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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 279 Documents
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AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAUN SAMPARE (Glochidion philippicum (Cav.) C.B.Rob.) PADA MENCIT PUTIH JANTAN (Mus musculus) YANG DIINDUKSI PEPTON Amala, Ima Choirul; Sarimanah, Jamilah; Wijayanti, Tri
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art10

Abstract

Background: Sampare leaves (Glochidion philippicum (Cav.) C.B. Rob.) contain secondary metabolites, including flavonoids, tannins, steroids, alkaloids, and saponins, which exhibit antipyretic potential.Objective: This study aimed to evaluate the antipyretic efficacy of the ethanolic extract of sampare leaves in a peptone-induced fever mouse model.Method: The ethanolic extract of sampare leaves was prepared via maceration, and its secondary metabolites were qualitatively identified using standard test-tube reagents. For the in vivo study, twenty-five male Swiss mice (Mus musculus) were randomly divided into five groups. Group I (negative control) received a 0.5% CMC-Na suspension, and Group II (positive control) received paracetamol at a dose of 65 mg/kg body weight (BW). Groups III, IV, and V were administered the ethanolic extract at doses of 200, 400, and 800 mg/kg BW, respectively. Pyrexia was induced via subcutaneous injection of peptone (0.5 mL/g BW). Rectal temperatures were measured using a digital thermometer every 15 minutes for a duration of 180 minutes. Data were analyzed using the Shapiro-Wilk test, followed by repeated measures ANOVA and an appropriate post-hoc test.Results: The maceration process yielded 20.05% (w/w) of ethanolic extract. Phytochemical screening confirmed the presence of tannins, flavonoids, steroids, alkaloids, and saponins. Furthermore, the in vivo evaluation showed that the extract exhibited significant antipyretic activity. The 800 mg/kg BW dose demonstrated the highest antipyretic activity, which was significantly different from the negative control (p < 0.05) and comparable to the positive control (paracetamol). Conclusion: Sampare leaf ethanol extract had antipyretic activity, with an effective dose of 800 mg/kg body weight in mice.
Antioxidant and antiangiogenic potential of kebiul (Caesalpinia bonduc (L) Roxb.) from South Bengkulu as a chemopreventive agent Wulandari, Septi; Wibowo, Risky Hadi; Nurwidiyani, Ria; Hayati , Risda; Nadia; Putri , Amey
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art8

Abstract

Background: Kebiul seeds are an Indonesian medicinal plant with potential antioxidant and chemopreventive properties against cancer. The development, growth, and invasion of malignant cancer closely link to angiogenesis, which antioxidant effects can influence.Objective: This study aims to evaluate the antioxidant activity of kebiul seeds based on the IC50 and their anti-angiogenesis effects.Method: Extraction was performed using the maceration method using ethyl acetate, n-hexane, and ethanol. The anti-angiogenesis test was conducted using the chorioallantoic membrane (CAM) method, while the antioxidant activity was assessed using the diphenylpyrrolhydrazyl (DPPH) method.Results: The finding revealed the antioxidant activity values, as indicated by the IC50, were 45.225 ppm for the ethanol extract (strong antioxidant), 86.190 ppm for the n-hexane extract (strong antioxidant), and 146 ppm for the ethyl acetate extract (medium antioxidant). Anti-angiogenesis tests were conducted across various solvents and concentrations. Significant anti-angiogenesis effects were observed at concentrations of 10, 50, and 1000 ppm. The n-hexane extract yielded average scores of 0.33, 0.66, and 1.3, indicating a good effect. The ethyl acetate extract had average scores of 0.33, 0.5, and 0.66, suggesting a weak effect, while the ethanol extract showed mean scores of 1.33, 1.66, and 2, indicating a strong effect. Conclusion: Ethanol extract demonstrates the most potential as a chemopreventive agent.
Factors affecting glycemic control and kidney function in type 2 diabetes mellitus patients in Yogyakarta Ardhiani, Menit; Febrianti, Yosi; Ningrum, Vitarani Dwi Ananda; Wijaya, Diani Puspa
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art7

