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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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DIAGNOSIS DINI TOKSOPLASMOSIS KONGENITAL DENGAN PCR CAIRAN AMNION Umatul Khoiriyah
Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2005)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTToxoplasmosis is caused by infection with the protozoan Toxoplasma gondii. CongenitalToxoplasmosis is an infection resulting from the transplasental passage of the parasites frominfected mother to the fetus. An acute infection in pregnant women associated with a range ofoutcomes from subclinical infection to intra uterine death.Early diagnosis is important to makedecision, therapy or abortion. At present, prosedur diagnostic of congenital toxoplasmosis usesconventional methode especially serological test,but the conventional methode is time consuming,and has high risk. PCR amniotic fluid is one methode to make dignostic of conegenitaltoxoplasmosis. This is very sensitif and rapid (24 hours) and safer than serological tes of thefetalblood.PCR can be done from 15 week after gestation.Key word: congenital toxoplasmosis- PCR- amniotic fluid.
EKSPLORASI SIFAT FISIKOKIMIA 2-BENZILIDEN-SIKLOHEKSANA-1,3- DION BERDASAR PERHITUNGAN KIMIA KUANTUM SEMIEMPIRIK Enade Perdana Istyastono
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTAromatic cyclic endione has been predicted qualitatively as anticancer agent. 2-Benzylidenecylclohexane-1,3-dione is the simplest aromatic cyclic endione compound. Physicochemistryproperties of 2-benzylidene-cylclohexane-1,3-dione have been explored. The properties wereexplored by semiempirical quantum-chemical calculations using the computational chemistryapproach. Vibrations spectrum of 2-benzylidene-cylclohexane-1,3-dione has been used todetermine the best semiempirical method. The AM1 semiempirical method was found to be themost appropriate method to describe the structure of 2-benzylidene-cylclohexane-1,3-dione andexplore the physicochemistry properties.Keywords : anticancer, physicochemistry, semiempirical quantum-chemical calculation, 2-benzylidene-cylclohexane-1,3-dione.
IDENTIFIKASI DAN ANALISIS AKRILAMIDA DALAM KOPI SERBUK (TUBRUK) DAN KOPI INSTAN DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI M Hatta Prabowo; Ari Wibowo; Fitri Yuliani
Jurnal Ilmiah Farmasi Vol. 9 No. 1 (2012): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol9.iss1.art1

Abstract

ABSTRAKAkrilamida merupakan salah satu zat yang dapat menyebabkan kanker pada manusia dan bersifat neurotoksik. Akrilamida dapat terbentuk akibat pemanasan suhu tinggi terhadap makanan yang mengandung karbohidrat dan asam amino. Karbohidrat dan asam amino merupakan senyawa utama yang terkandung dalam biji kopi. Penelitian ini bertujuan untuk mengetahui jumlah akrilamida pada serbuk kopi dan kopi instan yang beredar di masyarakat. Metode analisa akrilamida dilakukan dengan metode KCKT menggunakan fase gerak asam fosfat:asetonitril:akuabides (1:5:94 v/v/v), fase diam kolom Sunfire C18 (150 x 4,6 mm id, 5μm), dan laju alir 0,15 mL/menit dengan detektor UV 202 nm. Hasil uji validasi metode yang dilakukan memberikan linearitas 0,999 (range 2-20 μg/mL), LOD 0,94 g/mL dan LOQ 2,86 μg/mL, presisi dengan RSD 0,47 %, dan akurasi serbuk kopi 91-94% serta kopi instan 99-102%. Kadar yang diperoleh menunjukkan kadar akrilamida pada serbuk kopi dan kopi instan masing-masing sebesar 7,03 ± 0,01 μg/g dan 5,71 ± 0,03 μg/g. Kadar akrilamida dalam serbuk kopi dan kopi instan dinyatakan aman berdasarkan FDA apabila konsumsi kopi tidak melebihi 16 g/hari.Kata kunci: akrilamida, serbuk kopi, kopi instan, KCKT, validasiABSTRACTAcrylamide is a substance that can cause cancer on human and is neurotoxic. Acrylamide is formed due to high temperature heating of foods that contains carbohydrates and amino acids. Carbohydrates and amino acids are the major compounds that contained in coffee beans. This study aims to determine the levels of acrylamide in ground coffee and instant coffee that have different process of manufacture. Method of analyze of acrylamide were perfomed by HPLC (High Performance of Liquid Chromatography) method using mobile phase that consists of phosphoric acid : acetonitrile : aquabides (1:5:94 v/v/v), the stationary phase was Sunfire C18 column (150 x 4.6 mm, 5μm), and the flow rate was 0-15 mL/minute and the detection using UV 202 nm. The result of the study was validation of method that provide the linearity 0.999 (range 2-20 μg/mL), LOD of 0.94 μg/mL and LOQ of 2.86 μg/mL, the precision with RSD of 0.47%, and accuracy for ground coffee of 91-94% and instant coffee of 99-102%. The study found acrylamide levels in ground coffee and instant coffee were 7.03 ±0.01 μg/g dan 5.71 ± 0.03 μg/g respectively. These levels were considered safe for up to 16 g for consume of coffee.Keywords : acrylamide, ground coffee, instant coffee, HPLC, validation
PENGHAMBATAN PELEPASAN ENZIM -HEXOAMINIDASE DARI SEL MAST OLEH ZEORIN, SENYAWA DARI AEGLA MARMELOS CORREA Agung Endro Nugroho; Sugeng Riyanto; Mohd. Aspollah Hj. Sukari; Kazutaka Maeyama
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

