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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Children with Standard Risk Acute Lymphoblastic Leukemia in Induction And Consolidation Phase Amarullah, Adinugraha; Hasmono, Didik; Ugrasena, IGD; Yulistiani, Yulistiani
Folia Medica Indonesiana Vol. 54, No. 1
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Abstract

Prednisone has an important role in the therapy of patient with standard risk ALL. Patients with standard risk ALL receiving high dose prednisone as therapy and supraphysiology dose of prednisone are expected to cause suppression in HPA-axis (Hypothalamic Pituitary Adrenal axis). This suppression could reduce immune system in children with ALL and increase infection risk because reduction of cortisol level. In Indonesia, we did not find study about the incident of adrenal suppression after high dose prednisone therapy, especially in induction to consolidation phase ALL patient. The aim of this study was to analyze adrenal suppression after high dose prednisone therapy on children with standard risk acute lymphoblastic leukemia in induction and consolidation phase. This study has received a certificate of Ethical Clearance No. 588/Panke.KKE/X/2016, a longitudinal observational, prospective, non-randomized trial involving children with ALL who received prednisone for 49 days during the induction phase. We collected and compared laboratory result of cortisol level in children with ALL and received prednisone therapy during induction to consolidation phase. Sample was taken at week 0,4,5,6,7,8,10,12 in the course of ALL chemotheraphy Indonesian protocol year 2013. Serum was examined using methods CLIA ADVIA Centaur® XP. Between June 2016 – January 2017, 13 patients (8 males, 5 females) were included in this study. Decrease of cortisol level after prednisone therapy occured in week-10 as much as 53% compared with week-0 (p=0.027). Cortisol level increased 64% of week-12 compared with week-10 (p=0.003). In conclusion, high dose prednisone is not significant to causing adrenal suppression in induction phase of ALL patients, and the reducing cortisol level is reversible.
Quality of Life of Diabetic Foot Ulcer Patients with Hyperbaric Oxygen Therapy Kusnanto, Kusnanto; Dismalyansa, Dismalyansa; Pradanie, Retnayu; Arifin, Hidayat
Folia Medica Indonesiana Vol. 55, No. 2
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Abstract

DM with ulcer can result in a decrease in the quality of life of patients and need to reduce the intensity of pain and odor on the ulcer, preventing amputation and Hyperbaric Oxygen as an adjuvant therapy in accelerating wound healing. This study aims to explain the effect of HBO on the quality of life of patients with diabetic foot ulcers at RSAL Dr. Ramelan Surabaya. Methods: The research used quasi-experimental design with a non-equivalent control group design approach. The samples were 70 patients from population of all diabetes patients who suffered from diabetic foot ulcers at RSAL Dr. Ramelan. Data were collected by WHOQOL-BREF questionnaire. Analyzed byWilcoxon signed rank test and Mann Whitney U test. Result: Mann Whitney in the post test, the physical p-value domain (0.000), psychological domain (0.012), social domain (0.003), and environmental domain (0,001), where the intervention group has a better value than the control group. Wilcoxon signed rank test results on the physical domain (0,000), psychological (0,012), social (0,003), and environmental (0,001), meaning there were significant differences between pre post test in intervention group. Discussion: Diabetes mellitus patients with foot ulcers given hyperbaric oxygen showed improvement on wound condition, thus reducing pain and medical needs. This makes patients motivated, reduce anxiety, and improve interpersonal support and confidence. Therefore, it is necessary to socialize the effect of HBO on DM patients with foot ulcer, as a treatment option in improving the quality of life of DM patients with foot ulcers.