Abstract

Background: Type 2 Diabetes Mellitus (Type 2 DM) is a metabolic disease whose prevalence continues to increase and can cause various complications, one of which is diabetic nephropathy, which can lead to kidney failure. Objective: To evaluate the association of sociodemographic and clinical factors of diabetic type 2 patients with HbA1c and eGFR.Methods: A cross-sectional study was conducted among 170 diabetic patients at community pharmacies in Yogyakarta from January 2022 to January 2023. Data were collected from patients' medication records, laboratory results of HbA1c, creatinine, eGFR, and structured questionnaires. A Chi-square test was performed to analyze group differences in categorical variables.Results: Duration of diabetes mellitus (p = 0.021), comorbid hypertension (p = 0.040), and diabetes medication therapy (p < 0.001) were associated with good HbA1c control. Serum creatinine levels were significantly associated with age (p < 0.001). Age (p < 0.001), BMI (p = 0.039), education (p = 0.022), duration of diabetes (p = 0.044), and hypertension comorbidity (p = 0.040) were the factors that affected eGFR. However, no significant correlation was found between HbA1c and serum creatinine (r = 0.114; p = 0.134) or between HbA1c and eGFR (r = 0.026; p = 0.739).Conclusion: There is no significant correlation between glycemic control (HbA1c) and renal function markers (serum creatinine and eGFR) in type 2 diabetic patients.
Phytochemical profiling and in vitro biological evaluation of white dragon fruit (Hylocereus undatus) peel fractions toward HeLa cell line Krisridwany, Annisa; Sari, Sindi Novita; Winanta, Aji; Heresmita, Perdana Priya; Febriansah, Rifki
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art9

Abstract

Background: Cancer is a complex disease characterized by dysregulated cell growth and the potential to invade surrounding tissues. Current therapeutic approaches continue to expand, including increasing interest in bioactive compounds derived from natural products. This study aims to evaluate the biological activity of ethanol, n-hexane, and ethyl acetate fractions of Hylocereus undatus (white dragon fruit) peel extract against the HeLa cervical cancer cell line.Method: The extraction process was performed using the maceration method, and phytochemical screening was conducted using stain reagents. The cytotoxicity test was carried out using the MTT assay with concentrations of 1000, 500, 250, 125, 62.5, and 31.25 µg/mL, while morphological changes were observed under an inverted microscope.Results: The phytochemical screening indicated that alkaloids, steroids, and triterpenoids were present in the n-hexane fraction; flavonoids and tannins in the ethanol fraction; and flavonoids, alkaloids, and tannins in the ethyl acetate fraction. The highest IC50 value (311.27 µg/mL) was observed on the n-hexane fraction compared to the other fractions. The HeLa cell line showed shrinkage after treatment with all fractions. Conclusion: Of the three tested fractions, cytotoxicity was observed solely in the n-hexane fraction, whereas the ethyl acetate and ethanol fractions remained inactive against HeLa cells.
Utilizing big data and data mining to detect adverse drug reactions in pharmacovigilance systems Taufiqurrahman , Muh.; Simanullang, Raymon; Alichia Ayu Susan; Nainggolan, Angel Natalia; Dinda Alya Arianti; Donangsia Wunga Sogen; Falen Sindi Ayugistia; Pijaryani, Indria
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art2

