cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
MEDULA
Contact Email
medulafk@uho.ac.id
Phone
+628114058258
Journal Mail Official
medulafk@uho.ac.id
Editorial Address
Fakultas Kedokteran Universitas Halu Oleo, Kampus Hijau Bumi Tridharma Andonuhu, Kendari 93232
Location
Kota kendari,
Sulawesi tenggara
INDONESIA
MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Published by Universitas Halu Oleo
ISSN : 23391006     EISSN : 24430218     DOI : https://doi.org/10.46496
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
MEDULA invites contributions to original and fundamental research in the field of health, which must be submitted for peer reviewed articles. The journals focus and scope are contemporary medicine through biomedical research, genetics, and medical technology, Patient care practices, Disease prevention, Disease epidemiology, Family medicine, Health care center management, New drug development through research on the effectiveness of medicinal plants in treating disease, Development of traditional medicines frequently used by local communities, Utilization of marine biota for medicinal purposes, Social aspects related to the implementation of medical education and other relevant fields
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 50 Documents
 1   2   3   4   5 
The Effect Of Isometric Handgrip Exercise In Reducing Blood Pressure Of Hypertension Patients In Bajoe Village, Soropia Subdistrict, Konawe Regency Wikal Sulistia Dwi Putra; Amiruddin Eso; Pranita Aritrina Syafri; Yenti Purnamasari
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.35

Abstract

ABSTRACT Background. Hypertension is a condition where systolic blood pressure is ≥140 mmHg and diastolic pressure is ≥90 mmHg at rest. Isometric handgrip exercise is one type of exercise that is effective in reducing blood pressure in patients with hypertension. The purpose of this study was to determine the effect of isometric handgrip exercise in reducing blood pressure in hypertensive patients in Bajoe Village, Soropia Subdistrict, Konawe Regency. Methods. This study used a pre-experiment research design with a one group pretest posttest design approach with the independent variable being isometric handgrip exercise and the dependent variable being blood pressure. The sample in the study was the community of Bajoe Village, Soropia Subdistrict, Konawe Regency who suffered from hypertension as many as 30 people who were taken using Purposive Sampling technique and data analysis using Paired sample t test. Data obtained from blood pressure measurements measured before and after doing isometric handgrip exercise for 5 minutes in 5 consecutive days. Results. The results obtained from 30 samples showed that isometric handgrip exercise intervention reduced mean systolic blood pressure by 7.35 mmHg (p = 0.000) and mean diastolic blood pressure by 2.53 mmHg (p = 0.000). Conclusion. There is an effect of isometric handgrip exercise in reducing blood pressure of hypertensive patients in Bajoe Village, Soropia Subdistrict, Konawe Regency.
Anti-inflammatory Activity of Kappaphycus Alvarezii Using Protein Denaturation Inhibition Method Windy Zafa Amalia; Sulastrianah; Arimaswati
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.37

Abstract

ABSTRACT Background: Inflammation is the body's reaction to injury or tissue damage. As an NSAID, diclofenac sodium is frequently used. But since this medication has adverse effects, a substitute is required. Flavonoids found in K. alvarezii may have therapeutic uses and anti-inflammatory potential. Purpose: The goal of this research was to investigate the anti-inflammatory effect of K. alvarezii utilizing the protein denaturation inhibition method. Method: The IC50 was utilized to test anti-inflammatory effect through protein denaturation inhibition. Diclofenac sodium served as a positive control. The data were then analyzed with an independent t-test. Result: The anti-inflammatory activity test produced an IC50 of 197.94 ppm for extract K. alvarezii and 35.7 ppm for diclofenac sodium. The statistical test found a significant difference between seaweed ethanol extract K. alvarezii and sodium diclofenac (p = 0.000). Keywords: anti-inflammatory; Kappaphycus alvarezii; protein denaturation inhibition.
The Antibacterial Activity of Arabian Bidara Leave (Ziziphus spina-christi L.) against the growth of Escherichia coli Sufiah Asri Mulyawati; Amiruddin Eso; Yusni Nurul Hidayah
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.38