Case Report: Cranial Vault Reduction Cranioplasty for Severe Hydrocephalus Suryaningtyas, Wihasto; Parenrengi, Muhammad Arifin
Folia Medica Indonesiana Vol. 56, No. 2
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Extreme hydrocephalic macrocephaly is still encountered in developing countries due to delayed treatment, rapidly progressing hydrocephalus and family socioeconomic problems. Reduction cranioplasty was used with several techniques to address the issue. The study aimed to determine the safety and feasibility of barrel-stave technique for reducing the size of extreme hydrocephalic macrocephaly. Three post-diversion patients underwent surgical reconstruction. Children with head circumference more or equal to two standard deviation above mean on given age, no active wound at the area of surgery, presentation of sufficient "potential removable fluid” that allows dura reduction and no active shunt infection were eligible. The surgical procedure includes modified pi, barrel-stave technique, and diversion of the cerebrospinal fluid and subdural collection. Clinical data were recorded. Three patients with age range of 2 month to 2 years old underwent the surgery. Two patients had shunt implanted at least 1 month before the surgery and 1 patient had an ETV procedure 3 months before the reduction. The frontal-occipital circumference before surgery ranged from 50 to 63 cm. The maximum reduction that could be achieved was 15 cm. One patient (2 months old) died within 24 hour due to failure to cope with excessive blood loss. Two patients were followed up for 3 months and 6 months without complications. Reduction cranioplasty using barrel-stave techniques is an option for children with extreme large head that poses a mechanical or cosmetic problem. Risk and pitfalls should be considered and taken care meticulously, especially the age and blood loss.
Implementation on stimulation, detection, and early intervention of child growth and development (sdidtk) program in puskesmas mojo, surabaya still emphasize on growth screening Susanti, Dwi; Sustini, Florentina
Folia Medica Indonesiana Vol. 52, No. 1
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Abstract

It's Important to conduct child development screening regularly in primary health services, so child developmental delay cases can be detected and treated as early as possible. Child development screening program in Puskesmas should been carried out integrated with growth screening in Stimulation, Detection, and Early Intervention of Child Growth and Development (SDIDTK) Program. Aims of this study was to gathering informations about the implementation of child development screening activity conducted by Puskesmas Mojo. This was a cross sectional study with kualitatif method. Primary data taken from under 5 years old child's mothers, kindergarten teachers, cadres, and health staff of Puskesmas Mojo. Secondary data gotten from PWS KIA report of Puskesmas Mojo.Results of SDIDTK activities in Puskesmas Mojo according to PWS KIA report, achieve 88.1% in 2013 and 95.2% in 2014. Child development screening activities done infrequenly in Posyandu. Routine activities of Posyandu was growth/nutrition screening. Child development screening activities done by visiting kindergarten school every 6 month but not every child getting development screen, only those who suspicious have developmental delay because of minimum number of staff and aids. Results of SDIDTK activities in Puskesmas Mojo only represents child growth screening activities.
Profile of Tuberculosis in Children in Taman District, Sidoarjo Regency, Indonesia Oktaviani, Ranti Dewanti; Lestari, Pudji; Maranatha, Daniel; Setyoningrum, Retno Asih
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • Pediatric tuberculosis patients profile using the medical records was determined. • The most pediatric tuberculosis patients under five years have pulmonary tuberculosis. • Pediatric tuberculosis patients received BCG immunization had a contact with adult tuberculosis patients histories. Abstract: The prevalence of tuberculosis (TB) in Indonesia is 391 per 100,000 population with the number of deaths around 110,000 cases in 2016. This study is descriptive research that aims to determine the profile of pediatric TB patients using the medical records at Taman public health center the period 2016-2019 with a total sampling technique. The sample in this study were 31 pediatric patients aged 0-14 years with a history of TB. Pediatric TB patients aged >5 years (58.1%) and who aged ≤5 years (41.9%). Pediatric TB patients had pulmonary tuberculosis (83.9%) and those who had extrapulmonary tuberculosis (16.1%). Pediatric TB patients aged ≤5 years had good nutritional status (32%) and who had poor nutritional status (27.2%). Meanwhile, pediatric TB patients aged >5 years had poor nutritional status (22.7%) and who had good nutritional status (18.1%). Pediatric TB patients who had a history of contact with adult TB patients (86.7%) and who did not have a history of contact with adult TB patients (13.3%). Pediatric TB patients who had received BCG immunization (86.2%) and who had not received BCG immunization (13.8%). This study concludes that most pediatric TB patients are >5 years old, almost all pediatric TB patients have pulmonary tuberculosis. Pediatric TB patients aged ≤5 years are more likely to have good nutrition. Meanwhile, there were more pediatric TB patients aged >5 years who had poor nutritional status. Almost all pediatric TB patients had a history of contact with adult TB patients and had received BCG immunization.
