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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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PENGARUH SUSU KEDELAI DOSIS 25 ml/kg BB TERHADAP BIOAVAILABILITAS TEOFILIN PADA TIKUS PUTIH JANTAN Farida Hayati; Arief Rahman Hakim
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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Abstract

Research has been conducted to study the effect of soya milk 25ml/kg BW per oral toward theophyline bioavailability when given concomittantly in male white rats. The study was done by using of wistar male white rats, weight 200-300 grams, age 3-4 month. The experimental design used was completely randomized design with two groups treatment, which each group test contained five rats. The first group (control) was given single dose pre-treatment of theophyline (25 ml/kg BW, orally), the second group (treatment) was given theophyline and soya milk (25 ml/kg BW, orally) with theophyline 25mg/kg BW. Blood samples were taken periodically from eye vein of rat in the 0,25; 1; 1,5; 3; 5; 6; 8; 10; and 24 hours. Determination of theophyline levels was done with HPLC by using Orcutt and friends method (1977) modified on the 269 nm wavelength. The concentration of theophyline was determined based on a standard curve. Theophyline bioavailability i.e. tmax, Cmax, and AUC0 inf was determined from the concentration to time data . Bioavailability parameters in the first group were tmax 2,36 ± 0,44 hours, Cmax 18,97± 2,06, AUC0 inf 231,48± 34,94 ug.hours/ml and bioavalibility parameters in the second group were tmax 2,08 ± 0,"l 7 hours, Cmax 24,11 ± 1,54, AUC0,nf 210,13±7,25 ug.hours/ml. The results indicated that soya milk was not found to be able to change theophyline bioavailability (P>0,05).
BIOACTIVE CONSTITUENTS FROM THE LEAVES OF MELASTOMA MALABATHRICUM L. Deni Susanti; Hasnah M. Sirat; Farediah Ahmad; Rasadah Mat Ali
Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2008)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTPhytochemical and bioactivity studies of the leaves of Melastoma malabathricum L.(Melastomataceae) have been investigated. The n-hexane extract yielded -amyrin, patriscabatrineand auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gavequercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts andisolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidantassay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op-trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition morethan 90% in the FTC method. Quercetin was found to be the most active as radical scavenger inDPPH method with IC50 of 0.69 M. -Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl)glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPAmouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively.Keywords: Antiinflammatory, Antioxidant, Flavonoids, Melastomataceae, Melastomamalabathricum, Terpenoid
AKTIVITAS ANTHELMINTIKA EKSTRAK ETANOL DAN EKSTRAK KLOROFORM RIMPANG BENGLE (Zingiber purpureum Roxb.) TERHADAP CACING Ascaridia galli Schrank SECARA IN VITRO BESERTA PROFIL KROMATOGRAFI LAPIS TIPIS Intan Permata Dewi; Wiharni Wiharni; C.J. Soegihardjo; Endang Darmawan
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTPurple ginger (Zingiber Purpureum Roxb.) could be use as therapy for ascariasis. Theanthelmintic activity test by in vitro has been tested to get the validity of the effect. The maincomponents of the test is powder of purple ginger rhizoma which had been extracted bypercolation method with ethanol and maseration method with kloroform. Anthelmintic test had beendone by immersion method. The Ascaridia galli Schrank was soak in natrium chloride 0,9 %,pyrantel 0,125 %, extract ethanol 0,702 %, 1,404 %, 2,808 %, 5,616 % and exstract kloroform0,644 %, 1,288 %, 2,576 %, 5,152 %. From the test it could be concluded that the extract has theanthelmintic effect. The result evolution had been done by one way ANOVA method (P
ANALISIS RESIDU ANTIBIOTIK KLORAMFENIKOL DALAM DAGING IKAN GURAMI (Osphronemus gouramy, Lac) MENGGUNAKAN METODE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY Ari Wibowo; Lukysanita Muliana; M. Hatta Prabowo
Jurnal Ilmiah Farmasi Vol. 7 No. 1 (2010)
Publisher : Universitas Islam Indonesia

