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Jurnal Farmasi Udayana
Published by Universitas Udayana
ISSN : 23017716     EISSN : 26224607     DOI : https://doi.org/10.24843/JFU.2025.v14.i02
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Udayana is an electronic journal which is managed by Pharmacy Department Faculty of Mathematic and Natural Science Udayana University. This journal which is a media of research publication and review article on all aspects of pharmaceutical science that is innovative, creative, original and based on scientific . Articles published in this journal include drug discovery, drug delivery systems and drug development. This journal covers specific fields in pharmaceuticals such as medicinal chemistry, pharmacology, pharmacokinetics, pharmacodynamics, pharmaceutical analysis, drug delivery systems, pharmaceutical technology, pharmaceutical biotechnolofies, herbal medicines and active components as well as clinical evaluation of medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 21 Documents
 1   2   3 
REVIEW: TANAMAN LOKAL BALI BERDASARKAN USADA TARU PRAMANA SEBAGAI ANTIINFLAMASI UNTUK NYERI DISMENORE Ni Luh Purnama Kuinasari
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p07

Abstract

Artikel ini membahas potensi tanaman herbal Bali berbasis Usada Taru Pramana sebagai agen antiinflamasi alami untuk mengatasi nyeri dismenore. Dismenore merupakan kondisi umum yang sering dialami remaja wanita, disebabkan oleh peningkatan prostaglandin yang memicu kontraksi otot rahim, sehingga menimbulkan nyeri. Penggunaan obat sintetis seperti NSAID memang efektif, namun berisiko menimbulkan efek samping. Oleh karena itu, diperlukan alternatif pengobatan yang lebih aman dan alami. Melalui studi literatur, artikel ini menyoroti lima tanaman tradisional Bali, kayu manis, pepaya, jeruk purut, andong, dan cengkeh yang secara turun-temurun digunakan dalam pengobatan dismenore. Kandungan senyawa aktif seperti flavonoid, tanin, saponin, dan minyak atsiri dalam tanaman-tanaman tersebut memiliki aktivitas antiinflamasi dan relaksan otot yang berperan dalam meredakan nyeri haid. Kata kunci: Antiinflamasi; Dismenore; nyeri haid; pengobatan tradisional; tanaman herbal Bali; Usada Taru Pramana
Literatur Review: EFEKTIVITAS ANTIBAKTERIAL DAUN JAMBU BIJI (Psidi guajava L.) TERHADAP Streptococus mutans PENYEBAB KARIES GIGI I Gede Bayu Surya Ekayana
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p05

Abstract

Oral health is an essential component of overall health and significantly affects quality of life. One of the most common oral health problems is dental caries, which is the destruction of tooth tissue caused by enamel demineralization triggered by acid produced from carbohydrate metabolism by plaque bacteria, particularly Streptococcus mutans. Guava leaves (Psidium guajava L.) are known to contain active compounds with antibacterial properties. Research has shown that these active compounds can inhibit the growth of Streptococcus mutans and disrupt dental biofilm formation, making them a potential preventive agent against caries. Articles were collected from PubMed, Google Scholar, and ScienceDirect using Boolean search techniques. Of the 538 articles identified, 10 were selected based on inclusion criteria and topic relevance. The review results show that guava leaf extract can reduce Streptococcus mutans colony counts both in vitro and in vivo, demonstrating effectiveness comparable to 0.2% chlorhexidine without adverse side effects. Furthermore, combining guava leaf extract with other agents, such as nanosilver and guava bark extract, has been shown to enhance antibacterial activity through synergistic mechanisms. Therefore, it can be concluded that guava leaves have strong potential as a natural, effective, and safe alternative for the prevention of dental caries.
GAMBARAN KEPATUHAN PASIEN PENYAKIT PARU OBSTRUKTIF KRONIK (PPOK) DALAM PENGGUNAAN TERAPI INHALER DI INSTALASI RAWAT JALAN RSD DR. A. DADI TJOKRODIPO (RSDADT) BANDAR LAMPUNG Nurul Irna Windari; Nadiaishla Dzakia Hanan; Muhammad Hilmi Fathurrahman
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p01

