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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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ASPEK FARMAKOLOGI TETRAHIDROKURKUMIN: METABOLIT UTAMA KURKUMIN Agung Endro Nugroho
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTTetrahydrocurcumin is a main metabolite product from biotransformation process of curcuminin the body. Biotransformation of curcumin is fast and occurred during absorption process ingastrointestinal tract. The biotransformation of curcumin to tetrahydrocurcumin and the stability oftetrahydrocurcumin play important roles in the biological effects of curcumin in the body. Thepresent article discussed about the pharmacological aspects of tetrahydrocurcumin.Tetrahydrocurcumin was reported possessing several pharmacological activities such as:antioxidant, anti-inflammatory, hepatoprotector, anti-allergy, protective for atherosclerosis and renaldamage, and also anticarcinogenesis. It’s main pharmacological activity is antioxidant, which isunderlying and responsible for the other activities. The antioxidant activity of tetrahydrocurcuminwas reported better than this of curcumin. The main factors for the antioxidant or free radicalscavenger effects of tetrahydrocurcumin are it’s aromatic/phenolic hydroxy and -diketon moieties.Key words : tetrahydrokurcumin, curcumin, pharmacology, antioxidant
KAJIAN DRUG-RELATED PROBLEMS DAN GAMBARAN KUALITAS HIDUP PASIEN HEMODIALISIS RUTIN LANJUT USIA DI RSUP DR. SARDJITO YOGYAKARTA Ndaru Setyaningrum; Djoko Wahyono; I Dewa Putu Pramantara
Jurnal Ilmiah Farmasi Vol. 9 No. 1 (2012): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol9.iss1.art4

