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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
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Articles 639 Documents
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PEDIATRIC HAND BLAST INJURY PROFILE IN EMERGENCY ROOM OF DR. HASAN SADIKIN GENERAL HOSPITAL BANDUNG Ismiarto, Yoyos Dias; Arif, Yoan Putrasos
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.006 KB) | DOI: 10.15395/mkb.v51n2.1643

Abstract

In the past, blast injuries were mainly caused by war-related incidents. However, despite the current lack of war-related activities, blast injuries are still seen due to unintentional low explosive material blasts which are mostly seen on children?s hand. However, the classification for the severity of this type of injury is still unclear. The aim of this study was to assess the incident, patterns, and severity of hand blast injuries among pediatric patients treated in Dr.Hasan Sadikin General Hospital. Twenty two pediatric patients in Dr. Hasan Sadikin Hospital Bandung from 2013?2017 were included in this study. All data were extracted retrospectively from patient medical records and the degree of injury severity was assessed using Hand Injury Severity Score (HISS). There were 22 hand injuries caused by explosion identified in 18 boys (82%) with the age range of 5 to 15 years. Hand injuries from explosions have a specific pattern with the hand radial side experiencing the most severe damage including the thumb (16 cases), index finger (16 cases), and middle finger (14 cases). The severity of the injuries varied from mild (3 cases) to moderate (4 cases), severe (7 cases), and major (8 cases).  A high incidence of major hand blast injuries is found among pediatric patients with the hand radial side tends to suffer the most severe damage.Profil Cedera Tangan Akibat Ledakan pada Anak di Ruangan Gawat Darurat RSUP Hasan Sadikin BandungCedera akibat ledakan di masa lalu terutama disebabkan oleh situasi peperangan. Saat ini cedera akibat ledakan masih terjadi terutama pada tangan anak yang disebabkan oleh ledakan bahan berdaya rendah yang tidak disengaja. Namun, klasifikasi untuk menentukan derajat keparahan cedera masih belum jelas. Tujuan dari penelitian ini adalah menganalisis insidensi, pola, dan derajat keparahan cedera terhadap pasien yang dirawat di Rumah Sakit Hasan Sadikin. Penelitian ini melibatkan 22 pasien anak di Rumah Sakit Dr. Hasan Sadikin Bandung periode 2013-2017. Semua data didapatkan secara retrospektif dari rekam medis pasien. Tingkat keparahan cedera dinilai menggunakan Hand Severity Severity Score (HISS). Dua puluh dua cedera tangan akibat ledakan teridentifikasi. Kelompok ini sebagian besar terdiri atas 18 anak laki-laki dengan rentang usia 5 hingga 15 tahun. Cedera tangan akibat ledakan memiliki pola tertentu, dengan sisi radial tangan mengalami kerusakan paling parah di antaranya 15 kasus mengenai ibu jari, 16 kasus mengenai jari telunjuk, dan 14 kasus mengenai jari tengah. Tingkat keparahan cedera bervariasi dari kasus ringan sebanyak 3 kasus, sedang sebanyak 4 kasus, berat sebanyak 7 kasus, dan parah sebanyak 8 kasus. Cedera ledakan di tangan anak memiliki angka kejadian yang tinggi dalam kategori berat dengan sisi radial tangan cenderung menderita kerusakan paling parah.
Body Profile and Arthroscopic Anterior Cruciate Ligament Reconstruction Using Autograft Hamstring Tendon Bangkit Primayudha; Ghuna Arioharjo Utoyo; Renaldi Prasetya; Hermawan Nagar Rasyid
Majalah Kedokteran Bandung Vol 52, No 1 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (862.404 KB) | DOI: 10.15395/mkb.v52n1.1707