Abstract

ABSTRACT Background: The primary cause of mortality for children, according to the World Health Organization, is infectious illnesses. Escherichia coli is one of the bacteria that may infect people. Infections caused by E. coli have historically been treated with antibiotics. Antibiotic resistance, however, can result from improper usage. Arabian Bidara is a plant that has been shown to possess antibacterial qualities, making it a viable alternative therapy. The antibacterial properties of this plant's leaves effectively combat a variety of dangerous germs and pathogens. Purposes: to determine the effectiveness of the ethanolic extract of bidara arabic leaves as an antibacterial against the growth of Escherichia coli bacteria. Methods: This research are an experimental study with a post test only control group design with the independent variable being the treatment of arabic bidara leaf extract, the dependent variable being the zone of inhibition against Escherichia coli . Positive control in the form of ciprofloxacin and negative control using distilled water. The concentrations used were 1500 ppm, 2000 ppm, 2500 ppm and 3000 ppm with three repetitions. Results: This study showed that the ethanolic extract of bidara arabic leaves could inhibit the growth of Escherichia coli bacteria with a strong zone of inhibition at concentrations of 2000 ppm, 2500 ppm, and 3000 ppm and an inhibition zone category classified as weak at a concentration of 1500 ppm. Conclusion: There is antibacterial effectiveness of the ethanolic extract of the leaves of the arabic bidara (Ziziphus spina-christi L.) against the growth of Escherichia coli bacteria. Keywords: Antibacterial; Escherichia coli ; Ziziphus spina-christi L
VAS Pain Analysis Before and After Genicular Nerve Block in Different Types Occupations of Knee Osteoarthritis Patients in Orthopedic Polyclinic Hati Mulia General Hospital Kendari Febriski Okta Bimantara S; Muhammad Rustam HN; Tien
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.39

Abstract

ABSTRACT Background: Knee OA patients suffer from joint pain, stiffness, instability, and swelling. This causes a decrease in the quality of life and daily activities. Knee osteoarthritis is a multifactorial disease, namely modifiable and non-modifiable factors. One of the modifiable risk factors for OA is occupation. One of the therapies for knee OA is Genicular Nerve Block (GNB). Purposes: to determine the correlation between the type of work and VAS of pain before and after genicular nerve block in knee OA patients at the Orthopedic Clinic, Hati Mulia General Hospital, Kendari. Methods: This quasi-experimental research used a one-group pretest-posttest design approach without control. This study has conducted using a questionnaire (informed consent, respondent form, and VAS sheet) from 29 OA patients before and after genicular nerve block (GNB) was performed at the orthopedic polyclinic of Hati Mulia General Hospital for the period November 2021. The dependent variable observed was VAS and the independent variable observed was the type of work. Data analysis used the Spearmen and Wilcoxon statistical test and if p <0.05, it indicated that there was a correlation between the independent and dependent variables. Results: Analysis of the correlation between occupational type and VAS pain before genicular nerve block (GNB) obtained p-value = 0.624, the correlation between occupational type and VAS pain after GNB obtained p-value = 0.716, and the influence before and after GNB on VAS pain obtained p-value = 0.000. Conclusion: There was no correlation between the occupational type and the pain VAS before and after Genicular nerve block (GNB) there was a difference before and after the Genicular nerve block (GNB) on the pain VAS. Keywords: Osteoarthritis, ocupational type, VAS, GNB
Effectivity Test of Ethanol Extract of Arabic Bidara Leaf (Ziziphus Spina-Christi L.) As Antibacterially Against Growt Bacteria Pseudomonas aeruginosa and Bacillus cereus Vira Adiningsi; Amiruddin Eso; Yenti Purnamasari
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 2 (2024)
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v11i2.40

