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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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UJI IRITASI PRIMER LOTION EKSTRAK ETANOLIK DAUN KEMANGI (Ocimum basilicum Linn) PADA KELINCI JANTAN BERDASARKAN PARAMETER INDEKS IRITASI PRIMER Arba Pramundita Ramadani; Ari Marstiyani
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTKemangi (Ocimum basilicum L.) is Lamiaceae family, consists of volatile oil, saponin,flavonoid, tanin, and polifenole. One of its functions is as an antioxidant. The antioxidantmechanism is blocking free radical oxidative bound with LDL (Low Density Lipoprotein) (Udupa,2006). This study explores kemangi as a lotion formulation on its primary iritation effect using malerabbits. Kemangi leaves are extracted with soxhletation method and formulated on lotion. Primaryirritation test is conducted by using patch test on 12 male rabbits. Rabbits are divided into 2 groups,with incision and without incision. Each of it got same treatments normal control aquadest, lotionbase control, and 4 tapering dose of kemangi leaves extract. Each treatment is done 6 times ondifferent rabbits, with incision and without incision group. The treatment is applied on rabbits backafter 3 stage shaving. For incision group, after 3 stages shaving the skin is scratched with minorincision on cell surface. Toxic symptom is observed during 24 hours and 72 hours after lotionapplication. The study result is analyzed qualitatively and quantitatively. Qualitative analysisshowed that any erythema found as reddish spot on the rabbits back skin, but no edema found.Primary irritation index as quantitative analysis showed 0,083 for normal control aquadest; 0,207 forlotion base control; 0,292 for 0,25g/inci2kemangi leaves extract; 0,416 for 0,5g/inci2kemangileaves extract; 0,582 for 1 g/inci2kemangi leaves extract; 0,642 for 2 g/inci2kemangi leaves extract.It means kemangi leaves extract have no primary irritation effect.Keywords: Kemangi, patch test, anti oxidant
PENGHAMBATAN QUORUM SENSING SEBAGAI ALTERNATIF TERAPI PENYAKIT INFEKSI YANG DISEBABKAN OLEH BAKTERI Shofyatul Yumna Triana; Farida Juliantina Rachmawati
Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTThe latest discoveries in the field of microbiology have proved that bacteria communicate eachother. The process of cell to cell communication is called quorum sensing. Quorum sensing wasfirst discovered in two luminous bacteria called Vibrio harveyi and Vibrio fischeri. These bacteriaemit light in response to increase in cell population density. Density-dependent light production isaccomplished trough the release and detection of hormone-like molecules called autoinducers thataccumulate in the environment as the bacterial density increases. Quorum sensing is believed toregulate competence in development, sporulation, virulence factor induction, sporulation andnutrient flux along with other events in pathogenic bacterial infections. Recently, many scientisthave been doing research in the field of quorum sensing. If the signaling systems among thebacteria were able to be blocked, the dangerous effects from bacteria then possibly be prevented.In other word, if the quorum sensing mechanism were stopped, the disease can be prevented oreven cured instead of antibiotics use.Keyword : bacterial infection – quorum sensing - inhibiton
HUBUNGAN PENGETAHUAN, SIKAP DAN KETAATAN BEROBAT DENGAN DERAJAT SISTOLE DAN DIASTOLE PASIEN HIPERTENSI DI PUSKESMAS SUKAMERINDU KOTA BENGKULU Dirhan Dirhan
Jurnal Ilmiah Farmasi Vol. 9 No. 1 (2012): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol9.iss1.art3