Abstract

The incidence of obesity in Indonesia has increased from 14.8% in 2013 to approximately 21.8% in 2018. There is no published data regarding assessments on functional outcomes and complication after Anterior Cruciate Ligament (ACL) reconstruction in patients with different Body Mass Index (BMI) in Indonesia. The aim of this study was to describe the distribution of ACL injury and compare the functional outcomes after ACL reconstruction using hamstring tendon autograft in patients with different BMI categories.This was a retrospective study in 2 groups of patients with different BMI categories: normal BMI group (18.5 to 24.99) and high BMI group (≥25), who had undergone surgeries for ACL injury in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, during the period of 2017 to 2018. Data were collected from medical records and direct examination on  functional outcome measurement using Lysholm score.This study comprised of 71 patients who were followed for a minimum of 6 months. Of 71 patients, 43 were in the normal BMI group and 28 were in the high BMI group. No significant differences in postoperative functional outcome between the groups when assessed using Lysholm score. In normal BMI group 95% were graded as excellent to good while5% were in the fair functional category. Meanwhile, in the high BMI group, 86% were graded as excellent to good and 14% were graded as having fair functional results. ACL reconstruction with Hamstring tendon autograft results in a good functional score and a high succes rate in both BMI groups. High BMI does not adversely affect functional outcomes as both BMI groups gain equal benefits. Rekonstruksi Anterior Cruciate Ligament Menggunakan Autograft Tendon HamstringInsidensi obesitas di Indonesia meningkat dari 14.8% pada tahun 2013 menjadi 21.8% pada tahun 2018. Tidak ada publikasi data yang menilai hasil akhir fungsional dan komplikasi setelah operasi rekonstruksi Anterior Cruciate Ligament (ACL) pada pasien dengan indeks massa tubuh (IMT) yang berbeda di Indonesia. Tujuan dari penelitian ini membandingkan hasil akhir fungsional menggunakan skor Lysholm setelah rekonstruksi ACL pada pasien dengan IMT yang berbeda. Penelitian ini bersifat retrospektif yang dibagi menjadi 2 kelompok penelitian dengan IMT yang berbeda; yaitu IMT normal (18.5–24.99) dan IMT yang tinggi (≥25), yang dilakukan operasi cedera ACL di Rumah Sakit Hasan Sadikin periode tahun 2017-2018. Penelitian ini terdiri dari 71 pasien dan dilakukan pengamatan selama minimal 6 bulan dengan jumlah pasien kelompok IMT normal sebesar 43 pasien, sedangkan 28 pasien pada kelompok IMT yang tinggi. Tidak ada perbedaan signifikan diantara kedua kelompok pada hasil akhir fungsional pasca operasi ACL. Kelompok IMT normal terdiri dari 95% dinilai sebagai excellent sampai good dan 5% dinilai sebagai fair, sedangkan untuk kelompok IMT yang tinggi terdiri dari 86% dinilai sebagai excellent sampai good dan 14% dinilai sebagai fair hasil fungsional. Simpulan, operasi rekonstruksi ACL memiliki skor akhir fungsional yang bagus dan angka kesuksesan yang tinggi pada kedua kelompok IMT.
Effect of Dietary Sodium on α, β, and γ Epithelial Sodium Channel (ENaC) Gene Expression in Kidney Tubules of Wistar Rats Ronny Lesmana; Genta Syaifrin Laudza; Trianing Tyas Kusuma; Hanna Goenawan; Yulia Sofiatin; Yuni Susanti Pratiwi; Nova Sylviana; Setiawan Setiawan
Majalah Kedokteran Bandung Vol 51, No 4 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.233 KB) | DOI: 10.15395/mkb.v51n4.1764