Abstract

Penyakit Paru Obstruktif Kronik (PPOK) merupakan penyakit kronis tidak menular dengan angka kematian tinggi. Kepatuhan terhadap terapi inhaler sangat penting dalam pengobatan PPOK, namun kepatuhan pengobatan terhadap penggunaan inhaler umumnya buruk. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik dan kepatuhan penggunaan inhaler pasien PPOK. Penelitian ini dilakukan di RSD Dr. A. Dadi Tjokrodipo (RSDADT) Bandar Lampung pada periode September – Oktober 2024 dengan jumlah sampel yang memenuhi kriteria inklusi dan eksklusi sebanyak 46 sampel dari total populasi sebanyak 53 pasien PPOK. Penelitian ini merupakan penelitian deskriptif non eksperimental dengan pendekatan cross sectional dengan teknik total sampling menggunakan kuesioner Test of Adherence to Inhaler (TAI) dan dianalisis secara univariat. Hasil penelitian menunjukkan karakteristik 46 responden didominasi oleh usia ≥60 tahun (76,1%), jenis kelamin laki-laki (91,3%), tingkat pendidikan SD (34,8%), bekerja (58,7%), dan sudah berhenti merokok (89,1%). Berdasarkan kepatuhan penggunaan inhaler pasien PPOK didapatkan kepatuhan baik (39,1%), kepatuhan sedang (43,5%), dan kepatuhan rendah (17,4%). Hasil menunjukkan kepatuhan didominasi oleh pasien dengan kategori kepatuhan sedang.
The Inhibitory Activity Test of Green Amaranth (Amaranthus hybridus L.) Leaf Ethanol Extract Using Ultrasound-Assisted Extraction (UAE) Method Against the Growth of Staphylococcus epidermidis Anhar Muflih; Nita Triadisti; Annisa Salsabela; Islan Nor
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p04

Abstract

Staphylococcus epidermidis is a microorganism often found on almost all skin surfaces. Uncontrolled growth of S. epidermidis can cause skin dysbiosis such as acne. Generally, doxycycline, clindamycin, and tetracycline are used as synthetic antibiotic agents for S. epidermidis, but the search for new natural antibiotic agents to treat acne due to S. epidermidis needs to be developed, such as green spinach leaf extract (Amaranthus hybridus L.). Green Spinach is known to have antioxidant, antianemia, anti-inflammatory, antihyperlipidemic, antidiuretic, antifungal and antimicrobial activities, duet to the presence of secondary metabolites, such as alkaloids, steroids, tannins, saponins, and flavonoids. This study aims to analyse the antibacterial activity of green spinach leaf ethanol extract by considering the extract's inhibition zone. Green spinach leaves were extracted by Ultra Assisted Extraction (UAE) with 96% ethanol, and testing was carried out using the disc diffusion method. The results of this study showed that spinach leaf extract with concentrations of 15%, 30%, and 45% gave sequential results of 11.3 ± 0.06 mm, 12.2 ± 0.1 mm, and 12.5 ± 0.1 mm, including the category of strong inhibitory response.
Literatue Review : Biochemical and Pharmacological Prospects of Enhalus acoroides as a Source of Antifibrotic Compounds for National Drug Development Vivi Shofia
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p02

Abstract

Fibrosis is a progressive pathological process characterized by excessive accumulation of extracellular matrix and represents a major cause of organ failure, including in the kidney, liver, and lung. Currently available antifibrotic therapies have limited efficacy and are associated with potential adverse effects, highlighting the urgent need for new drug candidates derived from natural sources. The seagrass Enhalus acoroides, which is abundant in Indonesian waters, has been reported to contain flavonoids, polyphenols, sterols, and bioactive fatty acids that may modulate oxidative stress and inflammation, two key mechanisms involved in fibrogenesis. This review aims to evaluate the biochemical and pharmacological potential of E. acoroides as a source of antifibrotic compounds for national drug development. The methodology involved a literature review of scientific databases focusing on phytochemical profiles, pharmacological activities, and molecular mechanisms related to fibrosis. The findings indicate that E. acoroides exhibits significant antioxidant and antibacterial activities, contains major secondary metabolites (notably flavonoids and phenolics), and shows mechanistic relevance to the TGF-β/Smad signaling pathway, a central regulator of fibrogenesis. In conclusion, E. acoroides has promising potential as a candidate antifibrotic phytopharmaceutical; however, further validation through in vitro, in vivo, and advanced pharmaceutical formulation studies is required
Formulasi Lotion Ekstrak Etanol Daun Kopi Arabika (Coffea arabica L.) dan Ekstrak Etanol Daun Perepat (Sonneratia alba Sm.) Sebagai Antioksidan Maizatul Ummah
Jurnal Farmasi Udayana Vol. 14, Issui 2, Tahun 2025
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2025.v14.i02.p03

