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MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Published by Universitas Halu Oleo
ISSN : 23391006     EISSN : 24430218     DOI : https://doi.org/10.46496
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
MEDULA invites contributions to original and fundamental research in the field of health, which must be submitted for peer reviewed articles. The journals focus and scope are contemporary medicine through biomedical research, genetics, and medical technology, Patient care practices, Disease prevention, Disease epidemiology, Family medicine, Health care center management, New drug development through research on the effectiveness of medicinal plants in treating disease, Development of traditional medicines frequently used by local communities, Utilization of marine biota for medicinal purposes, Social aspects related to the implementation of medical education and other relevant fields
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 50 Documents
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Relationship Between Food Consumption Patterns and Nutritional Status in Nambo Sub-District Community Aisyah Az-Zahrah Mansur; Nina Indriyani Nasruddin; Amiruddin Eso
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Background: Nutritional status is an individual's health condition, which is determined by the degree of physical need for energy and nutrients obtained from food. The most important behavior that can affect nutritional status is consumption pattern. This is because the quantity and quality of consumed food and drink will affect nutritional intake, which in turn it will affect the health of individuals and society. Purposes: The purpose of this study is to determine the relationship between consumption patterns of carbohydrate source foods and nutritional status in the people of Nambo District. Method: This research is an observational analytic study with a cross sectional approach. This study's population includes all residents of the Nambo District. The research sample consisted of 106 respondents, who were selected using the purposive sampling technique. Data collection included examining nutritional status by weighing and measuring height as well as conducting interviews using Food Recall 24 Hours for 2 days. Data were analyzed by Spearman's rank test. Results: The results of this study indicate that there is a significant relationship (p < 0.05) between the consumption patterns of carbohydrate source foods and nutritional status in the people of Nambo District, and the value of r = 0.493 indicates the strength of the correlation between consumption patterns of carbohydrate source foods and nutritional status in the people of Nambo District is moderate in nature with a positive correlation direction, which indicates a unidirectional correlation direction. Conclusion: There is a relationship between consumption patterns of carbohydrate source foods and nutritional status among the people of Nambo District.
Development of Drug Delivery System for Sinus Mucosal Tissues with Mucoadhesive Thermosensitive Sol-Gel Components: Analysis of Evidence from Laboratory to Animal Research Muhammad Ilham Dhiya Rakasiwi; Ahmad Fadhil Ilham; Natan Kevin Partogu Siagian
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
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Background: Chronic rhinosinusitis (CRS) is a chronic inflammation of the nasal cavity (12 weeks or more). Until now, the pharmacological treatment for CRS using a nasal drug delivery system (DDS) has been frequently chosen due to the convenience of the administration. However, nasal DDS shows several disadvantages, such as the vulnerability of sinus mucosa to irritation and medication. Purpose: To assess available literature evidence regarding nasal DDS based on sol-gel using P407 and HPMC for CRS therapy. Methods: A literature search on nasal DDS development using sol-gel thermosensitive mucoadhesive P407 and HPMC was conducted through Pubmed and Proquest journal databases. The supporting articles were searched using specific keywords with inclusion criteria. Results: Sol-gel with P407 (15,5% w/w) and HPMC (0,4% w/w and 0,7% w/w) shows gelation temperature 34.18±0.06oC and 32.76±0.45oC respectively, and virtually clear gel. Rheological evaluation of sol-gel DDS shows modulus G’>G” at 8oC (solution form), while at 32oC shows modulus G’<G” (elastic gel form). In vitro test of dexamethasone release shows velocity 70-81 μg/cm2 h−1/2 after 72 hours of administration. Ex vivo test shows slow permeation of dexamethasone at sinus mucosa for 8 hours. Conclusion: Based on the in vitro and ex vivo models, the thermosensitive mucoadhesive gel composed of p407 and HPMC produced extended drug release profiles in conditions mimicking the human nasal cavity, which indicated their suitability for treating a range of conditions affecting the nasal cavity/sinuses.
Correlation between Lymphocyte Count and RT-PCR Cycle Threshold Value in Patients with Corona Virus Disease-19 at RS Pelamonia Makassar Rosdiana Mus; Sasminiarti; Mutmainnah Abbas; Elpira Asmin; Titin Agustina
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
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Background: COVID-19 caused by Coronavirus (CoV) attacks the human respiratory system. COVID-19 as an outbreak at the end of 2019 caused deaths all over the world. Diagnosis of COVID-19 through RT-PCR and laboratory test such as lymphocyte was count. Purposes: The aims of the research is the relationship between CT values and lymphocytes. Methods: This type of observational research with a cross sectional study. The sample technique in this study is purposive sampling. The data used is secondary during the July-December 2021 period at the TK II Pelamonia Makassar Hospital. The population in this study was all Covid-19 patients at TK II Pelamonia Makassar Hospital with inclusion criteria of positive RT PCR results, aged 25-50 years and without history of autoimmune disease. The results of lymphocyte and CT values used medical record data. The sample size was 130 subjects accordance theinclussion criteria. Results: The research subjects were 130 subjects consisting of 71 (54.6%) male and 59 (45.4%) female. The mean age of the research was 37.88 years. The average of lymphocyte count is 27.95 and average of CT values is 32.30. Conclusion: There is no relationship between lymphocytes and CT values with gender and there is no significant relationship between CT values with the lymphocytes counts.
The Immunization Status and Nutritional Knowledge Level of the Mother Influence the Nutritional Status of Toddlers in the Nambo Primary Health Care Working Area, Kendari City Milati Hamidah; Sulastrianah; Nina Indriyani Nasruddin
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
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Background: Due to their golden age of physical development and intelligence, infants nutritional status requires special consideration. Preliminary investigations at the Nambo Primary Health Care found that 19 toddlers suffered from wasted, with four being severely wasted. Purpose: The purpose of this study is to examine the influence of the toddler's immunization status and the mother's level of nutritional education on the nutritional status of infants in the Nambo Primary Health Care working area. Methods: This study utilized a case-control design in the Nambo Primary Health Care working area from November to December 2022. This investigation included 69 toddlers as participants (23 toddlers in the case group and 46 toddlers in the control group). We gathered data by administering a questionnaire and measuring the toddler's weight and height, which we analyzed using the chi-square test and Fisher’s Exact test. Results: Results indicated that immunization status significantly influences the nutritional status of infants (OR = 4.594; p = 0.034; 95% CI: 1.183–17.840). The mother's nutritional knowledge has a significant effect on the nutritional status of toddlers (OR = 10.587; p = 0.000; 95% CI = 3.118–37.818). Conclusions: The nutritional status of toddlers in the Nambo Primary Health Care Working Area, Kendari City, is influenced by the nutritional knowledge and vaccination status of their mothers.
Ethanol Extract Activity of Teak Leaves (Tectona grandis L) Against Histopotological Appearance of Pancreatic Organs in Rats (Rattus norvegicus) Model Type II DM Nuralifah; Parawansah; Ruslin; Rachma Malina; Emma Haerunnita
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
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Background: Diabetes mellitus is a disease characterized by increased blood glucose levels and changes in the histopathological structure of the islets of Langerhans of the pancreas. One of the plants used empirically as an antidiabetic is the teak plant (Tectona grandis Linn). The content compounds that are thought to act as antidiabetics are flavonoids. Purpose: The purposes of this study is to determine the activity of the ethanol extract of Tectona grandis L leaves which has antihyperglycemic activity as seen from the histopathology of the pancreas of white rats (Rattus norvegicus). Methods: Modeling diabetes mellitus in test animals was carried out by inducing 40 mg/kg BW streptozotocin intraperitoneally. There were 6 treatment groups, namely the normal control group, the positive control group, the negative control group, and the teak leaf ethanol extract group at doses of 100, 200, and 300 mg/kg. Results: The ethanol extract of Tectona grandis leaves has repair activity for regenerating endocrine cells in the islets of Langerhans with an average number of endocrine cells in the normal control group of 483 cells, positive control group 474 cells, negative control 318 cells, dose 100 mg/kg body weight 450 cells, a dose of 200 mg/KBB 462 cells and a dose of 300 mg/KBB 469 cells and it can regenerate endocrine cells. Conclusion: the ethanol extract of Tectona grandis L leaves at a dose of 300 mg/kg BW has activity in repairing endocrine cells with cell morphology almost resembling normal cells.