Abstract

Hypertension is a condition of persistently high blood pressure. It is currently a big health issue as its prevalence is high in Indonesia and its complications are numerous and deadly. Salt intake is one of the modifiable factors of hypertension. According to a study by Indonesian Ministry of Health, salt consumption in Indonesia is almost two times greater than the recommended salt diet from WHO. Sodium reabsorption in kidney plays a role in regulating blood pressure. Epithelial sodium channel (ENaC) is one of the structures that function in sodium reabsorption in kidney tubules. This study was conducted at the Central Laboratory and Animal Laboratory of the Faculty of Medicine Universitas Padjadjaran from June to Desember 2018. The aim of this study was to analyze the effect of high sodium diet on the expression of ENaC gene in kidney tubules of rats. Twelve Rattus norvegicus wistar rats were divided into two groups of control and treatment. Treatment group was given daily 2 mL NaCl solution treatment using gavage for 8 weeks. The expression of ENaC α, β, and γ was obtained by running tissue samples from kidney cortex and medulla in polymerase chain reaction and electrophoresis. The result showed that there was an insignificant decrease in ENaC α, β, and γ gene expressions in both kidney cortex and medulla of the treatment group when compared to control groupThis study concludes that ENaC gene expression is not significantly affected by high sodium diet.Pengaruh Diet Tinggi Natrium terhadap Perubahan Ekspresi Gen Epithelial Sodium Channel (ENaC) pada Tubulus Ginjal TikusHipertensi merupakan kondisi tekanan darah tinggi dalam waktu lama. Prevalensi dan komplikasi hipertensi menyebabkan hipertensi menjadi isu kesehatan yang cukup besar. Jumlah asupan garam merupakan faktor hipertensi yang dapat dimodifikasi. Berdasar studi Kementrian Kesehatan Indonesia, konsumsi garam di Indonesia rerata dua kali lipat lebih banyak daripada rekomendasi WHO. Reabsorpsi natrium pada ginjal berperan penting pada regulasi tekanan darah. Fungsi ini diperankan oleh epithelial sodium channel (ENaC) yang berfungsi untuk reabsorpsi natrium. Penelitian ini dilakukan di Laboratorium Sentral dan Laboratorium Hewan Fakultas Kedokteran pada Juni–Desember 2018. Tujuan penelitian ini menganalisis efek diet tinggi natrium pada ekspresi gen dari ENaC di tubulus ginjal pada tikus. Duabelas ekor tikus Rattus norvegicus dibagi menjadi dua kelompok, yaitu kontrol dan perlakuan. Kelompok perlakuan diberikan 2 mL larutan NaCl setiap hari selama 8 minggu. Larutan diberikan melalui paksa (gavage). Ekspresi gen ENaC α, β, γ dari korteks dan medula ginjal diamplifikasi dengan PCR dan dideteksi dengan elektroforesis. Pita protein dari gel elektroforesis dinilai intensitasnya dengan software ImageJ. Hasil dari elektroforesis menunjukkan penurunan ekspresi gen ENaC α, β, γ di korteks dan medulla pada kelompok perlakuan dibanding dengan kontrol. Studi ini menyimpulkan ekspresi gen ENaC pada korteks dan medulla ginjal tidak signifikan dipengaruhi oleh diet tinggi natrium.
Correlation between Ankle-Brachial Index Score and Diabetic Polyneuropathy Degree of Severity Uni Gamayani; Miftahurachman Miftahurachman; Nushrotul Lailiyya; Handika Sonjaya Juhana
Majalah Kedokteran Bandung Vol 51, No 3 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n3.1543

Abstract

Diabetic polyneuropathy (DPN) is the most prevalent chronic microvascular complication of type 2 diabetes mellitus (DM). The severity of DPN is categorized based on symptoms, signs, and nerve conduction study (NCS) abnormality into grades 0, 1a, 2a, and 2b. Pathogenesis of DPN consists of metabolic and vascular processes. In addition, macrovascular factor also plays a role in the pathogenesis of DPN. Macrovascular diseases, such as peripheral arterial disease (PAD), could be diagnosed using the ankle brachial index (ABI). Several studies have proven a strong correlation between ABI and DPN; hence, this study aimed to examine the correlation between ABI score and DPN severity. This was a cross sectional analytic study on. 73 type 2 DM patients who met the inclusion and exclusion criteria and visited the outpatient Endocrine Clinic and Neurophysiology laboratory of the Department of Neurology Dr. Hasan Sadikin General Hospital Bandung, during the priod of June to October 2018. ABI examination were performed after DPN indication was evident from results of physical examination, lab tests, and NCS. Rank Spearman statistical analyses were performed to assess the correlation between ABI score with DPN severity and the result was considered significant if p value <0.05. No correlation was found between ABI score DPN severity and between ABI score and DPN symptoms, signs, and NCS abnormality. Hence, ABI score does not correlate with DPN severity stage. Hubungan Skor Ankle-Brachial Index dengan Derajat Keparahan Polineuropati DiabetikaKomplikasi kronis mikrovaskular diabetes mellitus (DM) tipe 2 yang sering ditemukan adalah polineuropati diabetika (PND). Derajat keparahan PND berdasar gejala, tanda, dan abnormalitas pemeriksaan konduksi saraf tepi (KST) dibagi atas derajat 0, 1a, 2a, dan 2b. Patogenesis PND terdiri atas proses metabolik dan vaskular. Faktor makrovaskular diduga memiliki peranan terhadap terjadinya PND. Penyakit arteri perifer oklusif (PAPO) adalah penyakit makrovaskular yang dapat dideteksi dengan pemeriksaan ankle brachial index (ABI). Beberapa penelitian membuktikan hubungan antara skor ABI dan PND. Penelitian ini bertujuan menilai hubungan antara skor ABI dan derajat keparahan PND. Penelitian bersifat observasi analitik studi potong lintang yang dilakukan pada 73 penyandang DM tipe 2 yang memenuhi kriteria inklusi dan eksklusi di Instalasi Rawat Jalan Klinik Endokrin dan Laboratorium Neurofisiologi KSM/Departemen Neurologi RSUP Hasan Sadikin Bandung periode Juni sampai Oktober 2018. Pemeriksaan ABI dilakukan setelah pemeriksaan klinis PND, laboratorium darah, dan KST. Korelasi antara skor ABI dengan derajat keparahan PND dinilai menggunakan analisis statistik Rank Spearman, signifikan jika p <0,05. Tidak terdapat korelasi antara skor ABI dan derajat keparahan PND. Tidak terdapat korelasi gejala PND, tanda PND, maupun abnormalitas uji KST dengan skor ABI. Skor ABI tidak berkorelasi dengan derajat keparahan PND, baik gejala PND, tanda PND, maupun abnormalitas uji KST. 
CRANIAL CHARACTERISTICS, MAXILLOFACIAL, AND SKULL BASE STRUCTURE OF NON-HUMAN PRIMATE (ADULT MACACA FASCICULARIS): A PRELIMINARY STUDY FOR CRANIAL CRANIOTOMY MODEL Bolly, Hendrikus Masang Ban; Indah, Astrina Rosaria; Faried, Ahmad; Noverina, Rachmawati; Arifin, Muhammad Zafrullah; Wirakusumah, Firman Fuad
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n2.1650

