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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
Arjuna Subject : -
Articles 651 Documents
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Protein and Phosphate Intakes are Associated with Hyperphosphatemia in Hemodialysis Patients at Sanglah Hospital, Bali, Indonesia Made Dyah Vismita Indramila Duarsa; Yenny Kandarini; Gede Wira Mahadita; Ni Nyoman Shinta Prasista Sari
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.2656

Abstract

Increased chronic kidney disease (CKD) mortality rate is significantly associated with increased blood phosphate levels. Hyperphosphatemia control is one of the main focuses in the management of hemodialysis (HD) patients. A high protein diet has been suggested to prevent malnutrition in hemodialysis patients. However, a high protein and phosphorus diet has the risk of increasing the phosphate level in the blood circulation, leading to a higher mortality rate of hemodialysis patients. This study aimed to prove that the level of protein and phosphate intake is associated with hyperphosphatemia in CKD patients with routine HD. This was cross-sectional analytical study conducted from September to October 2020 on 66 CKD patients who underwent hemodialysis. Subject characteristics and phosphorus and protein intake data were obtained from a questionnaire food recall adapted from the Food and Agriculture Organization of the United Nations. Data consumption patterns were processed using the nutritional survey software to obtain the nutritional values. Data were analyzed using the Chi-Square test to identify the relationship and risk between hyperphosphatemia and diet protein, phosphorus, and protein-phosphorus ratio. The confidence level in this study was 95%. There was a significant relationship between protein and phosphorus intake in hyperphosphatemia in CKD patients. The risk factors for hyperphosphatemia were high phosphorus intake (p=0.018; OR=3.886;95% CI: 1.212–12.460) and adequate protein intake (p=0.035; OR=3.674; 95% CI: 1.049-12.865). This study showed no significant relationship between phosphorus-protein ratio, protein-phosphorus ratio, and hyperphosphatemia incidence. In conclusion, high protein intake and excessive phosphorus intake provide a significant relationship to the incidence of hyperphosphatemia in CKD patients undergoing routine hemodialysis.
Profile and Frequency of One Hundred Ankle Osteoarthritis Cases in an Indonesian Tertiary Hospital Muhammad Farhan Ibrahim; Kurnia Wahyudi; Raden Andri Primadhi
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.2636

Abstract

Osteoarthritis is one of the most common cases in orthopedics and traumatology clinic. Ankle osteoarthritis is less common than osteoarthritis of hip and knee. Limited data and literature resulted in suboptimal treatment strategy. The purpose of this study was to describe the profile and frequency of ankle osteoarthritis at Dr. Hasan Sadikin General Hospital Bandung, a tertiary referral hospital in Indonesia. A cross-sectional descriptive observational study was conducted on all patients diagnosed with ankle osteoarthritis enrolled in the medical record database at Dr. Hasan Sadikin General Hospital Bandung, Indonesia in November 2020–November 2021. Results showed that the majority of the patients were female (52%), aged ≥60 years old (44%), graduated from senior high school education (56%), and housewives (30%). The 100 patients were proportionally distributed with most of them were categorized as suffering from secondary osteoarthritis with post-trauma predominance. From the perspective of body mass index, 85% patients were classified as above normal. As many as 76% of patients presented to the hospital in an advanced stage. With the high rate of posttraumatic ankle osteoarthritis, concerns should be given more to the ankle trauma management, as well as to the population with high body mass index. Increased health promotion for general population and health care providers is also needed to reduce the tendency of late presentation at the health care facility.
Role of P27kip1 Protein, P45skp2 Coactivator, and P38jab1 Coactivator in Preventing Rhabdomyosarcoma (RMS) in Oral Cavity of Children Inne Suherna Sasmita; Ratna Indriyanti; Willyanti Soewondo
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.259

Abstract

Rhabdomyosarcoma is a rare malignant tumor that attacks the differentiation of skeletal muscle and usually affects children, contributing to about 60% of all soft tissue sarcomas. The purpose of this study was to examine the relationship between p27Kip1 immunoexpression and p45Skp2 and p38Jab1 coactivators, as well as the relationship between p27Kip1 immunoexpression and p45Skp2 and p38Jab1 coactivators on stages and prognosis of oral RMS in children. This was a restrospective study on the immunoexpression of p27Kip1 and p45Skp2 and p38Jab1 coactivators on RMS cells. The RMS stage was determined according to the American Joint Committee of Cancer/AJCC of stages 1–4, and were divided into group I (stages 1 and 2) and group II (3 and 4). Samples were retrieved fromt he paraffin blocks of patients with embryonal RMS. Each paraffin block was cut, and 6 samples with 5 µm thickness from each block were examined using p27Kip1, p45Skp2, and p38Jab1 proteins. The analysis was performed using a linear regression test on the relationship between p27Kip1 and p45Skp2 and p38Jab1, resulting in a p-value of 0.000 (<0.05) and a coefficient value of b -1.36. Meanwhile, the stage was analyzed  using the Wald test of 8.0688, resulting in a p-value   of 0.0045 with a significant negative correlation. Analysis on the relationship between p45Skp2 and p38Jab1 and the RMS stage was performed using the Gamma test, resulting in a significant positive correlation (p<0.05).
Shear Bond Strength of Dental Cements on Titanium Alloy: Use of Different Restorative Materials Behnaz Ebadian; Mahsa Abbasi; Mohsen Karbasi
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.2772

