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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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PENETAPAN KADAR ÃŸ-KAROTEN PADA BEBERAPA JENIS CABE (Genus Capsicum) DENGAN METODE SPEKTROFOTOMETRI TAMPAK Tri Octaviani; Any Guntarti; Hari Susanti
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Beta carotene is provitamin essential role for vitamin A formation. Most of vitamin Asources are ÃŸ-carotene. In the body, ÃŸ-carotene will be converted into vitamin A. Chilies areconsidered as one of the essential food. Chillies are known as very good sources of ÃŸ-carotene.Therefore, it is important to conduct a research in order to observe the content of ÃŸ-carotene inthe chillies using visible spectrophotometry. Fresh chillies were extracted with a mixture ofhexane:acetone:ethanol (2:1:1) v/v using a maceration method. After the extraction process wascomplete, aquabidest was added. The extraction result was non-polar phase. It was separatedand evaporated. The residue was further subjected to qualitative and quantitative analysis102 PharmaÒ«iana, Vol. 4, No. 2, 2014: 101-109obtained. Qualitative analysis by using Carr-Price method. Determination of ÃŸ-carotene wasconducted using visible spectrophotometry method at 452,4 nm. The qualitative test resultsshowed that the Capsicum annuum L. Var. abreviatum Fingerhuth, Capsicum annuum L. Var.Longum sendt) and Capsicum frutescens L. contain ÃŸ-carotene. From the research, it wasobtained that the average levels of ÃŸ-carotene on the Capsicum annuum L. Var. abreviatumFingerhuth was (10,54Â±0,07) mg/100g, Capsicum annuum L. Var. Longum sendt was(5,57Â±0,13) mg/100g and Capsicum frutescens L. was about (0,36Â±0,01) mg/100g. Statisticalanalysis using LSD test of ÃŸ-carotene levels in the Capsicum annuum L. Var. abreviatumFingerhuth, Capsicum annuum L. Var. Longum sendt) and Capsicum frutescens L. weresignificantly different at P of 0.05.

ANALISIS KUALITATIF KANDUNGAN SAKARIDA DALAM TEPUNG DAN PATI UMBI GANYONG (Canna edulis Ker.) Aprilia Kusbandari
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Canna Tubers (Canna edulis Ker.) is one of the plants producing carbohydrates. ItsÂ also contains of protein, fat, vitamins, minerals,Â phosphorus, iron and more calciums. The purpose ofÂ this study is to identify ofÂ sugarÂ in the powder and starch from canna tuber is a hydrolysis and didnâ€™t hydrolysis. The method of qualitative analysis with tube testÂ andÂ Thin Layer Chromatography (TLC). The result indicated that before hydrolysisÂ canna powderÂ gaveÂ sucrose (Rf = 0.45) and mannose (Rf=0.51), while after hydrolysis it gaveÂ glucose (Rf=0.44), fructose (Rf=0.61) and mannose (Rf=0.51). In addition, canna starch gaveÂ Â glucose (Rf=0.44) and maltose (Rf=0.35).

EFEK EKSTRAK ETANOL GANGGANG HIJAU (Ulva Lactuca L) TERHADAP BERAT BADAN DAN KADAR TRIGLISERIDA TIKUS JANTAN YANG DIBERI DIET LEMAK TINGGI Wahyu Widyaningsih; Nina Salamah
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Previous studies showed the potential of melatonin of green algae ( Ulva lactuca L ) to reduce the risk of coronary heart disease with the activity of antihiperlipidemia. Obesity and hiperlipidemia were the risk factor of degenerative diseases such as heart disease. This research aims was explore the effect of ethanol extract of green algae against weight, consumption of rat feed test white male rat were given high fat diet . Research was started with extraction green algae with ethanol 96 % to obtained concentrated extract. The extract was tested to wistar rats age of 2 months. Animals test divided into 6 group. Group I was control group, treated with high fat diet of lard 2 ml / 200g BW, of group II given high fat diet and simvastatin, group III, IV and V given high fat diet and green algae extract doses 50 mg/ Kg BW, 100 mg/Kg BW and 200 mg/ Kg BW. Group VI is the control group without diet fat high. Treatment was conducted over 28 days. Measuring normal of his weight every five day for 28 days and in measuring consumption feed with measure weight feed the rest of feed early 20 g. The difference of data weight rats per 5 days and consumption fodder for 28 days counted area under curve ( AUC ) from curves time versus weight. The measurement of triglycerides levels. The result showed the high fat diet with lard 2 ml / 200g BW for 28 days reduce weight and consumption feed mice in a significantly than control without high fat diet. The treatment with extract ethanol dose of 50 , 100 and 200 mg / Kg BW did not reduce weight, feed consumption, triglyceride levelsofÂ mice were given high fat diet.

