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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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Green synthesis and antibacterial potential of Artemisia vulgaris extract in silver nanoparticles against wound bacteria Laura Soon; Phui Qi Ng; Jestin Chellian; Thiagarajan Madheswaran; Jithendra Panneerselvam; Alan Hsu; Philip Michael Hansbro; Kamal Dua; Trudi Collet; Dinesh Kumar Chellappan
Jurnal Ilmiah Farmasi Vol. 16 No. 1 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss1.art2

Abstract

 Abstract  Background: Artemisia vulgaris (A. vulgaris), a well-known Chinese traditional herb, is a potential agent for wound healing. The herb is reported for its antibacterial properties and is commonly used to control bleeding in women. In our project, we have developed A. vulgaris in silver nanoparticles to enhance its effect. Silver is already used in marketed wound bandages for its antibacterial effect. Understanding that it has a huge potential to be a safe and effective treatment for wounds, this study investigated the antibacterial effects of the synthesised AgNP on common wound bacteria.Objective: The objectives of this study are to synthesise A. vulgaris in silver nanoparticles and investigate the anti-bacterial effect of on wound bacteria. Method: The AgNP was synthesised by green synthesis method, which is done by mixing the silver nitrate solution with different concentrations of A. vulgaris extracts. The disc diffusion test, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests were carried out to investigate the antibacterial effects of the AgNP on common wound bacteria including K. pneumonia, P. aeruginosa, E. coli, B. cereus, S. aureus, and two strains of MRSA. The AgNP was also tested on probiotics using the disc diffusion test to investigate its effect on the probiotics.Results: The AgNP containing all plant concentrations were able to inhibit the growth of gram negative and gram positive bacteria. However, it required a higher concentration to inhibit the gram positive bacteria. The plant extracts and silver nanoparticles enhance each other’s effect to inhibit the growth of bacteria. Nanoparticles containing the A. vulgaris extracts have less inhibitory effects on probiotics compared to antibiotics and silver nitrate alone. However, statistical analysis showed that the antibacterial effect of the treatment was not statistically significant.Conclusion: The AgNP demonstrated anti-bacterial effects on both gram positive and gram negative wound bacteria, but the effect of the treatment is not statistically significant.Keywords: Artemisia vulgaris, silver nanoparticles, antibacterial, wound bacteria 
Acute toxicity study of Andrographis paniculata (Burm.f) Ness herbs and Gynura procumbens (Merr) leaves extracts combination Kurnia Rahayu Purnomo Sari; Nofran Putra Pratama; Nadia Husna
Jurnal Ilmiah Farmasi Vol. 16 No. 1 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss1.art5

Abstract

AbstractBackground: Development of medical plants as an alternative treatment needs support in terms of scientific evidence to increase public confidence to ensure the safety of its use. Recent research on Andrographis paniculata (Burm. f) Ness and Gynura procumbens (Lour.) Merr showed that the combination of these extracts has a potential to be developed into antihyperglycemic agent and there’s no any potential toxicity for each extract.Objective: The aim of this study was to evaluate the acute toxicity level of these two extracts combination. From this research, it is expected that information can be obtained regarding the safety of extracts to support the further development of the extract combination.  Method: The method that used in this research is based on OECD 423. Observation was intensively done to animal behavior 4 h after acute exposure and continued up to 14 days after acute exposure to evaluate whether there were animal died. After the 15 days, all the animals were sacrificed and the vital organ was isolated for histological study.Results: The results showed that the exposure of these combination didn’t caused any to toxicity symptoms and there’s no animals died. Histological study on hepar showed that there’s no mayor damage in the hepar even after exposure of 2000 mg/kgBW dose.Conclusion: The combination of ethanol extract of A. paniculata herbs and G. procumbens leaves was categorized as unclassified (>2000 mg/kgBW) in term of toxicity levels based on Globally Harmonized Classification System.Keywords: Andrographis paniculata (Burm.f) Ness, Gynura procumbens (Lour.) Merr, acute toxicityIntisariLatar belakang: Pengembangan tanaman obat sebagai alternatif pengobatan perlu dukungan dari segi scientific evidence untuk meningkatkan kepercayaan masyarakat dan menjamin keamanan penggunaannya. Penelitian terbaru tentang sambiloto dan sambung nyawa menunjukkan bahwa kombinasi ekstrak tersebut berpotensi untuk dikembangkan menjadi agen antihiperglikemia dan dibutuhkan pemastian keamanannya.Tujuan: Penelitian bertujuan untuk mengevaluasi potensi ketoksikan secara akut kombinasi ekstrak larut etanol herba sambiloto dan daun sambung nyawa.Metode: Metode yang digunakan pada penelitian ini mengacu pada panduan OECD 423. Pengamatan yang dilakukan termasuk pada tingkah laku hewan uji tikus betina galur Wistar berjumlah 15 ekor, secara intensif terhadap gejala toksisitas selama 4 jam awal setelah paparan sediaan uji kemudian dilanjutkan hingga 14 hari pasca paparan untuk melihat ada/tidaknya hewan uji yang mati. Pada hari ke-15, seluruh hewan uji dikorbankan dan dibedah untuk diisolasi, ditimbang organ vitalnya dan dilakukan pengamatan histologi. Hasil: Hasil penelitian menunjukkan bahwa kombinasi ekstrak tersebut tidak menyebabkan gejala toksik terhadap hewan uji dan tidak ada satupun hewan uji yang mati. Hasil histopatologi organ hepar menunjukkan bahwa kombinasi ekstrak ini tidak menunjukkan efek berbahaya pada organ hepar hewan uji yang telah diberi paparan akut dengan dosis 2000 mg/kgBB. Kesimpulan: Ketoksikan kombinasi ekstrak larut etanol herba sambiloto dan daun sambung nyawa masuk dalam kategori unclassified (>2000mg/kgBB) menurut Globally Harmonized Classification System.Kata kunci : Andrographis paniculata (Burm.f) Ness, Gynura procumbens (Lour.) Merr, toksisitas akut 
ANALISIS LOG LINEAR TERHADAP FAKTOR-FAKTOR RESIKO CARCINOMA SERVIX UTERI DI RS BETHESDA YOGYAKARTA TAHUN 2002-2004 Edy Wibowo; Ade Yayu Ratna Inten
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTThis research was done at Yogyakarta Bethesda hospital Jend. Sudirman, as a mean to knowthe association among risk factors at disease of Carcinoma servix uteri. This study used secondarydata from medical records and conducted with retrospektif method. The subjects in this researchwere patient of Carcinoma servix uteri at Bethesda hospital from 2002-2004. From the medicalrecords, researcher used three variables, they were age of patient, children amount and age whenthe patient first married. Statistical analysis that used was Log Linear analysis with BackwardElimination method with level of signifikansi equal to 0.15. From the analysis result can beconcluded that there were interaction between children amount, age of patient and age when thepatient first married to the prevalence of carcinoma servix uteri. The woman with children amountmore than 5 people, above age 50 year and also age of first married less than 20 year will have thehighest possibility to have carcinoma servix uteri.Key words : carcinoma servix uteri, risk factor and log linear analysis.
KAITAN PENGGUNAAN OBAT ANALGETIK DAN ANTI INFLAMASI NON STEROID DENGAN KEJADIAN GAGAL GINJAL KRONIK PADA PASIEN HEMODIALISIS DI RSU PKU MUHAMMADYAH YOGYAKARTA Woro Supadmi; Lukman Hakim
Jurnal Ilmiah Farmasi Vol. 9 No. 2 (2012): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol9.iss2.art2

Abstract

Gagal ginjal kronik merupakan masalah kesehatan, sosial dan ekonomi dengan peningkatan insidensi, prevalensi dan morbiditas. Penelitian ini bertujuan untuk mengetahui apakah ada kaitan dan nilai odds ratio antara penggunaan analgetik dan OAINS dengan kejadian GGK di RSU PKU Muhammadiyah Yogyakarta. Penelitian ini menggunakan rancangan case control, kelompok kasus adalah pasien gagal ginjal kronik yang melakukan hemodialisa dan kelompok kontrol adalah pasien yang melakukan rawat inap tidak terdiagnosa GGK. Data sekunder diperoleh dari rekam medik pasien, data primer diperoleh melalui wawancara mendalam dengan panduan lembar pertanyaan. Data dianalisis dengan tabel 2x2 chi-square. Hasil penelitian menunjukkan bahwa penggunaan analgetik tidak berkaitan dengan kejadian GGK (OR 0,1;p>0,05;CI 0,018-0,366). Penggunaan OAINS berkaitan dengan kejadian GGK (OR 4,4; p<0,05;CI 0,906-21,97). Penggunaan analgetik dan OAINS berkaitan dengan kejadian GGK (OR 5,1;p<0,05;CI 1,057-24,78). Lama penggunaan analgetik tidak berkaitan dengan kejadian GGK (OR 1,4;p>0,05;CI 0,307-5,94), jumlah tablet penggunaan analgetik berkaitan dengan kejadian GGK (OR 23;p<0,05;CI 3,981-131). Lama penggunaan OAINS tidak berkaitan dengan kejadian GGK (OR 0,4;p>0,05;CI 0,018-7,29), jumlah tablet penggunaan OAINS berkaitan dengan kejadian GGK (OR 12;p<0,05;CI 0,936-153). Lama penggunaan analgetik dan OAINS tidak berkaitan dengan kejadian GGK (OR 0,6;p>0,05;CI 0,036-6,9), jumlah tablet penggunaan analgetik dan OAINS tidak berkaitan dengan kejadian GGK (OR 1,1;p>0,05;CI 0,138-7,934).Kata kunci : analgetik, faktor risiko, GGK (Gagal Ginjal Kronik), OAINSABSTRACTChronic renal failure is a matter of health, social and economi with increasing incidence, prevalence and morbidity. This study was aimed to observe assosiation between the used of analgesics and NSAIDs and calculate odds ratio of chronic renal failure incidence at PKU Muhammadiyah Hospital in Yogyakarta. The study used analytical observation with case control desingn,group of case cosisted as chronic renal failure patients who do hemodialysis and group of control who are not diagnosed with chronic renal failure. Secondary data were obtained from patient’s medical records, the primary data were obtained through indepth interview by guided questionnaire. Data analysis was using the 2x2 table and analyzed with chi square test to find out the correlation and the odds ratio between the use of analgesics and NSAIDs of chronic renal failure incidance. The used of analgesics not assosiation of chronic renal failure incidence (OR 0.1;p>0.05;CI 0.018 to 0,366). The used of NSAIDs assosiation of chronic renal failure incidence (OR 4.4;p< 0,05;CI 0.906 to 21.97). The used of analgesics and NSAID assosiation of chronic renal failure incidence (OR 5.1;p<0.05;CI 1.057 to 24.78). Duration of the used of analgesics not assosiation of renal failure incidence (OR 1.4;p>0.05;CI 0.307 to 5.94), the used total tablets analgesics correlation of chronic renal failure incidence (OR 23;p<0.05;CI 3.981 to 131). Duration of the used of NSAIDs was not assosiation of chronic renal failure incidence (OR 0.4;p>0.05;CI 0.018 to 7.29), number of totals tablets NSAIDs assosiation of chronic renal failure incidence (OR 12;p<0.05;CI 0.936 to 153). Duration of the used of analgesics and NSAIDs were not assosiation of chronic renal failure incidence (OR 0.6;p>0.05;CI 0.036 to 6.9), number of totals tablets to the used of analgesics and NSAIDs were not assosiation of chronic renal failure incidence (OR 1.1;p>0.05;CI 0.138 to 7.934).Keywords: analgesics, chronic renal failure, NSAIDs, risk factors
AKTIVITAS ANTIOKSIDAN CENDAWAN SUKU PLEUROTACEAE DAN POLYPORACEAE DARI HUTAN UI Abdul Mun’im; Azizahwati Azizahwati; Trastiana Trastiana
Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2008)
Publisher : Universitas Islam Indonesia

