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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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Treatment pattern and direct medical costs of pediatric outpatients with actuate respiratory infection at X hospital in Jambi Hendri Pranata; Rasmaladewi Rasmaladewi; Mukhlis Sanuddin
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art10

Abstract

Abstract  Introduction: Acute respiratory infection is common among the general public. Such disease and its associated symptoms encourage higher consumption of medicine. Varied medications for ARI patients incur different costs of each patient, which eventually lead to higher healthcare costs.Objectives: To identify the treatment patterns and direct medical costs among ARI pediatric patients at X Hospital in Jambi. Methods: This research was an observational study with retrospective data collection. The samples were collected in 2018.Results: The results showed that the most-frequently administered antibiotic for ARI pediatric patients was cefixime (29.17%), while the most-commonly used supportive therapy for ARI pediatric patients was the combination of antihistamines, antipyretics-analgesics, decongestant, and corticosteroid (16.67%). The total direct medical cost to ARI pediatric patients was IDR 191,097.Conclusion: The mean direct medical cost for ARI therapy was IDR 191,097. More administered therapy resulted in higher medical costs.Keywords: ARI, child, antibiotics, direct medical costs IntisariLatar belakang: Infeksi saluran pernafasan akut merupakan penyakit yang umum terjadi pada setiap kalangan masyarakat. Infeksi saluran pernafasan akut dan juga gejala yang di timbulkannya mengakibatkan tinggi nya penggunaan obat-obatan. Bervariasinya obat yang di konsumsi oleh pasien ISPA menyebabkan pembebanan biaya yang beragam dari setiap pasien yang pada akhirnya akan mempengaruhi beban biaya kesehatan yang akan ditanggung.Tujuan: Untuk mengetahui pola pengobatan dan biaya medis langsung pasien ISPA anak rawat jalan di Rumah Sakit X Jambi.Metode: Penelitian ini merupakan penelitian observasional dengan pengumpulan data dilakukan secara retrospektif. Sampel diambil pada tahun 2018.   Hasil: Hasil penelitian didapatkan bahwa antibiotik yang paling banyak digunakan pada pasien anak penderita ISPA adalah sefiksim sebesar 29,17%. Sedangkan terapi suportif yang paling banyak digunakan untuk pasien anak ISPA adalah kombinasi golongan antihistamin, antipiretik analgetik, dekongestan, kortikosteroid sebanyak 16,67%. Biaya total rata-rata medis langsung pada pasien ISPA anak rawat jalan yaitu sebesar Rp. 191.097.Kesimpulan: Biaya medis langsung yang harus dikeluarkan untuk terapi pada penyakit ISPA yaitu rata-rata sebesar Rp. 191.097. Semakin banyak terapi yang di berikan maka semakin tinggi pula biaya yang akan dikeluarkan.Kata kunci: ISPA, anak, antibiotik, biaya medis langsung
Stability studies of mefenamic acid Self-Nanoemulsifying Drug Delivery System (SNEEDS) preparation with oleic acid as the oil phase Yandi Syukri; Septiani Eka Cahyani; Bambang Hernawan Nugroho
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art5

