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Journal of Health Science and Pharmacy
Published by Yayasan Cipta Anak Bangsa (YCAB) Publisher
ISSN : -     EISSN : 30906148     DOI : https://doi.org/10.36685/jhsp
Core Subject : Health, Social,
Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Health Science and Pharmacy adalah jurnal ilmiah yang ditinjau oleh rekan sejawat, yang berfokus pada publikasi penelitian berkualitas tinggi di bidang ilmu kesehatan dan farmasi. Jurnal ini menyediakan platform bagi akademisi, peneliti, dan profesional kesehatan untuk berbagi temuan penelitian terbaru, inovasi klinis, dan kemajuan teknologi di bidang terkait kesehatan. Cakupan jurnal meliputi farmakologi, farmakokinetik, formulasi obat, manajemen farmasi, kesehatan masyarakat, epidemiologi, kesehatan lingkungan, kesehatan dan keselamatan kerja, promosi kesehatan, nutrisi klinis, kedokteran preventif, dan kebijakan kesehatan. Jurnal Ilmu Kesehatan dan Farmasi menerbitkan artikel penelitian asli, tinjauan sistematis, laporan kasus, dan komunikasi singkat yang memberikan kontribusi signifikan terhadap perkembangan ilmu kesehatan. Dengan standar editorial yang ketat dan proses peninjauan rekan sejawat yang komprehensif, jurnal ini berkomitmen untuk menerbitkan penelitian berbasis bukti yang dapat diterapkan dalam praktik klinis dan memiliki dampak positif pada peningkatan kualitas layanan kesehatan dan pengembangan strategi pengobatan yang lebih efektif dan aman di Indonesia dan global.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 92 Documents
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Analysis of Vitamin C Content in Grapefruit (Citrus maxima) Using the Iodimetric Titration Method Aisya Azzahra; Wa Ode Syafriah; Hasty Hamzah
Journal of Health Science and Pharmacy Vol. 3 No. 1 (2026): January - April
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v3i1.1567

Abstract

Background: Citrus maxima, commonly known as pomelo, is a rich source of nutrients, particularly vitamin C, which is essential for human health. This study focuses on determining the vitamin C content in grapefruit using the iodimetric titration method. Objectives: The primary objective of this research is to quantify the vitamin C levels in grapefruit (Citrus maxima) using the iodimetric titration technique. Methods: The study involves both qualitative and quantitative testing of grapefruit filtrates. The qualitative test includes adding 0.1 N iodine solution to the filtrate in a test tube and noting the number of drops required for the color to change to clear, indicating the presence of vitamin C. For the quantitative analysis, a 1% starch indicator, 0.1 N iodine standard solution, and sodium thiosulfate standard solution were prepared. The 0.01 N iodine solution was standardized using sodium thiosulfate, and the vitamin C content in the grapefruit was determined. Results: The vitamin C content in grapefruit (Citrus maxima) was found to be 3.957 mg/g. Conclusion:This study successfully quantified the vitamin C content in grapefruit using the iodimetric titration method, providing valuable information on its nutritional value. Keywords: Pomelo (Citrus maxima), Vitamin C, Iodimetric titration, Nutritional analysis, Titration method.
Knowledge, Attitudes, and Determinants of Beyond-Use Date (BUD) Drug Management in the Community Aprilia Syafaria; Evi Mustiqawati; Restu Harisma Damayanti
Journal of Health Science and Pharmacy Vol. 3 No. 1 (2026): January - April
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v3i1.1570

