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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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Pengaruh penambahan sukrosa terhadap mutu sabun transparan dari ekstrak etanol herba pegagan (Centella asiatica L.) Heru Sasongko; Andarini Siwi Mumpuni
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Centella asiatica is a kind of herbs which contains antioxidant that be trusted to overcome of various skin problems such as keloids, cellulite, and black stains. One of the additional ingredients used to make the transparent soap is sucrose or frequently called white sugar. In the process of making the transparent soap, white sugar is served to help the transparency of soap. The purpose of this research is to find out the effect of increasing the sucrose toward the degree of the transparency of the soap, stability of physical properties before and after storage for eight weeks and find out the skin response towards the soap by doing irritability test towards some respondents. Pegagan extract transparent soap is varied with the concentration of sucrose 11 %, 13%, and 15 %. The soap which is produced is conducted with a series of tests of physical characteristics include transparency, pH, water content, and the stability of the foam. The results showed that the addition of sucrose affects the level of transparency and soapy water levels and no effect on pH and foam stability. Irritation test of the respondents showed most respondents did not become irritated. The stability of the physical characteristic of the form of the soap is good because during eight weeks of the usage there are no significant

AKTIVITAS SITOTOKSIK ISOLAT 5 FRAKSI ETIL ASETAT EKSTRAK PETROLEUM ETER DAUN Phaleria macrocarpa (Scheff.) Boerl. PADA TURUNAN SEL KANKER SERVIKS MANUSIA (HeLa) Dwi Utami
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cervical cancer is a malignant tumor in cervix which is occupy the second possition that cause the death of Indonesia’s women under the breast cancer. One of the traditional medicine that can be used to cure cancer is Phaleria macrocarpa (Scheff.)Boerl leaves. The petroleum eter extract of Phaleria macrocarpa (Scheff.)Boerl leaves has antiproliferation activity againts cervical cancer cell lines (HeLa) with IC50 9 µg/ml (Kintoko & Azimahtol Hawariah, 2007). This research was aimed to detect cytotoxic activity of isolate 5 of ethyl acetate fraction of petroleum ether extract of Phaleria macrocarpa (Scheff.)Boerl leaves againts HeLa cell lines. Initially, the powder of Phaleria macrocarpa (Scheff.)Boerl was extracted using Soxhlet apparatus with petroleum ether. The extracts was concentrated and partitioned until ethyl acetate fraction was obtained. The fraction of ethyl acetate was isolated using Preparative Thin Layer Chromatography on silica gel F254 as stationary phase and n-hexane : ethyl acetate (9 : 1) as mobile phase. Cytotoxic activity against HeLa cell lines was determinated by LC50 value by direct counting. The isolation by preparative thin layer chromatography resulted five isolate on Rf value : 0,05 ; 0,10 ; 0,20 ; 0,60 ; and 0,90. The LC50 values of isolate 5 (Rf : 0,90) was 123,60 µg/ml.

Factors relate to the hypercreatininemia event of patients at the risk of metabolic syndrome in Jetis I public health center Akrom Akrom; Endang Darmawan; Nuril Maulida
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Metabolic syndrome (MS) is a risk factor for chronic kidney disease (CKD). Adherence to drug therapy is one of the keys to achieving therapeutic targets in MS. Hyperuricemia (>7mg/dL in men &>5.4mg/dL in women) and hypercreatininemia (>1.3 mg/dL) is a sign of kidney function deficiency. Kidney function deficiency is the result of uncontrolled blood pressure and blood sugar levels in MS patients. The objective of the study was to know the description of the incidence of hypercreatininemia and factors related to the incidence of hypercreatininemia in outpatientÂ at risk of Â MS at Jetis Public health center (PHC) I, Bantul, Yogyakarta. The analytical observational research with cross sectional design was performed on 99 MS outpatient at Jetis I Public Health Center (PHC) who fulfilled the inclusion criteria and approved the participation in the study. Blood urea and creatinine levels were determined by spectrophotometer 5010. Demographic, diagnosis and treatment data were colleccted Â from medical record. Patient adherence data were collected by interview. Patient compliance was measured by a medication compliance questionnaire. Demographic and clinical Â data are presented descriptively. Bivariate analysis with chisquare was performed to determine the value of the relationship between sex, age, hyperuricemia and adherence to the incidence of hypercreatininemia. Â About 30.3% of total of outpatients at risk of MS at Jetis I PHC, Bantul, is non-adherence and 69.7% is adherence to the treatment. As many as 44.4% of respondents have hypercreatininemia and 8.1% of respondents have hyperuricemia. There was a relationship between adherence and female sex with the prevalence of hypercreatininemia with an odds ratio of 3.8, 0.26 and 7.1 respectively. Based on the data of the study concluded that non-adherence, male sex and hyperuricemia are associated with the prevalence of hypercreatininemia in patients at risk of MS in Jetis I PHC.