Abstract

AbstractBackground: Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with low solubility in water.Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) play a role to improve the solubility and bioavailabilityof mefenamic acid.Objective: This study aimed to determine the stability of mefenamic acid in SNEDDS formulation throughvarious stability studies.Methods: The stability studies conducted consisted of centrifugation test, heating-cooling cycle test, freezethaw cycle test, robustness to dilution, accelerated storage test, and determination of drug content.Results: The centrifugation test, heating-cooling cycle test, and freeze-thaw cycle test showed no phaseseparation in the samples. The robustness to dilution and accelerated storage test resulted in 2 formulas ofmefenamic acid loaded SNEDDS having good stability with 10% oleic acid, 80% tween 80, 10% PEG 400 and10% oleic acid, 70% tween 80, 20% PEG 400. The determination of drug content in both of these formulationsshowed 98.20 ± 0.04% and 90.98 ± 0.06%.Conclusion: The SNEDDS formulation of mefenamic acid in this study had good stability.Keywords: SNEDDS, mefenamic acid, stability study, oleic acid IntisariLatar belakang: Asam mefenamat merupakan obat anti inflamasi non steroidal (AINS) dengan kelarutan yang rendah di dalam air. Salah satu cara untuk meningkatkan kelarutan dan bioavailabilitas asam mefenamat membuatnya dalam bentuk sediaan Self Nano-Emulsifying Delivery Drug System (SNEDDS)Tujuan: Penelitian ini bertujuan untuk menentukan stabilitas SNEDDS asam mefenamat terhadap berbagai studi stabilitas yang dilakukanMetode: Uji stabilitas dilakukan dengan uji sentrifugasi, uji siklus panas-dingin, uji siklus beku-cair, uji ketahanan, uji penyimpanan dipercepat, dan uji kadar.Hasil: Hasil dari evaluasi uji sentrifugasi yaitu tidak terjadi pemisahan, pada uji siklus panas-dingin dan uji siklus beku-cair tetap stabil dan tidak terjadi pemisahan fase. Hasil dari uji ketahanan dan uji penyimpanan dipercepat menunjukkan 2 formula SNEDDS asam mefenamat yang memiliki stabilitas yang baik dengan komponen Asam Oleat 10%, Tween 80 80%, PEG 400 10% dan Asam Oleat 10%, Tween 80 70%, PEG 400 20%. Pada uji kadar diperoleh kadar asam mefenamat selama penyimpanan pada formula diatas adalah 98,20 ± 0,04 % dan 90,98 ± 0,06 %.Kesimpulan: Dapat disimpulkan sediaan SNEDDS asam mefenamat memiliki stabilitas yang baik terhadap berbagai studi stabilitas yang dilakukan.Kata kunci : SNEDDS, asam mefenamat, studi stabilitas, asam oleat
Comparison of antioxidant activities of tespong herbal (Oenanthe javanica DC.) extract and nanoextract using DPPH method In Rahmi Fatria Fajar; Dewi Rahma Fitri; Nisa Fitriyani; Michael Chuanvin
Jurnal Ilmiah Farmasi Vol. 17 No. 1 (2021): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol17.iss1.art1

Abstract

Background: Tespong herbs (O. javanica DC.) contain numerous chemical compounds considered beneficial for medications, including flavonoids, phenols, and tannins, which can function as antioxidants. Nanoparticles are materials with a size range of 1-1000 nanometers which can increase the bioavailability of drugs, thus accelerating the drug delivery system in the body.Objective: The aim of this study is to identify the characteristics of herbal extract and nanoextract of Tespong and to compare their antioxidant activity.Methods: Extraction of tespong herbs was done using maceration for three days, nanoextract was formulated using the ionic gelation method with herbal extract of tespong, chitosan, and Na-TPP. Antioxidant activity testing was carried out using the DPPH method.Results: The water content of tespong herbal extract was 1.78%, and the total ash content was 4.95%.  The tespong herbal nanoextract was 148.1nm in diameter with a polydispersity index of 0.362 and a zeta potential value of -39.16 mV. The IC50 values of tespong herbal extract and nanoextract were 65.424 ppm and 97.106 ppm, respectively, which fell into the strong category.Conclusion: Tespong herbal extract had a higher antioxidant activity compared to its nanoextract.Keywords:   Tespong herb, nanoextract, chitosan, Na-TPPIntisariLatar Belakang: Herba tespong (O. javanica DC.) memiliki banyak kandungan senyawa kimia yang bermanfaat dalam pengobatan diantaranya ialah senyawa flavonoid, fenol dan tanin yang dapat berfungsi sebagai antioksidan. Nanopartikel merupakan material dengan ukuran 1-1000 nanometer yang penggunaannya dapat ditujukan untuk meningkatkan bioavailabilitas obat sehingga mempercepat sistem penghantaran obat dalam tubuh.Tujuan: untuk mengetahui karakteristik ekstrak herba tespong, karakterisasi nanoekstrak herba tespong dan mengetahui perbandingan nilai aktivitas antioksidan ekstrak herba tespong dengan nanoekstrak herba tespong.Metode: Ekstraksi herba tespong menggunakan metode maserasi selama tiga hari, formulasi nanoekstrak menggunakan metode gelasi ionik terdiri dari ekstrak herba tespong, kitosan dan Na-TPP. Pengujian aktifitas antioksidan menggunakan metode DPPH.Hasil: Pengujian kadar air ekstrak menunjukkan angka 1,78% dan kadar abu total ekstrak sebesar 4,95%. Pada pengujian karakterisasi nanoekstrak herba tespong yang dibuat memiliki diameter rata-rata sebesar 148,1 nm dengan indeks polidispersitas sebesar 0,362 dengan nilai potensial zeta sebesar -39,16 mV. Nilai IC50 antioksidan ekstrak dan nanoekstrak herba tespong (O. javanica DC.) berturut –turut sebesar sebesar 65,424 ppm dan 97,106 ppm termasuk kategori kuat.Kesimpulan: Ekstrak herba tespong memiliki aktivitas antioksidan lebih tinggi dibandingkan nanoekstrak herba tespong.Kata Kunci: Herba tespong, nanoekstrak, kitosan, Na-TPP
Solid dispersion of quercetin-PVP K-30 and its effects on the antioxidant activity Zahara Gayo; Henny Lucida; Erizal Zaini
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art6