Abstract

Background: The obligation to include the Beyond Use Date (BUD) on medication containers constitutes an essential component of pharmaceutical management aimed at ensuring the safe, rational, and effective use of medicines. BUD refers to the time limit for the use of a drug product after compounding, preparation, or after the primary packaging has been opened or compromised. The absence of proper BUD labeling may increase the risk of medication misuse, as drugs used beyond their BUD may experience reduced stability, degradation of active substances, and potential negative health effects. Despite its importance, the implementation of BUD labeling on medication packaging in Indonesia remains limited. Objectives: This study aimed to determine the level of knowledge, attitudes, and associated factors related to Beyond Use Date (BUD) management of medicines among the community at Waborobo Public Health Center, Betoambari Subdistrict, Baubau City. Methods: This study employed a descriptive non-experimental design. The sampling technique used was purposive sampling, involving 88 respondents who sought outpatient treatment at Waborobo Public Health Center between May and June 2024. Primary data were collected using a structured questionnaire. Data were analyzed using descriptive statistical methods and the Chi-square test to examine associations between variables. Results: The results showed that, among 88 respondents, the majority demonstrated a fairly good level of knowledge regarding drug BUD management (74.14%). Additionally, 74.37% of respondents exhibited positive attitudes toward BUD management. Chi-square analysis revealed a significant association between knowledge of BUD management and educational background (p = 0.000; C = 0.527), as well as between knowledge and attitude (p = 0.000; C = 0.501). A significant relationship was also identified between educational background and attitudes toward BUD management (p = 0.025; C = 0.408). Conclusion: The community at Waborobo Public Health Center generally demonstrated fairly good knowledge and positive attitudes regarding Beyond Use Date (BUD) management of medicines. Educational background was significantly associated with knowledge and attitudes, indicating that education plays an important role in improving public awareness and appropriate medication management practices. Strengthening educational interventions may enhance proper BUD implementation in the community. Keywords: Beyond Use Date; medication management; community knowledge; attitudes; public health
Overview of Sorawolio Community Knowledge and Attitudes About Scabies Aurellya Syalzabillah; Evi Mustiqawati; Wa Ode Syafriah
Journal of Health Science and Pharmacy Vol. 3 No. 1 (2026): January - April
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v3i1.1571

Abstract

Background: Scabies remains a significant public health concern in tropical regions, particularly in densely populated communities where close contact facilitates transmission. In Sorawolio Subdistrict, Baubau, the high prevalence of scabies is presumed to be associated with insufficient community knowledge regarding its prevention and treatment. As a contagious parasitic skin disease, scabies can adversely affect physical comfort, social interaction, and overall quality of life. Therefore, understanding the level of community knowledge and attitudes toward scabies is essential to support effective prevention and control strategies. Objectives: This study aimed to assess the level of knowledge and attitudes of the Sorawolio community toward scabies and its prevention. Methods: A quantitative descriptive study design was employed. The study involved 61 respondents aged 5–25 years who had previously experienced or were currently experiencing scabies, resided in Sorawolio, and consented to participate in the study. Data collection was conducted from July 14 to August 14, 2024, using structured questionnaires designed to measure respondents’ knowledge and attitudes regarding scabies prevention and management. Data were analyzed descriptively using frequency and percentage distributions. Results: The findings indicated that 50 respondents (82%) demonstrated good knowledge regarding scabies, while 6 respondents (10%) had moderate knowledge and 5 respondents (8%) had poor knowledge. These results suggest that the majority of the community possesses an adequate understanding of scabies, potentially influenced by health education programs previously implemented in the area. Regarding attitudes, 59% of respondents exhibited positive and supportive attitudes toward preventive measures, indicating a generally favorable disposition toward scabies control practices. However, the presence of respondents with limited knowledge reflects existing gaps in information dissemination. Conclusion: Overall, the majority of respondents in Sorawolio demonstrated good knowledge and positive attitudes toward scabies prevention. Nevertheless, a proportion of the community still exhibits insufficient understanding, underscoring the need for sustained health education initiatives and targeted outreach programs to enhance awareness and promote comprehensive preventive behaviors across the broader population. Keywords: scabies; knowledge level; community attitude; health education; disease prevention  
Utilization of N-Hexane Extract of Turmeric (Curcuma longa) as an Acid-Base Titration Indicator Sarmila; Sri Yolandari; Hasty Hamzah
Journal of Health Science and Pharmacy Vol. 3 No. 1 (2026): January - April
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v3i1.1575