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ABSTRACTZeorin or 6,22-Dihydroxyhopane is a compound isolated from Aegle marmelos Correacollected in Yogyakarta Indonesia. The molecular structure was confirmed in Universiti PutraMalaysia. This compound was obtained from petroleum ether extract of the leaves of Aeglemarmelos Correa. In present study, we investigated the effects of zeorin on the -hexoaminidaseenzyme release from mast cell culture. The experiment was performed by using rat basophilicleukemia (RBL-2H3) cell line, a tumor analog of mast cells. DNP24-BSA and thapsigargin were usedas immunologic and non-immunologic inducers for -hexoaminidase enzyme release from mastcells, respectively. The release of -hexoaminidase enzyme was determined by using colorimetricmethods with an enzyme substrate, p-nitrofenil-2-Acetamido-2-deoksi--D-gluko-piranosida, and amicroplate reader at 405 nm. In this study, treatment of 20 ng/mL DNP24-BSA and 0.5 Mthapsigargin could stimulate the release of -hexoaminidase enzyme from RBL-2H3 cells by25.421.62 % and 33.163.72 %, respectively. Zeorin showed potent inhibitory effects on the -hexoaminidase enzyme release, when the release induced by DNP24-BSA. In contrast, zeorin showweak inhibitory effects, when the -hexoaminidase enzyme release from RBL-2H3 cells induced bya Ca2+stimulant, thapsigargin. The IC50 values of zeorin’s effects on DNP24-BSA and thapsigarginexperiments were 33,71 M and >100 M, respectively. Based on the results, the inhibitory effect ofzeorin on the -hexoaminidase enzyme release from RBL-2H3 cells involving mechanisms relatedto the interaction of IgE on the mast cell surface or intracellular signal transductions involved inmast cell degranulation.Key words : Aegle marmelos Correa, zeorin, sel mast, -hexoaminidase enzyme
PERANAN BIOLOGI MOLEKULER DAN HTS (HIGH THROUGHPUT SCREENING) DALAM PENGEMBANGAN OBAT SINTETIK BARU Arief Nurrochmad
Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTRecently, the discovery of new drugs uses the new concept by modern techniques instead ofthe convenstional techniques. In the development of scientific knowledge, the role of molecularbiology and the modern techniques in the investigations and discovery new drug becomes theimportant things. Many methods and modern techniques use in the discovery of new drugs, i.e,genetic enginering, DNA recombinant, radioligand binding assay technique, HTS techniques (HighThroughput Screening), and mass ligand screening. In this review article, its focus in the role ofmolecular biology and HTS techniques (High Throughput Screening) which accelerated thediscovery of new drugs. The role of molecular biology will be the important things on thecharacteristic of structure of protein target as well as receptor that interact with the drug molecule orligand. By the modelling binding receptor technique, its will be known the conformation of bindingreceptor and ligand in the three dimension. In addition, by the quantum mechanics, molecularmechanics, and molecular dynamics will be identified the active sites, the consuming energy, andthe conformation of the structure of molecule drug as well as the receptor when its interactbiochemicaly. In other hand, the investigation of active compounds from natural resources stillconducted. The investigation of active compound from natural resources, at present use the HTStechniques (High Throughput Screening) could screen thousand extracts combine with HumanGenom Project data in this technique. By the HTS techniques (High Throughput Screening) will beperformed screening extract from the natural resources rapidly. Active compounds resulted fromthis technique, subsequently identified and characterized the structure of molecules and synthesisinstead of natural resources. Finally the compounds could be synthesized in the large scale.Themolecular biology and HTS technique will play the big roles on the discovery of new drugs. Themolecular bology techniques related the protein target and receptor have been changed the newparadigm in the design of new molecule drugs by rationally, wheares the HTS technique willaccelerated sceening active compounds from natural resources.Key words: molecular biology, HTS (High Throughput Screening), new drugs
PENGARUH TIPE BASIS SALEP TERHADAP AKTIVITAS ANTIFUNGI DARI MINYAK ATSIRI KULIT KAYU MANIS CINA (Cinnamomum cassia Nees ex Bl.) PADA PENGHAMBATAN PERTUMBUHAN Candida albicans C.J. Soegihardjo; Siti Zahliyatul M; Nur Widya Astuti
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTCinnamomum cassia Nees ex Bl. is known in the society as Chinese cinnamon. One ofthe uses of Chinese cinnamon is as a fungicide because of its volatile oil contents. The purpose ofthis research was to find out the base type effect of oil base, emulsion base, water soluble basetoward fungicide activity of Chinese cinnamon barks volatile oil on Candida albicans growthinhibition. The fungicide activity test of Chinese cinnamon barks volatile oil in the three base typeusing diffusion methods (agar plate) was done by measuring the diameter of inhibited area towardCandida albicans growth. The inhibited area diameter result was analyzed with one way anova testand continued with Tukey test at 95% confidential level. The obtained result showed that the threebase type was significantly different toward the fungicide activity of chinese cinnamon barks volatileoil. The largest inhibited area (from largest to the lowest) was water soluble base, emulsion base,and oil base.Keywords : minyak cassia, basis salep, Candida albicans
PERBANDINGAN DAYA ANTIQUORUM SENSING EKSTRAK N-HEKSAN, ETIL ASETAT DAN METANOL KULIT BATANG KRANGEAN (Litsea cubeba (Lour.) Pers.) TERHADAP Pseudomonas aeruginosa Tho’atun Ma'rufah; Triana Hertiani; Hady Anshory
Jurnal Ilmiah Farmasi Vol. 10 No. 1 (2013): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol10.iss1.art2