ANALISIS SGPT-SGOT EKSTRAK ETANOL DAGING BUAH PARE (Momordica charantia L.) PADA TIKUS JANTAN PUTIH GALUR WISTAR Dwi Ari Nugrahani; Vivi Sofia
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The traditional medicine in Indonesia which is the cultural heritage and hasbecome an integral part of the life of the nation Indonesia, want to be employed in theformal health care system. As the circulation of drugs in general terms, traditionalmedicine should fulfill the requirements of quality, safe, and efficacious. This studyaims to analyze the levels of SGPT, SGOT of suspension of the ethanol extract of bittermelon fruit (Momordica charantia L.) by orally. The study was conducted using a whitemale Wistar rats amounted to 36 animals, divided into 6 groups. Each group consistedof 6 male white rats. Group I (control) were given 0.5% CMC solution of 2.5 ml/200 gBW. Group II was given a suspension dosage doses of bitter melon fruit extract ethanol0.5 g/kg, then consecutive group III with the test preparation doses of 1 g/kg, the testpreparation group IV were given a dose of 2 g/kg, group V was given dosage test doseof 4 g/kg, and group VI were given the highest dose of the test preparation 8 g/kg. Theresults of acute toxicity tests on white male Wistar rats showed that administration ofethanol extract of peroral dosage suspension pare (Momordica charantia L.) singledose on white male Wistar rats from the dose of 0.5 g/kg until a dose of 8 g/kg did notsignificantly influence the value of SGPT, SGOT.

Formulation and physical stability test of oleanolic acid cream and gel Kartini Kartini; Endang Wahyu Fitriani; Laurances Tansridjata
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Plantago major has been empirically used for wound healing. One of its chemical compounds, oleanolic acid, exhibited wound healing activity on hyperglycemic rats. The aims of this study were to (1) formulate oleanolic acid into topical dosage forms i.e. cream and gel; and (2) evaluate the physical stability of the products. Oleanolic acid was formulated into the dosage forms using stearic acid, isopropyl palmitate and cetyl alcohol as the cream base and carbomer as the gel base. Cream and gel were then subjected into accelerated (40Â±2Â°C/75Â±5% RH) and room temperature (27Â±2Â°C/73Â±5% RH) stability test for six weeks. Physical stability was determined using parameters of visual appearance, specific gravity, viscosity and flow properties, for both gel and cream, as well as the type of emulsion and particle size for the cream. Data analysis were performed using one-way ANOVA and paired t-test. It is concluded that gel and cream of oleanolic acid were able to maintain their visual appearance, specific gravity, viscosity and flow properties during six weeks of storage. In addition, oleanolic acid cream could also maintain its particle size and type of emulsion during testing.Â

RESIDU PESTISIDA PIRETROID PADA BAWANG MERAH DI DESA SRIGADING KECAMATAN SANDEN KABUPATEN BANTUL Iin Narwanti; Eko Sugiharto; Chairil Anwar
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Pyrethroid pesticide residue in onion from Srigading Village, Sanden District,Bantul Regency has been investigated. The purpose of this study were to analyze,identificate and evaluate pyrethroid pesticide residues in onion. Onion sample wasextracted using homogenizer with acetone solvent. Clean-up was done usingchromatography column using florisil and determination of pesticide residue in thesamples was carried out by gas chromatography apparatus equipped with electroncapture detector (GC-ECD). The result showed that pesticide residues in onion samplein the range level: -cypermethrin (98.8-245.6 ppb) and -cyhalothrin (14.4-120.0ppb). The following pesticides have been detected in some of samples of onion analysed,but they have been detected above the Maximum Residue Limit (MRL).

PENGARUH DIABETES MELLITUS TERHADAP RESISTENSI ASPIRIN PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT BETHESDA YOGYAKARTA Hardi Astuti Witasari; Rizaldy Taslim Pinzon; Erna Kristin
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The secondary prevention of ischemic stroke can be implemented by giving aspirin.However, some cases of aspirin resistance have been found. The purpose of this study was toexamine the influence of diabetes mellitus on the risk of aspirin resistance in ischemic strokepatients at Bethesda Hospital Yogyakarta. This study was using a nested case-control studydesign. The Cases group was subjects who resistance to aspirin therapy. The control group wassubjects who response to aspirin therapy. The factors that affect the incidence of aspirinresistance were analyzed by bivariate analysis chi square test. The proportion of diabetesmellitus in resistant group was bigger than the aspirin responsive group. Its odds ratio (OR) was1.605 (95% CI, 0.641 to 4.017) (p=0.155). Conclusion: Ischemic stroke patients at BethesdaHospital Yogyakarta with diabetes mellitus were not proved to have a bigger risk of aspirinresistance than the patients without diabetes mellitus.