Abstract

Background: Adverse Drug Reactions (ADRs) remain a global health problem, increasing morbidity, mortality, and costs. The Spontaneous Reporting System (SRS), while central to pharmacovigilance, suffers from underreporting and delayed signal detection. Advances in big data and data mining offer solutions to these limitations.Objective: This review evaluates the use of statistical, Bayesian, and artificial intelligence (AI)-based methods to improve early detection of ADR signals in large pharmacovigilance databases.Method: A literature review was conducted on 12 studies applying statistical methods (reporting odds ratio and proportional reporting ratio), Bayesian approaches, and AI techniques (machine learning and natural language processing) to datasets including FAERS, WHO VigiBase, VigiFlow, and national AEFI systems.Results: Disproportionality analysis aided early screening but was limited in detecting rare events and prone to false positives. Bayesian methods improved stability and accuracy for low-frequency signals. Machine learning enhanced predictive performance and reduced false alarms, while NLP facilitated processing of unstructured reports. The combined application of these methods enhanced sensitivity, specificity, and validity of pharmacovigilance systems. Conclusion: The integration of big data with statistical, Bayesian, and AI approaches significantly advances pharmacovigilance by enabling faster and more accurate ADR detection, though challenges in data quality, privacy, and clinical validation remain.
Uji Aktivitas Krim Tabir Surya yang Mengandung Ekstrak Etanol Alga Coklat (Sargassum sp.) Rosidah, Sofiatun; Sayekti, Endah; Rahmalia, Winda
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art6

Abstract

Background: Sunscreen protects the skin against ultraviolet (UV) radiation, particularly UVB, which is a major contributor to skin damage. Brown algae (Sargassum sp.) are rich in phenolic antioxidant compounds with potential as natural sunscreen agents. However, research on the incorporation of ethanolic extracts of Sargassum sp. into topical cream formulations and on the evaluation of both their photoprotective activity and formulation stability remains limited. This study therefore offers a fresh perspective on the dual role of brown algae extracts as natural sunscreen ingredients and stabilizing components in cosmetic preparations.Objective: This study aims to develop a cream formulation containing the ethanolic extract of Sargassum sp. and to evaluate its sunscreen activity.Method: The extract was obtained by maceration using 96% ethanol and subsequently subjected to phytochemical analysis. Cream formulations were prepared with six concentrations of the extract (0, 0.07, 0.13, 0.20, 0.27, and 0.43%) and evaluated for homogeneity, pH, spreadability, and in vitro Sun Protection Factor (SPF) using a UV-Vis spectrophotometer.Results: All cream formulations were stable, homogeneous, and exhibited pH values between 4.7 and 5.8, consistent with SNI 16-4399-1996 standards. The highest SPF value was observed in the 0.43% formulation, reaching 6.234 ± 0.503, which is categorized as extra protection. The sunscreen activity is attributed to phenolic compounds in the extract, which possess both antioxidant properties and UV-absorbing capacity.Conclusion: Sunscreen cream formulations containing the ethanolic extract of Sargassum sp. met the required physical stability standards. SPF testing revealed that the 0.43% extract formulation (KTS5) produced the highest SPF value, 6.234 ± 0.503, which is classified as extra protection and indicates optimal sunscreen activity.
Effect of astaxanthin-enriched virgin coconut oil concentration on lip balm properties and sun protector factor (SPF) activity Prayitno, Dwi Imam; Rahmalia, Winda; Herlina, Elisabet
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art1

Abstract

Background: Our previous research successfully extracted astaxanthin from fermented Acetes shrimp (cincalok) using virgin coconut oil (VCO), resulting in astaxanthin-enriched VCO (VCOA). This innovative approach demonstrates the feasibility of incorporating VCOA into cosmetic preparations. In particular, its application in lip balm formulationsObjective: This study aimed to formulate a lip balm incorporating VCOA in combination with tengkawang butter.Method: The physical properties and sunscreen activity of the lip balm were evaluated as a function of storage duration at room temperature. The study examined the influence of varying concentrations and compositions of astaxanthin-enriched virgin coconut oil (VCOA) and illipe fat on the formulation. Key parameters assessed included homogeneity, pH stability, color stability, and melting point.Results: The test results indicated that a homogeneous lip balm was obtained when a high concentration of VCOA (15-30% w/w) was used and was stable for 28 days of storage. The acidity level (pH: 4.56-6.69) and melting point of the lip balm (50–67°C) have met the Indonesian National Standard. The presence of VCOA causes the lip balm to be yellow to orange. The resulting lip balm shows a sun protection factor (SPF: 51.1674 ± 0.0364) value with an ultra-protection category.Conclusion: In this study, astaxanthin was extracted from cincalok using VCO to produce VCOA, which was directly applied as a lip balm ingredient. The application of VCOA at the highest concentration (30%) yielded lip balm with excellent homogeneity, stable pH and melting point in accordance with SNI standards, the most pronounced color, and the highest SPF value.
Penetapan Nilai Rujukan Retikulosit pada Remaja Perempuan Menggunakan Sysmex XN-1000 Hematology Analyzer Ratnaningsih, Tri; Kaslam, Surawijaya Bakhtiar; Rinastiti, Pranindya
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art3