Standardization of the Ethanol Extract of Mahkota Dewa Leaves (Phaleria macrocarpa (Scheff.) Boerl) Using Non-Specific Parameters Wa Ode Sitti Musnina; Dwi Ayu Reskia Anwar; Agustinus Widodo; Akhmad Khumaidi
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
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Background: Medicinal plant extracts have been widely developed for use in health services. Medicinal plant extracts derived from raw material can be used in the form of dry, viscous, and liquid extracts according to the active ingredients contained therein and the intended use. Traditional medicines circulating in Indonesia must meet quality, safety, and efficacy. One of the medicinal plants whose empirical use is widely known by the people of Indonesia is Mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl). Purpose: It is to standardize the ethanol extract of Mahkota Dewa leaves to ensure its quality, safety, and pharmacological properties. The standardization carried out is non-specific parameters based on Indonesian Herbal Pharmacopeia. Methods: The leaves of Mahkota Dewa were collected from Parigi Moutong, Donggala, and Sigi Regon, and extracted using maceration method with ethanol. The ethanol extract was then tested for non-specific parameters including drying shrinkage, water content, total ash content, acid insoluble ash content, specific gravity, residual ethanol solvent, total plate number contamination yeast -mold number, Pb and Cd metal contamination Results: Based on the non-specific standardization parameter test results, the ethanol extract of Phaleria macrocarpa (Scheff.) Boerl leaves met the Indonesian herbal pharmacopeia standards; however, the Cd metal contamination test exceeded the established standards. Based on one-way ANOVA analysis, there were four standardization parameters that were differed significantly (sig <0.05), namely drying shrinkage, moisture content, total ash content, and determination of heavy metal content.
Correlation between the Fazekas Scale for the Degree of Leukoaraiosis and the Score on the Mini Mental State Examination (MMSE) for Cognitive Disorders Nurcholish Akbar Monayo; Junus A.B. Baan; Rafikah Rauf; Andi Alfian Zainuddin; Cahyono Kaelan
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
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Background: Leukoaraiosis is part of the aging process and an indicator of brain damage in the elderly, which is characterized by cognitive dysfunction. However, the correlation between cognitive impairment and patients with leukoaraiosis is still poorly understood. Purpose: To assess the correlation between the degree of leukoaraiosis and cognitive impairment. Methods: The research was conducted at RSUP. Dr. Wahidin Sudirohusodo, Makassar in May 2022 until the sample was sufficient, using a cross-sectional research design. The study included all patients who were older than 40, who received a magnetic resonance imaging (MRI) test, and who fulfilled the inclusion and exclusion criteria. The Ethics Commission gave its approval to this study. The Fazekas scale was used to measure the severity of leukoaraiosis, and the MMSE score was used to measure cognitive impairment. The application SPSS version 26.0 was used to analyze the data. Univariate tests was used to minimum and maximum values, standard deviation, frequency, percentage, or mean. Bivariate test was used to Spearman's correlation test. bivariate test using Spearman's correlation test. Results: This study consisted of 39 people; 10 people (25.6%) had mild cognitive impairment and 29 people (74.4%) did not have cognitive impairment, 6 people (15.4%) had leukoaraiosis degree, 0, 18 people (46.2%) had leukoaraiosis grade 1 , 10 people (25.6%) had a degree of leukoaraiosis 2, and 5 people (12.8%) had a degree of leukoaraiosis 3. There was a negative correlation between the degree of leukoaraiosis and cognitive impairment (p = 0.008). Conclusion: The degree of leukoaraiosis using the Fazekas scale can be used for early diagnosis of cognitive disorders, so that it can immediately prevent the severity of cognitive disorders.