Abstract

AbstractBackground: Quercetin (3,3’,4’,5,7-pentahydroxil-flavon) is a flavone and secondary metabolite known as flavonoid. Quercetin belongs to class II BCS that has low solubility and high permeability. The poor solubility of quercetin restricts the accessibility and bioavailability.Objectives: To increase the solubility, dissolution, and antioxidant activity in a solid dispersion system.Methods: Preparation of quersetin-PVP K-30 solid dispersion was conducted using the freeze-drying method at -96 degree C for 24 hours with a ratio of 1:1, 1:0.5, and 0.5:1 and a 1:1 physical mixture of quercetin-PVP K-30. The solid dispersion of quercetin-PVP K-30 was characterized by Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD) analysis, and FT-IR spectrophotometric analysis. Solubility test was analyzed using a UV-Vis spectrophotometer, dissolution test was done using a paddle-type dissolution tester, dissolved quercetin concentrations were analyzed using a UV-Vis spectrophotometer, and antioxidant activity was determined using the DPPH method in a UV-Vis spectrophotometer.Results: SEM analysis showed the formation of quercetin-PVP K-30 solid dispersion using the freeze-drying method, and the form changed into anhydrate as seen from the XRD results with the presence of new crystalline peaks in solid dispersion, which were not seen in pure quercetin and PVP K-30. Quercetin-PVP K-30 solid dispersion could increase the solubility by 54-fold at a ratio of 0.5:1 with 94.36%±0.85 quercetin dissolved in 120 minutes. The formation of this solid dispersion affected the antioxidant activity which was observable from the IC50 value at the best ratio of 0.5:1 reaching 0.714 microgram/mL while the IC50 value of pure quercetin is 1.102 microgram/mL.Conclusion: The formation of quercetin solid dispersion could increase the solubility and dissolution and affect the antioxidant activity.Keywords: solid dispersion, freeze-drying, quercetin, antioxidantIntisariLatar Belakang: Kuersetin (3,3’,4’,5,7-pentahydroxil flavon) adalah flavon dan merupakan metabolit sekunder yang dikenal dengan flavonoid. Kuersetin tergolong dalam BCS kelas II yaitu memiliki kelarutan rendah dan permeabilitas tinggi (low solubility and high permeability drugs), kelarutan kuersetin yang buruk membatasi aksesibilitas dan bioavailabilitasnya.Tujuan: Untuk meningkatkan kelarutan dan disolusi kuersetin serta melihat pengaruhnya terhadap aktivitas antioksidan kuersetin.Metode: Pembuatan dispersi padat menggunakan metode freeze dry pada suhu -96 derajat C selama 24 jam.Hasil: Dengan pembuatan disepersi padat kuersetin-PVP K-30 dapat meningkatkan kelarutan, disolusi dan dapat meningkatkan aktivitas antioksidan kuersetin.Kesimpulan: Uji statistik menggunakan ANOVA dua arah menunjukkan uji kelarutan dan disolusi pada pembentukan dispersi padat kuersetin-PVP K-30 terdapat perbedaan yang signifikan (p= 0,000 (Sig<0,05)).Kata Kunci: Dispersi padat, Freeze Dry, Kuersetin, Antioksidan
The relationship between sosiodemographic factors and public knowledge of herbal medicines in two districts in Sleman Regency Dian Medisa; Hady Anshory; Putri Litapriani; Rezky Fajriyati M
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art1

