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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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The Effect of Cinnamomum burmannii Water Extraction Against Staphylococcus aureus, Enterobacter spp., Pseudomonas aeruginosa, and Candida albicans: In Vitro Study Novita, Bernadette Dian; Sutandhio, Silvia
Folia Medica Indonesiana Vol. 55, No. 4
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Abstract

High-intensity exercise (3000-meter runner) contributes to muscle fatigue. Fatigue can be determined by measuring blood lactate levels. Blood lactate levels are a product of anaerobic metabolism. Lactate accumulation due to anaerobic physical activity can inhibit the glycolytic enzyme that affects decreased ATP production, damage of the calcium and sodium pumps in the muscles and causes fatigue. This study aimed to analyze the effect of vitamin E on the level of fatigue through the response of blood lactate levels in the runner 3000 meters. This research was a quasi-experimental research with a pretest-posttest design. Research subjects were 9 volunteer athletes (3000 meters runners) Aceh province, male, and aged 15-20 years. The treatments were vitamin E at a dose of 1x400 IU per day and administered for 14 days. Blood lactate levels were examined using the method of calorimetry. The statistical analysis was using the homogeneity test of variance (Levene's test), the normality test (Kolmogorov-Smirnov test) and paired t-test with a significant level of 5% (p-value<0.05). The results showed that blood lactate levels decreased approximately 13.93% after vitamin E supplementation. There was no significant difference (p=0.27) between blood lactate levels before and after vitamin E supplementation in athletes. In conclusion, vitamin E supplementation did not significantly lower blood lactate levels therefore vitamin E did not significantly reduce muscle fatigue in men's athletics.
Back Matter Vol. 56, No. 1 March (2020) Matter, Back
Folia Medica Indonesiana Vol. 56, No. 1
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Duplication and Multiseptate Urinary Bladder: A Rare Case Report Zulfikar, Muhammad Fawzi; Djatisoesanto, Wahjoe; Tarmono, Tarmono
Folia Medica Indonesiana Vol. 57, No. 3
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Abstract

The multiseptate bladder is a congenital bladder anomaly that is very rare and often accompanied by other congenital abnormalities. This condition could result in intravesical obstruction and kidney failure in more serious conditions. A 3-year-old girl without any complaint was consulted by the Pediatric Surgery Department with postoperative cloacal type malformation anorectal (MAR) postero-sagittal anorecto-vagino-urethroplasty (PSARVUP) + sigmoidectomy. Magnetic Resonance Imaging (MRI) of the pelvis showed the appearance of four interconnected multiple fluid lesions. Cystoscopy was performed and found many septa with varied positions and forms. From the cystography during the operation, it was seen duplication of the right and left bladder. There was no further operative treatment in the field of urology because no urinary tract obstruction and normal renal function were found in this study.
Expression of Melanoma Antigen Genes A11 and A12 in Non-Small Cell Lung Cancer Mastutik, Gondo; Rahniayu, Alphania; , Isnin Anang Marhana; Amin, Mochamad; Trianto, Heru Fajar; I'tishom, Reny
Folia Medica Indonesiana Vol. 59, No. 4
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Abstract