Effect of sandblasting time on the roughness of the metal cobalt-chromium (co-cr) during denture metal framework production Kusdarjanti, Endang; R, Dwiyanti Feriana; Inayati, Eny
Folia Medica Indonesiana Vol. 52, No. 3
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Abstract

One of the stages of manufacture of denture metal framework that is sandblasting, ie cleaning the remnants of investment material after metal casting process and remnants of metal oxide on the surface. After fitting in the master model, then the metal framework dentures do sandblasting again until smooth before elektropolishing. The tools used are sandblaster, material Al2O3 (aluminum oxide) size of 250 lm. The time it takes about 1 minute, but the time of 1 minute when applied to student practicum D3 is still not clean and there are still remnants of planting material castings and metal oxide on the surface of the Co-Cr. Objective: To determine the effect of time on pembutan teeth iruan sandblasting the metal frame of the metal surface roughness Co-Cr. This study is experimental laboratories. A sample of tablet shape with a diameter of 7mm, 2mm thick metal. Number of samples 24 tablets were divided into 4 groups each group consisting of six tablet samples. Distribution of the sample group of the study are as follows; Group 1; Sandblasting metal surfaces with 250 µm Al2O3 time of 1 minute, Group 2; Sandblasting metal surfaces with Al2O3 250 ?m 2 minutes, Group 3; Sandblasting metal surfaces with Al2O3 250 µm 3 minutes, Group 4; the group did not do sandblasting. Data were analyzed with ANOVA statistical analysis of the lane with 0:05 significance level. If there is a significant difference between groups duiji with HSD test. There were significant differences in surface roughness Co-Cr metal between the control group without sprayed with the spray group at 1 minute, 2 minutes and 3 minutes. In conclusion, the surface of a metal frame that is not done sandblasting coarser than done sandblasting. The longer the time sandblasting increasingly produce a smooth surface of a metal frame. Sandblasting is perfectly need sufficient time is 2-3 minutes.
Literature review: hyperbaric oxygen therapy on mucormycosis infection in oral cavity Laihad, Fanny Margaretha; Sudiana, I Ketut; S, M Guritno
Folia Medica Indonesiana Vol. 53, No. 2
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Mucormycosis infection is an invasive, acute and rapidly progressing fungal infection with high mortality rate unless it was identified promptly. Oral manifestations of these infections, some times appeared as palatal ulcer and can be triggered by tooth extraction on maxilla or mandibula in which the organ is not cured but even damage the gingival and alveolar bone. Hyperbaric oxygen (HBO) therapy is the administration of 100% pure oxygen in a pressurized room more than 1 atmophere that can be used for therapy of mucormycosis infection in oral cavity. The aim of this study is to analyze the use of hyperbaric oxygen therapy on mucormycosis infections in oral cavity in 30 journals and 1journal of suspected case of mucormycosis infection post dental extraction from 1980 until 2016. Hyperbaric oxygen therapy was used as the last and adjunctive therapy after antifungal and surgery in 30 jounals but in 1 suspected case, hyperbaric oxygen therapy was given earlier. The need for consideration to provide early HBO therapy in case of mucormycosis infection in oral cavity will improve prognosis and survival rate of the patient.
The acute effect of erythropoietin on glucose levels during ischemia reperfusion injury in rats Tsompos, Constantinos; Panoulis, Constantinos; Toutouzas, Konstantinos; Zografos, George; Papalois, Apostolos
Folia Medica Indonesiana Vol. 52, No. 1
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The aim of this experimental study was to examine the effect of erythropoietin on rat model and particularly in an ischemia reperfusion (HR) protocol. The effect of that molecule was studied biochemically using blood mean glucose (Gl) levels. Materials and methods: 40 rats of mean weight 247.7 g were used in the study. Gl levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D. Results were that Epo administration non-significantly increased the gl levels by 5.59% +6.46% (p=0.3208). Reperfusion time non-significantly increased the gl levels by 5.63%+6.45% (p=0.4098). However, erythropoietin administration and reperfusion time together produced a non significant combined effect in increasing the gl levels by 4.94%+3.81% (p= 0.1892). Conclusions: Results of this study indicate that erythropoietin administration, reperfusion time, or their interaction non-significantly increase the blood glucose levels in short-term. Opposite bibliographic data are considered more reliable, until a greater sample provide clearer results.