Abstract

AbstractIntroduction: The use of herbal medicines in the community is increasing, both in developing and developed countries.. Most people use herbal medicine for generations or based on experience. Therefore, it is necessary to analyze the public knowledge about herbal medicine to support the use of herbal medicines appropriately and correctlyObjective : To determine the relationship between sociodemographic characteristic with public knowledge level about  herbal medicine in Sleman Regency.Methods: Survey research conducted on the people of Minggir and Cangkringan districts, Sleman Regency. Sampling of 240 respondents was done by cluster sampling method. Data obtained from the distribution of questionnaires that have been validated to the public. The correct answer was counted and scored, then responden who score greater or equal to the mean were grouped into good knowledge, whereas those who score less than mean were grouped into poor knowledge. Data were analyzed by univariate and bivariate by chi-square test.Result : The majority of respondents were women (61.2%) and the most age was 26-45 years (46.7%). The respondents' knowledge is the best in the domain of how to use herbal medicine with an average percentage of correct answers 67.6%. In the domain of side effects, the average percentage of answers is only 47.7%. Overall respondents who had a good level of knowledge were 66.2% and respondents who were poorly knowledgeable were 33.8%. The results of the bivariate analysis showed no correlation between sociodemographic characteristics and knowledge level about herbal medicine (p> 0.05).Conclusion: Most people in Sleman Regency have good knowledge about herbal medicine. However, education still needs to be done about herbal medicines, especially the efficacy and side effects. Keyword: knowledge, herbal medicine, sleman regencyIntisariLatar Belakang: Penggunaan obat herbal (OH) di masyarakat semakin meningkat, baik di negara berkembang maupun negara maju. Sebagian besar masyarakat menggunakan obat herbal secara turun temurun atau berdasarkan pengalaman. Oleh karena itu, perlu dilakukan analisis terhadap pengetahuan masyarakat tentang obat herbal untuk mendukung penggunaan obat herbal dengan tepat dan benar.Tujuan: Untuk mengetahui hubungan sosiodemografi dengan tingkat pengetahuan masyarakat tentang obat herbal pada dua kecamatan di Kabupaten Sleman.Metode: Penelitian survey yang dilakukan pada masyarakat Kecamatan Minggir dan Cangkringan, Kabupaten Sleman. Pengambilan sampel sebanyak 240 responden dilakukan dengan metode cluster sampling. Data diperoleh dari pembagian kuesioner yang telah tervalidasi. Responden yang memiliki skor di atas nilai rata-rata termasuk dalam kategori berpengetahuan baik, sedangkan jika dibawah atau sama dengan rata-rata termasuk kategori berpengetahuan buruk. Data dianalisis menggunakan uji chi-square.Hasil: Mayoritas responden adalah wanita (61,2%) dan usia paling banyak 26-45 tahun (46,7%). Persentase pengetahuan yang paling baik yaitu pada domain efek samping obat herbal (78,3%), sedangkan pengetahuan yang terendah tentang cara penggunaan obat herbal (32,1%). Lima puluh lima persen responden memiliki pengetahuan yang baik tentang obat herbal secara keseluruhan. Hasil analisis bivariat menunjukkan faktor sosiodemografi tidak berhubungan secara signifikan dengan tingkat pengetahuan responden tentang obat herbal (p<0,05).Kesimpulan: Faktor sosiodemografi tidak berhubungan dengan tingkat pengetahuan tentang obat herbal. Pengetahuan tentang obat herbal dapat ditingkatkan melalui pemberian edukasi yang sesuai dengan kebutuhan dan kondisi sosiodemografi masyarakat.Kata kunci: pengetahuan, obat tradisional, Kabupaten Sleman
Isolation of alkaloids compound of ethanol extract of mangrove perepat (S. alba) root and its antibacterial activity Madyawati Latief; Muhaimin Muhaimin; Hilda Amanda; Indra Lasmana Tarigan; Siti Aisyah
Jurnal Ilmiah Farmasi Vol. 17 No. 1 (2021): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol17.iss1.art2

