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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
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Gangguan Kosmetik Karena Kelainan Pigmentasi Kulit Hardyanto Hardyanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 13, No 04 (1981)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Patients with pigmentary changes on their skin seek advise primarily for cosmetic reasons, although these are usually asymptomatic and without systemic consequencei. The most common types of pigmentary disturbances are 'freckles, melasma, lentikines, melanoderma, vitiligo and leukoderma.This article discusses normal melanogenesis, and clinical features, pathogenesis and treatment of pigmentary abnormalities of the skin,Patients suffering from pigmentary abnormalities attending the clinic of the Department of Dermatology and Venereology, Gadjah Mada University Hospital, are presented, From 1978 to 1979, 450 patients were noted. 26% males and 74% females, with the following breakdown: 18.2% melasma, 20.2% freckles, 12.4% melanoderma, 6.4% lentigo, 84.7% vitiligo and 8.1% leultoderma . -Key Words: pigmentary abnormalities - hyperpigmentation and hypopigmentation - epidermal melanin unit - hydrocluinon - psoralen
Farmakologi Klinik Suatu Introduksi Samekto Wibowo Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 7, No 02 (1975)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Perkembangan keadaan memerlukan bidang pengetahuan Baru yakni: farmakologi klinik. Hal yang perlu diperhatikan ialah fungsi, organisasi dan keperluan-keperluannya. Hanya saja, sebelum putusan ke arah pembinaan farmakologi klinik haruslah didapat persesuaian dalam hal kebutuhannya, baik bagi rumah sakit maupun bagi fakultas kedokteran.Fungsi harus dijelaskan dulu, fungsi akademik dalam fakultas kedokteran dan fungsi service dalam rumah sakit. Adanya laboratorium farmakologi klinik dan service klinik akan banyak menghemat tenaga dan alat yang akan diperlukan oleh sebuah rumah sakit. Daripada tiap departemen rumah sakit membuat laboratorium sendiri-sendiri, akan lebih baik ada laboratorium sentral farmakologi klinik. Dan harus diingat, bahwa nanti mencakup pula status administratif, perencanaan staf tehnicus dan professionil, ruang kantor dan laboratorium serta fasilitas rumah sakit termasuk out-patient dan tentu saja dana (Wardell, 1974).Melihat kondisi kebutuhan yang sama, nampaknya Indonesia sudah harus mulai berfikir ke arah itu. Jalan awal yang paling sederhana ialah memberikan pelajaran farmakologi klinik pada mahasiswa. Dari sini perkembangan lebih lanjut farmakologi klinik akan dibina.
Amplification and cloning of block 2 of the gene encoding Merozoite Surface Protein-1 (MSP-1) of Plasmodium falciparum isolated from Kokap, Yogyakarta Elsa Herdiana Elsa Herdiana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 34, No 02 (2002)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Falciparum malaria remains a major public health problem in tropical and subtropical countries including Indonesia. The disease is caused by Plasmodium falciparum and spread by Anopheline mosquitoes. The widespread of Plasmodium which are resistant to antimalarial drugs and Anopheline mosquitoes which are resistant to insecticides have urged to look for alternative solutions including the development of protective vaccines. Several vaccine candidates have been studied, one of them is Merozoite Surface Protein-1 (MSP-1) which is expressed on the surface of merozoite. It was shown that this protein induces protective immune responses. Variation on the gene encoding MSP-1 of Plasmodium falciparum has been well documented but such data from Indonesia population have never been studied. Objective: The aim of this study is to amplify and clone MSP-1 gene of P. falciparum isolated from Kokap, Yogyakarta.Methods: Block 2 of the gene encoding MSP-1 was amplified by Polymerase Chain Reaction (PCR) and the PCR amplification products were cloned using pGEM® -T vector and transformed into Escherichia coil JM 109.Result: From 19 PCR results, 3 were cloned and 10 colonies were picked up. Nine of 10 showed the MSP-1 gene insertion by PCR method.Conclusion: Block 2 of the gene encoding MSP-1 of P. falciparum isolated from Kokap, Yogyakarta was successfully amplified by PCR method. This study resulted in 9 recombinant plasmids which contained MSP-1 gene as the outcome of cloning and transformation into E.coli.Key words: P. falciparum - MSP-1 - PCR - Amplification - Cloning
The pattern of bacterias causes pneumonia on Sardjito General Hospital January 1, 1990 - December 31, 1994 Barmawi Hisyam Barmawi Hisyam
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 30, No 03 (1998)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Pneumonia has high morbidity and mortality. The clinical classification of Community Acquired Pneumonia (CAP) and Hospital Acquired Pneumonia (HAP) and the empirical treatment have beneficial means to prevent the severity of the disease. A retrospective study had been conducted, by evaluating the medical record of the patients hospitalised in the Department of Internal Medicine Dr. Sardjito General Hospital, January 1, 1990 -December 31, 1994. There were 221 cases of pneumonia, the major frequency on range 45-64 years old: 84 (38,01%), men/women ratio: 1.5 : 1. The CAP was more than HAP: 200 (90,50%) vs 21 (9,50%). Bacterias causes CAP: Streptococcus alpha 36 (29,75%), Staphylococcus aureus 28 (23,14%) and Klebsiella pneumonia 27 (22,31%). While the bacteria cause of typical HAP: Klebsiella pneumoniae 1 (100%), mixed bacterias causes HAP: Streptococcus alpha 3 (33,33%), Staphylococcus aureus 3 (33,33%) and Klebsiella pneumoniae 2 (22,22%). There were no difference the pattern of bacterias causes CAP or HAP.Key Words : the pattern of bacteria - typical bacteria - mixed bacterias - CAP - HAP
Thyrotoxic periodic paralysis: A case report Ahmad H Asdie Ahmad H Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 19, No 02 (1987)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The paper presented two cases of periodic paralysis complicating Graves' disease of the Indonesians. Clinical presentation and laboratory findings were concomitant with classical description of thyrotoxic paralysis in these cases. The precipitating factor in our cases is thought to be severe physic- al activities done several hours before paralytic attacks. Hypokalemi a probably also precipitates the episode of paralytic attack, but not convincing since without specific treatment of hypokalemia the paralysis recovered spontaneously. In one case, the periodic paralysis reappeared several time after treatment with anti-thyroid medication, but can be controlled with beta-blockers, propranolol 4 dd 20 mg. Key Words.. thyrotoxic periodic paralysis - Graves' disease - beta-blockers - hypokalemia - Indonesians.
Pendidikan Medis Ekstramural A.Adi Sukadana A.Adi Sukadana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 12, No 04 (1980)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Kata kunci: Pendidikan Medis Ekstramural
Mucosal IgA response in the colon against pneinnococcal polysaccharide antigen Marsetyawan HNE Soesatyo Marsetyawan HNE Soesatyo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 02 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The humoral IgA response to bacterial polysaccharide antigen in rats was investigated in vivo. Rats were immunized with pneumococcal polysaccharide type-3 (PPS-3) via different routes, i.e. in the Peyer's patch (iPP), in the colon (I.C.), peritoneal cavity (LP.), and intravenous (I.V.). The development of specific antibody-forming cells (AFC) and their isotypes in the intestinal mucosa, gut-associated lymphoid tissue. (GALT), mesenteric lymph nodes (MLN) and spleen were studied by immunohistochemistry. The serum antibody levels were measured by enzyme-linked " lll unosorbent assay (ELISA).The results showed that iPP immunization evoked high numbers of anti-PPS-3 AFC of the IgA isotype in the mucosa of the small intestine and in the Peyer's patch. On the contrary, the I.C. route did not elicit a mucosal response, though a few AFC were found in the MLN and spleen. Following I.P. priming, a specific IgA response was found, especially in the MLN and spleen, and low response was detected in the villi. A high response was found in the parathymic lymph nodes (PTLN). The I.V. immunization gave rise to the development of AFC in the spleen. particularly of the 1gM isotype. There was no mucosal responses to PPS-3 antigen in the colon arise irrespective of the route of immunization.Key-words : IgA-colon-antibody-forming cells- pneumococcal polysaccharide antigen -immunohistochemistry
Epidemiology of filariasis malayi in Muara Padang Village, Muara Padang SubDistrict, Banyuasin District, South Sumatra, Indonesia Erwin Edyansyah Soeyoko Sri Sumarni
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Filariasis is still a public health problem in Indonesia especially in rural areas. In South SumatraProvince, 186 patients with chronic filariasis were reported in 2009 and 130 of them came fromBanyuasin District. In Muara Padang SubDistrict, there were 7 patients with chronic filariasisand 1 of them lived in Muara Padang Village. A finger blood survey has never been conducted inMuara Padang Village since elimination program started in 2002. The aim of the study was toevaluate epidemiology of filariasis malayi in the Muara Padang Village. This was a descriptivestudy using cross sectional design. Data were collected from finger blood survey, blood tests forreservoir host (cats), stage 3 of filarial larvae (L3) in mosquito and microfilaria periodicityexamination. From 520 finger blood samples collected from the inhabitants, microfilaria was notobserved. However, 1 subject was found to have elephantiasis caused by filariasis malayi asindicated by swelling leg below the knee. Moreover, 1 subject showed descending lymphangitissymptoms accompanied by fever, headache and weakness even though in blood examinationmicrofilaria was not found. Among 17 samples collected from cats, microfilaria of Brugia malayiwas not observed. However, animal filarial i.e. Dirofilaria repens was observed in 11 samplescollected. Among 701 mosquitoes dissection and examination, L3 was not found. Due to thefact that the microfilaria was not observed in all samples, microfilaria periodicity examinationwas not conducted. In conclusion, microfilaria of B. malayi was not observed in Muara PadangVillage. However, microfilaria of D. repens was observed in cats.
Cataracta Dengan Persoalannya Gunawan Gunawan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 5, No 04 (1973)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Di antara berbagai macaw operasi mata operasi cataractalah yang paling banyak terjadi.Di terangkan rnengenai sejarah cataracta, juga ditinjau mengenai patogenese, gejala klinik serta terapi cataracta.Keadaan penderita cataracta di Bagian Ilmu Penyakit Mata Fakultas Kedokteran menunjukkan bahwa 3% dari pengunjung Balai Pengobatan Mata Universitas Gadjah Mada tahun 1972 menderita cataracta. Dan 30% dari semua macam operasi mata di Rumah Sakit Mata Universitas Gadjah Mada adalah operasi catacacta. Hanya sedikit penderita yang menginginkan kacamata setelah mengalami operasi cataracta.
Usia Lanjut Anonim Anonim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 03 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Key Words: Ageing

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