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Abstract

Penggunaan kloramfenikol (CAP) pada hewan produksi untuk tujuan non-terapetik berpotensi menimbulkan akumulasi residu CAP pada jaringan dan organ hewan tersebut. Manusia yang mengkonsumsi produk ternak yang mengandung residu CAP dapat berdampak buruk bagi kesehatannya, karena berpotensi menimbulkan reaksi hipersensitivitas, deperesi sumsum tulang belakang (anemia aplastik), bahkan resistensi CAP pada manusia. Komoditi perikananan yang sering menggunakan antibiotik untuk meningkatkan produksinya adalah ikan gurami (Osphronemus gouramy, Lac). Penelitian ini bertujuan untuk menganalisis kadar residu antibiotik CAP dalam daging ikan gurami dengan metode HPLC (High Performance Liquid Chromatography), kemudian kadar yang diperoleh dibandingkan dengan BMR (Batas Maksimum Residu) antibiotik pada bahan makanan asal hewan (SNI 01-6366-2000). Kurva kalibarsi menunjukkan linieritas yang baik pada range 5 – 40 ng/ml (r = 0,9995). Hasil penelitian menunjukkan ikan gurami yang dijual diketiga pasar tradisional yaitu sebesar 0,276; 0,281; 1,168 ng/g. Kadar residu CAP yang diperoleh tidak melebihi BMR berdasarkan batasan pada Standar Nasional Indonesia (0,01 mg/kg), namun kadar CAP dari salah satu pasar tidak memenuhi persyaratan oleh European Union (0,3 μg/kg). 
FORMULASI TABLET EKSTRAK KANGKUNG AIR (Ipomoea aquatica F.) DENGAN VARIASI KADAR AMILUM MANIHOT SEBAGAI BAHAN PENGHANCUR Sutrisna Khaidir; Mimiek Murrukmihadi; Aris Perdana Kusuma
Jurnal Ilmiah Farmasi Vol. 11 No. 1 (2015): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

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Abstract

Ipomoea aquatica F. are plant that has a hypoglycemic effect. Ipomoea aquatica F. was  formulated into tablet dosage forms to produce benefits in terms of practicality and accuracy of therapeutic doses.Disintegrant has effect to release the active substance rate of the tablet so that drug effects can be felt by patients with diabetic immediatly. The purpose of this study was to determine disintegration time of Ipomoea aquatica F. extract tablets with various levels of amilum manihot and determine the best concentration of amilum manihot based on the evaluation of physical properties of tablets.Ipomoea aquatica F. extracts was obtained from the maceration using 96% ethanol, than concentrated by rotary evaporator. The extracts were tested qualitatively by TLC with petroleum eter: aceton: dietil amin mobile phase (10:4:1), the phase silica gel F254 with Rf value about 0,625.  Tablets were formulated with amilum manihot concentration variation of 10%, 15% and 20% by wet granulation method. Physical properties of granules were tested such as powder flow, angle of repose, porosity and compressibility index.Tablets were tested to know physical properties such as weight uniformity, sizeuniformity, hardness, friability and disintegration time.The results showed that variaton levels of amilum manihot decrease disintegration time. Variation of amilum manihot was affected in disintegration time, and the optimumt formula with was achieved by 15% amilum manihot. 
KARAKTERISASI FISIKOKIMIA DAN LAJU DISOLUSI DISPERSI PADAT IBUPROFEN DENGAN PEMBAWA POLIETILENGLIKOL 6000 Erizal Zaini; Rahmi Nofita; Salman Salman; Ima Kurniati
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

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ABSTRACTSolid dispersions of the antiinflamation drug ibuprofen and polyethylene glycol 6000 (PEG6000) were prepared by the melting method in order to increase the dissolution rates of this poorlywater-soluble compound. The temperature/composition phase diagram of binary system wasanalyzed by termal analysis hot-stage microscopy, showing an eutectic formation. Polarized lighthot stage microscopy and X-ray-powder diffraction confirmed, that solid dispersion techniquedecrease the crystalliny of ibuprofen after melting and solidifying of a 4/6 (w/w) mixture of ibuprofenand polyethylene glycol 6000 respectively, which the results enhanced dissolution rates comparedto the physical mixtures and ibuprofen intact. However, no such chemical interactions in the solidstate were confirmed by FTIR spectra which showed the presence of ibuprofen crystalline in soliddispersion.Keywords: solid dispersions, ibuprofen, polyethylene glycol 6000
SEL LEMAK DAN PERANANNYA DALAM PENYAKIT Ika Fidianingsih
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