Abstract

Different dental cements and restorative materials may have various impacts on the shear bond strength (SBS) to titanium alloy of dental implants, and some fluoride-containing cements may destroy the oxide layer of Ti alloys. The aim of this study was to evaluate the retention and SBS of different dental cements to titanium alloy using different restorative materials and also the corrosive effect of dental cements on titanium alloy. In this in-vitro study, a total of ninety titanium alloy discs (10×3 mm) and restorative material discs (7×3mm) consisting of Co-Cr soft metal, zirconia, and Ni-Cr were constructed. Three dental cement of 2 different compositional classes, glass ionomer (GI) and zinc phosphate (ZP), were used to cement the discs (n=10 in each paired disks). SBS was evaluated using a universal testing machine with a cross-head speed of 1mm/min. A stereomicroscope (×32) and a scanning electron microscope were used to determine the fracture pattern and titanium corrosion, respectively. Data were then analyzed statistically using one-way ANOVA and Tamhane comparison test (P<0.05). The mean SBS of studied groups ranged from 0.12±0.07 to 6.2±0.97 Mpa, with the Ni-Cr and zirconia were demonstrated as the materials with the highest and lowest SBS to GI and ZP, respectively. The cements created a strong bond to the  Co-Cr soft metal while the GI cement remained on restorative material disc surfaces in all samples, except in the zirconia sample. Mixed patterns were mostly seen in ZP cement groups. To conclude, applying fluoride-containing cements have no effect on titanium.
Intravenous Dexamethasone as Prophylaxis Against Laryngeal Edema Associated with Changes in Sound Quality in Patients Undergoing Total Thyroidectomy Eduardus Gilang Putra; Maman Abdurahman; Kiki Ahmad Rizki
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.2540

Abstract

Thyroidectomy is a relatively safe surgical procedure for thyroid gland removal with a with mortality and morbidity rates of less than 2–3%. Complication in the form of sound changes often goes unnoticed in post-thyroid patients despite its high incidence rate, i.e., 87% of all surgical cases. Laryngeal edema as the underlying cause can be triggered by intubation or extubation during anesthesia; malfunction of the strap muscles; surgery that directly causes injury to the superior laryngeal nerve; and recurrent laryngeal nerve injuries. Several studies on the use of dexamethasone to prevent or reduce laryngeal edema that occurs after thyroidectomy have been conducted with controversial results. This study was conducted to solve this controversy. This was a double-blind randomized prospective study on thyroid tumors patients who underwent thyroidectomy at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from December 2020 to May 2021. This study evaluated dexamethasone effects on the patient’s sound changes using the Sound Handicap Index (VHI) questionnaire before surgery, day 1 after the surgery, and day 7 after the surgery. Analysis showed that the VHI significantly decreased on day 1 (p<0.01) and on day 7 (p<0.01), and the difference between the VHI on day 1 (D-1) and day 7 (D-7) was significant (p<0.01). When analyzed using the bivariate analysis, no statistically significant difference was found between the VHI variable before surgery, D-1, and D-7and VHI H7 in the group of patients using dexamethasone and without dexamethasone. Dexamethasone administration has no significant effect on laryngeal edema associated with changes in sound quality.
Front Cover, Editorial Team, Table of Contents, and Back Cover front back cover
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Microbial Culture Characteristics and Antimicrobial Susceptibility Patterns Associated with Vesicovaginal Fistula Gugum Indra Firdaus; Tjahjodjati Tjahjodjati
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.2511

Abstract

Vesicovaginal fistula (VVF) is commonly linked with recurrent urinary tract infection (UTI). Thus, the patterns of the pathogenic microorganism becomes important consideration in the management of this disease. This study aimed to describe patient profiles, disease etiology, and antimicrobial susceptibility patterns of microorganisms in VVF patients. This retrospective study was conducted on 49 medical records of vesicovaginal fistula patients seen from January 2016 to December 2020. The most prevalent age group of the patients was 40-50 years old. Analysis demonstrated that the leading etiology for VVF among these patients was malignancy (73.47%). The antimicrobial susceptibility was tested using the disc diffusion method and Escherichia coli (44.90%) and Proteus mirabilis (14.29%) were identified as the bacterial pathogens most frequently isolated from urine samples. Of the 39 patients with significant growth of organism cases, 29 (74.35%) had symptomatic UTIs. The isolated gram-negative bacteria had excellent sensitivity to aztreonam, ertapenem, and meropenem, with a more than 90% susceptibility rate, while the  gram-positive bacteria had good sensitivity to amikacin, cefepime, tigecycline, aztreonam, ertapenem, and meropenem, with a more than 90% susceptibility. In conclusion,  bacterial culture and antibiotic susceptibility test (AST) remains an essential part of managing VVF and their results can be used as a reference for empirical therapy. Amikacin, cefepime, tigecycline, aztreonam, ertapenem, and meropenem should be considered for treatment of UTIs associated with VVF.
A Ten-Year Study on Risk Factors of Orchiectomy in Testicular Torsion Rulianov Rulianov; Kuncoro Adi; Ferry Safriadi
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.2514