Abstract

ABSTRAKPertumbuhan populasi lanjut usia secara global meningkat paling cepat diantara kelompok usia lain. Populasi lanjut usia berhubungan dengan penurunan fungsi ginjal dan berbagai komorbiditas akibat proses penuaan. Pasien lanjut usia dengan gagal ginjal kronik berisiko tinggi mengalami drug-related problem (DRP) sehingga berpengaruh terhadap kualitas hidup pasien. Penelitian ini dilakukan untuk mengetahui hubungan kejadian DRP dengan kualitas hidup pasien hemodialisis rutin lanjut usia. Penelitian cross sectional terhadap pasien hemodialisis rutin periode 22 Oktober 2012 – 22 Januari 2013. Kajian DRP berdasarkan data pengobatan kemudian ditelaah secara literatur dan wawancara pasien. Pengukuran kualitas hidup menggunakan kuesioner SF-36. Penilaian kepatuhan dan efek samping obat masing – masing menggunakan Modified Morisky Scale dan Naranjo Scale. Karakteristik 38 subjek penelitian usia < 70 tahun (24 pasien) dan ≥ 70 tahun (14 pasien); jenis kelamin pria (26 pasien) dan wanita (12 pasien); lama hemodialisis < 8 bulan (8 pasien) dan ≥ 8 bulan (30 pasien); penyerta DM (23 pasien) dan non DM (15 pasien). Kajian DRP 53 kejadian berupa interaksi obat (30 kejadian); ADR (8 kejadian); pemilihan obat kurang tepat (4 kejadian); gagal menerima obat (4 kejadian); dosis sub terapi (3 kejadian); terapi tanpa indikasi (2 kejadian); dosis berlebihan (1 kejadian); dan indikasi tanpa terapi (1 kejadian). Hasil pengukuran rerata kualitas hidup±SD (52,16±11,82); PCS±SD (44,52±13,91); dan MCS±SD (60,27±14,00). Hasil analisis korelasi Pearson kualitas hidup dengan kejadian DRP bermakna tidak signifikan (p>0,05). Penelitian ini tidak menunjukkan korelasi signifikan antara kejadian DRP dengan kualitas hidup pasien hemodialisis rutin lanjut usia.Kata kunci : DRPs, hemodialisis, lanjut usia, kualitas hidup, RSUP Dr. Sardjito YogyakartaABSTRACTThe growth of elderly population increase fastest among the other age group. The elderly population been related to decrease renal function and other comorbidity as consequence of aging. The elderly patient with chronic kidney failure on high risk of drug-related problem (DRPs) so can attribute to patient’s quality of life (QoL). The aim of this study is to know how about corelation of DRPs event and QoL of elderly patient on routine hemodialysis. This is a cross sectional study about elderly patient on routine hemodialysis on period October 22th 2012 – January 22th 2013. The study of DRPs based on medication list then been analyzed theoritically and interview to patient. The measuring of QoL use SF-36 questionaire. Assessment of adherence and drug side effect use Modified Morisky Scale and Naranjo Scale. There were 38 subjects analized, age < 70 years old (24 patients) and ≥ 70 years old (14 patients); gender men (26 patients) and women (12 patients); duration hemodialysis < 8 months (8 patients) and ≥ 8 months (30 patients); comorbidity DM (23 patients) and non DM (15 patients). There were 53 events DRPs consist of drug interactions (30 events); ADR (8 events); inproper drug selection (4 events); failure to receive drug (4 events); subtherapeutic dose (3 events); drug use without indication (2 events); overdose (1 event) and untreated indication (1 event). The result of mean QoL±SD (52.16±11.82); PCS±SD (44.52±13.91); and MCS±SD (60.27±14.00). The Pearson corelations of QoL and DRP event is not significant (p>0.05). This study show not significant correlation between DRPs event and QoL of elderly patient on routine hemodialysis.Keywords : DRPs, Dr. Sardjito Hospital Yogyakarta, elderly, hemodialysis, quality of life
UJI DISINTEGRASI DAN DISOLUSI TERBANDING TABLET ALOPURINOL GENERIK BERMEREK DAN GENERIK BERLOGO YANG BEREDAR DI PASARAN Bambang Hernawan Nugroho; Yandi Syukri; Anik Ariyani
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTAllopurinol is a pyrimidine derivative that effective to normalize levels of uric acid in bloodand urine. Allopurinol is very slightly soluble in water, but it has high permeability (BCS class II) sothat the dissolution is an important determine to express the drug bioavailability. Additional materialdifferences and the production process of each plant can cause differences in the quality of theresulting allopurinol tablets. This study aimed to compare the quality of branded generic andgeneric products allopurinol tablets in the quality of disintegration and dissolution. This study used 5kinds branded generic (A, B, C, D, E) and 5 kinds of generic products (F, G, H, I, J). Disintegrationtest carried out according to USP-NF 32ndedition by the medium of water at 37 ± 2°C. Dissolutiontests conducted according to USP-NF 32ndedition using apparatus 2 (paddle methode), the speedof rotation 75 rpm, in 0.01 N HCl medium at 37 ± 0.5°C. The data obtained compared with therequirements listed in the Indonesia Pharmacopoeia 4thedition and USP-NF 32ndedition, and thenstatistically analyzed by T test at 95% confidence interval. Results of disintegration and dissolutiontests met the requirements in the literature. Statistical test results showed that products haddifferent disintegration and dissolution profile.Keywords: allopurinol, disintegration, dissolution, tablets
KETOKSIKAN AKUT TABLET EFFERVESCENT DARI EKSTRAK DAUN SIRIH (Piper betle L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR Farida Hayati; Retno Murwanti; Dwi Brilyani Sandy
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

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ABSTRACTA research on acute toxicity of effervescent tablet from Piper betle leaf extractum on wistaralbino male rats was done. This research aimed to determine acute toxicity potential ofeffervescent tablet from piper betle leaf extractum, evaluated clinical symptom that perhaps occurdue to the giving of effervescent tablet, single dosage orally on 24 hours to 15 days observation.The research uses male rats, which are divided into 5 groups. Group I was negative control withaquadest. Group II was given sample with 0,38 g/kgBW dosage. Then, succesively group III with1,03 g/kgBW dosage, group IV with 2,79 g/kgBW dosage and group V was given test sample withhighest dosage, that was 7,50 g/kgBW dosage. On the basis of data analysis result having beenperformed both quantitively and qualitatively, it could be said that in general, the giving ofeffervescent tablet from Piper betle leaf extractum single dosage orally on male rats from 0,38g/kgBW dosage to highest level (7,50 g/kgBW) or approximately 19,74 times of therapy dosage,didn’t cause toxic effect. It didn’t cause mortality on research animal. So we can determine thequasi LD50, that was bigger than 7,50 g/kgBW, according to Loomis criteria (1978), that acutetoxicity potential of effervescent tablet from piper betle extractum was practically not toxic category.Key words: acute toxicity, effervescent tablet, Piper betle
PENINGKATAN DISOLUSI FUROSEMIDA DENGAN PEMBENTUKAN KOMPLEKS INKLUSI MELALUI KOPRESIPITASI MENGGUNAKAN β- SIKLODEKSTRIN Nurul Ainah; Yandi Syukri; M. Hatta Wibowo
Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTFurosemide is a diuretic drug, which is insoluble in water. Due to this condition, it is needed away to increase the dissolution rate with forming of inclusion complex in copresipitation systemwhich produce as solid dispersion product using β-cyclodextrin carrier. The copresipitation systemwas made up of 1 : 0,5; 1 : 1; 1 : 1,5 and 1 : 2 variation concentration of furosemide- β-cyclodextrin. The characteristic forming of inclusion complex in solid dispersion system wasevaluated by infrared analysis and then followed by HyperChem molecular model analysis. Thedissolution test was done in order to see the increasing of dissolution rate and this test is usedbuffer phosphate pH 5,8 as the medium with rotation speed 100 rpm at 37 ± 0,50C for 60 minutes.The amount of dissoluted furosemide was then analyzed by spectrophotometric test. Thedissolution parameter with Dissolution Efficiency (DE) is conducted in 10, 30, and 60 minutes. Thedata were analyzed with Two Way ANOVA at p
IDENTIFIKASI DAN PENENTUAN KONSENTRASI ION LOGAM Cr, Fe, Cu, Zn, Cd dan Pb PADA DEBU JALANAN DI SEKITAR KAWASAN MALIOBORO YOGYAKARTA Allwar Allwar
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTIdentification and determination of heavy metal ions Cr, Fe, Cu, Zn, Cd and Pb on the duststreet around Malioboro area have been done. Malioboro area is one of the shopping centre andpedestrian tourism place in Yogyakarta that is the most crowded area. In summer season,Malioboro was not pleasant to visit caused by dry and hot climate, crowded and smell of exhaustedautomobile. These reason have been used to select Malioboro as a place for collecting dustsample. The dust has been obtained from five different locations such as location A station Tugu,location B Mall Matahari, location C governor office, location D pasar Bringharjo and location Ecross section of pos office. The dust sample was analyzed to identify and determine its metal ionscontain Cr, Fe, Cu, Zn, Cd and Pb using Atomic Absorption Spectrophotometry. The result of thisexperiment show that the highest concentration of ion metals at each location are Cu 656,75μg/gat location A , Fe 548,16μg/g at location B, Fe 420,16μg/g at location C, Pb 729,16μg/g at locationD and Fe 652,16µg/g at location EKey words: Dust sample, Malioboro street, Cr, Fe, Cu, Zn, Cd and Pb, Atomic AbsorptionSpectrophotometry
UJI AKTIVITAS HEPATOPROTEKTIF TEH HIJAU KOMBUCHA PADA TIKUS PUTIH YANG DIINDUKSI PARASETAMOL M.Thesa Ghazali; Puguh Novi Arsito
Jurnal Ilmiah Farmasi Vol. 9 No. 2 (2012): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol9.iss2.art3