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ABSTRACTIt is well know that adipose tissue mass increase greatly in obesity. In Indonesia obesityprevalence tends to increase. It raised the risk of morbidity and total cost attributable to obesityrelated disease. The adipose tissue is energy storage, fatty acids being released when fuel isrequired. It is now adipose tissue expresses and secretes factors with impotant endicrine functions.These factor include adiponectin, adipsin, leptin, protein of the renin-angiotensin system,plasminogen activator-1, other cytokines and resistin. A better understanding of the endocrinefunction of adipose tissue will give evidence of links between increased productios of someadipocyte factors and the metabolic and cardiovascular complications of obesity.Key words: adipose tissue, obesity, endocrine organ
ISOLATION AND IDENTIFICATION OF FLAVONOIDS FROM WATER FRACTION OF SECANG WOOD (Caesalpinia sappan. L) WITH THIN LAYER CHROMATOGRAPHY AND UV-VIS SPECTROPHOTOMETRY METHODS Lolyta Fournia Sari; Suparmi Suparmi; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTAim of this research was to determine chemical structure of flavonoid from water fraction ofSappan wood. The flavonoid was isolated by Soxhlet xtraction using methanol and infundation.First, the detection of flavonoid was done using Thin Layer Chromatography (TLC) with statioramphase silica gel GF 254 and mobile phase ethyl acetate : acetyc acid 15 % (9:1 v/v) smoked byNH3, and detected under UV 366 nm, showed 5 spots with hRf 7, 50, 61, 68, and 80. PreparatifTLC was done to water fraction, disolveed in methanol and detected with UV-Visspectrophotometry using diagnostic reagents NaOH, NaOAc, NaOAc+H3BO3, AlCl3, ACl3+HCl andcompared with references. In fraction 1, 2, and 5 showed isoflavon with 7-OH, substitution oxygenin position six. In fraction 3 showed isoflavon with 7-OH, substitution oxygen in position six, 6,7diOH in A ring, and o-diOH in 6,7 or 7,8. In fraction 4 showed isoflavon with 7-OH, substitutionoxygen in 6, o-diOH in 6,7 or 7,8 and 5-OH.Key Words: Caesalpinia Sappan. L, Flavonoid, TLC, UV-Vis Spectrophotometry
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL KULIT BUAH RAMBUTAN (Nephelium lappaceum L. ) TERHADAP PENANGKAPAN RADIKAL BEBAS DPPH Hady Anshory; Suparmi Suparmi; Arif Setiadi Tamimy
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTRambutan fruits are consumed by people for additional food and medical use. Pericarp oframbutan has been known to have some active compounds such as flavonoid. Many flavonoidsfrom plants are known to have anti radical activity effect or antioxidant. It is very interest todetermine of antioxidant activity from ethanol extract of rambutan pericarp (Nephelium lappaceumL.). Antioxidant activity was carried out spectrophotometry by using DPPH (2,2-diphenyl-1-picrylhydrazyl) as a reagent. The extract and vitamin E (-tocoferol) concentration was made 2, 3,4, 5, and 6 g/ml. The increasing concentration of extract and vitamin E has caused the scavengingof free radical DPPH. The amount of free radical scavenging DPPH was calculated based on itsabsorbance, measured at  521 nm. The result showed that anti radical activity of ethanolic extractof rambutan pericarp (EC50 = 1,62 g/ml) is higher than that of vitamin E (EC50 = 2,91 g/ml).Keywords : Rambutan, antioxidant, free radical DPPH
PENGEMBANGAN DAN VALIDASI METODE ANALISIS RIFAMPICIN ISONIAZID-PIRAZINAMID DALAM FIXED DOSE COMBINATION DENGAN METODE KROMATOGRAFI LAPIS TIPIS-DENSITOMETRI Muhammad Hatta Prabowo; Ari Wibowo; Laily Fauziyah
Jurnal Ilmiah Farmasi Vol. 9 No. 2 (2012): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol9.iss2.art4

