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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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ANALISIS COST-EFFECTIVENESS PENGGUNAAN SEFTRIAKSON DAN SEFOTAKSIM PADA TERAPI PROFILAKSIS APENDEKTOMI DI RS PKU MUHAMMADIYAH YOGYAKARTA TAHUN 2006-2007 Sri Aisyah Muhartati; Muh Muhlis; Woro Supadmi
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cost-effectiveness analysis of ceftriaxone and cefotaxim prophylactic antibioticsof appendectomy in PKU Muhammadiyah Hospital Yogyakarta from January 2006 toDecember 2007 has been studied. This study was aimed to explore the direct medicalcost, cost-effectiveness ratio, and determine whether drugs of ceftriaxone or cefotaximwhose had more effective cost. This study was carried out by descriptive retrospectivedesign. The population was all inpatients of appendectomy getting prophylaxisantibiotics with either ceftriaxon or cefotaxim therapy in PKU MuhammadiyahHospital Yogyakarta. The population target were the appendectomy patients in thethird class of PKU Muhammadiyah Hospital Yogyakarta from January 2006 toDecember 2007. The result indicated that direct medical cost of the patients gettingceftriaxone therapy was Rp 422.257, whereas the cost of the patients getting cefotaximtherapy was Rp 487.680. Cost-effectiveness ratio of whom getting ceftriaxone therapywas Rp 105.564/day, whereas the ratio of whom getting cefotaxim therapy was Rp162.560. Finally, it have not been able to determine which drug is more cost-effective.

Improvement of family caregiversâ€™ knowledge of polypharmacy in the elderly after health education Mustaming Mustaming; Rina Loriana; Azhari Azhari; Badar Badar
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The different health problems in elderly patients require complex management. However, if the use of medicines is uncontrolled, it will lead to polypharmacy. This study aimed to analyze the effect of health education on family caregiversâ€™ knowledge of polypharmacy particularly to prevent drug therapy problem in elderly patients. This quasi-experimental study used one-group pre-test post-test design. The population was family caregivers who had elderly members in their care and lived within the working area of Bengkuring Public Health Center. The population members were selected according to the inclusion criteria until a minimum sample size was reached. Having met the criteria, the respondents were asked to fill in a pre-test questionnaire before they partook in the health education for polypharmacy and a post-test questionnaire after their participation. The pre-test and post-test information were then analyzed using a paired t-test. This study revealed that the family caregiversâ€™ knowledge of polypharmacy improved by 32.5% with a probability value (p= 0.000< 0.001) less than the level of significance (5%). The contribution of the health education to the family caregiversâ€™ knowledge of polypharmacy was 74.3%. There was an improvement in the family caregiversâ€™ knowledge of polypharmacy after participating in the health education.

ISOLASI DAN AKTIVITAS LARVACIDA MINYAK ATSIRI AKAR (Curcuma mangga, Val.) TERHADAP LARVA Aedes Aegypti DAN PROFIL GC-MS NYA Lolita Lolita
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma mangga, Val. has been recognized as a traditional drug since a longtime ago. The active ingrediences of this plant especially the volatile oil containsmonoterpenes and sesquiterpenes. This research was aimed to study about thelarvacideâ€™s activity of the volatile oil Curcuma mangga, Val. rhizome and also toanalyze its chemical compounds using the GC-MS. The volatile oil was isolated fromCurcuma mangga, Val. with steam and water distillation. The test method for larvicidewas done by dissolving the substances into water and added by Tween 20 10% v/v to thethe volatile oil. The concentration of the volatile oil of Curcuma mangga, Val. rhizomewere 100 ppm, 150 ppm, 200 ppm, 250 ppm, 300 ppm, and 350 ppm. The concentrationof positive control â€œabateâ€ were 0,01 ppm; 0,025 ppm; 0,05 ppm; 0,1 ppm; 0,5 ppmwhile as the negative control was Tween 20 solution. The perception time of larvaeâ€™smortality was 24 hours. The chemical compound of Curcuma mangga, Val. can beanalysed by the GC-MS. Data of larvaeâ€™s mortality were used to estimate the values ofLC50 with the probit analyzis method. This study showed that the volatile oil of Curcumamangga, Val. have clear-brass colour, bitter taste, typically aromatic like mango,rendement equal to (1,23 Â± 0,029)% v/b and refractive index 1,4881. The value of LC50for the volatile oil of Curcuma mangga, Val. rhizome is (216,17 Â±12,51) ppm whileabate equal to (0,072 Â± 0,024) ppm. This finding indicates that abate were more potentto larvae of Aedes aegypti. The GC-MS showes 30 peaks chromatogram and six peakswhich indicates the possibility of alpha-pinene, camphene, beta-pinene, beta-myrcene,eukalyptole, ar-turmerone presence.