Abstract

The use of non-human primate (NHP) animal models, which anatomical and physiological similarities to human, is important for the sake of learning the anatomical properties. This study aimed to characterize the cranial, maxillofacial, and skull base structures of non-human primates as a potential model suitable for a cranial craniotomy model. Adult Macaca fascicularis (MF) skulls classified asspecificpathogen-free for TB, SIV, SV40, Polio, Foamy virus and Herpes B virus from PT Bio Farma (Persero) Animal Lab. Library were used to represent the anatomical model.The open access database from Mammalian Crania Photographic Archive 2nd Edition (MCPA2) was used for cranial characterization analysis. This study was performed at the Department of Neurosurgery, Dr. Hasan Sadikin General Hospital and the Animal Laboratory of PT. Biofarma (Persero) from November 2018 to January 2019. The skull base structures were assessed for its analogies with its human counterpart. Comparison by t-student analysis between male and female skulls shows the mean male cranial length (CL) is greater than in female (116.68 vs 102.50 mm), with p=0.000; the mean male bizygomatic width (BZB) is greater than in female (79.30 vs 69.70 mm) with p=0.001; the mean male posterior cranial breadth (CBN) is greater than in female (63.40 vs 58.79 mm) with p=0.019; and the mean male cranial base length (CBL) is greater than in female (63.32 vs 57.55 mm), with p=0.001. The skull of MF is suitable for Neurosurgery and Neuroscience study since the MF cranial characterization and structure are similar to that of human. Its structure is ideal for performing craniotomy since it has several characteristics such as cranial vault, maxillofacial structure with huge temporal muscle, and skull base structure.  Karakteristik Kranium, Maksilofasial, dan Struktur Dasar Tengkorak Non-human Primate Macaca fascicularis dewasa: Studi Pendahuluan untuk Model Craiotomi Kranium Penggunaan hewan model berasal dari primata bukan-manusia (NHP), dimana secara anatomis dan fisiologis mirip dengan manusia, sangat penting untuk dapat mempelajari struktur anatominya. Penelitian ini bertujuan untuk karakterisasi struktur kranium, maksilofasial dan dasar tengkorak primata (Non-human Primate) yang berpotensi sebagai model penelitian kraniotomi. Tengkorak dewasa Macaca fascicularis (MF) dari  Laboratorium Hewan PT Biofarma (Persero), bebas infeksi TBC, SIV, SV40, Polio, Foamy Virus,  dan Herpes B digunakan sebagai model anatomi. Basis data terbuka Mammalian Cranial Photographic Archive 2nd Edition (MCPA2) digunakan untuk analisis kranium. Penelitian dilakukan di Departmen Bedah Saraf RSHS dan Laboratorium Hewan  PT. Biofarma  pada November 2018?Januari 2019. Struktur tengkorak MF dipelajari analogi seperti pada struktur tengkorak manusia. Analisis uji-t tengkorak jantan dan betina menunjukan rerata panjang kranial (Cranial length, CL) jantan lebih panjang dibanding betina (116.68 vs 102.50 mm, p=0.000); rerata bizygomatic width (BZB) jantan lebih panjang dibanding betina (79.30 vs 69.70 mm, p=0.001); rerata posterior cranial breadth (CBN) jantan lebih panjang dibanding betina (63.40 vs 58.79 mm, p=0.019);dan rerata cranial base length (CBL) jantan lebih panjang dibanding betina (63.32 vs57.55 mm, p=0.001). Tengkorak MF sesuai untuk berbagai penelitian bidang bedah saraf dan neurosains. Karakterisasi kranial dan strukturnya sama dengan yang dimiliki manusia. Struktur kranium MF merupakan model ideal untuk kraniotomi berdasar karakteristik tulang tengkorak, otot temporal besar pada maksilofasial, dan struktur dasar tengkorak.
A REMS Scan-Based Report on Relation Between Body Mass Index and Osteoporosis in Urban Population of Medan at Royal Prima Hospital Adrian Khu; Michael Sumardi
Majalah Kedokteran Bandung Vol 52, No 1 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (423.568 KB) | DOI: 10.15395/mkb.v52n1.1827