Abstract

Quorum sensing adalah suatu bentuk komunikasi bakteri yang membantu mengatur perilaku koloni bakteri. Quorum sensing merupakan mekanisme komunikasi berdasarkan ekspresi gen dan populasi bakteri yang mempengaruhi perkembangan biofilm, pompa effluks, produksi toksin, dan faktor virulen lainnya. Quorum sensing inhibitor mengurangi patogenisitas organisme, mengurangi sifat virulen organisme, dan membantu sistem imun untuk membersihkan infeksi bakteri. Quorum sensing inhibitor dapat dikombinasi dengan antibiotik untuk membersihkan patogen yang persisten. Minyak atsiri kulit batang Krangean (Litsea cubeba) diketahui dapat menghambat pertumbuhan bakteri dan pembentukan biofilm Streptococcus mutans. Karena quorum sensing berperan dalam pembentukan biofilm maka dilakukan penelitian aktivitas daya antiquorum sensing kulit batang  Krangean terhadap Pseudomonas aeruginosa. Penentuan kadar hambat minimal dari ekstrak n-heksan, etil asetat, dan metanol dilakukan dengan metode mikrodilusi. Dari hasil penelitian, didapatkan hasil bahwa ekstrak etil asetat merupakan ekstrak yang paling aktif terhadap Pseudomonas aeruginosa dengan kadar hambat minimal 8µg/µl. Ekstrak aktif  etil asetat kemudian diuji daya antiquorum sensing dengan metode sumuran. Hasilnya menunjukkan bahwa ekstrak aktif etil asetat dengan loading sampel 25 mg per sumuran, memiliki aktivitas antibakteri dan hambatan produksi pioverdin. Senyawa aktif diidentifikasi dengan KLT kemudian dilakukan uji bioautografi.  Active compound group was unable to be determined by TLC then bioautography assay. Golongan senyawa yang terdapat di dalam ekstrak etil asetat yaitu alkaloid dan fenolik. 
EFEK ANTIHIPERGLIKEMIA INFUSA KANGKUNG DARAT (Ipomoea reptans Poir) TERHADAP KADAR GLUKOSA DARAH MENC1T JANTAN YANG DIINDUKSI STREPTOZOTOCIN Farida Hayati; Sitarina Widyarini; Helminawati Helminawati
Jurnal Ilmiah Farmasi Vol. 7 No. 1 (2010)
Publisher : Universitas Islam Indonesia

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Penelitian ini dilakukan untuk mengetahui efek antihiperglikemia infusa kangkung darat (Ipomoea reptans P.j pada mencit Swiss jantan yang diinduksi streptozotocin (STZ) dengan parameter pengukuran kadar glukosa darah puasa (KGDP) dan berat badan. Sebanyak 30 ekor mencit Swiss janlan berat 20 - 30 g dibagi menjadi 6 kelompok (N=5). Kelompok I (kontrol normal) yang tidak diberi perlakuan. Kelompok II (kontrol negatif) diberi STZ dosis 40mg/kgbb secara intra peritoneal selama 5 hari berturut-turut. Keiompok III (kontrol positif) diberi metformin 3,9 mg/20gBB. Kelompok IV;V:VI diberi infusa kangkung darat dosis 44,64mg/20gBB; 89,28mg/20gBB; 178,56mg/20gBB. Kangkung darat diberikan secara p.o selama 7 hari berturut-turut yaitu pada hari ke-13 sampai hari ke-19 seEelah pemberian STZ. Pengukuran KGDP pada hari ke-0 (sebelum pemberian STZ), hari ke-13, hari ke-20 dengan cara diarnbi darah secukupnya melalui ekor mencit Swiss jantan yang sudah dipuasakan sebelumnya dan diukur menggunakan glukotest . Data dianalisis dengan analysis of covarian (ANCOVA) dan analysis of varian (ANOVA) (p=0:05). Hasil penelitian menunjukkan bahwa berat badan mencit diabetes rata-rata mengalami kenaikan dibandingkan kelompok kontrol normal sebesar 0,2g/hari dan mencit Swiss jantan mengalami penurunan KGDP setelah diberikan infusa kangkung darat (Ipomea reptans P.) dosis 44,64mg/20gBB; 89,28rng/20gBB; 178,56mg/20gBB sebesar 21,27%; 34,44%: 31,18%.
RESVERATROL OLIGOMERS FROM DIPTEROCARPUS HASSELTII: CYTOTOXIC EFFECT AND CHEMOTAXONOMIC SIGNIFICANCE Muhtadi Muhtadi; Euis H. Hakim; Yana M. Syah; Lia D. Juliawaty; Jalifah Latip
Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2008)
Publisher : Universitas Islam Indonesia

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ABSTRACTTwo resveratrol tetramers, (-)-vaticanol B and (-)-hopeaphenol, were isolated from acetoneextract of the tree bark of Dipterocarpus hasseltii (Dipterocarpaceae), together with the knownresveratrol trimer, (-)-α-viniferin. The structures of these compounds were established based onspectroscopic evidence, UV, IR,1H-NMR,13C-NMR and determined by comparison with thestandard compounds. The cytotoxic activities of these compounds were evaluated against murineleukaemia P-388 cells. The IC50 values of all compounds were 42.2, 5.0 and 17.5 μg/ml,respectively. In addition, chemotaxonomic significance relationship between Dipterocarpus, Shoreaand Vatica will also be briefly discussed.Keywords: Chemotaxonomy, Cytotoxic, Dipterocarpaceae, D. hasseltii,Resveratroltetramer
PENGARUH PEMBERIAN PENTAGAMAVUNON-0 PADA AKTIVITAS GLUTATION-S-TRANSFERASE PADA HATI TIKUS SECARA IN VIVO Sudibyo Martono; Supardjan Amin M; Siti Zahliyatul Munawiroh
Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTGlutathione S-transferase is amount of enzymes catalyze conjugation reac-tion of glutathione(GSH) with electrofilic endogen compound or electrofilic xenobiotic. At the particular cancer there isincreasing GST, especially on mu and phi class that it cause therapy on cancer cell by citostaticdrug (commonly as electrofilic compound) not effectively. Pentagamavunon-0 (PGV-0) is antiinflammationcompound. Base on in vivo research denoted this compound has five timesstrengthened than curcumin to inhibit GST enzyme activity. But using PGV-0 by in vivo to GSTactivity never report or publish yet.This research was done by measuring isolated GST enzyme activity from rat liver was given invivo PGV-0, with nine groups treatment. Each group consist of control group without treatment,control group CMC-Na 0.5 % per oral and intraperitoneal DMSO, group with doses treatment ofPGV-0 20, 40, 80 and 160 mg/Kg BB per oral, rat group was given benzo(a)pirene (BP) 1 mg/KgBB i.p. and group was given BP 1 mg/Kg BB i. p. and PGV-0 80 mg/Kg BB per oral. GST enzymeactivity is measured from reaction of conjugate GSH and DCNB that it’s absorption/minute. Base onrate (absorption/minute) GST enzyme activity can be accounted. Then inhibition percentage can beaccounted from each rat treatment compared with control without treatment and solvent control.Analyze use statistic test (Kruskal-Wallis then continued by Mann-Whitney test), to know specificdifferent of GST class mu enzyme activity in rat liver at each treatments group.Result research denoted that PGV-0 give inhibition effect to GST class mu activity of rat liver byin vivo. Doses level did not give proportional result to GST class mu activity of rat liver. Doses levelof PGV-0 give optimum result to GST class mu activity of rat liver inhibition at 80 mg/Kg BB withinhibition value 19,99 % compared with CMC-Na as solvent.Key word: pentagamavunon-0, in vivo, glutathione S-transferase, inhibition

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