Abstract

Skin damage can be triggered by exposure to free radicals, making antioxidants important as skin protection agents. Arabica coffee leaves (Coffea arabica L.) and perepat leaves (Sonneratia alba Sm.) are known to have potential as natural sources of antioxidants. This study aims to formulate and evaluate lotion preparations containing ethanol extracts of these two leaves based on their physical characteristics and antioxidant activity. Four lotion formulas were prepared, namely K (without extract addition), FI (0.1% Arabica leaves + 1.0% perepat leaves), FII (0.5% Arabica leaves+ 0.5% perepat leaves), and FIII (1.0% Arabiva leaves + 0.1% Perepat leaves). The evaluation was conducted using an accelerated test (cycle test) on organoleptic properties, homogeneity, stability, pH, spreadability, adhesion, viscosity, emulsion type, and antioxidant activity, which were then analyzed descriptively. The results showed that formulas FII and FIII met the physical stability requirements. The antioxidant activity test showed that formula FIII had the highest activity with an IC₅₀ value of 45.41 ± 0.52 ppm compared to FI and FII. Based on these results, it can be concluded that lotion formula FIII is the best formulation in terms of stability and antioxidant effectiveness.
Peran Apoteker dalam Penjaminan Mutu dan Penanganan Keluhan Konsumen pada Industri Kosmetik: Analisis Kesesuaian SOP terhadap Regulasi BPOM dan CPKB Kevvy Buana Ibrahim; Ni Made Widi Astuti; Ni Putu Della Adelya Anggarani; Ni Komang Dwitara Aristya Santhi
Jurnal Farmasi Udayana Vol 15, No 1, Tahun 2026
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2026.v15.i01.p02

Abstract

Industri kosmetik di Indonesia berkembang pesat dan menuntut sistem penjaminan mutu, keamanan, serta informasi produk yang kuat sesuai regulasi Badan Pengawas Obat dan Makanan (BPOM) dan pedoman Cara Pembuatan Kosmetik yang Baik (CPKB). Penelitian ini bertujuan menganalisis peran apoteker dalam menjamin keamanan, mutu, dan informasi produk kosmetik, menggambarkan penanganan keluhan konsumen sesuai standar operasional prosedur (SOP) dan regulasi BPOM, serta menilai kesesuaian penerapan SOP industri dengan pedoman CPKB. Penelitian menggunakan desain deskriptif kualitatif melalui kajian literatur dan wawancara semi-terstruktur dengan apoteker yang bekerja pada bagian mutu di industri kosmetik skala kecil dan menengah, sedangkan data dari regulasi, SOP perusahaan, dan transkrip wawancara dianalisis secara deskriptif dengan membandingkan praktik di lapangan dengan ketentuan BPOM dan CPKB. Hasil menunjukkan bahwa apoteker berperan aktif dalam pengawasan bahan baku, proses produksi, pelulusan produk, penanganan produk tidak memenuhi syarat, dan pengelolaan keluhan konsumen sebagai bagian dari post-market surveillance internal, sementara penerapan CPKB secara umum sudah berjalan tetapi masih terkendala keterbatasan sumber daya manusia dan dokumentasi Corrective and Preventive Action (CAPA) yang belum optimal. Penguatan peran apoteker, perbaikan sistem dokumentasi, dan peningkatan dukungan manajemen diperlukan untuk lebih menjamin konsistensi mutu dan keamanan produk kosmetik pada industri skala kecil dan menengah.
A Comparative Study of Health Utility Value and in Type 2 Diabetes Mellitus Patients Treated With Oral Monotherapy or In Combination with Oral or Insulin Kadek Ida Krisnadewi; Kadek Hendra Darmawan; Dewayu Satrya Dewi
Jurnal Farmasi Udayana Vol 15, No 1, Tahun 2026
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2026.v15.i01.p01

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease with a high clinical and economic burden. This study aimed to compare health utility values and costs among T2DM patients receiving different therapeutic regimens, including oral monotherapy, oral combination therapy, insulin monotherapy, insulin combination therapy, and oral–insulin combination therapy. This study used an analytical observational design with a cross-sectional approach involving 119 patients. Data were collected using a structured questionnaire for patient characteristics and the EQ-5D-5L instrument to assess utility values, while cost analysis was conducted from the patient perspective, including direct and indirect costs. The results showed that oral monotherapy had the highest utility value (QALY 23.89) and a cost of Rp406.941,25 per patient/month, making it the most cost-effective therapy. In contrast, insulin-based therapies tended to have higher costs and lower utility values. Cost variations were observed across all components, with the highest drug costs found in insulin monotherapy. In conclusion, oral therapy, particularly monotherapy, represents the most economically and clinically efficient option. Early intervention and optimal disease management are essential to prevent disease progression and reduce long-term economic burden.
REVIEW: POTENSI PENGGUNAAN EKSTRAK BAHAN ALAM SEBAGAI ZAT WARNA, ANTIOKSIDAN DAN TABIR SURYA DALAM SEDIAAN KOSMETIK DEKORATIF UNTUK BIBIR Jenny Adilla Jamtoputri; Jessie Sofia Pamudji
Jurnal Farmasi Udayana Vol 15, No 1, Tahun 2026
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2026.v15.i01.p03