Abstract

Background. Infection disease is one of the major health problems in developing countries including Indonesia, one of which is nosocomial infection caused by Pseudomonas aeruginosa bacteria. On the other hand, food poisoning is still a serious problem in Indonesia especially caused by pathogenic bacteria, one of which is Bacillus cereus bacteria. Indonesia is famous for its potential as home to medicinal plants. One plant that can potentially be used as an alternative in the treatment of this bacterial infection is arabic bidara leaves. This study aims to find out the effectiveness of arabic bidara leaf ethanol extract (Ziziphus spina-christi L.) as antibacterial against bacterial growth of Pseudomonas aeruginosa and Bacillus cereus. Methods. This study was an experimental study with a post test only control group design with a free variable in the form of treatment of arabic bidara leaf extract, a bound variable in the form of an inhibitory zone against Pseudomonas aeruginosa and Bacillus cereus. Positive control of ciprofloxacin and negative control using aquades. The concentrations used were 1500 ppm, 2000 ppm, 2500 ppm and 3000 ppm with three repetitions. Results. An ethanol extract of arabic bidara leaves has an inhibitory zone classified as strong at concentrations of 2000 ppm, 2500 ppm, and 3000 ppm. Conclusion. There is an antibacterial effectiveness of arabic bidara leaf ethanol extract against bacterial growth of Pseudomonas aeruginosa and Bacillus cereus. Keywords: Antibacterial, Bidara Arab Leaves, Pseudomonas aeruginosa, Bacillus cereus
Transcranial Magnetic Stimulation Can Improve Cognitive Function and Brain-Derived Neurotrophic Peptide Levels in Post-Ischemic Stroke Patients Ulima Rahma Asri; Jumraini Tammasse; Andi Kurnia Bintang; Rina Masadah; Muhammad Akbar; David Gunawan Umbas
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.41

Abstract

ABSTRACT Background: Stroke can cause a significant burden of morbidity, including complications of impaired cognitive function. The problem being investigated is hypothesized to be related to brain-derived neurotrophic factor (BDNF), which can be increased by repetitive transcranial magnetic stimulation (rTMS). Purpose(s): To evaluate the effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on serum BDNF levels and cognitive function in ischemic stroke patients. Methods: A pre-test post-test control group, experimental study design, was applied to research conducted at Dr Wahidin Sudirohusodo Makassar and network hospitals in June 2023 until the sample size was met. All ischemic stroke patients who experienced impaired memory function were divided into control (medicamentous, n=10) and treatment (medicamentous + rTMS, n=11). Both at baseline and 14 days following therapy, their BDNF levels and MoCA-INA scores were assessed. ELISA examination is used to measure BDNF levels. The dependent T-test was used to analyze changes in MoCA-INA and BDNF scores in each group. Results: In the treatment group, the median MoCA INA score (26.00 (18.00-28.00) vs. 16.00 (13.00-21.00; p=0.001)) and BDNF levels (1.66 (0.78-3.59) vs. 1.55 (0.01-2.76); p=0.002) increased in two weeks. In contrast, the MoCA-INA score and BDNF levels in the control group did not show a statistically significant difference over a two-week period. MoCA-INA scores and BDNF levels in the treatment group showed a significant and favorable correlation, but not in the control group. Conclusion: rTMS can improve patients' cognitive function after ischemic stroke by improving BDNF levels. Keywords: Brain-derived neurotrophic factor, cognitive function, ischaemic stroke, repetitive transcranial magnetic stimulation
The Correlation Analysis of Macronutrient Intake and Balanced Nutrition Index with the Degree of Depression in Preclinical Medical Students Nina Indriyani Nasruddin; Edy Husnul Mujahid; Arimaswati; Sufiah Asri Mulyawati
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.42