Abstract

ABSTRAKTujuan penelitian ini adalah menganalisis hubungan pengetahuan, sikap dan ketaatan berobat dengan derajat sistole dan diastole pada pasien hipertensi di Puskesmas Sukamerindu Kota Bengkulu, khususnya mendeskripsikan pengetahuan tentang hipertensi, sikap, ketaatan berobat pasien hipertensi, dan mendeskripsikan derajat sistole dan diastole pasien hipertensi di Puskesmas Sukamerindu Kota Bengkulu, Menganalisis hubungan pengetahuan dengan derajat sistole dan diastole pasien hipertensi, sikap dengan derajat sistole dan diastole pasien hipertensi, dan menganalisis hubungan ketaatan berobat dengan derajat sistole dan diastole pasien hipertensi di Puskesmas Sukamerindu Kota Bengkulu.Pengetahuan pasien hipertensi sebagian besar (70,4%) sudah baik. Sikap pasien hipertensi mayoritas (79,6%) mendukung pengobatan hipertensi. Mayoritas pasien hipertensi (75,9%) taat berobat, dan sebagian besar (64,8%) bertekanan darah sistole berat dan sebagian besar (61,1%) bertekanan darah diastole sedang.Terdapat hubungan bermakna pengetahuan dengan derajat sistole dan diastole, dimana nilai p=0,000 untuk sistole dan untuk diastole nilai p=0,001, Terdapat hubungan yang bermakna sikap dengan derajat sistole dan diastole dimana nilai p=0,027 untuk sistole dan untuk diastole nilai p=0,018, dan terdapat hubungan yang bermakna ketaatan berobat dengan derajat sistole dan diastole dimana nilai p=0,000 untuk sistole dan derajat diastole nilai p=0,000.
PENGARUH VIRGIN COCONUT OIL (VCO) DI DALAM BASIS KRIM TERHADAP PENETRASI ZAT AKTIF Henny Lucida; Vinny Hosiana; Vivi Muharmi
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTA study on formulation of cream in a base containing Virgin Coconut Oil (VCO) withPiroxicam (1%) as a model has been undertaken. VCO concentration in the cream-base weremade 0 %, 31%, 36% and 41% respectively to determine the influence of VCO concentration on thepenetration profile of the drug. The profil of penetration was determined by using Franz diffusioncell (vertical type) with the mice’s skin and pH 8 phosphate buffer as membrane and mediumrespectively. Concentration of piroxicam released was determined spectrophotometically atwavelength 353.2 nm. Results indicated that the penetration profile of piroxicam from formula 1, 2and 3 followed zero order kinetic with the slope (k) of 0.0171 (r = 0.9913); 0.0217 (r = 0.9869) and0.0217 (r = 0.9939) respectively, while that from formula 4 followed Higuchi equation with the slope(k) of 0,0570 mg/sec2 / 1(r = 0.9853). The highest rate was observed from Formula 4 (VCOconcentration was 41%). Statistical análysis showed that VCO affected the release of piroxicamfrom the formulation significantly (p
UJI KEPEKAAN BAKTERI Escherichia coli HASIL ISOLASI DARI URIN PASIEN RUMAH SAKIT Dr. Sardjito TERHADAP ANTIBIOTIK GOLONGAN -LAKTAM Sri harnanik; Sri Mulyaningsih; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2005)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTUncontrolled use of antibiotic caused the emergence of bacteria strain resistant toward of antibiotic. The sensitivity assay of E. coli toward -lactam antibiotic has been done. The sensitivity assay was started with isolated bacteria from patients urine at Dr. Sardjito hospital followed by count total of colony/number of germ which growth and identified the bacteria. The Kirby Bauer method was performed. Antibiotic impregnated disk (ampicillin 30 g, sulbactam/ampicillin 20 g, cefotaxim 30 g, ceftazidime 30 g, ceftriaxon 30 g, cefpirom 30 g, cefepim 30 g and imipenem 10 g) were placed on agar plate previously streaked with suspension of E. coli (1.10 8 CFU/ml). The plates were incubated for 18-24 hours at 37 0 C. The diameters of the zone inhibition were measured, and compared to standar interpretive zone sizes. The result of the study showed that all of E. coli resistant toward antibiotic ampicillin; 65% resistant toward antibiotic sulbactam/ampicillin; 50% still sensitive toward antibiotic third cefalosporin generation that is cefotaxim, ceftazidime, ceftriaxon; more than 50% sensitive toward fourth cefalosporin generation like cefepim, cefpirom and all of pathogen bacteria E. coli sensitive toward antibiotic imipenem.Key Words : E. coli, -lactam antibiotic, Sensitivity assay, Urine of patient hospital.
POTENSI KEJADIAN INTERAKSI OBAT PADA PENGGUNAAN OBAT UNTUK PASIEN ANAK YANG DIRAWAT INAP DENGAN DIAGNOSA INFEKSI SALURAN PERNAFASAN DI SALAH SATU RUMAH SAKIT SWASTA DI SURAKARTA Saepudin Saepudin; Suci Hanifah; Wachidah Rahmawati
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTThis research was aimed at knowing potential drug interactions on drug prescribing fortreatment of hospitalized pediatric patients with respiratory tract infection. Research was carriedout at a private hospital in Surakarta and data were collected from medical records of patients werehospitalized during January – December 2005. Potential drug interactions were determinedtheoretically using some literatures on drug interaction. From total 186 patients included in thisresearch, 67.2% were 0-4 years old with common cold was the most diagnosed. There were 52.7%patients receiving 4-6 item of drugs and 76.9% patients were hospitalized during 1-3 days.Potential drug interactions were identified in 30.7% patients with 1.8% and 15.8% of them at level 1and 2 clinical significance, respectively. Statistically, there was a relationship between potentialdrug interactions and length of hospitalization (p = 0.001). Some further investigations(prospectively) are needed to ensure results from this research.Key words : drug interaction, respiratory tract infection, pediatric
JPH203 as a potential L-Type Amino Acid Transporter 1 (LAT 1) inhibitor in the development of cancer theragnostic compounds Yolanda Pertiwi; Driyanti Rahayu; Maula Eka Sriyani; Raden Bayu Indradi; Holis Abdul Holik
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art8

