African Journal of Clinical Medicine and Pharmacy Research
African Journal of Clinical Medicine and Pharmacy Research aims to publish rigorous, peer-reviewed scholarship that advances clinical medicine, pharmacy, and health-related sciences through scientifically sound, ethically grounded, and practically relevant research. • Clinical Advancement: disseminate high-quality studies that strengthen diagnosis, treatment, patient care, and evidence-based clinical practice. • Pharmacy and Therapeutics: promote research on drug development, pharmacology, pharmaceutical practice, therapeutics, and medication-related outcomes. • Health-Science Integration: encourage interdisciplinary links among medicine, pharmacy, pathology, microbiology, physiology, public health, and allied biomedical sciences. • Practice and Impact: support studies with meaningful implications for clinical decision-making, pharmaceutical care, healthcare systems, and patient safety. Submissions should clearly define the medical or pharmaceutical problem, report methods transparently, present defensible evidence, and articulate a meaningful contribution to clinical or pharmacy research. Scope AJCMPR welcomes original research papers and related scholarly contributions in clinical medicine, pharmacy, and associated health sciences, especially studies with clear scientific rigor, biomedical relevance, and practical healthcare implications. • Clinical Medicine: internal medicine, clinical diagnosis, therapeutic interventions, disease management, and patient-centered clinical studies. • Pharmacy Research: pharmacology, pharmaceutics, pharmaceutical chemistry, clinical pharmacy, drug safety, and rational use of medicines. • Biomedical and Laboratory Sciences: pathology, microbiology, physiology, molecular medicine, toxicology, and related translational or laboratory-based investigations. • Public and Applied Health: health systems, community health, medication adherence, healthcare delivery, and applied studies relevant to medical and pharmaceutical practice. • Interdisciplinary Health Research: studies bridging medicine, pharmacy, and allied health sciences with clear relevance to clinical or therapeutic outcomes. Priority is given to original research articles that demonstrate methodological rigor, ethical compliance, and a clear contribution to clinical medicine, pharmaceutical science, or evidence-based healthcare practice.
Articles
62 Documents
<![CDATA[Workplace Stress and Burnout among Employees in High-Technology and Research Institutions: A Review of Nursing Roles and Interventions ]]>
<![CDATA[Ajesha Musa Paul]]>;
<![CDATA[Abdullahi Isah Kuba]]>
<![CDATA[ African Journal of Clinical Medicine and Pharmacy Research Vol 3 No 3 (2026): African Journal of Clinical Medicine and Pharmacy Research ]]>
Publisher : <![CDATA[Darul Yasin Al Sys ]]>
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DOI: 10.58578/ajcmpr.v3i3.11825
<![CDATA[Workplace stress and burnout represent substantial threats to employee well-being and organizational effectiveness in demanding high-technology and research environments. This systematic review examined the principal causes and consequences of workplace stress and burnout, with particular attention to nursing-led interventions for their prevention and management. Peer-reviewed studies were identified through searches of PubMed, Scopus, and Google Scholar using terms including “workplace stress,” “burnout,” and “nursing interventions.” The reviewed evidence identified organizational, environmental, and psychological stressors as major contributors to burnout. Nursing-led interventions, particularly mindfulness-based stress reduction, cognitive behavioral therapy, and peer-support networks, were associated with reduced emotional exhaustion and improved job satisfaction. However, their implementation was constrained by organizational limitations, workforce adaptation challenges, and ethical concerns surrounding the integration of artificial intelligence into nursing practice. The findings further indicate that effective intervention requires organizational support, appropriate training for nurses in artificial intelligence, and the development of nursing-specific technological tools. This review demonstrates that addressing workplace stress and burnout in high-technology and research institutions requires an integrated approach combining evidence-based psychological interventions, peer support, technological preparedness, and supportive organizational policies. It contributes to the literature by consolidating nursing intervention strategies and identifying implementation priorities for improving employee well-being in technologically intensive workplaces.]]>
<![CDATA[Role of Heme Oxygenase-1 (HO-1) in the Pathogenesis of Hypertension among Young Adults: Association with Oxidative Stress, Inflammatory Markers, and Metabolic Profile ]]>
<![CDATA[Maijidda Abubakar Musa]]>;
<![CDATA[Kehinde Samuel Olaniyi]]>;
<![CDATA[Abdulkadir Aminu Dauda]]>;
<![CDATA[Stephanie Esosa Areloegbe]]>;
<![CDATA[Sadiya Gambo Mustapha]]>
<![CDATA[ African Journal of Clinical Medicine and Pharmacy Research Vol 3 No 3 (2026): African Journal of Clinical Medicine and Pharmacy Research ]]>
Publisher : <![CDATA[Darul Yasin Al Sys ]]>
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DOI: 10.58578/ajcmpr.v3i3.11826
<![CDATA[Hypertension in young adults is increasingly recognized as a multifactorial condition associated with oxidative stress, inflammation, endothelial dysfunction, and metabolic imbalance. This study investigated the relationship between heme oxygenase-1 (HO-1) and hypertension among young adults, with particular attention to oxidative stress markers, inflammatory mediators, and metabolic profiles. A case–control study was conducted involving 170 hypertensive and normotensive participants. Sociodemographic and clinical characteristics were assessed alongside blood pressure, body mass index (BMI), body weight, and biochemical markers, including HO-1, vascular endothelial growth factor (VEGF), insulin, nitric oxide (NO), iron, and adenosine deaminase (ADA). Compared with normotensive controls, hypertensive participants had significantly higher systolic and diastolic blood pressure (p < 0.05), as well as higher BMI and body weight. HO-1 concentrations were markedly lower in hypertensive participants (p < 0.00001), indicating reduced antioxidant capacity. Conversely, VEGF concentrations were significantly elevated (p < 0.00001), consistent with altered vascular regulation. Hypertensive participants also exhibited increased insulin concentrations (p < 0.01), reduced NO concentrations (p < 0.00001), and elevated iron and ADA concentrations (p < 0.00001), collectively reflecting metabolic dysregulation, impaired endothelial function, oxidative stress, and inflammatory activity. Correlation analysis revealed no significant associations between HO-1 and adenosine, ADA, or xanthine oxidase (p > 0.05). These findings identify a distinct biochemical profile of young-adult hypertension characterized by reduced HO-1 and NO concentrations alongside increased VEGF, insulin, iron, and ADA concentrations. Although the case–control design does not establish causality, the results highlight HO-1 as a relevant component of the oxidative and vascular alterations associated with hypertension and support further longitudinal and mechanistic investigation.]]>