Abstract

ABSTRACT Background: Depression is a mood disorder characterised by deep feelings and a loss of interest in things you like. Many teenagers, including medical students worldwide, suffer from depression, a mental health problem. Depression affects the way the body processes food and can cause changes in metabolism. A decrease in leptin levels can accompany depression symptoms, leading to a decrease in appetite and influencing changes in nutritional status. Purpose(s): This study aims to analyse the relationship between macronutrient intake and the balanced nutritional index (BNI) on depressive symptoms in pre-clinical students at the Faculty of Medicine, Halu Oleo University. Method: This study used a cross-sectional design. The number of samples in this research was 96. We obtained the macronutrient intake using the 2x24-day Food Recall and the Balanced Nutrition Index (BNI), questionnaire to assess whether the consumed food was in accordance with dietary recommendations. We obtained depressive symptoms by completing the Beck Depression Inventory-II (BDI II) questionnaire. We then analysed the data using the rank-spearman test. Results: Of the samples, 21.9% had insufficient carbohydrate intake, 16.7% had insufficient fat intake, and 3.1% had insufficient protein intake. Of the 96 samples, there were 5 students who experienced severe depression (5.2%). There is a weak positive correlation between carbohydrate intake and depressive symptoms (p = 0.017, r = 0.244). There is no correlation between BNI and depressive symptoms in pre-clinical students at the Faculty of Medicine, Halu Oleo University. Conclusion: Macronutrient intake, especially carbohydrates, has a correlation with depressive symptoms in pre-clinical students at the Faculty of Medicine, Halu Oleo University. Keywords: BNI;Depressive Symptoms;Macronutriens; Medical Students
Effect of Giving Galoba (Hornstedtia alliacea) Fruit Extract on Catalase Activity in Mice (Mus musculus) Hyperglycemia Induced by MultipleLow Dose-Streptozotocin (MLD-STZ) Elisa Melinia Perangin-angin; Rachmawati Dwi Agustin; Indrawanti Kusadhiani
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.43

Abstract

ABSTRACT Background: Hyperglycemia is a medical condition in which the fasting blood sugar level is ≥100 mg/dL. Prolonged hyperglycemia causes pancreatic β-cells to malfunction and causes a decrease in insulin secretion. Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia which occurs when there is an increase in blood glucose levels due to the pancreas not producing enough insulin or the body not using insulin effectively or a combination of both. Galoba fruit (Hornstedtia alliacea) is a plant endemic to Maluku that contains antioxidant compounds which are thought to increase catalase enzyme activity after hyperglycemia. Purpose(s): This study aimed to determine the effect of giving Galoba fruit extract (Hornstedtia alliacea) on the activity of the catalase enzyme in serum mice (Mus musculus) with MLD-streptozotocin induced (Multiple Low Dose Streptozotocin) hyperglycemia. Methods: This research was an experimental study with a post-test only group design. Twenty-four mice were divided into six treatment groups: normal control (KN), negative control (K-), positive control (K+), 100% concentration of Galoba fruit extract (P1), 75% concentration of Galoba fruit extract (P2), and Galoba fruit concentration was 50% (P3). Groups P1, P2, and P3 were induced using streptozotocin at a dose of 40 mg/kg BW in hyperglycemic mice and given an extract at a dose of 0.2 mL according to the concentration of each Galoba fruit. Group K+ was induced by streptozotocin and given metformin therapy at a dose of 0.2 mL. Induction of MLD-streptozotocin at a dose of 40 mg/kg for 5 consecutive days in a row. Administration of therapy in groups of K+, P1, P2, and P3 for 21 days. After the end of treatment, blood serum was taken from the heart to measure the activity of the catalase enzyme. Results: Galoba fruit extract (Hornstedtia alliacea) increased the catalase activity, but it was not significant effect on increasing the activity of the catalase enzyme (p> 0.05). The group of mice that experienced the greatest increase in enzyme activity came from the P3 group at 0.6716 U/mL (61%), followed by P2 at 0.6119 U/mL (57%), and P1 at 0.3435 U/mL (25%). Conclusion: The increased activity of the catalase enzyme was due to the presence of secondary metabolites of flavonoids and terpenoids from the results of phytochemical tests contained in Galoba fruit (Hornstedtia alliacea). Keywords: Catalase Enzyme ; Hornstedtia alliacea; Hyperglycemia
Accuracy of Conventional Radiographic Parameters in Predicting Posterior Ligamentous Complex (PLC) Rupture in Thoracolumbar Fracture Confirmed by Magnetic Resonance Imaging (MRI) Nelly; Mirna Muis; Muh. Ilyas; Karya Triko Biakto; Andi Alfian Zainuddin
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.44