Abstract

 Abstract  Background: Exploration of the chemical contents and bioactivities of mangrove plants is important to discover new therapeutic agents for society and to develop its medicinal values.Objective: This study aims to isolate alkaloid compounds from the ethanol extract of Sonneratia alba root which is likely to have an antibacterial activity.Methods: Isolation was carried out using fractionation and chromatography, while antibacterial activity test was performed using the disc diffusion methods.Results: Our phytochemical screening shows that the ethanol extract has a high concentration of alkaloid compounds. The alkaloid which contain in isolate (F4) is further confirmed through UV-Vis Spectra and FT-IR spectra. The ethanol extract exhibits the antibacterial activity against S.  aureus and E.  coli with the inhibition zone of 1.5 mm and 2.5 mm, respectively.Conclusion: Alkaloid compound has been isolated from Sonneratia alba and has potential as antibacterial agent.Keywords: mangrove perepat (Sonneratia alba), alkaloid, antibacterial agent Intisari Latar Belakang: Eksplorasi kandungan kimiawi dan bioaktivitas tanaman mangrove penting dilakukan untuk menemukan agen terapeutik baru bagi masyarakat serta mengembangkan nilai medisnya.Tujuan: Penelitian ini bertujuan untuk mengisolasi senyawa alkaloid dari ekstrak etanol akar Sonneratia alba yang berpotensi menghasilkan aktivitas antibakteri.Metode: Isolasi senyawa dilakukan dengan fraksinasi dan kromatografi, sedangkan antibakteri dilakukan dengan metode difusi cakram.Hasil: Hasil skrining fitokimia yang telah dilakukan menunjukkan bahwa ekstrak etanol memiliki kandungan  alkaloid yang tinggi. Kandungan alkaloid dalam Isolat (F4) telah dikonfirmasi secara spektrofotometri UV-Vis dan FT-IR. Aktivitas antibakteri ekstrak etanol terhadap S.  aureus dan E.  coli ditunjukkan dengan dihasilkannya zona hambat sebesar 1,5 mm dan 2,5 mm.Kesimpulan: Senyawa alkaloid berhasil diisolasi dari Sonneratia alba serta memiliki potensi sebagai agen antibakteri.Kata Kunci: mangrove perepat (Sonneratia alba), alkaloid, antibakteri
Selenium species in vegetables: benefits and toxicity for the body Alya Luthfiyani Heryadi; Ayu Shalihat; Rimadani Pratiwi; Mutakin Mutakin
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art7

