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INDONESIA
Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 822 Documents
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Genetic study on the impact of rs320 lipoprotein lipase polymorphism on dyslipidemia among Javanese Indonesians with type 2 diabetes mellitus Christine Patramurti; Dita Maria Virginia
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.31349

Abstract

Dyslipidemia commonly co-occurs with type 2 diabetes mellitus (T2DM), acting as a major factor in the elevated incidence of cardiovascular disease (CVD) within this population. One of the factors that raises the risk of dyslipidemia in people with T2DM is lipoprotein lipase (LPL) polymorphisms, particularly the rs320 variant. Associated with lipid metabolic pathways, the LPL rs320 genetic variant is considered a potential contributor to the dyslipidemia observed in several populations with T2DM. The influence of rs320 on dyslipidemia in individuals with T2DM, particularly among Javanese, remains uncertain. The objective of this study is to examine how the rs320 polymorphism affects dyslipidemic profiles among Javanese Indonesian individuals suffering from T2DM. This study included 103 Javanese individuals with T2DM. We detected the rs320 allele using the tetra-primer amplification refractory mutation system-based polymerase chain reaction (T-ARMS-PCR) method. We analyzed the participants' lipid profiles, with enzymatic methods used to measure serum triglycerides (TGs), total cholesterol (TC), and both high-density and low-density lipoprotein cholesterol (HDL-C and LDL-C). We assessed the association of the rs320 allele with dyslipidemia using chi-square tests. Our findings indicated that the rs320 allele was not significantly associated with dyslipidemia among Javanese individuals diagnosed with T2DM (χ² = 0.016, p = 0.900). This suggests the rs320 allele may not contribute to dyslipidemia, although other factors may play a role in Javanese people with type 2 diabetes. Further investigation is needed to identify genetic determinants of dyslipidemia in patients with type 2 diabetes and to potentially enhance personalized medicine based on individual genetics.
Formulation and anti-aging efficacy of Ambon banana peel (Musa paradisiaca L.) extracts in a stick mask Adek Chan; Rufina; Wan Tisya Muhaira; Rasyidah Azzahra; Seri Rezeki; Muhammad Amin Nasution; Muhammad Andry
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.31367

Abstract

Premature aging is often induced by oxidative stress resulting from ultraviolet (UV) radiation, which produces free radicals that harm lipids, proteins, and nucleic acids. The Ambon banana peel (Musa paradisiaca L.), often considered waste, is abundant in bioactive compounds such as flavonoids and phenolics, which demonstrate considerable antioxidant properties, thereby establishing it as a promising natural resource for anti-aging cosmetics. This study aimed to formulate and evaluate the efficacy of ethanol extract from Ambon banana peel (Musa paradisiaca L.) as a prospective anti-aging agent in stick mask formulations. The extract was obtained through maceration with 96% ethanol and subsequently analyzed for phytochemical constituents, antioxidant activity using DPPH and ABTS assays, and formulated into mask sticks with extract concentrations of 1% (F1), 3% (F2), and 5% (F3). Physical attributes such as organoleptic properties, uniformity, drying duration, and stability were assessed, while in vivo efficacy was examined in mice subjected to UV radiation, followed by histopathological analysis of epidermal thickness and melanocyte quantity. The extract demonstrated high levels of flavonoids (224.184 ± 0.252 mg QE/g) and phenolics (197.279 ± 0.250 mg GAE/g), with IC50 values of (12.88 ± 0.12) µg/mL and (17.15 ± 0.11) µg/mL in DPPH and ABTS assays, respectively. The stick mask formulations demonstrated adequate physical properties and stability, while in vivo evaluations indicated protective effects against UV-induced skin damage, particularly in the 5% formulation. The results indicate that Ambon banana peel (Musa paradisiaca L.) extract can be developed into an effective anti-aging mask stick with notable antioxidant and photoprotective properties.

Page 83 of 83 | Total Record : 822

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