Abstract

ABSTRACT Background: Most of spinal injuries involve thoracolumbar region and are unstable. Burst fracture with posterior ligamentous complex (PLC) rupture that is not treat with surgical intervention may develop progressive kyphotic. The initial radiological examination is conventional radiographs, which can be followed by computed tomography (CT) and magnetic resonance imaging (MRI). MRI provides detail-images of soft-tissue structures so that it may provide an accurate diagnosis in predicting PLC rupture. However, the usage of MRI is still limited because of its rare availability and when patients have contraindications to MRI such as metal implants. Purpose: This study aimed to predict whether some radiographic parameters are closely related to PLC rupture, as confirmed by MRI in thoracolumbar fracture. Methods: This research is a diagnostic study using secondary data from patients who had conventional radiographic and MRI examination at Radiology Department of Dr. Wahidin Sudirohusodo which is diagnose as compression fractures and burst fractures from December 2020 until August 2022 and total of 73 samples are obtained to measure the accuracy of conventional radiographic parameters with Youden index. Results: The mean age of the sample was 41.53 years (rage 21-59 years) with more male patients than female patients and most of the fracture site is at L1. Supraspinous distance (SSD), local kyphosis (LK) and Cobb’s angle (CA) have significant p values of 0.005, 0.013 and 0.000 (respectively). Meanwhile, the anterior vertebral body compression percentage (AVBC%) and anterior edge-inferior endplate angle (AEIEA) had insignificant p values. The sensitivity, specificity and accuracy of SSD, LK and CA varied, namely 68.76%, 88.89%, 79% for SSD; 75%, 66.67%, 75.3% for LK dan 75%, 77.78, 82.2% for CA. Conclusion: From five conventional radiographic parameters that is measured, only three parameters had significant p values, which is supraspinous distance (SSD), local kyphosis (LK), and Cobb’s angle (CA) with varying sensitivity, specificity and accuracy, meanwhile anterior vertebral body compression percentage (AVBC%) and anterior edge-inferior endplate angle (AEIEA) are not correlated for predicting PLC rupture. Keywords: Cobb’s angle; local kyphosis; posterior ligamentous complex; supraspinous distanc;, thoracolumbar injury
Neuroprotective Effect of Brain-Derived Neurotrophic Factor (BDNF) on Cerebral Infarct Volume and Clinical Severity of Acute Ischemic Stroke Satrio Wicaksono; Andi Kurnia Bintang; Muhammad Akbar; Muhammad Yunus Amran; Cahyono Kaelan; Isra Wahid
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.45

Abstract

ABSTRACT Background: Brain-Derived Neurotrophic Factor (BDNF) plays a crucial role in protecting nerves following ischemic stroke. The neuroprotective effects of BDNF on cerebral infarct volume and clinical severity after ischemic stroke need to be further studied in-depth. Purpose(s): The purpose of this study is to understanding the relationship between BDNF levels, cerebral infarct volume, and the severity of clinical conditions in acute ischemic stroke patients. Methods: This study is an observational nalytical research with a cross-sectional design. A total of 30 individuals who meet the inclusion criteria were included as samples. Cerebral infarct volume was measured using non-contrast head CT scans with the Broderick formulation, and clinical severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). The collected data were then analyzed using statistical tests. Results: There is a significant relationship between serum BDNF levels and cerebral infarct volume with a p-value of 0.004 and a correlation coefficient (r) of -0.509. Similarly, a significant relationship exists between serum BDNF levels and NIHSS with a p-value of 0.042 and a correlation coefficient (r) of -0.374. Conclusion: There is a negative correlation between serum BDNF levels and cerebral infarct volume in acute ischemic stroke patients, as well as a negative correlation between serum BDNF levels and clinical severity in acute ischemic stroke patients. Keywords: BDNF; Infarct Cerebri Volume; NIHSS

Page 4 of 5 | Total Record : 50

 1   2   3   4   5 

Filter by Year

2022 2025


Reset
Filter By Issues
All Issue Vol. 13 No. 1 (2025): Desember Vol. 12 No. 2 (2025): Juli Vol. 12 No. 1 (2024): Desember Vol. 11 No. 2 (2024) Vol. 11 No. 1 (2023): Akhir Vol. 10 No. 3 (2023): Suplemen Vol. 10 No. 2 (2023): April Vol. 10 No. 1 (2022): Oktober