Abstract

Body Mass Index (BMI) and osteoporosis are two major medical issues in practical life. Body Mass Index is recognized as an index to determine body fat mass while osteoporosis is a condition that decreases bone mass density and disrupts bone architecture, which will eventually affect bone strength and increase the risk of fracture. This study aimed to determine the relationship between BMI and osteoporosis using REMS. This was a cross-sectional study on 300 patients, 21 years of age and above, who underwent Radiofrequency Echographic Multi-Spectrometry (REMS) scan during October 2018 to September 2019 in Royal Prima Hospital, Medan, North Sumatra, Indonesia. Osteoporosis was defined based on densitometer parameters for spine and neck of femur while the BMI categories used were underweight (< 18.5 kg/m2), normal-weight (18.5-22.9 kg/m2), overweight (23-24.9 kg/m2), pre-obese (25-29.9 kg/m2), obese type 1 (BMI 30-40 kg/m2), and obese type 2 (40.1-50 kg/m2). Correlation between osteoporosis and BMI was analyzed using Spearman correlation test. The median BMIs for Spine osteoporosis and Neck of Femur osteoporosis groups were 23.24 and 22.51, respectively. Meanwhile, the central tendency of the bone mass density (gr/cm2) of the spine and neck of femur osteoporosis were 0.70 and 0.53, respectively. There was a significant correlation between BMI and the incidence of the neck of femur (R coefficient = -0.690) and spine (R = -0.390) osteoporosis. Hence, lower BMI increases the potential of the neck of femur and spine osteoporosis.Laporan Berbasis Pemindaian REMS tentang Hubungan Antara Indeks Massa Tubuh dan Osteoporosis pada Penduduk Kota Medan di Rumah Sakit Royal PrimaIndeks Massa Tubuh (IMT) dan osteoporosis merupakan dua masalah medis utama dalam kehidupan sehari-hari. Indeks Massa Tubuh telah diakui sebagai indeks yang digunakan untuk menentukan massa lemak tubuh sementara osteoporosis merupakan kondisi yang menurunkan kepadatan tulang dan mengganggu arsitektur tulang yang pada akhirnya memengaruhi kekuatan tulang dan meningkatkan risiko fraktur. Penelitian ini bertujuan untuk menentukan hubungan antara BI dan osteoporosis dengan menggunakan Radiofrequency Echographic Multi-Spectrometry (REMS). Penelitian ini merupakan penelitian potong lintang pada 300 pasien berusia 21 tahun ke atas yang menjalani pemindaian REMS selama periode Oktober 2018 sampai September 2019 di RS Royal Prima Medan. Osteoporosis ditentukan berdasarkan parameteri densitometri untuk tulang belakang dan leher femur sementara kategori BMI yang digunakan adalah berat badan (BB) kurang (<18,5 kg/m2), BB normal- (18,5-22,9 kg/m2), BB berlebih (23-24,9 kg/m2), pra-obesitas (25-29.9 kg/m2), obesitas tipe 1 (BMI 30-40 kg/m2), dan obesitas tipe 2 (40.1-50 kg/m2). Korelasi antara osteoporosis dan BMI dianalisis dengan menggunakan uji korelasi Spearman. Median IMT untuk osteoporosis pada tulang belakang dan leher femur adalah, secara berturut-turut, 23,24 dan 22,51. Terdapat perbedaan antara IMT dan insiden osteoporosis leher femur (R=-0,690) dan tulang punggung (R=-0,390). Dengan demikian, IMT yang lebih rendah meningkatkan kemungkinan osteoporosis di leher femur dan tulang belakang.
Profile of Medicolegal Cases at Department of Forensics and Legal Medicine of Dr. Hasan Sadikin General Hospital Bandung, Indonesia Noverika Windasari; Naomi Yosiati
Majalah Kedokteran Bandung Vol 51, No 4 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n4.1524