PEMANFAATAN PERASAN BUAH KEPEL (Stelechocarpus burahol (Blume) Hook & Thomson) SEBAGAI ANTISEPTIK LUKA Prasojo Pribadi; Elmiawati Latifah; Rohmayanti Rohmayanti
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Fruit of kepel known contain of saponin and flavonoid, fruit of kepel is a plant that hasantibacterial and antiinflamation activity. This research purposed for made juice of fruit kepeland test of open wound healing process activity. Juice of fruit kepel is made with variety ofconcentration, which 20%, 40%, 60%, and 80%. Negative control used aquadest and positivecontrol used BetadineÂ® (Povidon Iodine). This type of research is experimental research,procedure start from the preparation of test materials, first identifying plants, then make fruitjuice of kepel and divide into several concentration, followed by grouping into six group of testanimals. All quantitative data were statistically analyzed using Anaylsis of Variance (Anova)and continued with Tukey Test, The lowest activity on the negative control and increase on thegroup of juice with concentration 20%, 40%, 80%, and 60%, higher activity on the positivecontrol. With wound healing broad parameters result that the group fruit juice of kepelconcentration 60% and 80% showed the statistically analyzed was more significant (p<0.05) 178 PharmaÒ«iana, Vol. 4, No. 2, 2014: 177-183than the negative control. So it can be taken conclusion that fruit juice of kepel concentration60% and 80% having wound healing activity.

In-Vivo Analgesic And Anti-Inflammatory Effects Of Eel (Anguilla bicolor bicolor) Oil Heru Sasongko; Nur Indria Kusumastuti; Gea Ros Alifa; Aulia Ayu Rahmawati
Pharmaciana Vol 9, No 1 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Analgesic and anti-inflammatory tests of eel (Anguilla bicolor bicolor) oil on animal models have been performed. Previous studies have proven that oral administration of EPA and DHA exhibits analgesic and anti-inflammatory effects. Gas Chromatography analysis shows that eel contains EPA and DHA. In this research, the analgesic activity was evaluated with the acetic acid-induced writhing test and hot plate test, while the anti-inflammatory properties were identified using carrageenan-induced inflammation. In the writhing test, 25 male Swiss Webster mice were divided into five groups. Group I was given 0.5% CMC-Na as a negative control, group II was given 65 mg/kg b.w. of Acetosal as a positive control, group III-V was given eel oil at different doses, namely 2400, 4800, and 9600 mg/kg b.w. of the mouse. For the hot plate test, 6.5 mg/kg b.w. of tramadol acted as the positive control. Similar to the analgesic effect analysis, the anti-inflammatory test also divided 25 male Wistar rats into five groups. Group I as a negative control was given 0.5% CMC-Na, Â group II was given 9 mg/kg b.w. of diclofenac potassium as a positive control, and group III-V were given eel oil at different doses, namely 1500, 3000, and 6000 mg/kg b.w. of the rat. The results of the acetic acid-induced writhing test and hot plate test showed that when compared with the positive and negative controls, eel oil had a potential analgesic activity with a significance value of p< 0.05. The analgesic effects were noticeable at doses of 2400, 4800 and 9600 mg/kg b.w. in the writhing test and at 4800 and 9600 mg/kg b.w. in the hot plate test. The anti-inflammatory test showed that eel oil was efficacious when administered at the doses of 1500, 3000, and 6000 mg/kg b.w. with percentage inhibition of 34.35%, 35.132%, and 40.28%, respectively.Â

STABILITAS KONSENTRASI GLUKOSA DARAH SIMPAN JANGKA PENDEK DALAM TABUNG BERTEKNOLOGI PEMISAH JELl Ayi Furqon; Hilman Nurmukhlis; Sussylawati Kasiman
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Serum glucose level is screening for diabetic patients. Preanalitical factors such as sample preparation and handling will influence the quality of final result of determination. Gel sparation technology used for faster sparation between plasma or serum and blood cells. This technology was applied in clinical laboratory technology in stead of public health laboratory. Requested test of glucose level determination is higher then other analytes. Direct contact of blood cells to serum will reduce availability of glucose in serum due to glycolysis process as well as without additional enzyme inhibitors such as fluoride and without separating cells from serum immediately. Serum separating Tube (SST) contains gel and clot activators, it will work faster than plain tube does to become serum. Main purpose of research, how stability of glucose level between SST tube and plain tube . Experimental steps are preparing fresh blood that is collected from 16 voluntered students, incorporating the glucose oxidase enzymatic assay and quality control. Test performed at immediately, late 4 hours, and very late 12 haours. Statistical method for the time to time analysis, one way Anova is used within significant level 0.05. From 16 serum (duplicates), glucose serum level was reduced early at 4 - 12 hours by 8,1 mg/dl (p-value = 0.013) and 7,7 mg/dl (p-value 0.012). Percents increases of glucose level within plain tube 4 hours by 4,75% and within 12 hours by 13,12%. The increased serum glucose level in SST tube were at early 4 hours and 12 hours by 4,33% and 12,29% respectively. Conclussion, glucose serum level is in steady at room temperature until 4 hours for both SST Tube as well as plain tube

PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP AKTIVITAS ANALGESIK DAN ANTIINFLAMASI MELALUI EKSPRESI ENZIM SIKLOOKSIGENASE Rini Sulistyawati; Pramita Yulli Pratiwi
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kelor (Moringa oleifera L.) contains flavonoid as a major of bioactive constituent. Quercetin as a flvonoid group inhibits COX-2 in inflammatory process. This study aimed to determine the effect of etanol extract of the kelor leaves on the analgesics and antiiinflamatory in mice. Etanol extract of the kelor leaves were evaluated for analgesics activity through writhing assay test at doses of 12.5; 25 and 50 mg/kgBW using Â Swiss albino mice. On the other hand antiinflammatory assay was performed by carrageenan induced paw edema of the etanol extract of the kelor leaves at 35; 70 and 140 mg/kgBW. Aspirin and sodiumdiclofenac were employeed as a standard for analgesic and antiinflammatory studies respectively. The result of the analysis show that etanol extract of the kelor leaves at doses 25 and 50 mg/kgBW decrease the number of writhing so that it have an analgesic power of 76.41Â±2.73% and 80.41Â±5.20%. Etanol extract of the kelor leaves at dosage 140 mg/kgBW show 24.30Â±2.960% antiinflammatory power and 46.37Â±6.434% on decreased COX-2 expression.

EFEK FRAKSI ETIL ASETAT EKSTRAK ETANOL AKAR PASAK BUMI (Eurycoma longifolia, Jack) TERHADAP AKTIVITAS FAGOSITOSIS MAKROFAG SECARA IN VITRO Aminda Nur Arifah; Nurkhasanah Nurkhasanah
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Eurycoma longifolia has been used as a remedy for detoxification, aphrodisiaca, anticancer andimmunistimulant. The quassinoids of pasak bumi root extract, have antioxidant activity andimmunomodulatory activity by increasing IL-12. This study aims to determine the effect of the ethylacetate fraction of ethanolic extract of pasak bumi root on macrophages phagocytic activity in vitro.Macrophages were isolated from peritoneal fluid of male Balb/Cmice, and thenwere cultured for 24hours in 24 well plate. The ethyl actetate fraction ethanolic extract of pasak bumi root withconcentration of 10, 50, and 100 Âµg/ml, lipopolysaccharides and dimethyl sulfoxide were added, andincubated for 1.5 hours. The phagocytosis tests was carried out by adding latex with density5x104/well and incubated for 1.5 hours at incubator (5% CO2,37oC). Macrophage were then stained byGiemsa. The results showed that the percentage of active phagocytic cells treated with ethyl actetatefraction of ethanolic extract of pasak bumi root of 10, 50 and 100 Âµg/ml, lipopolysaccharides, anddimethyl sulfoxide were 95.4%, 90%, 85.4%, 83.4%, and 79% respectively. Phagocytic capacity attreatment levels of 10, 50, and 100 Âµg/ml, lipopolysaccharides,and dimethyl sulfoxide were 469; 439.8; 360.8; 204.6; and 147.6 respectively. The result showed thatreatment of ethyl acetate fractionof ethanolic extract of pasak bumi root can increase the phagocytic activity of macrophages in vitro.