Abstract

AbstractBackground: Cancer has become a major cause of global health problems. Latest research currently focuses on an approach to cancer therapy that involves specific target molecules and theragnostic (therapy and diagnostic) agents. Among the specific target molecules in cancer therapy is LAT1, which is over expressed in cancer cells but under expressed in normal cells. Therefore, LAT1 inhibition can become an alternative to cancer therapy. A number of studies have shown that JPH203 specifically inhibits LAT1, thus reducing amino acid absorption into cancer cells and inhibiting cancer cell growth.Objective: The main objective of this literature study was to determine the potential of JPH203 as a LAT1 inhibitor to be developed into a novel theragnostic agent for cancer.Methods: Various studies were summarized to outline the development of JPH203 as a therapy targeting LAT1 and potential candidate of theragnostic compounds.Results: The results of the literature study showed that JPH203 as a selective LAT1 inhibitor was able to efficiently suppress the growth of cancer cells with a low IC50 value.Conclusion: The activity of LAT1 as an amino acid transporter of cancer cells could be selectively inhibited by JPH203, thereby allowing JPH203 to be reconsidered as a potential therapy in the development of theragnostic compounds against cancer.Keywords: JPH203, theragnostic, LAT1 inhibitorIntisariLatar belakang: Kanker telah menjadi penyebab masalah kesehatan utama di dunia. Saat ini penelitian terbaru berfokus pada pendekatan terapi kanker yang melibatkan molekul target yang spesifik dan menggunakan senyawa teranostik (terapi dan diagnostik). Salah satu molekul target spesifik dalam terapi kanker adalah LAT1 yang terekspresi berlebih pada sel kanker, namun sedikit pada sel normal. Oleh karena itu, inhibisi LAT1 dapat menjadi alternatif terapi kanker. Beberapa penelitian menunjukkan inhibitor yang secara spesifik menghambat LAT1 adalah JPH203, sehingga penyerapan asam amino ke dalam sel kanker dapat berkurang dan menghambat pertumbuhan sel kanker.Tujuan: Tujuan utama dari studi literatur ini adalah untuk mengetahui potensi JPH203 yang merupakan inhibitor LAT1 dalam perannya sebagai senyawa teranostik baru terhadap penyakit kanker.Metode: Berbagai penelitian dirangkum mengenai pengembangan JPH203 sebagai terapi pentarget-LAT1 dan potensinya sebagai kandidat senyawa teranostik.Hasil: Hasil studi literatur yang dilakukan menunjukkan bahwa JPH203 sebagai inhibitor selektif LAT1 mampu menekan pertumbuhan sel kanker secara efisien dengan didapatkan hasil IC50 yang rendah.Kesimpulan: Aktivitas LAT1 sebagai transporter asam amino sel kanker dapat dihambat secara selektif oleh JPH203, sehingga dapat dipertimbangkan kembali sebagai target terapi potensial yang dapat digunakan dalam pengembangan senyawa teranostik kanker.Kata kunci : JPH203, teranostik, inhibitor LAT1
Acute toxicity test ethanol extract of kerehau leaf (Callicarpa longifolia Lamk) using OECD 420 method Aulia Nurfazri Istiqomah; Shintya Safitri; Elis Susilawati
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art2

Abstract

AbstractBackground: Kerehau is empirically used as cooling powder to treat acne. Based on previous research, kerehau leaves have a number of activities, including wound healing, antidiabetic, and anti-inflammatory.Objectives: This study aimed to determine the safety level of a single dose of ethanol extract of kerehau leaves within a 24-hour administration period.Methods: Acute toxicity testing of ethanol extract of kerehau leaves was carried out on female Webster mice. Test animals were divided into 4 treatment groups, consisting of 1 control group and 3 test groups. The testing method referred to OECD (Organization of Economic Cooperation and Development) 420 with modified doses of 2000mg/kgBW, 5000 mg/kgBW, and 8000 mg/kgBW. The observations were made on the behaviour of animals towards toxicity symptoms for 4 hours after administration of the test substance as well as death. The death and weight gain were observed for 14 days. On the 15th day, animals were sacrificed, blood was taken, and biochemical parameters were measured. The heart, kidneys, liver, spleen, and lungs were harvested and weighed. Data was analysed using Oneway ANOVA continued with LSD and Post Hoc.Results: The results showed that ethanol extract of kerehau leaves did not cause death in all of the groups. There were significant differences in liver weight, SGPT, and SGOT levels (p< 0.05) at the dose of 5000 mg/kgBW. No toxicity symptoms and death were found until the end of the experiment.Conclusion: LD50 value of ethanol extract of kerehau leaves was above 8000 mg/kgBW with heart as the most affected organ.Keywords: Ethanol extract of kerehau leaves, acute toxicity test, OECD 420.Latar Belakang : Beragam  khasiat yang dimiliki daun kerehau menjadi dasar dilakukannya uji toksisitas akut untuk mengetahui adanya potensi toksik dan organ sasaran yang dipengaruhi.Metode : Metode pengujian toksisitas akut diadaptasi dari OECD 420 dengan dosis 2000 mg/kgbb, 5000 mg/kgbb dan 8000mg/kgbb. Pengamatan dilakukan  terhadap gejala toksik yang muncul, kematian dan berat badan. Pada hari ke-15 dilakukan pengukuran SGPT, SGOT , kreatinin dalam darah, indeks organ jantung, ginjal, hati, limpa dan paru-paru serta histopatologi organ hati dan ginjal.Hasil : Hasil penelitian menunjukkan ekstrak etanol daun kerehau mempengaruhi organ hati secara bermakna namun tidak menyebabkan kematian hingga dosis 8000mg/kgbb.Kata kunci : Ekstrak etanol, daun kerehau, toksisitas akut, OECD 420.
Standardization parameters for cocoa pods (Theobroma cacao L.) Nida Isti Azah; Resmi Muchtarichie; Yoppi Iskandar
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art9

Abstract

Abstract  Background: Cocoa (Theobroma cacao L.) pods are a waste from chocolate production which has medicinal benefits. Cocoa pods have scientifically proved to have pharmacological activities.Objective: Standardization of plants to be used as medicine is required to control the quality and ensure the safety, efficacy, and quality.Methods: Data on the standardization parameters of cocoa pods were collected from journals published during the period 2010-2020 by searching in Google, Google Scholar, and Research Gate.Results: Standardization parameters of cocoa pods consisted of macroscopic and microscopic examinations, ash content, solute concentration in solvents, phytochemical screening, and thin layer chromatography.Conclusion: Macroscopic examination showed that the skin of cacao fruit has a brownish-yellow color and purplish red, a specific odor, and a bitter taste with four forms, namely amelonado, angoleta, cundeamor, and calabacil. Microscopic examination showed a collection of stone cells and hair covering. The moisture content of cocoa pods fulfills the requirement which is below 10%. The total ash content is 5.80 - 7.41, and the acid-insoluble ash content is 0.45 - 0.64. The concentration of solute in water is higher than in ethanol with 22.69 and 5.21, respectively. The phytochemical screening showed that cocoa pods have flavonoids, saponins, quinones, tannins, steroids, triterpenoids, monoterpenes, and sesquiterpenes. The thin-layer chromatography indicated the presence of phenolic compounds, catechol tannins, flavonoids, and terpenoids.Keywords: Cocoa pods, standardization, Theobroma cacao IntisariLatar belakang: Kulit buah kakao (Theobroma cacao L.) merupakan limbah dari produksi cokelat yang bermanfaat sebagai obat dan terbukti secara ilmiah memiliki berbagai aktivitas farmakologi.Tujuan: Standardisasi tanaman yang akan digunakan sebagai obat berguna untuk mengontrol kualitas serta memastikan keamanan, khasiat, dan mutunya.Metode: Data parameter standar kulit buah kakao dikumpulkan dari jurnal yang diterbitkan selama kurun waktu 2010-2020 dengan pencarian menggunakan situs pencarian seperti google, google scholar, dan researchgate.Hasil: Parameter standardisasi kulit buah kakao meliputi pemeriksaan makroskopik, mikroskopik, nilai kadar abu, kadar zat terlarut dalam pelarut, penapisan fitokimia, dan kromatografi lapis tipis.Kesimpulan: Pemeriksaan makroskopik, kulit buah kakao memilki warna kuning kecokelatan dan merah keunguan, bau khas, rasa pahit, dengan empat bentuk yaitu amelonado, angoleta, cundeamor, dan calabacil. Pemeriksaan mikroskopik menunjukkan adanya kumpulan sel batu dan rambut penutup. Kadar air kulit buah kakao sesuai dengan syarat yaitu berada dibawah 10%. Nilai kadar abu total 5,80 - 7,41 dan kadar abu tak larut asam 0,45 - 0,64. Kadar zat terlarut dalam air lebih tinggi dari etanol dengan nilai masing-masing 22,69 dan 5,21. Dari hasil penapisan fitokimia kulit buah kakao menunjukkan adanya senyawa flavonoid, saponin, kuinon, tannin, steroid, triterpenoid, monoterpen dan seskuiterpen. Pada kromatografi lapis tipis menunjukkan adanya senyawa fenolik, tannin katekol, flavonoid, dan terpenoid.Kata kunci : Kulit buah kakao, standardisasi, Theobroma cacao
Assessment of physicochemical properties and comparison of the dissolution profile of amoxicillin caplets Een Widiyasari; Teuku Nanda Saifullah Sulaiman
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art4