Abstract

Hepatoprotective and Antifibrotic Effects of Indonesian Propolis Diding Heri Prasetyo; Sarsono Sarsono; Ida Nurwati; Prihandjojo Andri Putranto; Martini Martini; Nabila Aushaf Prasetyo
Majalah Kedokteran Bandung Vol 51, No 3 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (901.973 KB) | DOI: 10.15395/mkb.v51n3.1768

Abstract

Liver cirrhosis is the irreversible stage in liver damage process which occurs after liver fibrosis due to necro-inflammatory activities and liver fibrosis. Therefore, inhibition of liver inflammation and fibrosis is very important to prevent liver cirrhosis. This study aimed to analyze the effect of ethanol extract of propolis (EEP) from mount Lawu, Indonesia to prevent liver damage and fibrosis progression in mice with hepatic cirrhosis. This study was performed during the period of June 2018 to May 2019 on a sample of 32 male Balb/C mice divided into control group (P1), induction of carbon tetrachloride (CCl4 ) group (P2), induction of 50 mg/BW CCl4 + EEP group (P3), and (induction of 100 mg/KgBW CCl4 + EEP (P4) with each group consisted of eight mice. The CCl4 in olive oil was administered intraperitoneally three times a week for six weeks. Mean differences between group was determined using ANOVA test with a significance level of 0.05. The induction of CCl4 increased liver cell damage and serum alanin aminotransferase (ALT) level. However, the addition of EEP significantly (p<0.001) reduced liver cell damage as seen in P3 (54.38±4.17 per 100 liver cells) and P4 (37.13±4.36 per 100 liver cells) groups and serum alanin aminotransferase (ALT) as seen in P3 (291.19±113.92 U/L) and P4 (229.38±73.45 U/L) groups. The APRI scores were also reduced after EEP as seen in P3 (0.738±0.292) and P4 (0.513±0.253) groups. Thus, EEP isolates from Gunung Lawu can reduce liver cell damage and fibrosis in mice model of hepatic cirrhosis. Efek Hepatoprotektif dan Antifibrotik Propolis IndonesiaSirosis hati (SH) merupakan tahap ireversibel dalam proses kerusakan hati yang terjadi setelah fibrosis hati sebagai hasil aktivitas nekroinflamasi dan fibrosis hati. Oleh karena itu, penghambatan inflamasi hati dan fibrosis sangat penting untuk mencegah terjadi SH. Penelitian ini bertujuan menganalisis efek ekstrak etanol isolat propolis (EEP) gunung Lawu dalam mencegah progresifitas kerusakan dan fibrosis hati pada mencit model SH. Penelitian dilakukan di Laboratorium Histolgis Fakultas Kedokteran Universitas Sebelas Maret Surakarta dan Lembaga Penelitian dan Pengujian Terpadu (LPPT) Universitas Gajah Mada Yogyakarta . Penilitian ini dilakukan periode Juni 2018 sampai Mei 2019, dengan sampel 32 ekor mencit Balb/C jantan dibagi menjadi kelompok (P1) kontrol negatif, (P2) induksi karbon tetraklorida (CCl4 ), (P3) induksi CCl4 +EEP dosis 50 mg.kgBB-1, dan (P4) induksi CCl4 +EEP dosis 100 mg.kgBB-1, dengan tiap-tiap sampel terdiri dari delapan ekor mencit Balb/C jantan. CCl4 dalam minyak zaitun diberikan pada tikus Balb/C tiga kali seminggu selama enam minggu secara intraperitoneal. Uji ANOVA digunakan untuk menentukan perbedaan rata-rata antar kelompok dengan tingkat kemaknaan sebesar 0,05. Namun, penambahan EEP secara signifikan (p<0,001) menurunkan tingkat kerusakan sel hati seperti yang terlihat pada P3 (54,38±4,17 per 100 sel hati) dan kelompok P4 (37,13±4,36 per 100 sel hati) dan serum alanin aminotransferase (ALT) seperti yang terlihat dalam kelompok P3 (291,19±113,92 U / L) dan P4 (229,38±73,45 U / L). Hasil skor APRI menunjukkan kelompok P1(0,213±0,113) dan P2 (0,863±0,534), EEP dapat menurunkan skor APRI pada kelompok P3 (0,738±0,292) dan P4 (0,513±0,253). Simpulan, EEP isolat Gunung Lawu menurunkan tingkat kerusakan sel hati dan fibrosis pada mencit model SH.
CORRELATION BETWEEN SERUM MID-REGIONAL PRO-ADRENOMEDULLIN AND SEQUENTIAL ORGAN FAILURE ASSESSMENT (SOFA) SCORE IN PATIENT WITH SEPSIS Pujiyanti, Hapsari; Lismayanti, Leni; Rostini, Tiene; Parwati, Ida
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.557 KB) | DOI: 10.15395/mkb.v51n2.1456