Formulation of functional beverages from the combination of lime, tomato, and carrot using foam-mat drying method Kartini Kartini; Alfian Hendra Krisnawan; Lisa Calista Silvanus; Tiffanny Putri Wijaya
Pharmaciana Vol 9, No 2 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Â Lime, tomato, and carrot are natural ingredients widely used both as food and herbal medicines particularly because these plants contain various antioxidant compounds such as vitamin C, phenolics, flavonoids, and carotenoids. Since these materials are easily damaged when exposed to high temperatures, any processing methods that involve slight quality changes in the final product are favorable. This study aimed to formulate lime, tomato, and carrot into functional beverages using foam-mat drying method. Lime juice combined with either tomato paste or carrot juice was mixed with egg white and methylcellulose as foaming agents, then whipped using a mixer for 10 minutes to form a stable foam. The foam was placed in a stainless tray, flattened, and dried in an oven at 60Â°C for 5 hours. Once dried, the mass was scraped using a spatula, and the resultant dry powder was then evaluated for its physical characteristics and antioxidant activities using nitrite oxide (NO) method. The produced dry mass of lime, lime-tomato (1:1), and lime-carrot (1:1) had organoleptic characteristics, water content, sugar content, and food additives content in accordance with the Indonesian National Standard (SNI). Also, with the IC50 values of 4248, 4931, and 4218 Âµg/ml, the lime juice and its combination with tomatoes (1:1) and carrots (1:1) can be formulated into functional powder drinks that comply with the SNI quality requirements. Lime-carrot is a better combination than lime-tomato.

Tablet kunyah ekstrak etanol herba pegagan (Centella asiatica (L.), Urban) menurunkan kadar kreatinin tikus putih jantan (Rattus norvegicus L.) galur wistar yang diberi diet lemak tinggi Akrom Akrom, Dr., dr., M.Kes; Nur Prasetyawan
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

A chewable tablet dosage ethanol extract of herb gotu kola (TKEEHP) has developed. Research to determine the impact of TKEEHP on kidney function has been conducted. Gotu kola herb is one of the medicinal plants that allegedly serves as antioxidative nefroprotektor. The purpose of this study is to assess the effect of TKEEHP on the changes in serum levels of creatinine and urea of male Wistar rats that had been given a high-fat diet. The experimental research was conducted on 21 Wistar rats aged 2-3 months (150-200 g body weight). Rats were divided into seven groups. Group I (normal) was given normal diet. Group II, III, IV, V, VI, and VII were given a high fat diet for 5 weeks. In the week 5 and 6 group III (positive control) was given SimvastatinÂ®, group IV was given placebo tablets, and the group V, VI and VII were given 100, 200 and 300 mg / KgBW TKEEHP, respectively. At the end of week 6 rats have blood drawn through orbital sinus and then tested serum levels of creatinine and urea.Data examination of urea and creatinine serum levels were analyzed with ANOVA) and LSD with confience interval of 95%. The results showed TKEEHP reduce the levels of creatinine in male Wistar rats given a high fat diet, but did not affect serum urea levels. TKEEHP with the dose of 100 mg / KgBW, 200 mg / KgBW, and 300 mg / KgBW show potency to lower creatinine levels and decrease serum creatinine levels at the highest dose of 300 mg / KgBW.

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA