two babies were not delivered due to previability and maternal deaths before delivery. The patients passed away within 3–10 days of hospital admission. In conclusion, adequate and early intervention and management of pregnant women infected with COVID-19 are crucial in preventing maternal and neonatal deaths, especially in unvaccinated women.
Improvement of Cadres' Skills and Knowledge to Provide Comprehensive Health Services for the Elderly Djuari, Lilik; Dewanti, Linda; , Sulistiawati; Brilianti, Natasya Nurvita; Nurdiansyah, Farhan; Prajitno, Subur
Folia Medica Indonesiana Vol. 59, No. 2
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Highlights: Due to the increasing elderly population in Indonesia, this study must address the knowledge and skill gaps among health cadres in a number of Integrated Health Posts for the Elderly (Pos Layanan Terpadu Lanjut Usia/ Posyandu Lansia). Through this study, the health cadres increased their knowledge and skills, enabling them to provide comprehensive health services for the elderly. Abstract Numerous issues have arisen as a result of the large size and rapid growth of the elderly population, attesting to the need for serious efforts from all sectors to enhance their welfare. However, the health cadres at the Integrated Health Post for the Elderly (Pos Layanan Terpadu Lanjut Usia/ Posyandu Lansia) lacked the training that would have equipped them with the necessary knowledge and skills to carry out their duties. This study aimed to evaluate the significance of training for enhancing the cadres' knowledge and skills in providing comprehensive health services for the elderly. This study was quasi-experimental research with a pre-test and post-test design. The data analysis was performed using the Shapiro-Wilk test (p>0.05) and the Wilcoxon test (p<0.05). A total of 30 health cadres at Songgon Community Health Center were measured for their levels of knowledge and skills before and after the training. The training included filling out health evaluation charts, providing leaflets containing health counseling materials for the elderly, practicing exercise for the elderly, and singing an elderly marching song. Before filling out the health evaluation chart, the cadres had to measure the elderly's degree of independence as well as their mental, emotional, and nutritional status. The cadres also had to measure the weight, height, and blood pressure of the elderly. Prior to training, the cadres' knowledge of hospitalization referrals, independence, and physical exercise for the elderly was limited. The cadres' skills in filling out health evaluation charts, assessing mental, emotional, and nutritional status, measuring blood pressure, and instructing physical exercise were also inadequate. There was a significant difference in the knowledge and skills of the health cadres before and after training (p<0.05). In conclusion, there was an improvement in the health cadres' knowledge and skills regarding comprehensive health services for the elderly at the Posyandu Lansia.
Calciferol Status and Clinical Outcomes in Children with Congenital Heart Disease after Heart Surgery Effendy, Zulham; Rahayuningsih, Tri Yanti; Razi, Fachrul; Kurniawan, Hendra; , Azmi; Marzuki, Farhan; , Herdianta; Pratama, Rovy
Folia Medica Indonesiana Vol. 59, No. 2
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Highlights: Calciferol has cardioprotective properties, and a severe deficiency of calciferol is associated with septic shock, a longer duration of mechanical ventilation and treatment in the intensive care unit, and mortality. The role of calciferol in critical conditions has been described in several research reports, but relatively little is known about its function in pediatric cardiac surgery. Abstract Calciferol is a micronutrient and a secosteroid hormone that plays a role in maintaining the health of bones and soft tissues in the body, such as the myocardium, as well as the immune system. Hypovitaminosis D has been reported to be associated with poor clinical outcomes and child mortality in pediatric intensive care units. Children with congenital heart disease (CHD) are vulnerable to critical conditions and require early intervention due to heart failure. This study aimed to investigate the influence of calciferol status on the clinical outcomes of pediatric CHD patients who underwent heart surgery. A systematic literature review was conducted using the electronic databases from PubMed, Elsevier, and Cochrane. This study included observational and randomized control studies that assessed the calciferol status of pediatric CHD patients undergoing cardiac surgery. From a total of 168 studies, 8 studies were selected for review. The preoperative and postoperative calciferol status as well as clinical outcomes following pediatric cardiac surgery were reviewed. According to the findings, most pediatric CHD patients suffered from calciferol deficiency prior to corrective heart surgery, which further decreased postoperatively and was associated with clinical outcomes in the intensive care unit (ICU). Preoperative calciferol supplementation has been reported to enhance serum calciferol levels and is associated with good clinical outcomes in pediatric patients undergoing cardiac surgery.
Detection of Knockdown-Resistance Homozygous Mutant C1534C using Allele-Specific Polymerase Chain Reaction in Aedes Albopictus and Aedes Aegypti Fadila, Syananda Zahra; Setiawan, Ahmad Rudi; Fauziyah, Shifa; Madaniyah, Safira; Dewi, Eryantika Cipta; Naw, Sin War; Cahyaningrum, Sari Edi; , Tukiran; Sucipto, Teguh Hari
Folia Medica Indonesiana Vol. 59, No. 2
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Highlights: • This research analyzed a previously understudied subject in Surabaya, Indonesia, and discovered knockdown resistance (kdr) mutations in Aedes albopictus. • The findings of this study can prompt further research, including bioassay testing and the development of more potent insecticides. Abstarct : Dengue hemorrhagic fever (DHF) has been endemic in Indonesia for decades. Insecticides are necessary to manage the transmission of the dengue virus. However, prolonged use of insecticides can lead to insecticide resistance. This study aimed to examine the genotype of mosquitoes using the allele-specific polymerase chain reaction (ASPCR) method. The ASPCR method was chosen for genotype detection due to its high sensitivity, affordability, and ease of design. Five mosquitoes were collected from human habitation in four different areas of Surabaya, Indonesia, namely Kranggan, Ulul Azmi Mosque, Ploso, and Kalijudan. Among them, three samples were identified as Aedes albopictus (A1, A2, and A5) and two samples were identified as Aedes aegypti (A3 and A4). The frequency of resistant alleles was analyzed using the Hardy-Weinberg package in RStudio version 2023.03.1. This study revealed that two mosquitoes carried homozygous mutant alleles with a band of 113 bp and three mosquitoes carried homozygous wild-type alleles with a band of 93 bp. Cysteine-to-cysteine (C/C) mutations and phenylalanine-to-phenylalanine (F/F) mutations at codon 1534 were observed in Aedes aegypti and Aedes albopictus mosquitoes. The homozygous mutant alleles were found in Kranggan, Surabaya, Indonesia. Further research is required to assess insecticide resistance and knockdown resistance (kdr)-like mutation by collecting more representative samples from larger areas within the region of Surabaya. Nevertheless, this study can be used as a reference for vector control and early prevention of dengue fever.
The Effect of Cabbage (Brassica oleracea var. capitata L.) Extract on Macrophage and Blood Vessel Counts in Clean Wound Tissue of Male Rats (Rattus norvegicus) Tsania, Nidya Ulfana; Sandhika, Willy; , Sawitri
Folia Medica Indonesiana Vol. 59, No. 2
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Highlights : • Cabbage extract application accelerates wound healing and has anti-inflammatory effect. • Cabbage extract serves as an affordable source material for wound healing and anti-inflammation. Abstract Cabbage is a widely consumed vegetable known for its health benefits due to its rich nutrients and phytochemicals, especially phenolic compounds, which are known to have potent anti-inflammatory and antioxidant effects. This study aimed to investigate the effects of cabbage extract on wound healing by observing inflammatory responses in wound tissue. A total of 24 male rats were divided into four groups, with six rats in each group. The experiment was conducted for five days by administering cabbage extract to the treatment group and distilled water to the control group. Skin wound tissues were collected from all rats for histological observation by counting the number of macrophages and blood vessels. The results of the observation were analyzed statistically using an independent sample t-test with p<0.05. The results showed that the number of macrophages and blood vessels in the treatment group was significantly higher than the control group on the third day and significantly lower on the fifth day. In conclusion, the administration of cabbage extract can accelerate the inflammatory and proliferative phases of wound healing by promoting the migration of cells, including macrophages, resulting in accelerated angiogenesis. In addition, the decreased number of macrophages and blood vessels during the proliferative phase showed that the healing phase had reached a more advanced stage.
