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MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Published by Universitas Halu Oleo
ISSN : 23391006     EISSN : 24430218     DOI : https://doi.org/10.46496
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
MEDULA invites contributions to original and fundamental research in the field of health, which must be submitted for peer reviewed articles. The journals focus and scope are contemporary medicine through biomedical research, genetics, and medical technology, Patient care practices, Disease prevention, Disease epidemiology, Family medicine, Health care center management, New drug development through research on the effectiveness of medicinal plants in treating disease, Development of traditional medicines frequently used by local communities, Utilization of marine biota for medicinal purposes, Social aspects related to the implementation of medical education and other relevant fields
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 50 Documents
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The Activity of Notika Leaves (Archboldiodendron calosericeum Kobuski) Against Tumors Necrosis Factor Alpha (TNF-α) Levels in Rats Nuralifah Nuralifah; Parawansah Parawansah; Fadhliyah Malik; Nining Yulianti
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Background: Inflammation is a response process to tissue injury and infection. The inflammatory response causes the release of pro-inflammatory mediators such as IL-1, IL-6 and TNF-α which are the main cytokines in the acute inflammatory response. Plants that have the potential to be anti-inflammatory are notika leaves (Archboldiodendron calosericeum Kobuski). Purpose: This research was conducted to evaluate the anti-inflammatory activity of the ethanol extract of notika leaves against the levels of Tumor Necrosis Factor Alpha (TNF-α) in Wistar rats. Methods: The study used a post test only control group design. Rats were divided into five groups consisting of a positive control (diclofenac sodium), three extracts (100, 200 and 300 mg/kg BW) and Teeee carragenantrol gopre roups that are inlaporkan dari tanaman ketapang dalam spewa yang dilaporkan pada besar, dll --lar.negative control (NaCMC 0.5%). In vivo tests were carried out by induction of inflammatory using carragenan, administering preparations and measuring TNF-α levels using the ELISA method. Data were analyzed using the One Way ANOVA test. Results: The results showed that the mean levels of TNF-α in the positive control group (0.475 ng/L), negative control (0.816 ng/L), extract dose 100 mg/kgBW (0.67 ng/L), extract dose 200 mg/kgBW (0.7285 ng/L) and extract dosage of 300 mg/kgBW (0.7785 ng/L). Conclusion: The study concludes that the ethanol extract of notika leaves has anti-inflammatory activity against the levels of Tumor Necrosis Factor Alpha (TNF-α) in Wistar rats based on the reduction in levels with negative control and optimum dose was 100 mg/kgBW.
Correlation of Risk Factors with The Incidence Of Functional Dyspepsia Syndrome in Medical Faculty Students, Universitas Khairun Muhammad S.F. Syah; Abdul A. Manaf; Fera The
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
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Background: Dyspepsia is a collection of discomfort, epigastric pain, bloating, nausea, vomiting, belching and a feeling of fullness. Stress, diet, irritating food/drink, non-steroidal anti-inflammatory drugs, Helicobacter pylori bacteria, alcohol and smoking are risk factors for dyspepsia. Although it is ranked 8th out of 10 specific diseases in North Maluku, there has been no research regarding the association of risk factors with incidence in this group, especially in young people at Khairun University. Purpose: Knowing the relationship of risk factors with the incidence of functional dyspepsia syndrome in students of the Faculty of Medicine Khairun University. Methods: Observational and analytic case control study with Total Ramdom Sampling at Medical Faculty students 2018-2021.Results: In 136 samples, a statistically significant relationship (<0.05) was found between gender, stress level, consumption of irritating food or drink, consumption of non-steroidal anti-inflammatory drugs, smoking degree and the incidence of functional dyspepsia syndrome in students of the Faculty of Medicine, Khairun University, while diet and alcohol consumption did not have a significant relationship. Conclusion: Most of the risk factors affected the incidence of functional dyspepsia syndrome in students of the Faculty of Medicine, Universitas Khairun.