Abstract

Abstract  Background: Selenium is one of the essential trace elements in various biological body functions. The main source of Selenium in the body is food, one of which is vegetables. Vegetables collect Selenium from the soil which is then converted into various chemical species of Selenium. Such species should be recognized since each has different biological activities.Objective: The aim of this review was to identify chemical species of Selenium in vegetables as well as the benefits and toxicity for the body.Methods: Reference searches were done in Pubmed and Google Scholar databases with the keywords Selenium speciation in plants, selenite, selenate, selenomethionine, selenocystine, and se-methylselenocysteineResults: The results of speciation in several types of vegetables showed that the chemical species of Selenium abundantly found in vegetables were selenomethionine (SeMet), selenocystine (SeCys2) and se-methylselenocysteine (Se-MeSeCys), gamma-glutamyl-Se-methyl-selenocysteine, and inorganic species. Both Selenium-enriched vegetables and the species contained therein have a variety of benefits for the body. However, excessive consumption can also cause toxic effects.Conclusion: The chemical species of Selenium in vegetables can be either organic or inorganic. Both types of species have different benefits and toxic effects. Keywords: benefits, chemical species, Selenium, toxicity, vegetable Intisari  Latar belakang: Selenium merupakan salah satu trace element esensial yang penting pada berbagai fungsi biologi tubuh. Sumber utama Selenium dalam tubuh adalah makanan, salah satunya yaitu sayuran. Sayuran mendapatkan Selenium dari tanah yang kemudian diubah menjadi berbagai spesies kimia Selenium. Spesies kimia Selenium penting untuk diketahui karena setiap spesies memiliki aktivitas biologi yang berbeda Tujuan: Review ini ditujukan untuk mengetahui spesies kimia Selenium yang terdapat pada sayuran serta manfaat dan toksisitasnya bagi tubuh Metode: Penelusuran referensi dilakukan melalui database Pubmed dan Google Scholar, dengan kata kunci Selenium speciation in plant, selenite, selenate, selenomethionine, selenocystine, dan se-methylselenocysteineHasil: Hasil spesiasi pada beberapa sayuran menunjukkan spesies kimia Selenium yang banyak terdapat dalam sayuran adalah selenomethionine (SeMet), selenocystine (SeCys2), dan Se-methylselenocysteine (Se-MeSeCys), gamma-glutamyl-Se-methyl-selenocysteine, dan spesies anorganik. Baik sayuran yang diperkaya Selenium maupun spesies yang terkandung di dalamnya memiliki berbagai manfaat bagi tubuh. Namun konsumsi yang berlebih juga dapat menyebabkan efek toksik Kesimpulan: Spesies kimia Selenium yang terdapat pada sayuran dapat berupa spesies organik maupun spesies anorganik. Kedua jenis spesies ini memiliki manfaat serta efek toksik yang berbedaKata kunci : manfaat, sayuran, Selenium, spesies kimia, toksisitas
Confusion, difficulty concentrating, and slow response induced by ropinirole therapy in an elderly patient with secondary Parkinsonism: a case report Emilia Sidharta; Ivon Sindu Wijaya; Hanny Cahyadi
Jurnal Ilmiah Farmasi Vol. 16 No. 2 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss2.art3

Abstract

Abstract  Background: Ropinirole is a therapy that is widely used in patients with Parkinson's disease or Restless Leg Syndrome (RLS). Some research journals show that the long-term use of ropinirole can cause side effects. But unfortunately, there are no published studies from Indonesia that show the side effects of ropinirole..Objective: To report a case of several side effects induced by ropinirole therapyMethod : Assessment methods used were time series data collection followed by causality analysis using Naranjo Scale. Results:  This case reports several side effects such as confusion, difficulty concentrating, and  slow response experienced by a 75-year-old elderly patient who consumed ropinirole 2 mg as a therapy for Secondary Parkinsonism. Before using ropinirole, the patient had used levodopa-benserazide, trihexyphenidyl, and pramipexole to overcome Parkinson's for more than 3 years. During the period no side effects occurred. Side effects occurred after ropinirole therapy was given to patients.  The analysis using Naranjo Scale shows a score of 6 which means Probable.  Conclusion: The aim of this study is to raise awareness for health workers, especially pharmacists in order to increase alertness in patients using long-term medications such as those with Parkinson's.Keywords: side effect, secondary parkinsonism, ropinirole, elderly
Evaluasi penyimpanan obat di Puskesmas "X" Kabupaten Sleman Novi Dwi Rugiarti; Atika Nurul Hidayati; Dian Medisa; Diesty Anita Nugraheni
Jurnal Ilmiah Farmasi Vol. 17 No. 1 (2021): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol17.iss1.art8

Abstract

AbstractBackground: Medicines storage is one of the stages in drug management, which plays an essential role in ensuring the quality and availability of drugs. Therefore, it is necessary to evaluate medicines storage by comparing the performance with the storage efficiency indicators.Objective: This study aimed to determine the efficiency of medicines storage in “X” Primary Healthcare, Sleman Regency.Methods: This research was an observational study during April-May 2020 in “X” Primary Healthcare. Data collection was carried out retrospectively. Data were analyzed based on drug efficiency indicators, including the percentage of expired drugs, the percentage of dead stock, and turnover ratio (TOR).Results: The results showed 2.45% expired drugs, 2.45% deadstock, and 5.2 times TOR. The most expired drugs were pipemidic acid 400 mg, nifedipine 10 mg, and carbamazepine 200 mg.Conclusion: The storage of medicines in "X" Primary Healthcare was not yet efficient.Keywords: Drug storage, efficiency, primary healthcare
Inventarytation of medicinal plants as a self-medication by the Tolaki, Puundoho village, North Kolaka regency, Southeast Sulawesi Hasria Alang; Hastuti Hastuti; Muhammad Sri Yusal
Jurnal Ilmiah Farmasi Vol. 17 No. 1 (2021): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol17.iss1.art3

Abstract

AbstractBackground: Traditional medicine knowledge is one of the local wisdoms and is passed down from generation to generation. Traditional medicine needs to be preserved in order to maintain the continuity of this knowledge; besides that, it requires a balance between modern medicine and herbal medicine. Herbal medicine is easy to obtain in the surrounding environment, at affordable prices and guarantees the safety of medicinal chemicals that are harmful to the body. The use of drugs for a long period of time is a habit that is harmful to the body organs because they contain certain chemical compounds that are not safe for human vital organs, so it is necessary to make an inventory effort by digging up information from traditional healers. This research is expected to make a significant contribution so that the role of herbal plants can be maintained and developed in the future.Objective: to inventory the plant species which useful as traditional medicines used by traditional healers of the Tolaki tribe in Puundoho village.Method: The method used in this research is a qualitative exploration, through an emic approach or a community and ethical perspective supported by scientific literature. The use of qualitative methods in this study is intended to describe people's knowledgeResults: The interview results with three traditional healers (mbu'wai) in Puundoho village about plants that can be used as traditional medicines. It can be found on the side of the road, garden and yard. The part of the plant used is the whole plant or part of the plant such as roots, stems, or leaves. The method to blend it is boiled or mashed. The use of traditional medicines is applied orally or topically.Conclusion: The types of traditional medicinal plants used by the Tolaki tribe in Puundoho village can be obtained from yards, gardens, and roadsides including sidaguri, ciplukan, jeringan, bangle, purslane, bandotan, boborongan, turi, meniran, ­­­­banjar berrywit, mesoyi, ketepeng, guava, ginger, kencur, blechnum nails and ketepengKeywords: Herbal medicine, inventarytation, medicinal plants, traditional medicineIntisariLatar belakang: Pengetahuan pengobatan tradisional merupakan salah satu kearifan lokal dan diperoleh secara turun-temurun dari generasi kegenerasi selanjutnya. Pergeseran zaman dan modernisasi dikhawatirkan akan menggerus kearifan lokal tersebut, sehingga perlu dilakukan inventarisasi dengan cara menggali informasi dari para penyehat tradisional. Penelitian ini diharapkan akan memberikan kontribusi yang signifikan, sehingga peran tanaman herbal dapat terus terjaga dan dikembangkan di waktu mendatang.Tujuan: untuk menginventarisasi jenis-jenis tumbuhan yang bermanfaat sebagai obat tradisional yang digunakan oleh penyehat tradisional suku Tolaki di Desa puundoho.Metode: Metode yang digunakan dalam penelitian ini adalah eksplorasi yang bersifat kualitatif, melalui pendekatan emik atau perspektif masyarakat dan etik yang didukung literatur ilmiah. Penggunaan metode kualitatif dalam penelitian ini dimaksudkan untuk mendeskripsikan pengetahuan masyarakatHasil: Hasil wawancara dengan tiga penyehat tradisional (mbu’wai) yang ada di Desa Puundoho tentang tumbuhan yang dapat digunakan sebagai obat tradisional dapat ditemukan di tepi jalan, kebun dan pekarangan. Bagian tanaman yang digunakan adalah keseluruhan bagian tanaman atau sebagian tanaman seperti akar, batang atau daun. Cara meramunya yaitu direbus atau dihaluskan. penggunaan obat tradisional tersebut dilakukan secara cara oral atau topical.Kesimpulan: jenis tanaman obat tradisional yang digunakan oleh suku Tolaki di desa Puundoho dapat diperoleh dari pekarangan, kebun, dan pinggir jalan diantaranya sidaguri, ciplukan, jeringan, bangle, krokot, bandotan, boborongan, turi, meniran, rumput beriwit banjar, mesoyi, ketepeng, jambu air, jahe, kencur, paku blechnum dan ketepeng

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