Abstract

Most sepsis will develop into multi organ failure (MOF). To assess manifestation of MOF, SOFA score that includes several laboratory parameters for each organ is used. However, this requires time and is also costly. Recently, Mid-Regional Pro-Adrenomedullin (MR proADM) biomarkers are stated to be an alternative marker of MOF in sepsis because MR proADM is secreted by endothelials that may increase in sepsis or bacterial infection. The aim of this study was to analyze the correlation between serum MR proADM levels and SOFA score. This was a cross-sectional  observational analytical study conducted in Dr. Hasan Sadikin General Hospital (RSHS) Bandung from August 2017 to July 2018. This study was a part of the bigger sepsis biomarker study. Samples used in this study consisted of 50 stored serum from the Sepsis Biomarker study in which the MR proADM was measured. Analysis using Spearman?s correlation test showed a moderate positive correlation between serum MR proADM level and SOFA score (r = 0,582, p=0.000), showing that MR proADM serum was directly proportional to SOFA score. It is concluded that MR proADM can be considered as one of the biomarkers for multi organ failure.Korelasi Kadar Mid Regional ProAdrenomedullin Serum dengan Skor Sequential Organ Failure Assessment (SOFA) pada Penderita SepsisSebagian besar sepsis akan berlanjut menjadi multi organ failure (MOF). Untuk mengetahui MOF digunakan skor SOFA yang memerlukan beberapa parameter laboratorium untuk tiap-tiap organ dan membutuhkan waktu dengan biaya yang mahal. Saat ini diketahui biomarker Mid Regional proAdrenomedullin (MR proADM) dapat digunakan sebagai biomarker MOF pada sepsis karena MR proADM disekresi oleh endotel yang akan meningkat pada keadaan sepsis atau infeksi bakteri. Tujuan penelitian ini mengetahui korelasi kadar MR proADM serum dengan skor SOFA. Penelitian ini bersifat observasional analitik dengan rancangan potong lintang dilaksanakan di RSUP Dr. Hasan Sadikin (RSHS) Bandung pada bulan Agustus 2017 sampai Juli 2018. Penelitian ini bagian dari payung penelitian ?Biomarker pada sepsis?. Bahan pemeriksaan berupa bahan biologis tersimpan sebanyak 50 sampel dan dilakukan pemeriksaan MR proADM. Hasil analisis menggunakan Spearman?s correlation test menunjukkan korelasi positif sedang antara kadar MR proADM serum dan skor SOFA (r=0,582; p=0,000). Hal ini menunjukkan semakin tinggi kadar MR proADM serum maka semakin tinggi skor SOFA. Simpulan, terdapat korelasi positif sedang dan bermakna antara MR proADM dengan skor SOFA, sehingga MR proADM dapat dipertimbangkan sebagai salah satu biomarker pada multi organ failure.
Effect of Black Garlic Extract on Blood Glucose, Lipid Profile, and SGPT-SGOT of Wistar Rats Diabetes Mellitus Model Prihanti, Gita Sekar; Isnaini, Faradilla; Yudistia, Rieka; Faradilla, Alifa; Rahman, Masita
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1309.126 KB) | DOI: 10.15395/mkb.v51n2.1657