Abstract

Testicular torsion is a common urological emergency among children, peaking in neonates and pubertal age with an incidence rate of 3.8 in 100.000 (0.004%) annually. This study aimed to explore the characteristics of testicular torsion cases and risk factors for orchiectomy in testicular torsion patients. This was a retrospective study on medical records of patients diagnosed with testicular torsion underwent surgery at the urology department of Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from January 2009 to August 2019. Patient characteristics including age, duration of symptom, location, etiology, and degree of torsion were analyzed. A total of 86 cases of testicular torsion were identified, with most cases (54 cases, 62.8%) occured at the mean age 14.67 ± 2.4 years old. Most patients (69 patients, 80.2 %) arrived more than six hours after the onset, and 65 (75.5%) and 4 (4.6%) of them underwent orchiectomy and orchidopexy, respectively. The remaining patients (17 patients, 19.8%) came less than 6 hours after the onset and only 8 (9.3%) and 9 (10.4%) underwent orchiectomy and orchidopexy, respectively. Both duration of torsion (p = 0.000, P<0.05) and degree of torsion (p = 0.006 , P<0.05) were significantly correlated with orchiectomy. In conclusion,  the risk factor for orchiectomy is strongly related to duration and degree of torsion. The chance for testis salvation increases if torsion happens before 4.5 hours and the degree of torsion is below 180 degrees. Prompt diagnosis and treatment is the only key to testicular salvation.
Influence of Pesticide Intoxication Education on Farmer Knowledge and Attitude in Kalidoni District, Palembang City, Indonesia Thia Prameswarie; Dientyah Nur Anggina; Camelia Panache; Florence Triningtyas
Majalah Kedokteran Bandung Vol 54, No 4 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n4.2698

Abstract

Knowledge and attitude of farmers are among factors that influence pesticide intoxication in farms. They are influenced by several variables, including education. Farmers’ knowledge and attitude on pesticide intoxication may change after they receive interventions, such as education about pesticides. This study aimed to determine the level of knowledge and attitude of farmers on pesticide intoxication before and after an education session on pesticides in Sei Selincah Sub-district, Kalidoni District. This was a quasi-experimental observational analysis with a two-group pretest posttest design with a control group. This study used primary data from farmers in Sei Selincah Sub-district, Kalidoni District. Sampling was performed using the purposive sampling method and seventy-six respondents who met the inclusion and exclusion criteria were recruited. Results of the statistical tests using the Wilcoxon test showed that there was no difference in the level of knowledge and attitude of farmers before and after education, both fort the intervention group and the control group (p>0.05). Thus, education does not influence the level of knowledge and attitude on pesticides and pesticide intoxication among farmers.
Effectiveness of Basil, Lime, Honey, Candlenut, and Tiwai Onion Herbs Combination as Analgesics and Stamina Stimulator Andriyanto Andriyanto; Sharon Aurellia; Silmy Kamila Widyanti; Hamdika Yendri Putra; Leliana Nugrahaning Widi; Rindy Fazni Nengsih; Aulia Andi Mustik; Wasmen Manalu
Majalah Kedokteran Bandung Vol 54, No 4 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n4.2754

Abstract

Traditional medicine is generally considered to be safer than modern medicine because it has lower incidence of side effects and also relatively easy to obtain. The purpose of this study was to examine the analgesic effect of herbs made of basil, lime, honey, candlenut, and Tiwai onions as well as to evaluate the potential of these herbs as a stamina stimulator. This study was conducted at the Laboratory of Animal Management Unit, Faculty of Veterinary Medicine, IPB University, from January–February 2022. Mice were divided into four groups based on the treatment dose with each group consisted of five mice. An analgesic test was conducted using hot water immersion tail-flick test method and the stamina test was performed with swimming endurance test. Data obtained were analyzed using Microsoft Excel 2019 and Minitab 19. Significant differences of the average of each group were shown statistically using the one-way ANOVA and confirmed with Tukey test. Results showed that mice given the combination herbal medicine infusion of with a dose of 4 g/kg body weight had the highest average tail lift time compared to the controls (p<0.05). Mice with a treatment dose of 1 g/kg body weight had the highest analgesic power compared to the other treatment doses. The highest swimming duration was observed in group that received a dose of 1 g/kg body weight. It is concluded that this herbal combination can be used as an analgesic and a stamina stimulator.

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