Abstract

Background: Curcuma longa (turmeric) is a medicinal plant belonging to the Zingiberaceae family and is widely distributed in tropical regions. Turmeric contains various bioactive secondary metabolites, including curcumin, essential oils, and flavonoids. Curcumin, the principal pigment responsible for turmeric’s characteristic yellow color, exhibits pH-sensitive properties due to its amphoteric nature. This characteristic enables turmeric extract to respond to acidic and alkaline environments, indicating its potential application as a natural acid–base indicator. Objectives: This study aims to evaluate the effectiveness of turmeric extract as a natural indicator in acid–base titration and to compare its performance with standard synthetic indicators. Methods: An experimental approach was employed using the titration method. The titration process was conducted on three types of solution systems: (1) strong acid strong base, (2) weak acid strong base, and (3) strong acid weak base. Turmeric extract was used as the natural indicator. For comparison, two conventional synthetic indicators phenolphthalein and methyl orange were also applied. Observations focused on color changes and the corresponding pH values at the endpoint of each titration. Results: The findings demonstrated distinct color changes of turmeric extract in different solution systems. In the strong acid strong base titration, the color changed to orange-yellow at pH 8.06. In the strong acid weak base system, a pale yellow color was observed at pH 2.59. Meanwhile, in the weak acid strong base system, the solution exhibited a color transition from colorless to pink at pH 7.58. These results indicate that turmeric extract is responsive to pH variations and capable of signaling endpoint detection in titration processes. Conclusion: Turmeric extract shows potential as a natural acid–base indicator due to the pH-sensitive properties of curcumin. The observed color changes across different titration systems confirm its effectiveness in detecting acidic and alkaline conditions. Therefore, turmeric extract may serve as an alternative, environmentally friendly indicator in acid–base titration. Keywords: Turmeric extract; Curcumin; Natural indicator; Acid–base titration; pH sensitivity
Effectiveness Test of Soursop Leaf Ethanol Extract (Annona muricata L) as a Healer of Incision Wounds on Mice (Mus musculus) Skin Novianti Cahyani Junadi; Sri Yolandari; Suparman Supardi
Journal of Health Science and Pharmacy Vol. 3 No. 1 (2026): January - April
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v3i1.1583

Abstract

Background: Annona muricata (soursop) is a traditional medicinal plant widely used for wound treatment. Incision wounds are tissue injuries caused by sharp objects and may vary in severity from mild to severe. The wound healing process involves inflammatory, proliferative, and maturation phases, which can be influenced by bioactive compounds derived from natural products. Objectives: This study aimed to determine the effectiveness of ethanol extract of soursop leaves (Annona muricata L.) in accelerating the healing of incision wounds in Mus musculus. Methods: The extract was prepared using a maceration method of dried soursop leaf simplicia with 96% ethanol. A total of 15 white mice (Mus musculus) were divided into five treatment groups: (1) negative control (distilled water), (2) positive control (10% povidone iodine), (3) extract dose of 0.1 g, (4) extract dose of 0.2 g, and (5) extract dose of 0.3 g. An incision wound was made on the dorsal area of each mouse. Treatments were administered once daily for 14 days. Data were analyzed using one-way ANOVA followed by the Post Hoc LSD test to determine significant differences between groups. Results: The findings indicated that the ethanol extract of soursop leaves accelerated incision wound healing in mice, with the 0.3 g dose showing the highest effectiveness. Statistical analysis using one-way ANOVA revealed a significant difference among treatment groups (p < 0.05; p = 0.000). Further analysis using the Post Hoc LSD test confirmed significant mean differences between groups. Conclusion: The ethanol extract of soursop leaves (Annona muricata L.) is effective in accelerating incision wound healing in Mus musculus, with the 0.3 g dose demonstrating the most optimal effect. Keywords: Annona muricata L.; incision wounds; Mus musculus; ethanol extract; wound healing
Microplastic Contamination in Drinking Water: A Review Abdul Rahman; Ramadhan Tosepu; Surya Cipta Ramadhan Kete; Asnia Zainuddin; Mubarak; Ranno Marlany Rachman
Journal of Health Science and Pharmacy Vol. 2 No. 3 (2025): September - December
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v2i3.1689