Abstract

Dyslipidemia is one of the complications of diabetes mellitus (DM) that can lead to elevated total cholesterol, TG, and LDL. Increased SGOT-SGPT indicates damage of hepatic cells. Black garlic extract (Allium sativum L.), which contains polyphenol, flavonoid, and anthocyanin is thought to improve blood glucose, lipid profile, and SGPT-SGOT in human. This study aimed to observe the effect of black garlic extract on blood glucose, lipid profile, and SGPT-SGOT of Wistar Rats Diabetes Mellitus Model. This study was held in 2017 at Biomedical Lab Medical Faculty of Muhammadiyah Malang University. This was a true experimental study with post test only control group design. The rats were assigned to a positive control group and 3 treatment groups consisting of 6 experimental animals each and treatment was given for 25 days. Blood glucose lipid profile, and SGPT-SGOT levels were measured by a spectrophotometer. Data were analyzed using one-way ANOVA, Post Hoc Bonferroni, and Linear Regression tests. Differences were between different groups of rats (p=0,000) with a significant difference seen between all treatment groups and the control group based on  the Post Hoc Bonferroni test results (p=0.000). Black garlic extract reduced blood sugar by 91.4%, total cholesterol by 79.1%, TG by 69.5%, LDL by  81.3%, SGPT by 91.4%, and SGOT by 70.6%. This effect is seen across doses starting from 1.5 mg/200gBW to the highest dose of 6 mg/200gBW. It can be concluded that Black garlic extract (Allium sativum L.) affects  blood glucose, lipid profile, SGPT, and SGOT positively in male wistar (Rattusnorvegicus) rats diabetes mellitus model by decreasing blood sugar, lipid profile, SGPT, and SGOT levels. Pengaruh Ekstrak Black Garlic (Allium sativum. L) Jenis  Solo Peroral terhadap Kadar GulaDarah, Profil Lipid, dan SGPT-SGOT padaTikusWistarJantan (Rattusnovergicus) Model Diabetes Melitus Dyslipidemia adalah salah satu komplikasi diabetes mellitus (DM) yang dapat berpengaruh terhadap peningkatan kolesterol total, trigliserid (TG), dan low-density lipoprotein (LDL). Peningkatan serum glutamic oksaloasetat transaminase (SGOT) dan serum glutamic pyruvic transaminase (SGPT) mengindikasikan kerusakan pada sel hepar. Ekstrak bawang putih hitam (Allium sativum L.) mengandung polifenol, flavonoid, dan anthocyanin yang dipercaya dapat memperbaiki gula darah, profil lipid, dan SGPT-SGOT pada manusia. Penelitian ini dilaksanakan pada tahun 2017 di Laboratorium Biomedik Fakultas Kedokteran Universitas Muhammadiyah Malang dan menggunakan desain eksperimental post test kelompok kontrol. Kelompok kontrol positif dan 3 kelompok perlakuan yang terdiri dari 6 hewan coba di setiap kelompok selama 25 hari. Gula darah, profil lipid, dan kadar SGPT-SGOT diukur menggunakan spektrofotometer. Data dianalisis menggunakan uji ANOVA satu arah, uji Bonferroni post hoc, dan uji regresi linear. Uji ANOVA satu arah menunjukkan ada perbedaan antarkelompok perlakuan tikus (p=0,000). Hasil uji Bonferroni post hoc menunjukkan perbedaan signifikan (p=0,000) di semua kelompok perlakuan dan kontrol. Bawang putih hitam berpengaruh 91,4% terhadap penurunan gula darah, 79,1% terhadap penurunan kolesterol total, 69,5% terhadap penurunan TG, 81,3% terhadap penurunan LDL, 91,4% terhadap kadar SGPT dan 70,6% terhadap kadar SGOT. Dosis yang memiliki efek yang signifikan sudah mulai terlihat pada dosis awal yaitu 1.5 mg/200 gBB sampai pada dosis tertinggi 6 mg/200 gBB. Dapat disimpulkan bahwa ekstrak bawang putih hitam (Allium sativum L.) terbukti mempengaruhi kadar gula darah, profil lipid, dan SGPT-SGOT tikus Wistar jantan model diabetes mellitus (Rattusnorvegicus) yaitu menurunkan gula darah, profil lipid, dan SGPT-SGOT. 

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