Abstract

Rifampicin, isoniazid (INH) dan pirazinamid merupakan Obat Anti Tuberkulosis (OAT) yang tersedia dalam bentuk Fixed Dose Combination (FDC). Sediaan FDC ini lebih praktis dalam penggunaannya sehingga dapat meningkatkan kepatuhan pasien Tuberkulosis (TB) dalam mengkonsumsi obat. Namun pada beberapa penelitian masih ditemukan FDC yang subdosis yang dapat mengakibatkan pengobatan TB menjadi kurang optimal dan meningkatnya risiko resistensi OAT. Tujuan penelitian ini adalah mengembangkan metode analisis baru yaitu Kromatografi Lapis Tipis (KLT)-Densitometri yang memiliki validitas baik sehingga dapat menjadi alternatif metode analisis yang lebih mudah, cepat, murah dan praktis. Validasi metode yang dilakukan meliputi pengukuran linieritas, presisi, akurasi, batas deteksi dan batas kuantitasi. Parameter hasil validasi metode dibandingkan dengan persyaratan yang ada di Association of Official Analytical Chemist (AOAC) dan United States Pharmacopeia (USP) untuk penetapan kadar FDC. Sampel FDC yang mengandung rifampicin, INH dan pirazinamid dapat dipisahkan dengan fase gerak berupa n-heksan: 2-propanol: aseton: amonia: asam format dengan perbandingan 3:3,6:3:0,3:0,1 (v/v/v/v) dan nilai Rf yang diperoleh untuk rifampicin adalah 0,85, INH 0,6 dan pirazinamid 0,7. Hasil penelitian menunjukkan bahwa metode KLT-Densitometri dapat dikembangkan dan semua parameter validasinya memenuhi persyaratan AOAC. Hasil koefisien korelasi (r) rifampicin 0,999, INH 0,999 dan pirazinamida 0,999, perolehan kembali rifampicin 101,00 %, INH 94,36 % dan pirazinamid 95,69 %; nilai % RSD presisi rifampicin 0,55 %, INH 0,96 %, dan pirazinamid 0,98 %; nilai batas deteksi rifampicin 10,91 ppm, INH 10,38 ppm dan pirazinamid 42,14 ppm; nilai batas kuantitasi rifampicin 33,07 ppm, INH 31,45 ppm dan pirazinamid 127,7 ppm. Kadar terukur (mg) rifampicin, INH, dan pirazinamid per tablet adalah 157,37 mg, 75,26 mg dan 400,79 mg yang berarti sesuai dengan standar yang ditetapkan oleh USP.Kata kunci: KLT-Densitometri, rifampicin-INH-pirazinamid, validasiABSTRACTRifampicin, isoniazid (INH) and pyrazinamide are anti tuberculosis drugs (ATD) available in fixed dose combination (FDC) form. The FDC is more practical in usage so can improve tuberculosis patient obedience in consuming the drug. However, in some researches, there are still found subdose of FDC. Subdose of FDC that effected in less optimal TB medication and increase risk of ATD resistance. The high TB case in developing countries such as Indonesia require test of FDC drug dose evaluation. Objective of this research was to develop new analytical method, Thin Layer Chromatography (TLC)-densitometry having good validity so it may be easier, faster, cheaper and more practical analytical method alternative. Validation parameters consist of linearity, precision, accuracy, Limit Of Detection (LOD), and Limit Of Quantitation (LOQ). Parameter of method validation results was compared with requirement in Association of Official Analytical Chemist (AOAC) and United States pharmacopeia (USP) for determine active ingredient in sample. FDC sample containing rifampicin, INH and pyrazinamide can be separated with n-hexane: 2-propanol: acetone: ammonia: formic acid with proportion of 3:3.6:3:0.3:0.1 (v/vv/v) as mobile phase and Rf value for rifampicin, INH, and pyrazinamide were 0.85, 0.6, and 0.7, respectively. The results indicated that TLC-densitometry can be developed and all validation parameters complied with AOAC requirements. The correlation coefficient (r) of rifampicin 0.999, INH 0.999 and pyrazinamide 0.999; recovery of rifampicin, INH and pyrazinamide were 101.00 %, 94.36 % and 95.69 %, respectively. In addition, precision, % RSD for rifampicin, INH and pyrazinamide were 0.55 %, 0.96 %, and 0.98 % respectively; LOD for rifampicin, INH and pyrazinamide were 10.91 ppm, 10.38 ppm and 42.14 ppm, respectively; LOQ for rifampicin, INH and pyrazinamide were 33.07 ppm, 31.45 ppm and 127.7 ppm, respectively. Concentration of rifampicin, INH and pyrazinamide in a tablet were 157.37 mg, 75.26 mg and 400.79 mg that comply with USP standard.Keywords: rifampicin-isoniazid-pyrazinamide, TLC-densitometry, validation

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