Highlights: 1. In this study, new primers designed using the semi-nested polymerase chain reaction (PCR) method were utilized to identify MAGE-A11 and MAGE-A12 expressions in specimens collected from core biopsy, forcep biopsy, and bronchoalveolar lavage. 2. The histopathological analysis revealed positive expressions of MAGE-A11 and MAGE-A12 in specimens diagnosed with non-small cell lung cancer (NSCLC) as well as in specimens with no malignant cells. 3. This study provides evidence indicating that the detection of messenger ribonucleic acid (mRNA) of MAGE-A11 and MAGE-A12 by nested reverse transcription PCR can improve the accuracy of lung cancer diagnosis. Abstract The melanoma antigen gene (MAGE) belongs to the group of cancer-testis antigens that are exclusively expressed in germ cells but may be re-expressed in cancer cells. The highly expressed MAGE-A subfamily in lung cancer may potentially be a diagnostic and prognostic biomarker. This study aimed to identify MAGE-A11 and MAGE-A12 expressions in lung tumors obtained from core biopsy, forceps biopsy, and bronchoalveolar lavage specimens. A cross-sectional observational study was conducted on 90 patients clinically diagnosed with lung tumors. These patients received core biopsy, forceps biopsy, and bronchoalveolar lavage interventions after ethical approval was obtained. The complementary deoxyribonucleic acid (cDNA) quality was assessed by the polymerase chain reaction (PCR) of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The assessment was performed to ascertain if all specimens exhibited positive PCR amplification of the GAPDH gene. MAGE-A11 and MAGE-A12 were identified through a semi-nested reverse transcription PCR. The positive results were detected by measuring the PCR products, with MAGE-A11 and MAGE-A12 at base pairs (bp) of 858 and 496 in the first and second rounds, respectively. The expressions of MAGE-A11 and MAGE-A12 were observed in 3 (3.33%) and 40 (44.44%) out of 90 specimens, respectively. The prevalence rate of non-small cell lung cancer (NSCLC) was 31.11% (28/90). Among these cases, 3.57% (1/28) showed the expression of MAGE-A11, while 32.14% (9/28) exhibited the expression of MAGE-A12. Sixty-two (68.89%) out of 90 patients were diagnosed with no tumor cell malignancy. Out of 62 cases, 2 (3.23%) exhibited the expression of MAGE-A11, while 31 (50%) demonstrated the expression of MAGE-A12. MAGE-A11 and MAGE-A12 were detected in NSCLC and certain specimens with a pathological diagnosis that indicated the absence of malignant cells. In conclusion, MAGE A11 and MAGE A12 have potential markers to improve the pathological diagnosis of lung cancer. Further investigation is necessary to explore the expression of MAGE-A in correlation with lung cancer progression.
The Influence of Safety Communications and Safety Promotion Policies on Safety Performance among Nurses in The Emergency Department at a Tertiary Hospital in Surabaya, Indonesia Berliana, Ratih; Widajati, Noeroel; Saridewi, Nurhayati; Dwiyanti, Endang
Folia Medica Indonesiana Vol. 58, No. 4
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Highlights: • To reduce the occurrence of work-related accidents, the application of occupational safety and health principles in work activities is necessary. • This research analyzed the safety communications and safety promotion policies on the safety performance among nurses. • Safety communications have influence on safety performance, while safety promotion policies have no influence on safety performance. Abstract: The application of the occupational safety and health principles in work activities is expected to reduce the occurrence of work-related accidents. This research was conducted in the Emergency Department of a tertiary hospital of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2019 and aimed to determine the influence of safety communications and safety promotion policies on the safety performance among nurses. This research was a quantitative research with a cross-sectional design study. The population in this study were 208 emergency room nurses at Dr. Soetomo General Academic Hospital with a total sample of 68 people using a simple random sampling technique. The results showed that the correlation between safety communications variable with safety performance had a p-value of 0.035 (<0.05) and the correlation between safety promotion policies variable with safety performance had a p-value of 0.319 (>0.05), indicating that there was an influence of safety communications on safety performance, while there was no influence of safety promotion policies on safety performance among nurses in the Emergency Department of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Correlation between intracellular heat shock protein 70 expression and cervical lymph nodes enlargement in nasopharyngeal carcinoma Romdhoni, Achmad C; Herawati, Sri; Mustikaningtyas, Elida
Folia Medica Indonesiana Vol. 52, No. 1
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Tumor growth and metastasis in NPC patients suspected role of several molecular biomarkers that have been identified in tumor specimens of patients with NPC. Recent research states intracellular Hsp70 is a stress protein that is a main factor for the growth, invasion and metastasis of NPC. The purpose of this study is to analyze intracellular Hsp70 protein expression of NPC patients which correlate with staging of NPC as clinical manifestation. This study used cross sectional design. In this study, formalin-fixed paraffin-embedded biopsy specimens were obtained from 18 NPCs with all of histopathology and clinically divided into N0, N1, N2, N3. The expression of intracellular Hsp70 was obtained with immunohistochemistry using monoclonal antibody Anti Human Hsp70 antibodi from Santa Cruz Biotechnology, California, USA. Assessment of the staining was performed with Remmele methode by Histopathologies doctor Consultant. The Spearman's test was used to determine the relationship between expression of intracellular Hsp70 protein and enlargement cervical nodul of NPC. Statistical significance was defined as p <0,05. There were 18 patients NPC patients that met the inclusion and exclusion criteria. Showed negative intracellular Hsp70 expression by 16,67% for all sample in which consist 1 patient of N0, 1 patient of N1, 1 patient of N2, 0 patient of N3. Followed by 27,78% mild positive intracellular Hsp70 expression which consist 0 patient of N0, 2 patients of N1, 0 patient of N2, 3 patients of N3. Followed by 44,44% moderate positive intracellular Hsp70 expression which consist 0 patient of N0, 0 patient of N1, 1 patient of N2, 9 patients of N3. Followed by 11,11% strongly positive intracellular Hsp70 expression which consist 0 patient of N0, 0 patient of N1, 0 patient of N2, 2 patients of N3. Spearman test results test scores p = 0.01 with a correlation coefficient 0.606. Correlation of intracellular Hsp70 protein expression with enlargement cervical nodul of lymphe (N0, N1, N2, N3) in patients with NPC showed significant (p<0.05). In conclusion, there was correlation between increase of the intacellular Hsp70 expression and enlargement cervical nodul of lymphe in nasopharyngeal carcinoma.
Front Matter Vol. 55, No. 1 March (2019) Matter, Front
Folia Medica Indonesiana Vol. 55, No. 1
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Effect of Glucose Induction on Biofilm Density in Clinical Isolate Acinetobacter baumannii Patients in Intensive Care Unit of Dr. Soetomo Hospital, Surabaya Lindarto, Wira W; Wasito, Eddy Bagus; Debora, Kartuti
Folia Medica Indonesiana Vol. 56, No. 2
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This study aimed to analyze the effect of glucose induction on the clinical isolate biofilm density of Acinetobacter baumannii. Thirteen clinical isolates of A. baumannii non biofilm forming were collected from non-DM patients who were treated at the ICU of Dr. Soetomo Hospital, Surabaya, was treated with the addition of 0.08% glucose, 0.15% glucose, 0.2% glucose, and 0.4% glucose in TSB growth media, followed by biofilm density examination with Tissue Culture Plate Method (TCPM) using 96 wells flatbottomed polyesterene tissue culture plate and read by autoreader ELISA with a wavelength of 630 nm (OD630). Biofilm density obtained was analyzed using ANOVA statistical analysis. The results of OD630 showed that the biofilm density increased significantly at the addition of 0.2% and 0.4% glucose. There was a significant increase in biofilm density at the addition of 0.2% and 0.4% glucose so that the management of blood sugar levels in ICU patients was needed before and when medical devices were installed.
Analysis of Spatial Working Memory Using the Y-Maze on Rodents Treated with High-Calorie Diet and Moderate-Intensity Exercise Melbiarta, Rezy Ramawan; Kalanjati, Viskasari P.; Herawati, Lilik; Salim, Yusuf; Othman, Zulhabri
Folia Medica Indonesiana Vol. 59, No. 1
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Abstract