Relationship between Waist Circumference (Abdomen) & Triglyceride and Low Density Lipoprotein-Cholesterol (LDL-C) Levels in Premenopausal Women Mutmainnah Abbas; Thaslifa Thaslifa; Rosdiana Mus; Feby Muliyanti; Nurmiati S
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
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Background: Premenopausal is a period that women will experience before heading to the menopause phase in the age range of 4 5-55 years. In the premenopausal period it is characterized by the instability of the hormone estrogen which will affect lipid metabolism which is closely related to the increase in abdominal fat known as abdominal or central obesity. The instability of the hormone estrogen results in hormonal changes that affect the levels of lipids in the body such as TG and LDL-Chol levels in the blood. Purpose: This study aimed to determine whether there was a relationship between Waist Circumference (Abdomen) and Triglyceride and Low Density Lipoprotein-Cholesterol (LDL-C) Levels in Premenopausal Women. Methods: This study used an analytical correlative method with a cross-sectional study approach. This study involved 40 research subjects who met the criteria. Results: the pearson correlation test analysis determined the relationship between the abdominal waist circle and TG levels in premenopausal women, the results of the p value = 0.351 and the pearson correlation test value = 0.15 were obtained. In the correlation between waist circumference (abdomen) and LDL- Chol levels in premenopausal women, p-value = 0.164 with a pearson correlation value of 0.224 was obtained. Conclusion: There was no relationship between Waist Circumference (Abdomen) and Triglyceride and Low Density Lipoprotein-Cholesterol (LDL-C) Levels in Premenopausal Women.
Antibacterial Activity and Phytochemical Screening of Ethanol Extract of Cashew Leaves A. occidentale L. Against Escherichia coli Eka Astuty; Rolan Aponno; Is I. Hataul
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
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Background: All parts of the cashew tree Anacardium occidentale L. (especially the leaves and bark) have been widely used as traditional herbal medicines, and are used throughout the world. Thus, in recent decades, the traditional medicinal properties of the Anacardium plant, and its various biological effects are being studied extensively. Purposes: This study aimed to conduct a preliminary study of the antibacterial properties and phytochemical screening of the ethanol extract of cashew leaves. Methods: The antibacterial test of was determined by the Kirby-Bauer disc paper diffusion method. Qualitative test of phytochemical content was carried out using chemical reagents. Results: The results indicated that the ethanol extract of cashew leaves has an inhibitory effect on the growth of Escherichia coli. The smallest inhibition zone was found in the extract with a concentration of 10% of 5.75 mm and the largest was found at a concentration of 100% with a diameter of 14 mm. The phytochemical screening revealed that extracts contained; alkaloids, flavonoids, steroids, terpenoids, phenolics, saponins, and tanins Conclusions: The ethanol extract of cashew leaves was able to inhibit the growth of Escherichia coli test bacteria at all concentration variations. Phytochemical screening also found that the ethanol extract of cashew leaves contains alkaloids, flavonoids, steroid terpenoids, phenolics, saponins, and tannins which are known to have antibacterial properties.