Abstract

Background: Iron Deficiency Anemia (IDA) remains a significant health concern among adolescent females. Reliable and effective parameters are required for the monitoring of anemia. Reticulocyte, reported as absolute reticulocyte count or reticulocyte percentage, is a valuable parameter for assessing the degree of effective erythropoiesis in anemia cases. Establishing appropriate reference values is essential for accurate interpretation of reticulocyte measurements. Objective: This study aimed to establish reference intervals for reticulocyte parameters specifically in adolescent females using the Sysmex XN-1000 hematology analyzer. Method: A peripheral blood sample was collected from female high school students aged 14-19 years who were not menstruating at the time of sampling. Blood collection was done via venipuncture into K3-EDTA tubes and further analyzed using the Sysmex XN-1000 hematology analyzer.Results: The established reference intervals were as follows: reticulocyte percentage (Ret%) 0.665–2.099%; absolute reticulocyte count (Ret#) 0.0312–0.0977 × 10⁶/µL; and reticulocyte hemoglobin (Ret-He) 26.524–32.574 pg. Data were normally distributed (p > 0.05). Reference intervals were calculated using the formula mean ± 1.96 standard deviation, with a 95% confidence level.Conclusion: This study successfully established specific reference intervals for reticulocyte parameters in adolescent females using the Sysmex XN-1000 hematology analyzer.
Prevalensi dan Karakteristik Interaksi Obat Potensial pada Resep Pasien Anak Rawat Inap: Evidence dari Rumah Sakit Regional di Indonesia Rizky Aulia; Cholisoh, Zakky
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art4

Abstract

Background: Drug interactions represent a significant medication safety concern among pediatric inpatients. Pediatric patients possess distinct pharmacokinetic characteristics compared to adults, rendering them more vulnerable to adverse effects from concurrent drug administration. Objective: This study aimed to analyze potential drug-drug interactions (DDIs) in the prescriptions of pediatric inpatients at Dr. H. Andi Abdurrahman Noor Regional Hospital, Tanah Bumbu Regency. Method: A descriptive cross-sectional study with retrospective data collection was conducted on 143 patients meeting the inclusion criteria from a total of 221 patients during the period of September–November 2025. Drug interaction identification was performed using the drugs.com database. Results: Results showed that of the 143 analyzed prescriptions, 81 (56.6%) contained potential drug interactions, comprising 27 interacting drug pairs and a total of 107 interaction events. By mechanism, pharmacokinetic interactions predominated at 55.1%, followed by pharmacodynamic interactions at 44.9%. By severity, moderate interactions were most prevalent (54.2%), followed by minor (36.4%) and major (9.3%). The most frequently interacting drug pairs were paracetamol–ranitidine (18.7%), cefotaxime–gentamicin (13.1%), and diazepam–valproic acid (8.4%). The most clinically significant major interactions included diazepam–phenobarbital, gentamicin–furosemide, furosemide–propranolol, and dexamethasone–phenobarbital.Conclusion: These findings highlight the high prevalence of potential DDIs in pediatric inpatients and underscore the necessity for rigorous therapeutic monitoring and active clinical pharmacist involvement in the prescribing process.

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