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ABSTRACTSix mushrooms, Lentinus sajor-caju, Lentinus sp, Panellus sp. Polyporusgrammocephalus, Polyporus cf floccipes and Pseudopiptoporus sp (Pleurotaceae andPolyporaceae Family) were used to study antioxidant properties. Ethanolic extract of themushrooms showed scavengging ability on 1,1-diphenyl-2-picrylhydrazil (DPPH) radical. In thethyociante method, there is no significant inhibition of lipid peroxidation activities between samplesand positive controls. Phytochemical identification on ethanolic extract of Pseudopiptoporus spshowed that terpenes were the major component. This finding suggested that terpenes areresposible for antioxidant activity.Keywords: Antioxidant activity, DPPH, Pleurotaceae, Polycarpaceae, Thiocyanate method
EVALUASI POTENSI PELESTARIAN TUNAS HASIL KULTUR IN VITRO DARI TANAMAN OBAT CEPLUKAN (Physalis angulata,L.) Saepudin Saepudin
Jurnal Ilmiah Farmasi Vol. 1 No. 2 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTA tissue culture and plant generation for the ceplukan, Physalis angulata, L has beendeveloped. Callus were efficiently induced on Murashige and Skoog (MS) medium supplementedwith 0,1 ppm indole-3-acetic acid (IAA) and variation of 1, 2, 3, 4, and 5 ppm benzyladenine (BA).The regenerable callus differentiated into shoots. Phytochemical containing of the shoots weredetected and compared with the origin plant using Thin Layer Chromatography (TLC). Flavonoidwas showed by bright blue spot under UV 366 nm and became yellow after smoked by NH3 withHRf 43 and 69. Saponin was showed by yellow spot with HRf 18 and purple spot with HRf 45 aftersprayed by anisaldehyde-sulfuric acid. HRf of the shoots from culture and origin plant were thesame, showed that shoots contains the same phytochemical as the origin plant.Keyword: shoots, tissue culture, restoration, flavonoid, saponin
ANALISIS KINERJA INSTALASI FARMASIRUMAH SAKIT X PURWOKERTODITINJAU DARI PERSPEKTIF CUSTOMER BALANCED SCORECARD “KETERJARINGAN PASIEN” Fithria Dyah Ayu Suryanegara; Satibi Satibi; Achmad Fudholi
Jurnal Ilmiah Farmasi Vol. 10 No. 1 (2013): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol10.iss1.art4

Abstract

IFRS X Purwokerto merupakan salah satu rumah sakit pemerintah sebagai pelayanan publik. Pengelolaan keuangan IFRS X Purwokerto dikelola dengan sistem Badan Layanan Umum. Persentase pasien memiliki dampak terhadap pendapatan rumah sakit. Persentase pasien adalah salah satu pengukuran perspektif pelanggan pada metode balanced scorecard. Desain penelitian yang digunakan adalah studi kasus deskriptif. Data kuantitatif diperoleh dari dokumen penerimaan rawat jalan pada Desember 2008, dan dari data administrasi rumah sakit. Data kualitatif diperoleh dari wawancara dengan Kepala Departemen Farmasi Rumah Sakit X Purwokerto. Data kuantitatif dianalisis sebagai rata-rata persentase pasien yang dihadapi, dan data kualitatif adalah deskriptif analisis. Hasil menunjukkan rata-rata persentase pasien yang ditemui pada pasien rawat jalan IFRS X Purwokerto adalah 71,84%. Kepala Departemen Farmasi Rumah Sakit X Purwokerto mengatakan untuk mengoptimalkan persentase pasien perlu kerjasama semua segmen, dari stakehoulders (direktur dewan rumah sakit X Purwokerto dan pemerintah), dan perbaikan terus-menerus dari proses internal IFRS X Purwokerto.
Uji Kepekaan Bakteri Escherichia Coli Hasil Isolasi Dari Urin Pasien Rumah Sakit Dr. Sardjito Terhadap Antibiotik Golongan P-Laktam Sri Harnanik; Sri Mulyaningsih; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 2 No. 1 (2005)
Publisher : Universitas Islam Indonesia