Risk Factors for Acute Respiratory Infection in Toddlers: A Case Control Study Mira Juanita; Elpira Asmin; Vebiyanti Tentua
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Background: Acute Respiratory Infection (ARI) is a disease that attacks the upper and lower respiratory tract caused by bacteria and viruses. ARI is one of the causes of high morbidity and mortality in under-fives. Purposes: This study aims to determine the relationship between toddler age, immunization status, smoking habits of family members, mother's knowledge, and residential density to the incidence of ARI in the working area of ​​the Namlea Health Center in 2021 Methods: This study is a research study quantitative analysis using a case control research design. The sample in the case group was taken using the simple random sampling method and the control group was taken using the accidental sampling method. Results: the age of toddlers who were 36 months (55.2%), incomplete immunization status (46.9%), smoking habits of family members (68.8%), low maternal knowledge (30.2%), and density of bedroom occupancy (60.4%). The results showed that the OR values for each variable were age (2.896), immunization status (3.182), room occupancy density (3.355), mother's knowledge (4.308), and smoking habits of family members (3.462). Conclusions: age, immunization status, room occupancy density, mother's knowledge and smoking habits are risk factors for the incidence of ARI in the working area of the Namlea Public Health Center
Analysis of Condom Use Among Female Sex Workers as an Effort to Prevent HIV/AIDS in Kendari City: Cross Sectional Study Adius Kusnan; Nur I. Purnamasari; Nisa M. Arman; La O. Alifariki
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
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Background: One of the populations at high risk of HIV/AIDS is Female Sex Workers (FSW) due to unsafe sex behavior, namely changing partners. The use of condoms is one of the initiatives to prevent the transmission of HIV/AIDS, and its use can be influenced by various variables. Purpose: This research intends to comprehend what factors relate to condom use to female sex workers as a HIV/AIDS prevention effort. Methods: This cross sectional study is an observational analytic study conducted in Kendari City with a sample of 65 people according to the inclusion and exclusion criteria selected using purposive sampling, data analysis using the Pearson chi-square test. Results: According to the results of the study, it was found that most of the FSW were 20-30 years old (76.9%), from Kendari (73.8%), last education was high school (64.6%), marital status was unmarried (75.4%), had good knowledge regarding HIV/AIDS and condoms (58.5%), had positive attitudes about condom use (66.2%), had exposure to information about condoms to prevent HIV/AIDS (95.4%) and always used a condom (55.4%). The results of this study indicated that there was a relationship between knowledge (p-value = 0.012) and attitude (p-value = 0.027) of condom use in FSW. There was no correlation between information expose (p-value=0.084) with condom use in FSW. Conclusion: FSW who have less knowledge and negative attitudes tend to have implications for decreasing condom use.
Development Of Spray Gel From Ethanol Extract Of Bamboo (Polygonum pulchrum Blume) Plants Using Viskolam® and Hydroxypropyl Methyl Cellulose (HPMC) Gel Combination Base Wa O.S. Zubaydah; Vica Aspadiah; Muhammad Ammar
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
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Background: Bamboo plants are one of the traditional medicinal plants that are often used by the community. The stem of Polygonum pulchrum Blume contains a triterpenoid steroid compound that acts as an active antioxidant. Purpose: This study aims to determine the optimal formula for spray gel preparation of P. pulchrum Blume ethanol extract using Design Expert®. Methods: The stems of P. pulchrum Blume were extracted by maceration using 96% ethanol to obtain a thick extract. The extract obtained was formulated with spray gel preparations with variations in the concentration of viscolam® and HPMC F1(0,1%:0,1%), F2(0,4%:0,1%), F3(0,4%:0, 4%), and F4(0,1%:0,4%). The test was carried out by looking at the characteristics consisting of same tests: organoleptic, pH, viscosity, spray pattern, dry time and homogenity, and also to determined the stability of the spray gel before and after the cycling test. Optimization of the spray gel formula using a factorial design of 23 with a viscolam® factor and HPMC using dry time response, viscosity, and spraying pattern. After obtaining the optimum formula, hedonic testing was carried out by looking at the parameters of color, aroma, texture, and overall appearance. Results: The results showed that the optimum formula for the F2 formula was the concentration of viscolam® and HPMC 0.4%: 0.1%, as well as spray gel preparations that had been evaluated for stability and had met the stability test requirements based on the test parameters. Conclusion: the optimal formula for spray gel preparation of P. pulchrum Blume ethanol extract using Design Expert® was a formula with a combination of viscolam® gel and HPMC 0.4% : 0.1%.