Abstract

Background: Microplastics are plastic particles smaller than 5 µm that persist in the environment and resist natural degradation. Recent studies have demonstrated the presence of microplastics in various environmental media, including drinking water. This contamination raises public health concerns because microplastics can enter the human body through daily water consumption and may carry hazardous chemical substances, potentially causing long-term health effects. Objective: This study aims to examine the presence, characteristics, and potential health risks of microplastic contamination in drinking water through a systematic literature review. Method: A Systematic Literature Review (SLR) was conducted following the PRISMA guidelines. Scientific articles were obtained from Google Scholar, ResearchGate, PubMed, Scopus, and ScienceDirect using the keywords microplastic, drinking water, bottled water, and health risk. Data were analyzed descriptively, focusing on microplastic types, particle sizes, polymer composition, and identification methods. Results: Microplastics were detected in bottled water, refill drinking water, and tap water in several countries, including Indonesia. The dominant forms were fragments and fibers, with sizes ranging from 0.01 µm to >5 µm. The most common polymers were polyethylene terephthalate (PET), polypropylene (PP), polyethylene (PE), and polystyrene (PS). Identification methods included filtration, microscopy, ATR-FTIR, Raman spectroscopy, and SEM-EDS. Potential health risks include inflammation, oxidative stress, digestive disorders, and carcinogenic effects. Conclusion: Microplastics are confirmed contaminants in drinking water and may pose risks to public health. Strengthened monitoring, standardized detection methods, improved water treatment technologies, and public awareness are essential to reduce exposure.
Risk Factors for Diabetes Mellitus in Patients with Pulmonary Tuberculosis: A Review Hardianto; Wa Ode Salma; Jafriati; La Ode Muuhammad Sety; Asriati; Asnia Zainuddin
Journal of Health Science and Pharmacy Vol. 2 No. 3 (2025): September - December
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v2i3.1803

Abstract

Background: Pulmonary tuberculosis (PTB) remains a significant global health problem, particularly in middle- and low-income countries. The comorbidity of TB and Diabetes Mellitus (DM) is increasing as both conditions influence each other through immunological and metabolic mechanisms. Chronic hyperglycemia in DM can impair immune function, thereby increasing susceptibility to mycobacterium tuberculosis infection and worsening TB treatment outcomes. Objective: This study aims to identify and analyze the risk factors contributing to the incidence of Diabetes Mellitus in patients with pulmonary Tuberculosis based on the latest scientific evidence from the past five years. Method:  This study uses a Systematic Literature Review (SLR) approach guided by PRISMA. The articles analyzed were obtained from various scientific databases (Google Scholar, PubMed, Scopus, ResearchGate, and ScienceDirect) within the last five years (2020–2025). The keywords used include: Diabetes Mellitus, Pulmonary Tuberculosis, Risk Factors, and Comorbidities. The data were analyzed descriptively to identify similarities and differences in results among the studies. Results: A total of ten articles that met the inclusion criteria showed that advanced age, obesity, poor nutritional status, a family history of diabetes mellitus (DM), and irregular glycemic control are dominant factors that increase the risk of DM in pulmonary TB patients. Low socioeconomic status, unhealthy lifestyle, and low education levels also exacerbate the risk of TB-DM comorbidity. Results from various studies indicate that patients with DM have longer TB treatment durations, higher relapse rates, and lower cure rates compared to patients without DM. Conclusion:  The relationship between pulmonary TB and diabetes mellitus is reciprocal and complex, involving biological, social, and behavioral factors. An integrated control approach is needed through dual screening, nutritional education, blood glucose management, and cross-sector collaboration to reduce incidence rates and improve treatment success for TB-DM in the community.  
The Effectiveness of the Health Insurance Program in Improving Access to Health Services for Beneficiaries of Contribution Assistance: A Review Andi Isnaeni; Ramadhan Tosepu; Ruslan; Nani Yuniar; Mubarak; Asnia Zainuddin
Journal of Health Science and Pharmacy Vol. 2 No. 3 (2025): September - December
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v2i3.1863