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Uncontrolled use of antibiotic caused the emergence of bacteria strain resistant toward of antibiotic. The sensitivity assay of E. coli toward p-lactam antibiotic has been done. The sensitivity assay was started with isolated bacteria from patients urine at Dr. Sardjito hospital followed by count total of colony/number of germ which growth and identified the bacteria. The Kirby Bauer method was performed. Antibiotic impregnated disk (ampicillin 30 ng, sulbactam/ampicillin 20 ng, cefotaxim 30 ng, ceftazidime 30 jig, ceftriaxon 30 ng, cefpirom 30 ng, cefepim 30 ng and imipenem 10 ng) were placed on agar plate previously streaked with suspension of E. coli (1.10 CFU/ml). The plates were incubated for 18-24 hours at 37° C. The diameters of the zone inhibition were measured, and compared to standar interpretive zone sizes. The result of the study showed that all of E. coli resistant toward antibiotic ampicillin; 65% resistant toward antibiotic sulbactam/ampicillin; 50% still sensitive toward antibiotic third cefalosporin generation that is cefotaxim, ceftazidime, ceftriaxon; more than 50% sensitive toward fourth cefalosporin generation like cefepim, cefpirom and all of pathogen bacteria E. coli sensitive toward antibiotic imipenem.
EVALUASI PENGGUNAAN ANTIBIOTIKA PROFILAKSIS DARI ASPEK KETEPATAN JENIS, WAKTU DAN DURASI PEMBERIAN PADA PASIEN INSTALASI BEDAH SENTRAL SEBUAH RUMAH SAKIT SWASTA DI YOGYAKARTA Dimas Adhi Pradana; Iwan Dwiprahasto; Satibi Satibi
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

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ABSTRACTSurgical site infection is one of surgical infection that frequently happened in hospital sothat the use of antibiotic prophylaxis must be safe. The research was conducted to know incidenceof adverse event at usage of antibiotic prophylaxis in surgery installation. We use concordancesheet of antibiotic prophylaxis either from accuracy aspect of the drug type, administration time,duration of usage. Result analysis in the form of calculation relative risk of usage of antibioticdissected pre prophylaxis to risk the happening of surgical site infections cases. Result thisresearch show that relative risk value of usage of antibiotic to case of infection of operation hurtevaluated from inaccurate of type antibiotic 1,12 ( CI 95 %: 0,138-9,1), inaccurate aspect of gift time5,8 ( CI 95 % : 1,024 - 32,86) and from inaccurate aspect of duration of gift 3,21 ( CI 95 % : 1,043 -9,9).Keywords: antibiotic prophylaxis, surgical site infections, relatives risk
PERBANDINGAN EFEKTIVITAS TRAGAKAN DAN PVP SEBAGAI PENGIKAT TERHADAP SIFAT FISIK TABLET HISAP EKSTRAK JAHE (Zingiber officinale Roxb.) Wintari Taurina; Melinda Dewi M; Yandi Syukri; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 2 No. 2 (2005)
Publisher : Universitas Islam Indonesia

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ABSTRACTGinger (Zingiber Officinale Roxb) is a traditional plants usually used to relieve pain, rheumatism,and neutralize poison. The aim of this study was to get the optimum concentration of tragacanthand PVP as a binding agent in ginger lozenges formulation. The components from ginger wereextracted using percolation with ethanol 70% and then evaporated using rotary evaporator.Lozenges were made in three formulas ; formula 1 (5%), 2 (7,5%), 3 (10%) of tragacanth and PVPusing wet granulation method. Granules and tablets were tested for its physical properties, andanalyzed using Pearson correlation. The result showed that, all of three formulas were good,comply with a regulation of physical properties and disolution time in the mouth. Variation oftragacanth and PVP concentration affected physical properties of tablets. It showed that the greaterconcentration of tragacanth and PVP, the larger the hardness and the longer the disolution time oftablets. The third formula (tragacanth 10% b/v) gave an optimum physical properties and solubletime of tablets, with weight variety deviation 0,98%, hardness 10,18 kg, friability 0.11% anddisolution time 11.50 minutes. The three formulas were received by respondens withprerequirement of improving sweetness, repairing form and the color of tablets.Key words :Ginger lozenges, tragacanth, PVP, wet granulation method.

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