Abstract

Parasetamol adalah obat analgesik-antipiretik yang mempunyai efek hepatotoksik ketika digunakan pada dosis yang tinggi. Toksisitas parasetamol ini disebabkan karena pembentukan senyawa racun dari beberapa bagian obat yang dimetabolisme oleh sitokrom P450. Penelitian ini bertujuan untuk menguji aktivitas hepatoprotektif teh hijau kombucha pada tikus albino galur wistar. Gangguan hati akut dilakukan dengan cara menginduksi parasetamol dengan dosis 740mg/kg BB. Teh hijau kombucha diberikan dengan 0,5, 1,0, dan 1,5 ml peroral diberikan selama 7 hari. Parameter biokimia hati (kadar SGOT, SGPT) diukur dengan menggunakan spektrofotometer, dan kemudian dicatat berat hati tikus (bobot per 100 gram). Hasil penelitian menunjukkan bahwa teh hijau kombucha dengan dosis yang sudah ditentukan dapat mencegah peningkatan bobot hati tikus secara signifikan dengan nilai p <0,05 ketika dibandingkan dengan kelompok hewan uji yang diinduksi parasetamol. Teh hijau kombucha dengan dosis 1,0 ml lebih efektif dari dosis laim 0,5 dan 1,5 ml. Teh hijau kombucha memberikan efek hepatoprotektif secara signifikan dengan nilai p<0,05 dengan menurunkan aktitivas enzim serum seperti SGOT dan SGPT. Teh hijau kombucha dengan dosis 1,0 ml juga efektif menurunkan kadar SGOT dan SGPT. Kesimpulan dari penelitian ini adalah teh hijau kombucha mempunyai aktivitas hepatoprotektif yang baik.Kata kunci: efek hepatoprotektor, parasetamol, teh hijau kombuchaABSTRACTParacetamol is an analgesic-antipyretic drug that has hepatotoxic effect when taken in high doses. Paracetamol toxicity is due to the formation of toxic metabolites when a part of it is metabolized by cytochrome P450. This study was designed to evaluate the hepatoprotective activity of green kombucha tea (GKT) in wistar albino rats. Acute liver injury was induced by paracetamol (750mg/kg, b.w). GKT at the dose of 0.5, 1.0, and 1.5 ml, p.o was administered for 7 days. The biochemical parameters of liver such as serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT) levels were measured using spectrophotometer. Finally, the liver weight (Wt/100g b.w) of rats were recorded. GKT in all doses prevented the increase of liver weight significantly (p<0.05) when compared with paracetamol treated rats. The dose 1.0 ml of GKT was found to be the most effective than the other dose (0.5 and 1.5 ml). GKT produced hepatoprotective effect significantly (p<0.05) by decreasing the activity of serum enzyme such us SGOT and SGPT. The 1.0 ml dose of GKT also found to be the most effective dose to decrease the levels of SGOT and SGPT. It is concluded that the Green kombucha tea possesses good hepatoprotective activity.Keywords: green kombucha tea, hepatoprotective effect, paracetamol
DRUG UTILIZATION 90% (DU90%) PROFILE OF ANTIBIOTIC FOR TREATMENT OF HOSPITALIZED PATIENTS WITH URINARY TRACT INFECTIONS AT TWO HOSPITAL IN YOGYAKARTA Saepudin Saepudin
Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2008)
Publisher : Universitas Islam Indonesia

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ABSTRACTUrinary tract infections (UTIs) are the most common bacterial infection and account forsignificant morbidity and health care cost. It was well accepted that data of antibiotic utilization fortreatment of infectious diseases are needed in developing antibiotic use policy. Antibiotic utilizationstudy can provide useful information for improvement of the appropriate and effective antibiotic use.This research aims to compare antibiotic utilization for treatment of hospitalized patients withurinary tract infections at two hospitals in Yogyakarta based on drug utilization 90% (DU90%)profile. Data of antibiotic prescription were obtained from patient’s medical record for patientswhich were hospitalized during 2005 at hospital A (650 beds) and B (250 beds). Quantity ofantibiotics utilization was calculated as the number of defined daily dose (DDD) per 100 bed days(BD) based on ATC/DDD system released by WHO Collaborating Centre for Drug StatisticsMethodology. The antibiotics were ranked by percentage of DDD/100BD and antibiotics thataccounted for 90% (DU90%) were determined. Total of antibiotics use for hospitalized patients withUTIs at hospital A amounts to 65.77 DDD/100 BD included 14 classes, consisted of 24 agents ofantibiotic. Total antibiotics use at hospital B amounts to 58.22 DDD/100 BD included 9 classes,consisted of 13 agents of antibiotic. Ceftriaxone was the greatest antibiotic used at both hospitals.There were 9 items of antibiotics within DU90% at hospital A and 7 item of antibiotics at hospital B.There was a difference in the utilization of antibiotics for hospitalized patients with UTIs at twohospitals in Yogyakarta based on total number of antibiotics and number of antibiotics withinDU90% segment.Keywords : Antibiotic, ATC/DDD, DU90%, Urinary Tract Infections
PENGARUH TINGKAT PENDIDIKAN TERHADAP TINGKAT PENGETAHUAN MASYARAKAT TENTANG PENGOBATAN SENDIRI (SELF MEDICATION) DI WILAYAH KABUPATEN SLEMAN JOGJAKARTA Nanang Munif Yasin
Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2004)
Publisher : Universitas Islam Indonesia