Abstract

Kosmetik bibir merupakan sediaan dekoratif yang digunakan sebagai pewarna, pelembab, atau pelindung bibir. Kosmetik bibir dekoratif meliputi lip tint, lip balm, lipstick, lip gloss, dan lain-lain. Kandungan senyawa flavonoid seperti antosianin dan senyawa antioksidan dari bahan alam berpotensi untuk dijadikan sebagai pewarna alami dan tabir surya untuk kosmetik bibir. Tujuan dari penulisan review article untuk mengetahui bahan alam yang dapat berpotensi sebagai zat warna dan berpotensi sebagai tabir surya alami untuk sediaan kosmetik bibir. Metode penulisan menggunakan beberapa penelusuran data dari platform pencarian seperti Google Scholar, MDPI dan Pubmed meliputi artikel dalam jurnal nasional maupun internasional yang terakreditasi atau yang memiliki ISSN dan E-ISSN, terbit pada tahun 2015 hingga 2025. Hasil pemilihan artikel didapatkan 33 artikel yang akan direview. Bahan alam seperti bunga rosella (Hibiscus Sabdariffa L), umbi bit (Beta vulgaris), buah naga (Hylocereus lemairei), bunga telang (Clitoria ternatea L), dan lainnya mengandung senyawa antosianin dan antioksidan alami yang dapat dijadikan sebagai zat warna dan tabir surya untuk sediaan kosmetik bibir dekoratif. Penggunaan bahan yang berasal dari alam diharapkan dapat menghasilkan kosmetika dekoratif untuk bibir yang lebih aman dan ramah lingkungan.
Uji Fitokimia dan Daya Hambat Ekstrak Daun Kelor (Moringa oleifera) dan Rimpang Kunyit (Curcuma longa. L) terhadap Bakteri Staphylococcus aureus Shinda Salsabila Khalifatunnisa; Romsyah Maryam; Elsa Fitri Ana
Jurnal Farmasi Udayana Vol 15, No 1, Tahun 2026
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2026.v15.i01.p05

Abstract

Bakteri Staphylococcus aureus adalah bakteri gram positif yang bersifat patogen dan dapat membentuk koloni pada manusia, hewan, dan tumbuhan. Kolonisasi Staphylococcus aureus menjadi awal dari timbulnya infeksi yang dapat menyebabkan penyakit berat seperti pneumonia, sepsis, cardiditis pada manusia dan mastitis pada hewan. Bakteri ini memiliki kemampuan resisten terhadap antibiotik yang saat ini digunakan sebagai pengobatan standar infeksi. Senyawa fitokimia seperti flavonoid, tanin, fenolik, dan alkaloid dari tanaman dapat menjadi salah satu alternatif untuk pembuatan antibiotik. Tujuan dari penelitian ini adalah melakukan uji fitokimia dan daya hambat dari ekstrak kloroform-metanol daun kelor dan rimpang kunyit terhadap bakteri Staphylococcus aureus. Penelitian ini adalah penelitian eksperimen dengan pengambilan data secara kualitatif dan kuantitatif. Metode ekstraksi sampel menggunakan metode maserasi dengan pelarut kloroform-metanol. Uji fitokimia dilakukan untuk mengetahui kandungan saponin, alkaloid, flavonoid, tanin, terpenoid/steroid, glikosida, fenolik. Pada uji daya hambat menggunakan konsentrasi 50%,12.5%, dan kontrol positif antibiotik tetrasiklin. Hasil penelitian menunjukan dalam ekstrak daun kelor terdapat 6 senyawa fitokimia dan dari rimpang kunyit terindetifikasi 3 senyawa fitokimia dari total keseluruhan 7 uji. Ekstrak daun kelor dapat menghambat pertumbuhan bakteri Staphylococcus aureus sebesar 10,7-12,6 mm.

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