Highlights: • This article reports the use of the Y-maze as a simple yet effective method to measure spatial working memory in mice. • The Y-maze method can be used safely without exposing the animals to additional stressors, as evidenced by the absence of mortality following the test. Abstract: Spatial working memory (SWM) in humans and animal models with impaired cognitive functions has been analyzed through a number of methods. However, this is still understudied in animal models treated with a high-calorie diet (HCD) and moderate-intensity exercise (MIE). The Y-maze was utilized as the assessment method in this study. A 40 x 9 x 9 cm3 Y-maze was employed to observe the animal models' spontaneous alternation (SA) as the representation of their SWM. This was done by calculating the total alternation percentage divided by total entry minus two. A total of 17 female Mus musculus mice aged 8 weeks were tested in the Y-maze to investigate their SWM using SA calculations. Each mouse was analyzed for eight minutes and recorded in a dark and quiet room to minimize bias due to environmental noise and lighting. Comparing the treatment group's (HCD+MIE) SA to the control group's SA revealed no statistically significant difference (p=0.451). Seven mice in the treatment group performed similarly to the mice in the control group in the Y-maze test, with no significant difference in their ability to complete the task. The mice in the treatment group exhibited no motor impairment, as indicated by complete movements of all their extremities while exploring the Y-maze within the allotted time. In conclusion, the Y-maze can be used as a reliable method to analyze SWM in overweight/obese Mus musculus animal models treated with moderate-intensity physical exercise.
Dynamic Concentric Activity Can Increase the GLUT-1 Expression on Muscle Membrane on Diabetic Mice Yusuf, Havid; Safitri, Dini
Folia Medica Indonesiana Vol. 54, No. 2
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Diabetes mellitus is a type of a degenerative disorder that affects the body's ability to make or use insulin. The resistance of insulin may affect the decline of GLUT-1 expression of diabetic muscle, causing impaired glucose uptake. Dynamic concentric activity is one of the activity models based on muscle-contraction-type activity. This study used experimental method. The instrument in this study was a treadmill (brand: modified columbus treadmill) with 10-degree slope (uphill), with the velocity of 21 cm/sec (the speed options showed on the treadmill), and the duration of the exercise was 16 minutes and 30 seconds (measured using stopwatch). In this study, there were 3 groups of samples, Normal (K0), DM (K1), and DM + Dynamics Concentric (K2). Based on statistical results of correlation value p=0.00 (p<0.05), there was significant correlation between blood sugar level and GLUT-1. Dynamic concentric activity for diabetics had an effect in increasing the amount of GLUT-1, resulting in decreased blood glucose levels.

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