Role of immunoglobulin g (igg) from the induction of escherichia coli pili adhesion protein isolated from infertile male semen with 32.2 kda molecular weight as opsonin and anti-adhesion an in vitro escherichia coli infection Sukarjati, Sukarjati; Amilah, Susie
Folia Medica Indonesiana Vol. 53, No. 2
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Escherichia coli (E. coli), a major cause of male genital tract infections, is asymptomatic and may result in male infertility. We have succeeded in isolating and characterizing proteins of E. Pili coli isolates from semen of infertile men who function as adhesin with a molecular weight (MW) 32.2 kDa. This study aims to prove the ability of IgG results adhesion proteins induced pili of E. MW coli 32.2 kDa as opsonin to determine the value of the activity and phagocytic capacity and as an anti- adhesion by calculating the average number of E. coli that attached to human spermatozoa. E. coli infertile men's semen were cultured using standard bacteriology. Peritoneal macrophages were isolated from mice. Spermatozoa from donors were prepared using Sil with Select Plus. IgG was obtained from mice immunized with (1) PBS (control), (2) E. coli pili adhesion protein isolated from infertile men semen with MW of 32.2 kDa and (3) weakened E. coli isolated from infertile men's semen. Phagocytic activity value was determined by counting the number of cells activated macrophage phagocytosis process in 100 cells. Phagocytic capacity value was determined by counting the number of bacteria ingested by 25 macrophages. Anti-adhesion test was done by counting the number of bacteria attached to 100 spermatozoa. The results of this study showed difference (p=0.000) in phagocytic activity and phagocytic capacity (p=0.000) between treatment (1) and (2), and between treatment (1) to (3). However, treatment (2) and (3) did not differ neither in phagocytic activity (p=0.693) nor in phagocytosis capacity (p=0.125). Anti-adhesion test produces difference (p=0.000) in the number of E. coli that attached to human spermatozoa between treatments (1) and treatment (2), and between treatments (1) and (3). The number of E. coli that attached to human spermatozoa between treatment (2) and treatment (3) was not significantly different (p=0.371). In conclusion, IgG from the induction of E. coli pili adhesion protein of infertile men semen isolates with MW of 32.2 kDa can increase phagocytic activity and capacity as well as serve as an anti- adhesion. Thus, IgG from the induction of E. coli pili adhesion protein of infertile men semen isolates with MW of 32.2 kDa is protective against in vitro E. coli infection, so that it can be used as material to prevent male reproductive tract infections due to E. coli.
Prevalence and Population at Risk for Noise Induced Hearing Loss (NIHL) in Adolescent Students Yusni, Yusni; Ikbal, Ikbal; Meutia, Firdalena
Folia Medica Indonesiana Vol. 57, No. 3
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Noise-Induced Hearing Loss (NIHL) is a global health problem, often underestimated, and leads to permanent hearing loss. The prevalence of NIHL in adolescents has increased in line with the increasing use of cell phones. This study aimed to determine the prevalence of NIHL and analyze the population at risk (age, gender, and school) in adolescent students. The study design was a cross-sectional study. A total of 510 students consisting of female, n=288 and male, n=222; junior high school, n=203 and senior high school, n=307 were used as research subjects. This study was conducted on August-October 2015 at Darul Ihsan School, Banda Aceh, Indonesia. An audiometry examination was performed to determine the diagnosis of NIHL. Data analysis was using descriptive analysis and independent sample t-test(p<0.05). The results of this study were the prevalence of NIHL in adolescents aged 11-20 years was 18.88%. The highest percentage of NIHL was at the age of 15 years (34.57%). The number of NIHL was significantly higher (p=0.000*) in males (24.32%) compared to females (9.37%). The prevalence of NIHL was significantly higher (p=0.00*) in senior high school children (26.11%) compared to that in junior high school children (9.12%). In conclusion, the highest prevalence of NIHL was at the age of 15 years. NIHL was more common in male than in female students. NIHL was higher in high school students compared to junior high school students. The NIHL was related to age, gender, and school level.

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