Abstract

Background: Marketed drugs must meet the required standards to guarantee product quality. Amoxicillin is a generic compound marketed under various trademarks as copy drugs. Amoxicillin caplets are an immediate release dosage form of BCS class I. An essential aspect of evaluating copy drugs is to assess the equivalence for their treatment to the innovator drugs to ensure the safety and effectiveness of the circulating copy drugs.Objective: The study aims to evaluate the physicochemical properties and compare the dissolution profile of amoxicillin caplets available in the market.Methods: Five amoxicillin caplet products, four test products, and one reference product were tested for their physicochemical properties and dissolution. The dissolution test was carried out with a type II device at a speed of 75 rpm in 900 mL of media buffered at pH 1.2, 4.5, and 6.8 and at a temperature of 37 +/- 0.5degrees celcius. The dissolution profile was analyzed by comparing it with the similarity factor (f2) parameters.Results: Two of the four amoxicillin caplet products had a similar dissolution profile to the reference products, namely products A and B. Products C and D were dissimilar because f2 was lower than 50 at pH 4.5. The caplets tested had almost the same dimensions, and all caplets met the requirements for uniformity of content, hardness, disintegration time, and dissolution.Conclusion: Not all of the amoxicillin caplets in the market have a similar dissolution profile to the reference products. Keywords: caplets, amoxicillin, dissolution, similarity factor Intisari Latar belakang: Sediaaan obat yang dipasarkan harus memenuhi standar yang ditetapkan untuk menjamin kualitas produk. Amoksisilin merupakan senyawa generik, dipasarkan dengan berbagai merek dagang yang merupakan obat copy. Kaplet amoksisilin merupakan sediaan dengan pelepasan segera yang termasuk dalam BCS kelas I. Komponen penting dalam mengevaluasi obat copy yaitu menilai kesetaraan terapinya terhadap obat inovator sehingga dapat menjamin bahwa obat copy yang beredar aman dan efektif. Tujuan: Penelitian ini bertujuan untuk mengevaluasi sifat fisika kimia dan uji disolusi terbandingkan sediaan kaplet amoksisilin yang beredar dipasaran.Metode: Sebanyak 5 produk kaplet amoksisilin, 4 produk uji dan 1 produk pembanding diuji sifat fisika kimia dan disolusinya. Uji disolusi dilakukan dengan alat tipe II dengan kecepatan 75 rpm dalam 900 mL media yang dibuffer pada pH 1,2; 4,5; dan 6,8 dan suhu 37 +/- 0,5derajat celcius. Profil disolusi dianalisis dengan membandingkan profil disolusi dengan parameter similiarity factor (f2).Hasil: Hasil penelitian menunjukkan 2 produk dari 4 produk kaplet amoksisilin  memiliki kemiripan profil disolusi terhadap produk pembanding yaitu produk A dan B, sementara 2 produk yang lain tidak memiliki kemiripan karena nilai f2 kurang dari sama dengan 50 pada pH 4,5 (produk C dan D). Kaplet yang diuji memiliki dimensi yang hampir sama, semua kaplet memenuhi persyaratan keseragaman sediaan, kekerasan, waktu hancur dan disolusi.Kesimpulan: Kaplet amoksisilin yang beredar tidak semuanya memiliki kemiripan profil disolusi dibandingkan produk pembanding. Kata kunci : kaplet, amoksisilin, disolusi, similiarity factor

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