Standardization of durian fruit peels (Durio zibethinus Murr.) extract and antioxidant activity using DPPH method Muhtadi Muhtadi; Utami Ningrum
Pharmaciana Vol 9, No 2 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Durian fruit peels (Durio zibethinus Murr.) has been studied previously and reported to have pharmacological activity that has the potential to be antioxidant and antihypercholesterol. The ethanolic extracts of Durian fruit peels contained secondary metabolites, namely flavonoids, polyphenols, carotenes, and saponins. The purpose of this study to determine the non-specific parameters and specific parameters of the ethanol extract of durian fruit peels and to evaluate the antioxidant activity with the DPPH method. Standardization of herbal ingredients is an important thing to do so that the safety and quality of herbal medicines can be maintained. Two different cultivars of durian fruit peels are used, there are Medan and Monthong. The results of non-specific parameters between Medan and Monthong cultivars showed different moisture contentÂ (9.71 Â± 0.96; 12.06 Â± 0.34%, respectively), ash values (1.03 Â± 0.20; 1.78 Â± 0.07%, respectively), and water content (6.12 Â± 0.29; 7.16 Â± 0.25% respectively). Medan and Monthong cultivar extracts showed specific parameters showed different organoleptic information such as odor, color, and physical appearance, the content of water soluble compounds (36.39 Â± 1.90%), the value of ethanol soluble compounds (40.20 Â± 0.19; 45.27 Â± 1.02%, respectively), and flavonoid value (472 Â± 49.00; 310 Â± 13.45 mg/g sample), phenolic value (245 Â± 5.15; 148 Â± 8.54 mg/g sample). Antioxidant activity was indicated by IC50 values of each extract, namely MedanÂ of 78.83 Â± 1.67 Âµg/mL and Monthong of 72.77 Â± 6.60 Âµg/mL. Statistical tests showed the value of non-specific parameters and specific parameters of the two cultivars not differed significantly.Â

EFEKTIFITAS PEMBERIAN PROBIOTIK TERHADAP DURASI DIARE ANAK DI RUMAH SAKIT PKU MUHAMMADIYAH BANTUL YOGYAKARTA Sri Mulyani; Dyah Aryani Perwitasari; Nurcholid Umam
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Diarrhea is the second leading cause of childrenâ€™s death worldwide, including in Indonesia.With regard to reducing the number of death, it is highly needed to provide a quick and accurate treatment. In clinical practice, prebiotics has been widely used as a treatment, particularly in the case of acute diarrhea in children. However, it is still not recommended by WHO. This study is aimed to determine the treatment pattern of diarrhea in childrenâ€™s ward at PKU Muhammadiyah Bantul Hospital and determine whether probiotic supplementation on standard therapy results a decrease in the duration of diarrhea which is better than only the standard therapy in the management of acute diarrhea in children. This study used retrospective cohort design using data from medical records with diagnose acute diarrhea or acute gastroenteritis (ICD A09). The data was collected from January to December 2014, at childrenâ€™2 ward, PKU Muhammadiyah Bantul Hospital, Yogyakarta. Data was divided into three groups: (i) Group I those who were treated by using standard therapeutic with rehydration and zinc, (ii). Group II those who were treated by combination of rehydration, zinc and probiotics, (iii) Group III those who were treated with rehydration and probiotics. Data duration of diarrhea as an outcome of the effectiveness of probiotics analyzed statistically to determine differences in outcomes between groups. Among the three groups, Group I, Group II and group III gained an average duration of diarrhea 66.33 (SD 21.66) hours, 55.32 (SD 19.07) hours and 54.79 (SD 17.69) hours, respectively. The statistical test shows that there is significant different from diarrhea duration among the three groups (p = 0.014). The test results between probiotic groups (II and III) and the control group is significantly different with p-value 0.018 and 0.011, respectively. While the group II and group III do not differ significantly (p = 0.898). Treatment pattern therapy of diarrhea in PKU Muhammadiyah Bantul Hospital divided into three kinds of therapy. The first is rehydration therapy and zinc supplementation, the second is rehydration therapy and zinc supplementation and probiotics, the third is rehydration therapy and probiotics. Probiotic supplementation is proven effective in reducing the duration of diarrhea significantly compared to patients who were received standard therapy.

UJI TOKSISITAS SUBKRONIS EKSTRAK CURCUMA BEBAS MINYAK ATSIRI (ECBA) DITINJAU DARI PARAMETER PROFIL LEUKOSIT PADA TIKUS PUTIH GALUR WISTAR Verda Farida; Zullies Ikawati; Suwidjiyo Pramono
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The effect of Volatil Oil of Curcuma Extraxt or Curcumin extract withcentration of essential oil in reducing the levels of cholesterol in the blood has beenECBA as antihyperlipidemic agent is given for a long - term therapeutic purpose. Thisexperiment was performed to investigate the subchronic toxicity of ECBA on leukocytes profile ofWistar rats. ECBA was investigated at dose 15 mg, 120 mg, and 960 mg/200 g body weight for 90days in 40 male Wistar rats. CMC-Na was used for control. The blood was examined for theleukocytes profile on day 0, 45, and 90. The rats were still maintained under experimental conditionswithout giving ECBA until day 105 for the reversibility test. The result showed that the administrationof ECBA for 90 days did not affect leukocytes profile of Wistar rats.

