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Daerah istimewa yogyakarta
INDONESIA
Jurnal Kesehatan Reproduksi
Published by Universitas Gadjah Mada
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Core Subject : Health,
Health Professions
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Articles 195 Documents
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Kualitas Hidup Satu Tahun Pasien Kanker Serviks yang telah Dilakukan Histerektomi Radikal di RSUP DR. Sardjito Yogyakarta Fuadi, Afif; Pradjatmo, Heru; Kusumanto, Ardhanu
JURNAL KESEHATAN REPRODUKSI Vol 6, No 3 (2019)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.511 KB) | DOI: 10.22146/jkr.49348

Abstract

Latar Belakang: Kanker serviks merupakan kanker paling banyak ketiga yang ditemukan pada seorang wanita. Secara keseluruhan lebih dari 85% terjadi pada negara-negara berkembang. Insidensi rata-rata paling tinggi di wilayah Sub Sahara Afrika, Amerika Latin dan Karibia, Melanesia dan Asia Barat, Australia/Selandia Baru. Variasi geografis yang besar mencerminkan ketersediaan skrining yang memungkinkan untuk mendeteksi lesi prakanker dan prevalensi terjadinya infeksi Human Papillomavirus (HPV). Modalitas skrining dan strategi pengobatan telah berevolusi, dengan kemajuan terapi saat ini yang meliputi tindakan pembedahan, kemoterapi dan radiasi, penderita kanker serviks dihadapkan pada efek samping pasca pengobatan lengkap. Sehingga dapat menyebabkan penurunan kualitas hidup mereka.Tujuan: Mengetahui kualitas hidup satu tahun pasien kanker serviks yang telah dilakukan histerektomi radikal.Metode: Penelitian kuantitatif dengan pendekatan cross sectional dengan cara melakukan wawancara dengan pasien saat periksa di poli onkologi menggunakan instrumen dari EORTC QLQ C30 versi 3.Hasil dan Pembahasan: Rata-rata penderita kanker serviks berusia 45-55 tahun yaitu 21 orang (37,5%), tidak menopause, dengan paritas antara 1-2 dan indeks massa tubuh normal. Jenis histopatologi terbanyak adalah karsinoma sel skuamosa dan grade sedang. Sebagian besar tidak terdapat keterlibatan kelenjar getah bening, lymphovascular space invation (LVSI) dan tidak dilakukan kemoterapi adjuvan. Kualitas hidup pasien kanker serviks termasuk dalam katagori baik dengan nilai rata-rata status kesehatan global >87,5% dan pada domain skala fungsi dan gejala >90%. Hanya saja terdapat hubungan yang bermakna yang ditunjukkan pada variable usia dengan nilai p=0,020 dan RR=0,545 dan keterlibatan kelenjar gertah bening dengan nilai p=0,008.Kesimpulan: Pada penelitian ini kualitas hidup pasien kanker serviks yang telah dilakukan histerektomi radikal di RSUP Dr. Sardjito sangat baik.Kata Kunci: Kanker serviks; Kualitas Hidup; Histerektomi radikal
Faktor-Faktor yang Meningkatkan Prognosis Fetal dan Maternal pada Kehamilan dengan Kanker Ovarium Imantika, Efriyan; Prawitasari, Shinta; Hadiati, Diah Rumekti
JURNAL KESEHATAN REPRODUKSI Vol 6, No 3 (2019)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.597 KB) | DOI: 10.22146/jkr.51766