Correlation between Chest Radiograph and Lung Ultrasound with Clinical Appearance in Hyaline Membrane Disease Patients Wa O. Zerbarani; Sri Asriani; Mirna Muis; Ema Alasir
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
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Background: Hyaline membrane disease (HMD) is a respiratory distress disease in premature infants due to surfactant deficiency. The combination of clinical, laboratory and radiological features makes it easy to quickly, precisely & accurately establish HMD which is important for early therapy in preventing death. Purpose: Knowing the suitability between chest X-ray & Thorax ultrasound with the clinical picture in HMD patients. Methods: This study is an observational study with a cross sectional method conducted in the radiology & NICU section of Dr. Wahidin Sudirohusodo Makassar from August 2021 to January 2022. Sampling was done by consecutive sampling. The researcher performed a thorax ultrasound & assessed the chest x-ray. The results were verified by two pediatric radiology consultants. Results: The largest sample was in neonates at 34 weeks of gestation, 8 samples (21.1%), sex with 25 samples (65.8%), the highest birth weight between 1000-2000 grams 32 samples (84.2%) , the most preterm etiology was due to severe preeclampsia in 13 samples (34.2%), the most deliveries were by cesarean section 34 samples (89.4%), the highest APGAR Score was in moderate degree 25 samples (65.8%), the highest O2 saturation was between 90 -94%, namely 24 samples (63.2%), the most down scores were moderate degrees 15 samples (39.5%), HMD degrees based on chest radiographs were mostly grade II 25 samples (65.8%), HMD degrees based on thorax ultrasound the most in the moderate degree 19 samples (50%).Conclusion: Ultrasound is considered as the radiological modality of choice because it is safe, inexpensive, easy & sensitive to assess respiratory distress in neonates but is influenced by the operator's ability to apply it.
Factors Related to Nutritional Status of Toddlers in the Working Area of Soropia Health Center, Konawe Regency in 2021 Lisnawaty; Jafriati; Nurfajriyanti Hamka; Febriana Muchtar
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
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Background: Nutritional status is a state of health related to the use of food by the body. As a result of poor nutritional status during infancy, it can cause stunted growth, cause toddlers to be lazy to carry out activities related to energy production, disruption of the toddler's immune system so that they are susceptible to infectious diseases, inhibition of optimal brain growth, and changes in behavior such as apathy. Purposes: This study aimed to determine the relationship between parental income, and eating patterns in children under five with the occurrence of malnutrition in children under five in the working area of ​​Soropia Health Center. Methods: This research was a quantitative research that is observational analytic with a Cross Sectional Study approach. The number of samples were 50 toddler with a sampling technique using total sampling and for analysis using the Chi-Square test. Results: The results showed that there was a relationship between parental income (p=0.048) and eating patterns (p=0.000) with the nutritional status of children under five in the Soropia Health Center area in 2021. Conclusion:it was found that there was a relationship between parents' income and diet. on the nutritional status of children.
Correlation of Pelvimetry and Age Based on 3D CT Scan Examination Teuku Fadlian Syah; Mirna Muis; Rafikah Rauf; Andi Alfian Zainuddin
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
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Background: The radiological pelvimetry is a measurement by using 3D Computed Tomography (CT) which will pelvis shape. The Pelvimetry size is not always constant, but it can change due to several factors, among others are age, heredity, number of pregnancies. The age changes can be related to the adaptation to the sitting position and compensation of the spino-pelvic balance change having the impact on the walking style stability. Purposes: The research aims to analyze the correlation between the pelvimetry and age based on CT scans 3D examination of patients from January 2021 to April 2022 in General Central Hospital of Dr. Wahidin Sudirohusodo, Makassar Indonesia. Methods: The research used the cross sectional design with Spearman correlation test. Results: There were 105 samples involved in the research. The most age group ranged from 40 to 49 years old with the percentage of 32.4%. The average size of the conjugate vera is 11.49 cm (SD±0.95), obstetric conjugate is 11.46 cm (SD±0.92), diagonal conjugate is 12.27 cm (SD±0.87), interspinous diameter is 10 .15 cm (SD±0.95), intertuberous diameter is 10.58 cm (SD±1.02), and transverse diameter is 11.99 cm (SD±0.88). The research result indicates that the conjugate vera, obstetrical conjugate, diagonal conjugate, and intertuberous diameter have the correlation with the age (p<0.05), while the interspinous diameter and transverse diameter do not indicate the correlation (p>0.05). Conclusions: The conjugate obstetrics and conjugate diagonalis have weak correlation, while the moderate correlation strength occurs in the intertuberous diameter.

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