STUDI PENGELOLAAN OBAT SEBELUM DAN SESUDAH JKN DI PUSKESMAS JETIS KOTA YOGYAKARTA Alfira Oktaviani; Farida Baroroh
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The effective and efficient drugs management is very crucial in the whole success of public health center management. The government hold a program called National Health Insurance (JKN) in order to achive quality and cost control which is effective and efficient. The research was aimed to know the drugs management at the public health center in Jetis Yogyakarta which includes drug plan, drug demand, drug acceptance, drug storage, drug distribution and the process of drugs recording and reporting. This study used observasional descriptif desaign. Subjects for this study was the implementation of drugs management work instruktion in public health center .TheÂ technique data collection used triangulation or the combination among stuctured observation result in the form of check list, interview with the human rosources involved of drug management and observation the drug management documentation. The technique analysis used quantative-qualitative descriptive analysis with percentage. The results showed that the drugs management at the public health center Jetis Yogyakarta at the drug plan, was included in both criteria (before JKN 100% and after JKN 100%), the drug demand was included in the criteria quite well (before JKN 63.64% and 63.64% after JKN ), the drug acceptance was included in both criteria (before JKN 100% and after JKN 100%), the drug storage was included in both criteria (before JKN 80.56% and 83.33% after JKN), the drug distribution was included in both criteria (before JKN 76, 92% and after JKN 84.62%), the drug recording and reporting was included in both criteria (prior JKN after JKN 100% and 100%). The general drug management before and after JKN at the public health center Jetis Yogyakarta was applicable standards and good criteria with the percentage of drug management before JKN amounted to 83.91% and after JKN amounted to 86.21%.

EVALUASI UJI IRITASI DAN UJI SIFAT FISIK SEDIAAN EMULGEL MINYAK ATSIRI BUNGA CENGKEH (Syzigium aromaticum) Delia Komala Sari; Nining Sugihartini; Tedjo Yuwono
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Inflammation is the human body's response to a tissue damage as indicated by an increase of vascular permeability. One of the natural substances that can be used to treat inflammation is clove oil (MABC). This study aimed to evaluate the physical properties and MABC emulgel irritation test (Syzygium aromaticum). This experimental study was initiated by the emulgel formulation with three kinds of formula, with each formula contains MABC levels of 10% (F1), 12.5% (F2), and 15% (F3). The physical tests for emulgel was done including pH, spreading test and adhesive test and irritation test in guinea pigs using Draize test method. Statistical analysis by t test with a level of confidence 95% was conducted to detect a significant differences between the treatment groups. The emulgel formula with a concentration of 10%, 12.5% and 15% were physically stable, moreover the dispersive power test for each formula showed normal distribution data (p>0.05) and homogeneous (p>0.05), ANOVA test results obtained significantly different results in each formula (p<0.05), whereas the stickiness test results for each formula more than 30 minutes with pH 6. The results of irritation test by using Draize test Â method, indicated that each formula did not show any irritant effect.

Effect of sugar cane molasses and tofu waste on the inhibitory activity of cell free fermentation broth of streptomyces antibioticus K-6 Astrid Aulia Hamida; Noor Erma Nasution; Isnaeni Isnaeni
Pharmaciana Vol 9, No 2 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The use of waste as source of nutrition for human, animals, plants, and microorganism has been reported. The aim of this study was to observe the influence of sugar cane molasses (SCM) and tofu waste (TW) in various concentrations on the inhibitory effect of cell free fermentation broth (CFFB) of Streptomyces antibioticus K-6 isolated from plantationÂ soil compareÂ to International Streptomyces Project (ISP) standardÂ media. The fermentation was performed in 150 rpm rotary shaker at 37ÂºC for five days. TheÂ inhibitory activity wasÂ investigated using diffusion agar on the nutrient agar media to determine ratio of Â SCM and TW by which the largest growth inhibitory zone achieved. Escherichia coli ATCC 25922 was used as a test microorganism. 10% of Streptomyces antibioticus K-6 starter was inoculated into nine compositions Â of Â SCM, TW and its combination containing media. The result indicated that SCM and TWmight be used as the component of fermentation medium of Streptomyces antibioticus K-6 for producing active metabolites. The activity of Â CFFB was exhibited as a diameter of growth Â inhibitoryÂ zone Â against the Â test Â bacteria; in which the largest value (24.4 mm) was detected in the combination of 0.5% SCM and 0.5% TW containig medium after Â two days Â incubation.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA