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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Back Matter Vol.59 No.1 [3/2023] Indonesiana, Folia Medica
Folia Medica Indonesiana Vol. 59, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Effects of Sambiloto Ethanol Extract on Fatty Liver, SGOT/SGPT Levels and Lipid Profile of Wistar Strain White Rat (Rattus norvegicus) Exposed to High-Fat Diet Jong, FX Himawan Haryanto; Gunawan, Ari; Santoso, Mochamad Wirono Aman; Anjani, Susilowati; Tirthaningsih, Ni Wayan; Basori, Ahmad
Folia Medica Indonesiana Vol. 54, No. 2
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Abstract

The aim of this study was to analyze the effects of ethanol extract of sambiloto (Andrographis paniculata) on fatty liver percentage, serum glutamic oxaloacetic transaminase (SGOT) level and lipid profile of wistar strain white rat exposed to high fat diet. The study used randomized post test only control group design. Total sample was 50 male wistar strain rats (Rattus norvegicus) divided randomly into 5 groups (randomization). The normality test used was Kolmogorov Smirnov test (a=0.05). The homogeneity test used was Levene test (a=0.05). The comparative test was done using Anova test (analysis of variance) (a=0.05) or Brown-Forsythe test (a=0.05). The correlation test was done using Pearson test (a=0.05). The administration of sambiloto ethanol extract with doses of 100, 200 and 400 milligrams (mg)/kilogram (kg) body weight (BW) decreased the percentage of fatty liver (r=-0.950), SGOT (r=-0.964)/SGPT (r=(R=-0.973)/LDL (low-density lipoprotein) (r=-0.960) and increased HDL (high-density lipoprotein) levels (r=-0.923)=0.956) in white rats exposed to a high-fat diet. In conclusion, increased dose of ethanol extract of sambiloto can decrease the percentage of fatty liver, SGOT/SGPT and total cholesterol/TG/LDL and increase HDL level of white rats exposed to high fat diet.
Potassium monitoring in heart failure patients receiving combined therapy of captopril and furosemide Hubby, Hubby; Suharjono, Suharjono; Djafar, Zaenab
Folia Medica Indonesiana Vol. 52, No. 4
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Abstract

In the treatment of heart failure is recommended the use of a combination of ACEI (captopril) with diuretics (furosemide), ACEI has the side effect of hyperkalemia 10-38% in hospitalized patients and 10% in outpatients, is increased in patients with renal failure and diabetes mellitus, the use diuretics occur hypokalemia 5-20% in outpatients. Hyperkalemia and hypokalemia both should be avoided in heart failure patients, because it can cause cardiac conduction disorders such as cardiac arrhythmias This study aims to monitor levels of potassium in the use of combination therapy with furosemide captopril in heart failure patients. The study was conducted using the method Prospective Observational Cross Sectional Analysis, conducted in January-May 2015 in heart failure patients male and female NYHA II-III receiving combination therapy with furosemide Captopril met the inclusion criteria were treated in the department CVCU Dr. Wahidin Sudirohusodo Makassar. Potassium levels were measured pre and post administration of the combination therapy. A total of 37 patients met the inclusion and exclusion criteria in this study, 31 male patients (83.8%) and 6 female patients (16.2%) aged between 35-80 years, during this study after administration of the combination therapy, 5 patients (13.5%) had hypokalemia (<3.5 mmol/L) and 2 patients (5.4%) experienced hyperkalemia (> 5 mmol/L) and 30 patients (81.1%) of normal potassium levels (3,5 to 5.0 mmol/L). The test results paired t test p = 0.432 (p> α;α = 0.05) showed no significant differences between potassium levels pre and post potassium levels. In conclusion, the use of a combination of captopril and furosemide therapy, the risk of hyperkalemia and hypokalemia not significant but need to be monitored levels of potassium and ECG patient.
Case report: spontaneous (true) aneurysm of the superficial temporal artery Joalsen, Ivan; Sianturi, G; Niasari, M
Folia Medica Indonesiana Vol. 53, No. 2
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Abstract

Spontaneous aneurysms of the superficial temporal artery (STA) are rare. Although STA aneurysms have a relatively benign course, when compared with aneurysms of larger caliber arteries, they may occasionally lead to severe hemorrhage and be associated with a multitude of bothersome symptoms. The objective of this study was to report a case of 72-year old male presented with spontaneous STA aneurysm. A 72 years old male presented with a lump on his right temporal side without any previous history of trauma and there was history of long standing hypertension. The lump had first been noticed 2 years before and it had been gradually increasing in size especially within last 6 months. On physical examination there was a pulsatile mass around 2 cm in diameter just above right ear. There was no thrill and bruit. CT angiography showed findings compatible with a STA aneurysm. The patient underwent proximal and distal ligation of the superficial temporal artery and excision of the aneurysm. Histopathological examination confirmed a true aneurysm of STA. The post operative period was uneventful. In conclusion, spontaneous STA aneurysm was best managed by surgical procedure. It consists of ligation and excision. It is simple, safe, and avoids recurrence.
Effect of deacetylation degrees variation on chitosan nerve conduit for peripheral nerve regeneration Qulub, Fitriyatul; Widiyanti, Prihartini; Maulida, Hendita Nur; Indrio, Ludita Woro; Wijayanti, Tia Rahayu
Folia Medica Indonesiana Vol. 53, No. 2
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Abstract

Broken nerves could regenerate when exposed to simple injuries by using a nerve conduit that has appropriate physiological and mechanical ability to support the nerves regeneration around the fissure of trauma. One of the biopolymer for the conduit composition is chitosan because it is biocompatible, biodegradable, non-toxic, and has similarity structure as natural glycosaminoglycans. The aim of research is to synthesize chitosan with variation of Degrees of Deacetylation (DD) and characterize the DD influence on mechanical properties and biocompatibility. Research design is prospective observational. Chitosan was treated with a decrease in the DD method and an increase in the temperature with the strength of alkaline solution, which was NaOH solution with concentrations of 5%, 20%, 35%, and 50% within 2 hours with a heating temperature of 95°C. The results of each DD variation were 23.24, 46.55, 53.48, and 55.06. It was characterized by tensile test with tensile strength values of 0.25 - 1.18 MPa. The degradation test results tend to decrease with the increasing concentration of NaOH proving that samples are biodegradable. The surface morphology of samples shows a pore range of 61.52 μm - 220.3 μm. The best result is the chitosan sample with 35% NaOH because due to the tensile characteristic and a pore in accordance with normal standard. Tensile strength is around 0.41 MPa - 3.69 MPa and pore size around 40 μm – 250 μm to accelerate nerve regeneration. The results are expected to provide alternative solution of nerve conduit development for peripheral nerve defects.
Factors Associated with Timeliness of Hepatitis B Birth Dose: A Cross-sectional Study in North-Western Nigeria Ibrahim, Olayinka Rasheed; Ibraheem, Rasheedat Mobolaji; Aliu, Rasaki; Lawal, Ibrahim Magaji
Folia Medica Indonesiana Vol. 58, No. 2
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Abstract

Highlights: • Uptake of hepatitis B birth dose vaccine within 24 hours of birth is low in Katsina, north-western Nigeria. • The most common reason for delay presentation for hepatitis B birth dose vaccine is maternal illness. Abstract: No studies focused on the hepatitis B birth dose (HepB-BD) vaccine since Nigeria adopted the strategy to reduce hepatitis B viral infection. Hence, we determined the uptake of HepB-BD, factors associated with timeliness, and those that contributed to delay. This study was a cross-sectional descriptive study carried out at an immunization post in north-western Nigeria. We recruited 400 mother-infant pairs that presented for the first immunization and obtained relevant information, including socio-demographics and reasons for the delays. Of the 400 infants, 44 (11.0%) received HepB-BD within 24 hours (timeliness), 105 (26.3%) and 274 (68.5%) by day 7 and 14, respectively. Multivariate analysis showed that mothers' education (primary adjusted odds (AOR) 17, 95% CI 1.404, 204.611), secondary AOR 5.9, 95% CI 1.148, 29.895), and tertiary AOR 7.7, 95% CI 1.228, 48.545), and third born AOR 8.2, 1.625, 41.018) were associated with HepB-BD timeliness. Maternal-related factors were the commonest (129; 46.6%) for delayed HepB-BD, with maternal illness the most commonly cited reason (37; 28.7%). This study showed a deficient level of uptake of HepB-BD vaccines among infants. Factors that were associated with timeliness included maternal education and higher birth order. The commonest reason for delayed HepB-BD was maternal illness.
Bladder Chondrosarcoma in A Male: A Rare Case Report Tamrin, Muhammad Husni; Djatisoesanto, Wahjoe
Folia Medica Indonesiana Vol. 57, No. 3
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Abstract

Chondrosarcoma is a rare variant of bladder tumor and one of the rare types of soft tissue sarcoma. This case happened on a 36-year-old male who complained of lumps in his lower abdomen, accompanied by difficulties in passing urine and painful urination, without hematuria. We performed TURBT and histopathological examination showed low-grade chondrosarcoma. The patient was diagnosed with low-grade bladder chondrosarcoma. The patient was treated for chemotherapy and radiotherapy. However, after undergoing one cycle of chemotherapy, the patient refused to continue the therapy.
Nutritional status affects incidence of pneumonia in underfives Wicaksono, Henry
Folia Medica Indonesiana Vol. 51, No. 4
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Pneumonia is an acute infection disease which remains the main killer of children under 5 years old worldwide. Based on Unicef's report, 17% of all children death is caused by pneumonia. Indonesia was in 10th position of the highest incidence of pneumonia and diarrhea which caused the death of children under 5 years old in 2013. In Gane Luar Public Health Center, there were at least 3 patients with pneumonia every month during 2014. The risk factors are less exclusive breastfeeding, malnutrition, low birth weight, less coverage of measles vaccine, indoor air pollution, and the high level of occupation density. The purpose of this research was to determine the relationship between exclusive breastfeeding, nutrition status, the type of house flooring, and pneumonia incidence in children under 5 in working area of Gane Luar Public Health Center, South Halmahera. A case control study was conducted to each 25 samples of case and control which were collected by simple random sampling technique during July-December 2014. Data were collected through a questionnaire using interview method, observation, and physical examination, and then it's analyzed by Regression Logistic, Chi Square, and Odds ratio to check for strength of association between variables at 95% confidence level. The results indicated that nutrition status was significantly related to Pneumonia incidence (p = 0.019 ; OR 3.795), however exclusive breastfeeding (p = 0.29) and type of house flooring (p = 0.086) weren't. In conclusion, the nutrition status was significantly related to the incidence of Pneumonia in working area of Gane Luar Public Health Center.
Analysis of the expression of fas/cd95 and hsp70 in low and high grade urothelial cell carcinoma of the bladder Heryanto, Heryanto; Kusumastuti, Etty Hary; Rahaju, Anny Setijo
Folia Medica Indonesiana Vol. 53, No. 4
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Abstract

Urothelial Cell Carcinoma (UCC), also called transitional cell carcinoma of the bladder, is the most common malignancy in urinary tract. The prognosis of this disease is highly dependent on the histological grading at diagnosis. Fas/CD95 has a role in apoptotic process, whereas HSP70 has an antiapoptotic role. This study aimed to analyze the expression of Fas/CD95 and HSP70 in low grade and high grade urothelial cell carcinoma in the bladder. This was an analytic observational study with cross sectional approach. Population and sample were paraffin blocks of urothelial cell carcinoma in the Laboratory of Anatomic Pathology, Dr. Soetomo Hospital, Surabaya in the period of January 2011-December 2016. Each grading of urothelial cell carcinoma was randomly sampled. Immunohistochemystry with Fas/CD95 and HSP70 were performed. Expression of Fas/CD95 and HSP70 were assessed semiquantitatively. Expression of Fas/CD95 and HSP70 were analyzed using Mann-Whitney test and Spearman test. The results showed there was significant different in expression of Fas/CD95 and HSP70 in low and high grades in urothelial cell carcinoma. There was no significant correlation between the expression of Fas/CD95 and HSP70 in urothelial cell carcinoma. As a conclusion, the role of CD95 and HSP70 expression can be useful as marker for the diagnosis, especially in the determination of the grade of differentiation.
Analysis of Methyldopa Therapy on sFlt-1 Antiangiogenic Levels in Patients with Severe Preeclampsia Herwati, Teri Wina; Yulistiani, Yulistiani; M, Eddy Zarkaty
Folia Medica Indonesiana Vol. 54, No. 1
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Abstract

Methyldopa is the first-line drugs to treat hypertension in pregnancy. It can decrease blood pressure in preeclampsia by affecting a2-adrenoreceptors in central nervous system. However, it could also act by decreasing production of sFlt-1 antiangiogenic protein levels involved in the pathophysiology of hypertention in preeclampsia. The purpose of this study was to analyze methyldopa therapy on sFlt-1 antiangiogenic levels in the plasma of pregnant women with severe preeclampsia at the Obstetric Departement, Haji Hospital, Surabaya. This was a prospective study with observational cross-section study design. The sFlt-1 angiogenic levels were observed before and after (48 hours) methyldopa administration in severe preeclampsia patient with or without complications in the period of August to October 2016. Patient received methyldopa 250 mg or 500 mg, three times a day for clinical indications according a standard protocol. The study was approved by the ethical committee of Haji Hospital, Surabaya. There were 19 patients with preeclampsia who met the inclusion criteria, showed a decrease in the levels of sFlt-1 before and 48 hours after methyldopa therapy. Levels of sFlt-1 before methyldopa therapy in a dose of 250 mg was 10.15±10.00 (2.55-34.70) ng/ml and after therapy 8,37±9,20 (0.72-9.20) ng/ml, with a percentage decrease 17.54%. sFlt-1 levels before methyldopa therapy in a dose of 500 mg was 8.05±7.07 (2.55-20.76) ng/ml, after therapy 4.50±2.90 (2.19-9.95) ng/ml, with a percentage decrease 44.16%. Methyldopa therapy could decrease sFlt-1 levels of antiangiogenic factor in patients with severe preeclampsia.

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