Abstract

Background: Pregnancy complicated by ovarian cancer presents relation between controlled growth in pregnancy and uncontrolled growth in cancer. The management of pregnancy illustrate conflict between optimal maternal therapy and fetal life for best prognosis at all. The incidence was low but it occured in reproductive age women and most found in the first pregnancy. It is important to analyze factors that improve the prognosis of pregnancy and appropiate management to prevent fetal and maternal morbidity and mortality. Objectives: To analyze factor on pregnancy complicated by ovarian cancer that improve fetal and maternal prognosisMethods: This is descriptive analytic study with cohort retrospective design using medical records of pregnancy patient complicated by ovarian cancer that underwent treatment at Sardjito Hospital Yogyakarta on 2010, January till 2017, December. All statistical analysis were done by statistic software for computer.Results: There were 18 research subjek had been undergone treatment at Sardjito Hospital for 8 years. Factors on pregnancy related to prognosis of pregnancy complicated by ovarian cancer were late gestational age at the cancer diagnosis and epithelial histopathology type. That factors have better prognosis than early gestational age and non-epithelial histopathology clinically (p=0.18; CI 95% 0.4-104.2; OR 6,5) and (p=0.29; CI 95% 0.36-30.12; OR 3.28). Timing of surgery intervention improve prognosis of pregnancy statistically and clinically significant (p=0.02; OR=4.2). Conclusion: Factors on pregnancy complicated by ovarian cancer that is late gestational age at the cancer diagnosis, epithelial histopathology type and timing of surgery intervention type II-III improved fetal and maternal prognosis. Best management of pregnancy lead to better prognosis.Keywords: prognosis of pregnancy, ovarian cancer. 
Efektivitas Pendidikan Kesehatan Reproduksi Berbasis Seluler pada Calon Pengantin terhadap Peningkatan Pengetahuan Kesehatan Mayasari, Ade Tyas; Hakimi, Mohammad; Hani EN, Umu; Setyonugroho, Winny
JURNAL KESEHATAN REPRODUKSI Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.47128

Abstract

Background: Every individual needs to know about the issues of sexuality and reproduction before marriage so the reproduction health education is important to give to the prospective bride and groom.  Technology-based education is an innovative pathway for providing health information.Objective: to determine the effectiveness of reproduction health education on the improving of knowledge of the prospective bride and groom.Method: Quasi-Experimental research with pretest posttest in Non-equivalent Control Group Design.  The data were obtained from a knowledge questionnaire filled out by the prospective bride and groom. This research was conducted at KUA (the Civil Registry Office) Mlati and Gamping, Sleman Regency.Results and Discussion: There was an increase in the average posttest score of knowledge in each group.  Based on the results of the data analysis, it was found that the respondents who were given reproduction health education through cellular experienced a greater increase in the post-test score (the difference between the average pretest and post-test score is 5.67) compared to the group who were not given reproduction health education via cellular (the average difference between the pretest and post-test score is 2.2).  The Cellular-based reproduction health education significantly (p value = 0.00) influences the prospective bride and groom’s knowledge of the reproduction health.Conclusion: Cellular-based reproduction health education can improve the knowledge of the prospective bride and groom about the reproduction health. Keywords: Reproduction Health; Cellular; Knowledge; Premarital.
Problem Kesehatan Reproduksi Perempuan Usia Subur Eks Pengungsi Timor Timur Meo, Maria Lupita Nena; Nahak, Maria Paula Marla
JURNAL KESEHATAN REPRODUKSI Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.47534

Abstract

Background: The poverty issue affecting refugees, in principle, aggravates the reproductive health of refugee women..Objective: This study aims to capture the reproductive health problems of the eligible women of the former East Timor refugees in 3 refugee camps in Kupang regencyMethod: This study used a mixed method for 81 eligible women. Data were collected by questionnaire and in-depth interview. Data was analysed univariately and explanatively.Results and Discussion: This study found that 80.2% of women in their early teens at the time of their first pregnancy and 53.1% of eligible women who did not use contraception. Meanwhile, only 43.2% of pregnant women regularly did the Antenatal care (ANC), and only 37% of mothers did exclusive breastfeeding. The qualitative findings found 3 main themes; 1) Teenage pregnancy; 2) Pregnancy control; 3) Barriers in accessing reproductive serviceConclusion: Overall, teenage pregnancy has been a serious problem for refugee women, and it has been aggravated by the low awareness to use contraception and to do ANC. Therefore, the government needs to provide comprehensive, tolerant, and congruent reproductive health services based on culture and complexity of the problems in the refugee camp community. Keywords: Reproductive Health; Women; Refugees; East Timor
Status Kesehatan Remaja Perempuan yang Mengalami Perkawinan Anak Ratnaningsih, Muliani; Utami, Rahayu; Waksi, Fajar
JURNAL KESEHATAN REPRODUKSI Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.48889

Abstract

Background: Indonesia was one of ten countries with the highest child marriage rate, and second highest in ASEAN after Cambodia. According to data, South Sulawesi was province with the 4th position contributing to the marriage of children in Indonesia. In South Sulawesi, age of marriage less than 14 years is 0.5 percent, while age of marriage between 15 years to 19 years is 33.5 percent. Objective: This research aimed to know health status of adolescent girls who have conducted child marriage in Makassar City. Method: This research used descriptive research with quantitative approach. The variables in this research health status from child and mother. The population in this study were all girls aged 15-24 years that chosed by Snowball Sampling nonrandom method with sample size 101 girls. Results and Discussion: Health status in this study form mother and child. For mother, Body Mass Index (BMI) category owned by adolescent girls who experience child marriages, underweight 18 people (17.8%), ideal body weight 66 people (65.3%), and overweight 17 people (16.8%). For child, the status of the weight of the first child at birth, low birth weight (LBW) 8 people (9.9%), not experience LBW 73 people (90.1%). Conclusion: The description of the health status of adolescent girls shows some things that are not good for the health of adolescent girls that can be reviewed in terms of two things, namely the condition of the mother and the condition of the child. The most influential health conditions are the nutritional status of children, immunization of children, nutritional status of mothers, and some knowledge about reproductive health that is still low. Keywords: children; health; marriage; status
Pengaruh Psikokuratif terhadap Kadar VEGF-c, Kortisol dan Skor HADS Pasien Kanker Serviks Stadium Lanjut Soetrisno, Soetrisno; Sulistyowati, Sri; Tjiang, Rubin Enhui; Wujoso, Hari; Nurinasari, Hafi; Cahyanto, Erindra Budi
JURNAL KESEHATAN REPRODUKSI Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.50642

Abstract

Background: Cancer diagnosis and therapy that causes chronic stress, its progression to depression  increase cortisol and VEGF-c levels in advanced cervical cancer patientsObjective: To  know the VEGF-c, cortisol and HADS level  in advanced stage cervical cancer patients who get Psychocurative intervention Method : An experimental study of pretest – posttest controle group design in outpatient oncology clinic and ward of Doctor Moewardi General Hospital. Thirty subjects with advanced cervical cancer were randomly divided into 15 patients in the intervention group, and 15 in control. Psycho-curative intervention 4 times a month, 1 time a week, 60 minutes duration. Before and after intervention, each subject of the two groups was examined levels of VEGF-c, cortisol and HADS scores. Data obtained were analyzed by independent t test, Mann Whitney, Pair t and Wilcoxon with the 19th version of SPSS for Windows.Result and Discussion: Average VEGF-c levels before intervention 9006.53 ± 2181.49, after intervention 5631.20 ± 2071.55, p <0.001. The mean cortisol level before intervention was 12.29 ± 4.36, after intervention 6.71 ± 3.88, p <0.001. The mean HADS Anxiety score before intervention was 14.13 ± 3.02, after intervention 8.47 ± 3.07, p <0.001. Mean Depression HADS scores before intervention 13.80 ± 3.21, after intervention 7.20 ± 2.70, p <0.001.Conclusion : VEGF-c levels, cortisol, HADS anxiety scores and depression in patients with advanced cervical cancer decline after psychocurative intervention. Keywords : Psychocurative; VEGF-c; Cortisol; HADS; Cervical cancer
Hubungan Kadar β-hCG 12 Hari Pasca Transfer Embryo dengan Luaran Kehamilan Kurniawan, Agung; Widad, Shofwal; Hadiati, Diah Rumekti
JURNAL KESEHATAN REPRODUKSI Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.53479