Comparison of QTc Interval Before and After Hydroxychloroquine Therapy in Covid-19 Patients at Kendari City Hospital Jamaluddin; Yusuf Musafir Kolewora; Ditha Arisqa Nasir
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 3 (2023): Suplemen
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Background: Corona Virus Disease 19 (COVID-19) is caused by SARS-COV 2 which is of global public health concern. Hydroxychloroquine is a drug that is thought to be useful in treating COVID-19, but the mechanism of action of this drug is to block potassium channels and potentially extend the QTc interval. The purpose of this study was to determine the difference in QTc intervals before and after hydroxychloroquine therapy in COVID-19 patients at Kendari City Hospital. Methods:. This research is an observational analytic study, with a cross-sectional design, which was conducted at the Regional General Hospital of Kendari City. The number of samples in this study were 106 patients. Qtc interval values ​​before and after hydroxychloroquine therapy were collected using medical record data according to the inclusion criteria. Data was processed using paired t test analysis. Results: Bivariate analysis showed that there was a difference in the average Qtc interval before and after hydroxychloroquine therapy (409.02 vs 426.10, p<0.05). Conclusion:. There are differences in QTc intervals before and after hydroxychloroquine therapy in COVID-19 patients at Kendari City Hospital
Correlation between Knowledge and Hesitancy towards COVID-19 Vaccine in Pregnant Women in The Working Area of Ranomeeto Health Centre Yusril Marhaen; Juminten Saimin; Sulastrianah
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 3 (2023): Suplemen
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Background: Acceptance or refusal of vaccinations can be influenced by hesitancy about the COVID-19 vaccine. Hesitancy is determined by knowledge, attitudes, practices, and public concerns about the safety, efficacy, risks, and benefits associated with the COVID-19 vaccination program. Purpose: To determine the association between knowledge and hesitancy about the COVID-19 vaccine in pregnant women in the Ranomeeto Health Center Working Area. Methods: This is an analytic observational study with a cross-sectional approach. This study was conducted at the Ranomeeto Health Center, Konawe Selatan District. The number of samples is 77 people, collected by purposive sampling technique. Knowledge was measured using a knowledge questionnaire about the covid-19 vaccine. Hesitation was measured using a questionnaire about the COVID-19 vaccine. Data were collected and analyzed using the Chi-Square statistical test with a significance value of p<0.05. Results: The results showed that most pregnant women had good knowledge about the COVID-19 vaccine (42.9%) and had no hecitation about the COVID-19 vaccine (61.0%). Statistical tests obtained a significant p-value between knowledge and hesitancy about the COVID-19 vaccine (p=0.010). Conclusion: There is a significant correlation between knowledge and hesitancy about the COVID-19 vaccine in pregnant women in the Working Area of the Ranomeeto Health Center.
The Effect of Supportive Psychotherapy Ventilation Techniques on Blood Pressure and Pulse rate in Depressed and Anxious Patients Edy H. Mujahid; Erlyn Limoa
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 3 (2023): Suplemen
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Background: Rates of depression and anxiety disorders are increasing worldwide. Anxiety and depression are one of the comorbidities of cardiovascular disease, cardiovascular conditions are worse with no comorbid depression and anxiety. Depression and anxiety are independent risk factors for hypertension. Previous studies involving groups of patients who received psychotherapy were found to have decreased blood pressure. Objective: To determine the effect of Ventilation Technique Supportive Psychotherapy on Blood Pressure (BP) and Pulse Rate in Depressed and Anxious Patients. Methods: Experimental research with a pre-test, post-test design was conducted at dr.Wahidin Sudirohusdo Makassar General Hospital and its network in May - July 2020. The samples of this study were patients with depressive disorders and anxiety disorders who underwent routine treatment as many as 12 samples and 12 controls. The research subjects were measured with the Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating Scale (HDRS) and then checked blood pressure and pulse rate before and after the subject was given psychotherapy for 30 minutes. Data were analyzed using Pearson test. Results: The total sample was 12 treatment and 12 control people with an average age of 45.8. Statistically significant changes in systole blood pressure, diastole blood pressure and pulse rate were obtained before and after the provision of supportive psychotherapy ventilation techniques with a significant p value (p < 0.001). Based on the Pearson correlation test, the comparison of systole blood pressure, diastole blood pressure and pulse rate of the two groups was significant and the correlation was very strong (0.938) in systole blood pressure and (0.908) in diastole blood pressure and a strong correlation (0.729) in pulse rate. Conclusion: There was a significant reduction in systole blood pressure, diastole and pulse rate in the treatment group after receiving Ventilation Technique Supportive Psychotherapy when compared to the control.

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