Stress Levels and Seborrheic Dermatitis in the Class of 2020 Medical Students at a University in Indonesia , Eldy; Darmawan, Hari
Folia Medica Indonesiana Vol. 59, No. 2
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Highlights: 1. This research investigated a previously unexplored relationship between stress levels and seborrheic dermatitis in Indonesia. 2. It has been shown that a significant proportion of medical students are susceptible to sleep problems, which can negatively impact their academic performance and mental health. 3. This recent study found that seborrheic dermatitis affects men on average more frequently than women. Abstract : Seborrheic dermatitis is a common skin disease in the form of superficial inflammation with a papulosquamous morphology that often occurs in sebaceous gland-rich areas. Emotional stress is one of the contributing factors to the susceptibility of individuals to seborrheic dermatitis, while lack of sleep is associated with its exacerbation. This study aims to investigate the relationship between stress levels and seborrheic dermatitis cases among the class of 2020 students at the Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia. This study used an analytical-observational approach with a cross-sectional design. The sampling technique used was simple random sampling. The samples were from 114 medical students from the class of 2020 at Universitas Tarumanagara. The data were collected using an online Google Forms questionnaire and a dermatological assessment. The data were analyzed through statistical software, IBM SPSS Statistics for Windows, version 26.0 (IBM Corp., Armonk, N.Y., USA), using the Chi-square hypothesis test. The results showed a significant relationship between sex and seborrheic dermatitis cases (p=0.000). However, there was no significant relationship between stress levels and seborrheic dermatitis cases among the respondents (p=0.591). In conclusion, factors other than stress levels might contribute to the development or exacerbation of seborrheic dermatitis among the participants. Further research is needed to explore the potential underlying mechanisms and additional factors influencing the development and progression of seborrheic dermatitis.
Clinical Profiles and Il-6 Level Analysis of Critical Covid-19 Patients Receiving Lopinavir-Ritonavir Triyono, Erwin Astha; Rehatta, Nancy Margarita; , Nabilah; Tan, Feriawan
Folia Medica Indonesiana Vol. 59, No. 2
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Highlights: 1. Lymphocyte, procalcitonin, D-dimer and high IL-6 levels in COVID-19 patients are associated with a poor prognosis. 2. IL-6 serial measurement for COVID-19 patients may be a potential indicator for evaluating the severity and patient outcome. Abstract The COVID-19 pandemic has affected over 760 million individuals worldwide, resulting in more than 6.8 million reported deaths. Early detection of patient deterioration can assist in predicting outcomes and prioritizing healthcare services based on evidence-based indicators. Interleukin-6 (IL-6) is a cytokine that plays a role in the inflammatory process, making it a potential parameter for assessing a patient's inflammatory state. This study aimed to analyze the characteristics, laboratory profiles, and IL-6 levels of COVID-19 patients. This study used a retrospective cohort study design with medical record data. The characteristics (n=68) and IL-6 levels (n=52) of the patients on the first, third, and sixth days of treatment were recorded consecutively. The mean age of the patients was 49 years, with the majority being male (72%) and the most prevalent comorbidity being hypertension (29%). The average duration of hospitalization was 10.94 days. Shortness of breath was the most commonly reported symptom (45.6%). The medians of neutrophil-lymphocyte ratio, C-reactive protein, procalcitonin, ferritin, and D-dimer were above normal. Significant differences were observed in lymphocytes (p=0.046), procalcitonin (p=0.023), and D-dimer (p=0.000) between survivor and non-survivor patients. Significant dynamic changes in IL-6 levels were observed from the first day to the sixth day (p=0.014) and from the third day to the sixth day (p=0.041). In conclusion, risk stratification, laboratory profiles, and IL-6 levels play a role in assessing the severity and outcomes of COVID-19 patients.

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