Abstract

Background: Equitable access to healthcare services is widely recognized as a fundamental human right and a central objective of health system development, including in Indonesia. Despite this commitment, economically disadvantaged populations continue to face significant barriers to healthcare access, including financial constraints, disparities in service quality, and unequal distribution of health infrastructure. In response, the Indonesian government introduced the National Health Insurance program (Jaminan Kesehatan Nasional/JKN) to reduce financial barriers and expand access to essential healthcare services for poor and vulnerable populations. Objectives: This study aims to analyze the effectiveness of the JKN program, together with comparable health insurance schemes in other countries, in improving access to healthcare services among poor populations, while identifying supporting factors. Methods: A Systematic Literature Review was conducted following PRISMA guidelines. Relevant studies were identified through electronic databases, including Google Scholar, PubMed, Scopus, and ScienceDirect, using keywords related to health insurance, healthcare access, poor populations, program effectiveness, and health policy. Results: The indicate that JKN has increased healthcare utilization among poor households by reducing out-of-pocket expenditures and improving access to primary and referral services. Digital innovations, such as the JKN Mobile application, enhance efficiency but are limited by digital literacy gaps. Evidence from Laos and Rwanda shows similar improvements. Conclusion:  health insurance programs such as JKN expand healthcare access for poor populations; however, sustainability depends on health system readiness, equitable resource distribution, service quality, and policy support.
Digital Campaign Strategies to Reduce Schizophrenia Stigma Among Adolescents: A Review Yuli Solihati; Ruslan Majid; Syawal Kamiluddin Saptaputra; Asriati; Jumakil; Hilda Harun
Journal of Health Science and Pharmacy Vol. 2 No. 3 (2025): September - December
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v2i3.1877

Abstract

Background: Schizophrenia is a severe mental disorder often accompanied by negative stigma, especially among adolescents. This stigma remains a major barrier preventing individuals from seeking professional help. In the digital era, social media and online platforms offer new opportunities to deliver mental health education and campaigns that are accessible and engaging for young audiences. Objective: This study aims to identify and analyze effective digital campaign strategies to reduce stigma toward schizophrenia among adolescents based on recent literature findings. Method:  This research employed a Systematic Literature Review (SLR) guided by the PRISMA framework. Articles were collected from databases including Google Scholar, PubMed, Scopus, ResearchGate, and ScienceDirect within the 2020–2025 period. Data were analyzed descriptively to determine patterns and the effectiveness of digital campaign strategies. Results: The review found that the use of digital media such as motion graphics, short videos, infographics, and storytelling on platforms like Instagram, TikTok, and YouTube effectively increased knowledge, empathy, and reduced negative stereotypes toward individuals with schizophrenia. Approaches involving social contact and recovery stories were shown to have a significant positive impact on adolescents’ attitudes. Conclusion:  Digital campaigns are a promising strategy to reduce schizophrenia-related stigma among adolescents. However, challenges such as digital addiction, misinformation, and disparities in media literacy need to be considered. Campaigns should be evidence-based and supervised by mental health professionals to ensure their effectiveness and safety in promoting mental health awareness.
The Influence of Human Resource Management on Healthcare Workers' Performance through Workload as a Mediating Variable in Hospitals: Literature Review Dewi Sartika; I Putu Sudayasa; Ruslan; Nani Yuniar; Hilda Harun; Sartiah Yusran
Journal of Health Science and Pharmacy Vol. 2 No. 3 (2025): September - December
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v2i3.1885

Abstract

Background: Human resource management (HRM) plays an important role in improving the quality of healthcare services in hospitals, but its effectiveness is often influenced by the workload experienced by healthcare workers. High workloads can reduce performance through increased stress and fatigue, potentially acting as a mediating variable in the relationship between HRM practices and healthcare worker performance. Objective: This study aims to identify and analyze the influence of human resource management practices on the performance of healthcare workers, with workload as a mediating variable, based on empirical evidence. Method:  This study uses a Systematic Literature Review (SLR) approach based on PRISMA guidelines by examining scientific publications from Google Scholar, PubMed, Scopus, ScienceDirect, and ResearchGate. The selected articles are original research written in Indonesian or English, published between 2020 and 2025, and investigate the relationship between HR practices, workload, and healthcare worker performance in hospitals. Results: A review of ten studies shows that HR management practices such as recruitment, training, performance appraisal, compensation, and organizational support have a significant impact on healthcare workers' performance. Workload has been found to be an important factor that not only directly affects performance, but also mediates the relationship between HR management variables and job outcomes. International research reinforces these findings by showing that workload, burnout, work engagement, and other psychosocial factors can serve as mediating pathways between HR practices and healthcare worker performance, highlighting the complexity of the mechanisms that influence hospital service quality. Conclusion: HR management practices have been proven to affect the performance of healthcare workers, and workload plays a significant role as a mediator in this relationship. To optimize performance, hospitals need to strengthen HR policies that are integrated with workload management, psychosocial support, and strategies to improve the work environment in order to achieve sustainable healthcare worker performance.  

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