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A B S T R A C TThe motivation for taking self medication increased as well as the growth of drugsproduction in Indonesia. Self medication will taking a risk, so that it must be followed by the enoughsociety knowledge about medicine. The research about an Influence of Education Level to theSociety Knowledge Level about Self Medication in Sleman Yogyakarta had been done. Thisresearch tried to shoot the society knowledge level about the aspects corelated with self medicationand an influence between the education level increased to the society knowledge level about selfmedication. From this research, can be hopen that the problems about irrasional drug using in selfmedication will be decreased. A sample that had been used is the society in Sleman Yogyakarta.The sample had been taken by stratified random sampling. This research was explorative and thedata had been gotten by quisioner and interview. The analysis of data had been done by thedescriptive statistic analysis and interferention analysis. The result showed that there was asignifican difference between education level with medium and high education level aboautknowledge of self medication. Mean value were 63,35 ± 7,27 ; 68,56 ± 6,29 ; dan 68,69 ± 7,72 .The difference specially about drugs classification, side effect of drugs and characteristic of drug.The result showed that if the eduacation level increased, the society knowledge level about selfmedication will be increased.Key word : drug, self medication, knowledge, education level
KEAMANAN PEMBERIAN BERULANG EKSTRAK KANGKUNG DARAT (Ipomoea reptans,Poir) TERSTANDAR TERHADAP FUNGSI GINJAL DAN HEPAR MENCIT BETINA Farida Hayati; Retno Murwanti; Ginna Zabrina
Jurnal Ilmiah Farmasi Vol. 10 No. 1 (2013): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol10.iss1.art1

Abstract

Kangkung darat terbukti memiliki aktifitas antihiperglikemia pada mencit betina galur swiss yang diinduksi streptozotosin. Penelitian ini dilakukan untuk mendapatkan kajian keamanan pemberian berulang ekstrak kangkung darat terstandar terhadap fungsi ginjal dan hepar pada mencit betina. Dua puluh hewan uji dibagi ke dalam 4 kelompok, yaitu kelompok kontrol (akuades 10 ml/ kg), dosis I (ekstrak etanolik kangkung darat 480 mg/ kg), dosis II (ekstrak etanolik kangkung darat 759 mg/ kg), dan  dosis III (ekstrak etanolik kangkung darat 1200 mg/ kg). Ekstrak etanolik kangkung darat diberikan 1 kali sehari secara p.o. selama 14 hari. Pengamatan gejala toksik dilakukan selama 3 jam setelah pemberian senyawa uji. Kelompok dosis 1200 mg/ kg mengalami efek sedasi, konstipasi, dan feses berwarna hitam selama pemberian ekstrak etanolik kangkung darat terstandar, sedangkan kelompok lainnya tidak mengalami gejala toksik. Data berat badan, pemeriksaan ALT, dan pemeriksaan AST dianalisis secara statistik. Berat badan rata-rata hewan uji kelompok dosis 759 mg/ kg mengalami penurunan yang paling banyak dibandingkan kelompok lainnya dan berbeda signifikan dengan kelompok kontrol dari hasil analisis statistik. Kadar AST dan ALT mengalami peningkatan setelah pemberian berulang ekstrak etanolik kangkung darat selama 14 hari, dari hasil analisis statistik kadar ALT dan AST kelompok dosis 759 mg/ kg dan dosis 1200 mg/ kg berbeda signifikan dengan kelompok kontrol (p<0,05). Hasil histopatologi organ ginjal dan hepar hewan uji setelah pemberian berulang ekstrak etanolik kangkung darat terstandar selama 14 hari menunjukkan tidak adanya perubahan yang membahayakan pada organ.

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