Formulasi dan evaluasi granul effervescent ekstrak daun binahong (Anredera cordifolia (Tenore) Steen.) Indah Fortuna Rahmawati; Prasojo Pribadi; Imron Wahyu Hidayat
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The purpose of this research are to find out whether the formulation of effervescent granules from binahong leaves extract has met the standards for effervescent granules and determine the best formulation of effervescent granules. This research is descriptive experimental with data collection from evaluation of effervescent granules. To be able to make effervescent granules, extraction of binahong leaves must be made first. The extracts resulted from a maseration method with 70% ethanol. The effervescent granules formulation were made by 3 design based on their concentration F1 7.4%; F2 14.8%; and F3 22.2%. Effervescent granules of binahong leaves extract are prepared by using wet granulation method. Several physical tests were carried out on the results of effervescent granules of binahong leaves, including organoleptic test, moisture content test, pour volume test, volume of shringkage test, flow capacity test, dispersion test, and pH. The test results showed that all the effervescent granules of binahong leaves (Anredera cordifolia (Tenore) Steen.) have met the standard requirements as good granules. The third formula became the best formulation, With the best value in moisture content test, volume of shringkage test, flow capacity test, and pH.

PENETAPAN KADAR Pb PADA SHAMPOO BERBAGAI MERK DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM Farida Jaya; Any Guntarti; Zainul Kamal
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The source of lead pollution (Pb) can come from cosmetic product including shampoo. The purpose of thisresearch are to know wether there is Pb in the shampoo cosmetic based on different brands and colours of theshampoo. The sample of the shampoos that used in this research are A, B, C, and D. Each of the samples replicated5 times, then analyzed with atomic absorbtion specktrophotometry. Then, one of the sample are taken from onebrand with different colour and replicated 5 times. The result of this research shows that from the different brandof shampoos contain Pb. The average level of Pb that obtained from analysis are, brand A (0,4838 ppm 0,0538ppm), brand B (0,6935 ppm 0,3131 ppm), brand C (0,8354 ppm 0,0405 ppm), and brand D ( 0,9517 ppm0,0811 ppm). Whereas for the same shampoo brand but different in colour had average level of Pb: shampoo I (redcolour)= (0,5428 0,0192) ppm, Shampoo II (yellow colour) = (0,3606 0,0255) ppm, Shampoo III (blue colour)= (0,4385 0,0062) ppm, and Shampoo IV (green colour) = (0,1427 0,0133) ppm.

Antioxidant activity of methanolic extract from yellow paprika (Capsicum annuum, L.) by DPPH radical scavenging method Warsi Warsi; Any Guntarti
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Yellow paprika (Capsicum annuumL.) is one of fruit that contains of carotenoid compounds as an antioxidant. This reasearch was aimed to know an antioxidant capacity of methanolic extract from yellow paprika with 2,2â€“diphenylâ€“1â€“picrylhydrazyl (DPPH) radical scavenging method. The fresh yellow paprika was determined of its loss of drying by gravimetric. The yellow paprika extract was obtained by maceration using methanol as solvent. The content of Î²â€“carotene from this extract was analyzed qualitively by thin layer chromatography and UV-Vis spectrophotometer. The antioxidant activity of methanolic extract from yellow paprika was determined base on measurement of residual DPPH by UVâ€“Vis spectrophothometric at wavelength of 515.6 nm. The data was used to calculate % inhibition. Furthermore, IC50 value was determined to know potency of its antioxidant. The result of loss of drying yellow paprika fruit was obtained 6.33 Â± 0.02 %. The analysis with thin layer chromatography and UV-Vis spectrophotometer showed that this fruit was contain of Î²â€“carotene. The result of antioxidant activity analysis from yellow paprika fruit was obtained IC50 value of 0.3028 Â± 0.0093 mg/mL. The result of the research showed that the antioxidant potency of yellow paprika was less than Î²â€“carotene (IC50 0.0852 Â± 0.0009 mg/mL).

Pakan banyu (Croton argyratus Blume) stembark ethanol extract effectiveness to total spermatogenic cells of white male rats (Rattus norvegicus) Noor cahaya; M. Aditya Sholihin; Nurlely Nurlely
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Stembark of Pakan Banyu (Croton argyratus Blume) empirically used as traditional contraception. The stembark contained active substances as steroids, saponins and alkaloids tannins alleged antifertillity for men. The purpose of this study was to demonstrate the potential of Pakan Banyu stembark ethanol extract to the total number of spermatogonium cells, primary spermatocytes, spermatids and spermatozoa in male rats. This study was an experimental research design posttest only control group design using 20 male rats into 4 groups of 5 mice. The control rats were used in treatment group, the rats were given the pakan banyu stembark extract at a dose of 100, 200 and 500 mg / kg with 0.5% CMC Na suspending agent. The treatment was given orally for 15 days at the 16th days surgery was done to the testicles organs, then microanatomy preparations were made using paraffin method and using HE colour. Analysis of data using One-way ANOVA and Kruskal Wallis with 95% confidence level. The results showed that there is no effect of Pakan Banyu stembark ethanol extract against spermatogonium cells, primary spermatocytes, spermatids and spermatozoa.Â

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Muhammad Syahrir

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m.syahrir7406@unm.ac.id

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nurkhasanah@pharm.uad.ac.id

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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