Abstract

Latar Belakang: Subfertilitas merupakan salah satu permasalahan yang sering ditemukan di era modern ini. Berbagai metode ditemukan dan digunakan untuk meningkatkan angka keberhasilan reproduksi pada perempuan. Teknologi reproduksi berbantu memiliki risiko terjadinya keguguran dan kehamilan ektopik. Kadar serum β-hCG 12 hari pasca transfer embryo memiliki peranan penting dalam prediksi luaran kehamilan.Tujuan: Untuk memprediksi luaran kehamilan, sensitivitas, spesifisitas serta nilai ambang kadar β-hCG 12 hari pasca transfer embryo.Metode: Penelitian menggunakan  rancangan penelitian observasional kohort retrospektif di Klinik Permata Hati RSUP. Dr. Sardjito Yogyakarta tahun 2012 – 2015. Subyek penelitian 130 subyek yang terbagi menjadi 65 subyek dengan kadar β-hCG  <76 IU/l dan 65 subyek ≥76 IU/l. Luaran kehamilan diklasifikasikan sebagai viabel (janin hidup pada usia kehamilan ≥ 22 minggu) dan non viabel ( kehamilan biokimia, ektopik, mola dan keguguran).Hasil dan Pembahasan: Median dan minimum kadar β-hCG pada kehamilan viabel 167 IU/l dan 44 IU/l,  dan 53 IU/l dan 16 IU/l pada kehamilan non viabel. Terdapat hubungan yang bermakna antara kadar serum β-hCG 12 hari pasca transfer embryo dengan luaran kehamilan. Kadar  β-hCG  ≥76 IU/l sebanyak 50 (76,9%) pada kehamilan viabel  dan sebanyak 15 (23,1%) subyek pada kehamilan non viabel.  Kadar β-hCG <76 IU/l sebanyak 7 (10,8%) pada kehamilan viabel dan 58 (89,2%) pada kehamilan non viabel (p=0,000). Kadar β-hCG terendah pada kehamilan ganda 300 IU/l.Kesimpulan: Kadar β-hCG 12 hari pasca transfer embryo bermakna secara statistik dalam membantu memprediksi luaran kehamilan viabel dengan cut-off point 71,5 IU/l, sensitivitas 89,1 % dan spesifitas 79,5 %. Nilai positive predictive value (PPV) adalah 76,9 %, dan nilai negative predictive value (NPV) adalah  89,2%.Kata kunci: Teknologi reproduksi berbantu, subfertilitas, kadar β-hCG, transfer embryo, luaran kehamilan. 
Perbandingan Pemberian Parasetamol Oral dan Ketorolak Intravena dalam Membantu Keberhasilan Menyusui Pasca Seksio Sesarea Fidina, Dalri Nur; Attamimi, Ahsanudin; Prawitasari, Shinta
JURNAL KESEHATAN REPRODUKSI Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.53481

Abstract

Tujuan: Penelitian ini bertujuan untuk membandingkan pemberian parasetamol 1000 mg oral dan injeksi ketorolak 30 mg intravena dalam mengatasi nyeri terhadap keberhasilan menyusui pasca seksio sesarea. Metode: Penelitian ini merupakan penelitian non blinding, randomized controlled trial yang membagi subyek penelitian menjadi 2 kelompok. Kelompok kontrol adalah kelompok yang mendapat injeksi ketorolak 30 mg intravena dan kelompok perlakuan adalah yang mendapat parasetamol 1000 mg per oral yang kemudian dinilai nyeri dengan VAS dan keberhasilan menyusui dengan skor LATCH pada 24 jam setelah seksio sesarea. Chi square serta risiko relatif dipakai untuk uji statistik untuk membandingan 2 proporsi. Hasil: Penelitian ini melibatkan 86 subjek. Pada pemberian parasetamol 1000 mg per oral dan ketorolak 30 mg intravena didapatkan hasil tidak perbedaan bermakna terhadap nyeri (RR 1,16; 95% CI 0,84-1,16). Angka keberhasilan menyusui pada kedua kelompok dengan efek tidak nyeri dan nyeri didapatkan hasil tidak berbeda bermakna secara statistik. Kesimpulan: Pemberian parasetamol 1000 mg per oral tidak berbeda bermakna dibandingkan dengan pemberian injeksi ketorolak 30 mg intravena terhadap nyeri dan keberhasilan menyusui pasca seksio sesarea.   Kata Kunci: parasetamol, ketorolak, seksio sesarea, keberhasilan menyusui, nyeri
Pengaruh Pemberian Parasetamol Intravena untuk Mengurangi Nyeri Persalinan Kala 1 Fase Aktif Sitorus, Juli; Emilia, Ova; Nurdiati, Detty Siti
JURNAL KESEHATAN REPRODUKSI Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.53482

Abstract

Background: Labor was a physiological process, labor pain appeared from regularly uterine contraction, cervix distention and pressure to pelvic floor that stimulate free end nerves. Pain labor can influenced the mother, fetus and the progress of labor. There are various of effort to decrease pain labor by pharmacological or non pharmacological. The best therapy must be safe, effective, and minimal adverse effect to mother and fetus.Objective: To evaluate the effect of paracetamol intraveneous for pain relief in active labor versus saline water.Methods: In randomized controlled trial, with single blinded, 66 primigravid in active labor at RSUD Hj. ANNA LASMANAH Banjarnegara and RSUD Banyumas from November 2016 to January 2017. Sampels divided in two groups, paracetamol group (n=33) and normal saline group (n=33). The primary  outcome was the efficacy of paracetamol to relief pain. Intensity of the pain measure by VAS (visual analogue scale), pain measured before drug administration, after 30 minutes, at 1, 2, 3, and 4 hours in both groups. The secondary outcomes include the adverse effect to the mother and baby in both group.Results: The reduction in pain score was significantly greater in paracetamol group than normal saline after 30 minutes, 1, 2, 3, and 4 hours after adiministration of the drug (p<0.05). There was no adverse effect to mother and baby in both groups.Conclusion: Paracetamol intravenous statistically significant decreasing mean pain score than normal saline and safe in active labor.Keywords: Paracetamol, analgesia, active phase in labor
Hubungan antara Ekspresi P53 Mutan terhadap Operabilitas Kanker Serviks Stadium IIB Pasca Kemoterapi Neoajuvan Arsyad, Nur Rohmah; Siswosudarmo, Risanto; Kusumanto, Ardhanu
JURNAL KESEHATAN REPRODUKSI Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.53838

Abstract

Background: The therapy for stage IIB cervical cancer according to FIGO is concurrent chemoradiation. The neoadjuvant chemotherapy followed by radical hysterectomy is an alternative therapy to improve the survival rate of cancer patients. Cervical cancer is mainly caused by the infection of Human Papilloma Virus (HPV), which contains protein E6 and E7 that downregulate the apoptotic function of p53. The absent of p53 wild-type and the present of p53 mutation play roles on the cervical cancer pathogenesis.Objective: To analyze the association between the expression of mutant p53 to the stage IIB cervical cancer operability after neoadjuvant chemotherapyMethod: This study was a prospective cohort, using 40 of 67 patient who met eligibility criteria. The parafin block from cervical tissue were processed for immunohistochemical staining of p53 using Anti-mutant p53 antibody [Y5] ab32049, Abcam, USA. Two study groups were assessed as: 1) weak and 2) strong expression of mutant p53 expression after neoadjuvant chemotherapy based on H-score. Both group (weak and strong) were comparable in term of mutant p53 expression. In this study, the evaluation of operability was performed clinically. Age, BMI, histopathology, grade of differentiation, and regiment were also evaluated as the external variables. Chi square test, and logistic regression analysis were used for statistical analysis.Results and Discussion: The rate of cervical cancer operability after chemotherapy was 19 out of 40 (47.5%). The strong expression of mutant p53 was observed in 6 subjects (15%). There was no significant association between weak vs strong expression of mutant p53 to the operability of the cancer (RR 1.5, CI 95% 0.46-4.88, p 0.45). Multivariate analysis showed that combination (50 mg/m2 dan 5 fluorourasil 450 mg/m2) was significantly correlated the operability (OR 7.02, CI 95% 1.27-40.07,  p 0.03).  Conclusion: The expression of mutant p53 not correlate with operability after neoadjuvant chemotherapy, but combination  regiment was.Keywords: expression of mutant p53, stage IIB of cervical cancer, neoadjuvant chemotherapy, operability

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